Annual Report of the Municipal Officers of the Town of Lubec, Maine For the Year Ending March 1, 1913

\u3cp\u3eDesigners are frequently challenged by complex projects in which the problem space is unique, rapidly changing, and the information available is limited. In such cases, combining knowledge from different fields of expertise is required. Furthermore, collaboration during the design process is essential for achieving a meaningful and well-formed solution. Designers therefore regularly find themselves exchanging ideas and reflections in the form of emails, sketches, and images with a group of experts from different backgrounds, working altogether through the creation of a design, its development and proper implementation. This particular chapter focuses especially on issues of synchronous and asynchronous collaboration, team dynamics and the management and monitoring of the early stages of the design process. The overall aim is to identify the essential characteristics and needs of distributed teams when in remote collaboration during the early stages of the design process and to suggest a prototype environment based on the identified requirements and workflow.\u3c/p\u3

Píldoras formativas para mejorar la educación enfermera sobre programación temprana

Introducción: La obesidad infantil ha sido declarada la epidemia del siglo XXI. La programación temprana es un elemento esencial que debe utilizarse para prevenir enfermedades no transmisibles. Las enfermeras están en una posición única para aplicar este concepto, pero no está incluido en su educación. Objetivos: El desarrollo, implementación y evaluación del uso de píldoras educativas que se ofrecen a los estudiantes de enfermería para mejorar su conocimiento sobre la programación temprana. Metodología: Se trata de una investigación cuasi-experimental. Es un estudio pre/post con seguimiento longitudinal. Para la recolección de datos, se diseñaron tres cuestionarios de desarrollo propio para medir el nivel de conocimiento, la intención de actuar y la satisfacción con la metodología. El nivel de conocimiento y la intención de actuar se midieron antes y después de la intervención para ver el efecto de la intervención. Se midió la satisfacción con la metodología y los recursos utilizados después de la intervención. La población incluida en este estudio son los estudiantes de enfermería de primer y segundo año matriculados en dos asignaturas diferentes en el curso 2019/2020. Se estima que el tamaño de la población es de 200 estudiantes. Se ha organizado el proceso en tres etapas definidas: etapa inicial, etapa de elaboración y etapa de implementación. Resultados: Se han observado diferencias significativas en todos los parámetros medidos. Conclusiones: La intervención ha mejorado el conocimiento de las futuras enfermeras sobre la programación temprana, ha aumentado la intención de actuar y los estudiantes encuentran esta metodología adecuada para su formación

High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients

Background & aims Coronavirus disease 2019 (COVID-19) patients with severe complications have shown comorbidities with cardiovascular-disease, hypertension and type 2 diabetes mellitus; clinical disorders that share the common metabolic alterations of insulin resistance and dyslipidaemia. A high triglyceride to high density lipoprotein cholesterol (Tg/HDL c) ratio has been associated with reduced insulin sensitivity, metabolic syndrome and adverse cardiovascular events. Our aim in this study was to determine the association between different components of the lipid profile and particularly the Tg/HDL c ratio with severe complications like the requirement of invasive mechanical ventilation in COVID-19 patients. Methods We collected demographic, clinical and biochemical data to conduct a cohort study in 43 adult patients with confirmed COVID-19 diagnosis by quantitative polymerase chain reaction (qPCR) at baseline and in the subsequent 15 days. Patients were subjected to a very similar treatment scheme with the JAK1/2 inhibitor ruxolitinib. Descriptive statistics, variable association and logistic regression were applied to identify predictors of disease severity among elements and calculations from the lipid profile. Results Patients were aged 57 ± 14 years; 55.8% were male from which 75% required hospitalization and 44.2% were female who 58% were hospitalized. The most common comorbidities were type 2 diabetes mellitus (58%) and hypertension (40%). Hospitalized and critical care patients showed lower HDL c blood levels and increased Tg/HDL c ratio than those with outpatient management and mild/asymptomatic COVID-19. Tg/HDL c ratio correlated with variables of disease severity such as lactate dehydrogenase (LDH) levels (r = 0.356; p < 0.05); National Early Warning Score 2 (NEWS 2) (r = 0.495; p < 0.01); quick sequential organ failure assessment (qSOFA) (r = 0.538; p < 0.001); increased need of oxygen support (r = 0.447; p < 0.01) and requirement of mechanical ventilation (r = 0.378; p < 0.05). Tg/HDL c ratio had a negative correlation with partial oxygen saturation/fraction of inspired oxygen (SaO 2/FiO2) ratio (r = −0.332;p < 0.05). Linear regression analysis showed that Tg/HDL c ratio can predict increases in inflammatory factors like LDH (p < 0.01); ferritin (p < 0.01) and D-dimer (p < 0.001). Logistic regression model indicated that ≥7.45 Tg/HDL c ratio predicts requirement of invasive mechanical ventilation (OR 11.815, CI 1.832–76.186, p < 0.01). Conclusions The Tg/HDLc ratio can be used as an early biochemical marker of COVID-19 severe prognosis with requirement of invasive mechanical ventilation

Conexión inteligente para la gestión turística desde el aula al destino (CIGTAD)

Fac. de Comercio y TurismoFac. de Trabajo SocialFALSEsubmitte

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 11

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 11, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Asynchronous creative collaboration in distributed design teams

Computer-mediated collaboration has changed the work dynamics of creative industries. Designers are currently challenged to collaborate with other individuals who are spread around the globe. Motivated by a concept-driven approach, my work pursues a constructive design research and focuses on how to encourage the worldly creative agency of the designer in an asynchronous and distributed setting. To achieve this goal, I start by framing the designers as selfdetermining agents whose actions and interactions are embedded in a world devised of objects and individuals. Furthermore, I consider that every action and interaction transforms the designers themselves and the world they are interacting with. I strive to develop a framework, in the shape of paradigms, concepts and processes, that expresses the socio-temporal and coordinative perspective of creativity and improves the understanding of remote creative collaboration practices among designers. I believe the doctoral consortium will help me sharpening the focus of my contribution

Método automatizado de identificación y caracterización de unidades de paisaje

Within the framework of a study aimed at classifying the landscape of Huelva province (Andalusia, Spain) using an objective, reproducible and scalable method of identifying and characterising landscape units, we examined the value of this method for the detailed classification of one such landscape unit –designated Campiñas– with a surface area of 1086 km2. The method in question combined tools used in geographical information systems (GIS), multivariate analysis using the TWINSPAN classification (two-way indicator species analysis) and DCA ordination analysis (detrended correspondence analysis). The variables used were land use and plant cover, municipalities, and slope. The results obtained were validated by discriminant analysis and subjected to plot-level debugging. Three different landscape units were identified within the Campiñas type; these were delimited cartographically, and the distinctive diagnostic variables of each unit were identified. Most indicator variables were linked to land use, while the slope variable was of no significant value for differentiation purposes. Graphic ordination analysis revealed landscape-unit characteristics that could not be deduced from TWINSPAN analysis, and were thus supplementary to the information provided by that analysis. The results of discriminant analysis confirmed validation of the classification. The variables used were justified, and the method employed was compared to other automated approaches; classification results were also compared to those obtained from the classification used in the Atlas of the Landscapes of Spain. It was finally concluded that the TWINSPAN method was valuable for detailed landscape classification, for the reasons examined.En el marco de un estudio de clasificación del paisaje de la provincia de Huelva (Andalucía) mediante un método objetivo, reproducible y escalable de identificación y caracterización de unidades de paisaje, se ha planteado la utilidad del método para una clasificación a nivel de detalle de uno de los tipos de paisajes resultantes. El tipo de paisaje seleccionado ha sido el denominado Campiñas, con una extensión de 1086 km2. La metodología utilizada ha combinado herramientas propias de los sistemas de información geográfica (SIG) y el análisis multivariante de clasificación TWINSPAN (análisis de especies indicadoras de doble vía), así como el análisis de ordenación DCA (análisis de correspondencias). Las variables utilizadas han sido: usos y coberturas vegetales del suelo, municipios y pendiente. Los resultados obtenidos han sido sometidos a validación mediante análisis discriminante y a un proceso de depuración a nivel gráfico. Como resultado del estudio se han identificado tres unidades de paisaje dentro del tipo Campiñas, se han delimitado cartográficamente y se han identificado las variables diagnósticas propias de cada una de ellas. La mayoría de las variables indicadoras han sido relativas a los usos del suelo, mientras que la variable de pendiente no ha sido de valor significativo para tal diferenciación. El análisis gráfico de ordenación ha permitido constatar características de las unidades de paisaje no deducibles del TWINSPAN y que complementan la información derivada del mismo. Los resultados del análisis discriminante validan la clasificación realizada. Se justifican las variables utilizadas y se compara la metodología seguida con otros enfoques automatizados, así como los resultados de la clasificación con los obtenidos en la clasificación del Atlas de los Paisajes de España. Por último se concluye la utilidad de la metodología seguida, TWINSPAN, para una clasificación de paisajes a nivel de detalle, analizándose las razones de esta idoneidad