A composable, energy-managed, real-time MPSOC platform.

Multi-processors systems on chip (MPSOC) platforms emerged in embedded systems as hardware solutions to support the continuously increasing functionality and performance demands in this domain. Such a platform has to execute a mix of applications with diverse performance and timing constraints, i.e., real-time or non-real-time, thus different application schedulers should co-exist on an MPSOC. Moreover, applications share many MPSOC resources, thus their timing depends on the arbitration at these resources. Arbitration may create inter-application dependencies, e.g., the timing of a low priority application depends on the timing of all higher priority ones. Application inter-dependencies make the functional and timing verification and the integration process harder. This is especially problematic for real-time applications, for which fulfilling the time-related constraints should be guaranteed by construction. Moreover, energy and power management, commonly employed in embedded systems, make this verification even more difficult. Typically, energy and power management involves scaling the resources operating point, which has a direct impact on the resource performance, thus influences the application time behaviour. Finally, a small change in one application leads to the need to re-verify all other applications, incurring a large effort. Composability is a property meant to ease the verification and integration process. A system is composable if the functionality and the timing behaviour of each application is independent of other applications mapped on the same platform. Composability is achieved by utilising arbiters that ensure applications independence. In this paper we present the concepts behind a composable, scalable, energy-managed MPSOC platform, able to support different real-time and nonreal time schedulers concurrently, and discuss its advantages and limitations

A composable, energy-managed, real-time MPSOC platform

Multi-processors systems on chip (MPSOC) platforms emerged in embedded systems as hardware solutions to support the continuously increasing functionality and performance demands in this domain. Such a platform has to execute a mix of applications with diverse performance and timing constraints, i.e., real-time or non-real-time, thus different application schedulers should co-exist on an MPSOC. Moreover, applications share many MPSOC resources, thus their timing depends on the arbitration at these resources. Arbitration may create inter-application dependencies, e.g., the timing of a low priority application depends on the timing of all higher priority ones. Application inter-dependencies make the functional and timing verification and the integration process harder. This is especially problematic for real-time applications, for which fulfilling the time-related constraints should be guaranteed by construction. Moreover, energy and power management, commonly employed in embedded systems, make this verification even more difficult. Typically, energy and power management involves scaling the resources operating point, which has a direct impact on the resource performance, thus influences the application time behaviour. Finally, a small change in one application leads to the need to re-verify all other applications, incurring a large effort. Composability is a property meant to ease the verification and integration process. A system is composable if the functionality and the timing behaviour of each application is independent of other applications mapped on the same platform. Composability is achieved by utilising arbiters that ensure applications independence. In this paper we present the concepts behind a composable, scalable, energy-managed MPSOC platform, able to support different real-time and nonreal time schedulers concurrently, and discuss its advantages and limitations

The transprecision computing paradigm: Concept, design, and applications

Guaranteed numerical precision of each elementary step in a complex computation has been the mainstay of traditional computing systems for many years. This era, fueled by Moore’s law and the constant exponential improvement in computing efficiency, is at its twilight: from tiny nodes of the Internet-of-Things, to large HPC computing centers, subpicoJoule/operation energy efficiency is essential for practical realizations. To overcome the power wall, a shift from traditional computing paradigms is now mandatory. In this paper we present the driving motivations, roadmap, and expected impact of the European project OPRECOMP. OPRECOMP aims to (i) develop the first complete transprecision computing framework, (ii) apply it to a wide range of hardware platforms, from the sub-milliWatt up to the MegaWatt range, and (iii) demonstrate impact in a wide range of computational domains, spanning IoT, Big Data Analytics, Deep Learning, and HPC simulations. By combining together into a seamless design transprecision advances in devices, circuits, software tools, and algorithms, we expect to achieve major energy efficiency improvements, even when there is no freedom to relax end-to-end application quality of results. Indeed, OPRECOMP aims at demolishing the ultraconservative “precise” computing abstraction, replacing it with a more flexible and efficient one, namely transprecision computing

SARMENTI: Smart multisensor embedded and secure system for soil nutrient and gaseous emission monitoring

Demand for sustainably produced food is driving current strategies for intensification of the agricultural sector worldwide. To meet these challenges farmers will need to adopt a whole-farm approach to resource efficiency. They will increase their productivity with a better application of knowledge per hectare. Optimising soil fertility will enable farmers to maximise their productivity and profitability with higher grass and crop yield and quality

Engineering the fatty acid synthesis pathway in Synechococcus elongatus PCC 7942 improves omega-3 fatty acid production

Background: The microbial production of fatty acids has received great attention in the last few years as feedstock for the production of renewable energy. The main advantage of using cyanobacteria over other organisms is their ability to capture energy from sunlight and to transform CO2 into products of interest by photosynthesis, such as fatty acids. Fatty acid synthesis is a ubiquitous and well-characterized pathway in most bacteria. However, the activity of the enzymes involved in this pathway in cyanobacteria remains poorly explored. Results: To characterize the function of some enzymes involved in the saturated fatty acid synthesis in cyanobacteria, we genetically engineered Synechococcus elongatus PCC 7942 by overexpressing or deleting genes encoding enzymes of the fatty acid synthase system and tested the lipid profile of the mutants. These modifications were in turn used to improve alpha-linolenic acid production in this cyanobacterium. The mutant resulting from fabF overexpression and fadD deletion, combined with the overexpression of desA and desB desaturase genes from Synechococcus sp. PCC 7002, produced the highest levels of this omega-3 fatty acid. Conclusions: The fatty acid composition of S. elongatus PCC 7942 can be significantly modified by genetically engineering the expression of genes coding for the enzymes involved in the first reactions of fatty acid synthesis pathway. Variations in fatty acid composition of S. elongatus PCC 7942 mutants did not follow the pattern observed in Escherichia coli derivatives. Some of these modifications can be used to improve omega-3 fatty acid production. This work provides new insights into the saturated fatty acid synthesis pathway and new strategies that might be used to manipulate the fatty acid content of cyanobacteria.Work in the FDLC laboratory was financed by the Spanish Ministry of Economy and Competitivity (MINECO) Grant BFU2014-55534-C2-1-P. MSM. was recipientof a Ph.D. fellowship (BES-2012-057387) from MINECO

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

Brain microvascular endothelial cells (BEC) constitute the blood-brain barrier (BBB) which forms a dynamic interface between the blood and the central nervous system (CNS). This highly specialized interface restricts paracellular diffusion of fluids and solutes including chemicals, toxins and drugs from entering the brain. In this study we compared the transcriptome profiles of the human immortalized brain endothelial cell line hCMEC/D3 and human primary BEC. We identified transcriptional differences in immune response genes which are directly related to the immortalization procedure of the hCMEC/D3 cells. Interestingly, astrocytic co-culturing reduced cell adhesion and migration molecules in both BECs, which possibly could be related to regulation of immune surveillance of the CNS controlled by astrocytic cells within the neurovascular unit. By matching the transcriptome data from these two cell lines with published transcriptional data from freshly isolated mouse BECs, we discovered striking differences that could explain some of the limitations of using cultured BECs to study BBB properties. Key protein classes such as tight junction proteins, transporters and cell surface receptors show differing expression profiles. For example, the claudin-5, occludin and JAM2 expression is dramatically reduced in the two human BEC lines, which likely explains their low transcellular electric resistance and paracellular leakiness. In addition, the human BEC lines express low levels of unique brain endothelial transporters such as Glut1 and Pgp. Cell surface receptors such as LRP1, RAGE and the insulin receptor that are involved in receptor-mediated transport are also expressed at very low levels. Taken together, these data illustrate that BECs lose their unique protein expression pattern outside of their native environment and display a more generic endothelial cell phenotype. A collection of key genes that seems to be highly regulated by the local surroundings of BEC within the neurovascular unit are presented and discussed

Metabolite ratios as potential biomarkers for type 2 diabetes:a DIRECT study

Aims/hypothesis Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes. Methods We measured the levels of 188 metabolites in plasma samples from 130 healthy members of twin families (from the Netherlands Twin Register) at five time points during a modified 3 h hyperglycaemic clamp with glucose, GLP-1 and arginine stimulation. We validated our results in cohorts with OGTT data (n = 340) and epidemiological case–control studies of prevalent (n = 4925) and incident (n = 4277) diabetes. The data were analysed using regression models with adjustment for potential confounders. Results There were dynamic changes in metabolite levels in response to the different secretagogues. Furthermore, several fasting pairwise metabolite ratios were associated with one or multiple clamp-derived measures of insulin secretion (all p Conclusion/interpretation In this study we have shown that the Val_PC ae C32:2 metabolite ratio is associated with an increased risk of type 2 diabetes and measures of insulin secretion and resistance. The observed effects were stronger than that of the individual metabolites and independent of known risk factors.</p

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p <1 x 10(-4)) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.Peer reviewe