Analisis Peran Kepala Sekolah dalam Meningkatkan Kinerja Guru di SDI CIII Wolomarang

This study aims to describe the role of the principal in improving teacher performance at SDI CIII Wolomarang. The research used is descriptive qualitative. Data collection techniques are carried out through interviews, observations and documentation. The test of the validity of the data used in this study is a study using source triangulation. Miles and Huberman's data analysis techniques start from the stages of data collection, data reduction, data presentation and drawing conclusions. The results of this study show that: the role used by the principal is the role of Educator, Manager, Administrator, Innovator, Motivator, Supervisor, and Leader. This role has an effect in improving teacher performance, although it is not optimal and still needs to be evaluated and the principal continues to improve teacher performance for the advancement of the quality of school education

S. aureus and MRSA nasal carriage in dental students: a comprehensive approach

Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Staphylococcus aureus and MRSA are important clinical pathogens representing a serious public health problem. This study aimed to determine the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) nasal carriage among dental students, identify the factors that influence this carriage, and characterize MRSA. A prevalence of S. aureus and MRSA carriage of 25.2% and 0.86% was estimated, respectively, and SCCmec Type VI, was identified in all isolated MRSA. The low MRSA colonization rate can reflect good infection control practices followed by students.info:eu-repo/semantics/publishedVersio

Caracterização da antibioterapia no idoso

Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizA nível mundial, verifica-se um aumento da população idosa, devido à crescente esperança de vida e à diminuição da taxa de natalidade. Associada à idade avançada, diversas alterações, tanto a nível fisiológico, como psicológico e social ocorrem no idoso. As modificações derivadas do envelhecimento contribuem para o desenvolvimento e aparecimento de comorbilidades, bem como para o aumento do número de medicamentos consumidos. Em virtude destas alterações, o doente geriátrico apresenta-se como um indivíduo complexo. A resposta farmacocinética/farmacodinâmica dos fármacos pode-se encontrar alterada, contribuindo para um risco superior de reações adversas e interações medicamentosas quando comparada com a população mais jovem. Adicionalmente, a necessidade de realizar antibioterapia é superior devido à maior suscetibilidade a infeções nesta faixa etária. A instituição da terapêutica antibiótica no idoso é um processo complexo. O diagnóstico, a presença de múltiplas patologias e diversas medicações, as alterações naturais do envelhecimento e o maior risco de desenvolvimento de resistências são fatores que contribuem para aumentar a dificuldade no processo de decisão. Assim, a gestão da terapêutica antibiótica no idoso deve contemplar inúmeros fatores, baseando-se no perfil individual de cada doente, garantindo a efetividade e a segurança do tratamento, de modo a prevenir futuras complicações.Globally, the elderly population is increasing due to the rising life expectancy and declining birth rates. Associated with advanced age, several changes, both physiological, psychological and social occur in the elderly. Modifications derived from aging contribute to the development of comorbidities, as well as to the increase in the number of drugs consumed. Due to these changes, the geriatric patient is presented as a complex individual. The pharmacokinetic/pharmacodynamic response of drugs may be altered, contributing to a higher risk of adverse reactions and drug interactions compared to the younger population. Additionally, the need for antibiotic therapy is higher due to greater susceptibility to infections in this age group. The institution of antibiotic therapy in the elderly is a challenging process due to the difficulty in diagnosis, the presence of multiple pathologies and polipharmacy, the natural changes in aging and the increased risk of resistance development. Thus, the management of antibiotic therapy in the elderly should consider multiple factors, based on the individual profile of each patient, ensuring the effectiveness and safety of treatment, in order to prevent future complications

A contribuição da alfabetização para o bem-estar da população idosa

Dissertação de mestrado em Psicogerontologia comunitária. Instituto Politécnico de Beja, Escola Superior de Educação, 2014.O presente estudo teve como principal objetivo investigar de que forma a alfabetização pode contribuir para o bem-estar da população idosa. Para tal, foram comparados dois grupos, um alfabetizado e outro não, de ambos os sexos, com idades superiores a 65 anos. Desta forma, optou-se pela amostragem de conveniência. O instrumento utilizado para a recolha de dados foi a entrevista semidirectiva e com os resultados verificados através da análise de conteúdo foi elaborada uma proposta de intervenção. A primeira evidência observada foi a da resignação. Os idosos analfabetos, habituados a uma vida sem letras lidas ou escritas, mostraram conformidade face à sua situação pelo que, através desta investigação, se pretendeu contribuir para a desmistificação desse estado de apatia face à iliteracia na idade idosa e evidenciar o valor da literacia neste período da vida para o bem estar do ser humano

Students' Multirepresentation Ability in Completing Physics Evaluation Problems

This study aims to describe students' multi-representation ability in solving physics evaluation questions carried out by the qualitative description method in class X MIA 1 SMA Katolik St. Gabriel Maumere for the 2019/2020 school year. The data were obtained from the matter of physics evaluation on Newton's law material about the force of gravity. Data analysis is based on student work steps in solving evaluation questions. Data analysis results show that the ability of multi-representation in solving physics problems on Newton's law material about the force of gravity in the high category. The number of mathematical representations of 100%, image representation of 10%, then in the medium type only uses a mathematical description of 100% and in the low category using a mathematical representation of 100% and a verbal representation of 40%

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PENGGUNAAN KONTRASEPSI PADA PASANGAN USIA SUBUR (PUS) DI DESA PENFUI TIMUR WILAYAH KERJA PUSKESMAS TARUS KABUPATEN KUPANG

The low rate of contraceptive use illustrates the failure to implement family planning programs in a region. Coverage of CPR (Contraception Prevalence Rate) in East Penfui Village is 14.2%. The figure is still far from the national target of 66%. The factor that can influence the use of contraception is knowledge, information on health workers and community socio-culture. The purpose of this study was to determine the corelation between knowledge, information on health workers, socio-culture with contraceptive use in the East Penfui village, the working area of Puskesmas Tarus, Central Kupang District, Kupang Regency. This research is a descriptive analytic study with cross sectional method. The sample size was 113 couples of fertile age who were determined by means of multistage random sampling from 5 hamlets in the village of East Penfui, The instrument used was a questionnaire, the results were analyzed using the chi-square test with a 95% confidence level. The results showed, respondents who used contraception 46.9%, respondents with good knowledge were 98.2%, respondents who were exposed to information from health workers were 91.2%, respondents who had socio-cultural support were 83.2%. The conclusion of this study is that there is no corelation between the level of knowledge and the use of contraception (p = 1,000), there is a corelation between information on health workers and the use of contraception (p = 0.002), there is a corelation between socio-culture and the use of contraception (p = 0.012) in the village of East Penfui Region. Tarus Community Health Center, Kupang Regency. The suggestion from this research is the need to communicate behavior change continuously to the public to increase awareness of using contraception.   Keywords: contraception, knowledge, information, socio-cultureRendahnya angka penggunaan kontrasepsi menggambarkan terjadinya kegagalan penerapan program KB di suatu wilayah. Cakupan CPR (Contraception Prevalence Rate) Desa Penfui Timur yaitu sebesar 14,2%. Angka yang masih jauh dari target nasional yaitu 66%. Faktor yang dapat mempengaruhi  penggunaan kontrasepsi yaitu  pengetahuan, informasi petugas kesehatan dan sosial budaya masyarakat. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan, informasi petugas kesehatan, sosial budaya dengan  penggunaan kontrasepsi di desa Pefui Timur wilayah kerja Puskes Tarus Kecamatan Kupang Tengah Kabupaten Kupang. Penelitian ini merupakan penelitian deskriptif  analitik dengan metode  cross sectional. Besar sampel 113 Pasangan Usia Subur yang ditentukan dengan cara Multistage Random Sampling dari 5 Dusun di Desa Penfui Timur, instrument yang digunakan adalah kuesioner, hasil penelitian dianalisa menggunakan Uji chi-square dengan tingkat kepercayaan 95%. Hasil penelitian ini didapatkan, responden yang menggunakan kontrasepsi 46,9%,  responden yang berpengetahuan baik  sebesar 98,2%, responden yang terpapar informasi dari petugas kesehatan sebesar 91,2%, responden yang memiliki sosial budaya mendukung sebesar  83,2%. Kesimpulan dari penelitian ini adalah tidak terdapat hubungan tingkat pengetahuan dengan penggunaan kontasepsi (p = 1.000), terdapat hubungan informasi petugas kesehatan dengan penggunaan kontasepsi (p = 0.002), terdapat hubungan antara sosial budaya dengan penggunaan kontasepsi (p = 0.012) di desa Penfui Timur Wilayah Kerja Puskesmas Tarus Kabupaten Kupang. Saran dari penelitian ini adalah perlunya melakukan komunikasi perubahan perilaku secara terus menerus kepada masyarakat untuk meningkatkan kesadaran menggunakan kontrasepsi.   Kata Kunci: kontrasepsi, pengetahuan, informasi, sosial buday

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and CLN7 diseases and used fluorescent-conjugated bacterial toxins to label Gb3 to develop a cell-based high content imaging (HCI) screening assay for the repurposing of FDA-approved compounds able to reduce this accumulation within BD cells. We found that tamoxifen reduced the lysosomal accumulation of Gb3 in CLN3 and CLN7 cell models, including neuronal progenitor cells (NPCs) from CLN7 patient-derived induced pluripotent stem cells (iPSC). Here, tamoxifen exerts its action through a mechanism that involves activation of the transcription factor EB (TFEB), a master gene of lysosomal function and autophagy. In vivo administration of tamoxifen to the CLN7Δex2 mouse model reduced the accumulation of Gb3 and SCMAS, decreased neuroinflammation, and improved motor coordination. These data strongly suggest that tamoxifen may be a suitable drug to treat some types of Batten disease.This work was funded by the European Union’s Horizon 2020 research and innovation programme (BATCure, grant No. 666918 to DLM, JPB, SEM, TB and SS). JPB is funded by the Agencia Estatal de Investigación (PID2019-105699RB-I00/ AEI / 10.13039/501100011033 and RED2018-102576-T), Plan Nacional sobre Drogas (2020I028), Junta de Castilla y León (Escalera de Excelencia CLU-2017-03), Ayudas Equipos Investigación Biomedicina 2017 Fundación BBVA and Fundación Ramón Areces. SS was funded by a grant from the Mila’s Miracle Foundation. TB was supported by German Research Council (DFG) grant FOR2625. SM benefits from MRC funding to the MRC Laboratory for Molecular Cell Biology University Unit at UCL (award code MC_U12266B) towards laboratory and office space. We acknowledge Marcella Cesana for providing the TFEB virus. Graphical abstract was created using BioRender.com

A role for insulator elements in the regulation of gene expression response to hypoxia

Hypoxia inducible factor (HIF) up-regulates the transcription of a few hundred genes required for the adaptation to hypoxia. This restricted set of targets is in sharp contrast with the widespread distribution of the HIF binding motif throughout the genome. Here, we investigated the transcriptional response of GYS1 and RUVBL2 genes to hypoxia to understand the mechanisms that restrict HIF activity toward specific genes. GYS1 and RUVBL2 genes are encoded by opposite DNA strands and separated by a short intergenic region (~1 kb) that contains a functional hypoxia response element equidistant to both genes. However, hypoxia induced the expression of GYS1 gene only. Analysis of the transcriptional response of chimeric constructs derived from the intergenic region revealed an inhibitory sequence whose deletion allowed RUVBL2 induction by HIF. Enhancer blocking assays, performed in cell culture and transgenic zebrafish, confirmed the existence of an insulator element within this inhibitory region that could explain the differential regulation of GYS1 and RUVBL2 by hypoxia. Hence, in this model, the selective response to HIF is achieved with the aid of insulator elements. This is the first report suggesting a role for insulators in the regulation of differential gene expression in response to environmental signals