Rational synthesis of ternary PtIrNi nanocrystals with enhanced poisoning tolerance for electrochemical ethanol oxidation

The development of highly efficient and durable anode materials for ethanol electro-oxidation remains a challenge. Herein, we report the synthesis of Pt1−x−yIrxNiy nanocrystals via one-step procedure by ultrasonic-assisted co-reduction of the metal precursors using ascorbic acid as a mild reducing agent and pluronic F127 as a structure directing agent. The catalytic performance of this ternary catalyst towards electrochemical oxidation of ethanol was examined and compared to its mono and binary Pt counterparts (Pt, Pt1−xIrx, and Pt1−yNiy) that are synthesized by the same method. TEM analysis showed a porous nanodendritic structure for the synthesized ternary electrocatalyst with an average size of 20 ± 1 nm. The electrochemical measurements revealed an electrochemically active surface area, ECSA, of 73 m2 g−1. The as-synthesized ternary electrocatalyst showed an improved catalytic activity towards ethanol oxidation in 1 M KOH with a measured mass activity of 3.8 A mg−1 which is 1.7, 2.0, and 3.2 times higher than that of Pt1−xIrx, Pt1−yNiy, and Pt, respectively. Additionally, the Pt1−x−yIrxNiy nanocrystals expressed high poisoning tolerance (jf/jb = 4.5) and high durability compared to its mono and binary counterparts.Scopu

Assessment Of The Global Fallout Of Plutonium Isotopes In The Topsoil Of Qatar: Establishing A Baseline Concentrations Of 238pu, 239pu, And 240pu

A radio-analytical technique for determination of plutonium (Pu) isotopes in soil samples is tested against NIST and IAEA standard reference materials to determine its accuracy and precision for reliable results. The technique is then used in the investigation of 132 topsoil samples, collected from the natural environment of Qatar, to assess the effect of global fallout accumulation of these radionuclides in the region. Plutonium was sequentially leached form 1000 g of each soil sample using nitric and hydrochloric acids. The residual fine particles were separated by filtration and centrifuge. The solution was reduced to 1 ml by evaporation in dry oven and measured directly by CRC-ICP-MS/MS without prior chemical separation of Pu. The concentrations of 238Pu in the collected soil samples vary from < 0.026 - 0.058 fg/g (< 0.0160 - 0.0266 Bq/kg) with a mean value of 0.034 fg/g (0.0195 Bq/kg) and a median value of 0.032 fg/g (0.0195 Bq/kg). The concentrations of 239Pu fall in the range 5.67 - 166.09 fg/g (0.014 - 0.381 Bq/kg) with a mean value of 67.33 fg/g (0.154 Bq/kg) and a median value of 63.21 fg/g (0.145 Bq/kg). The concentrations of 240Pu fall in the range 1.48 - 28.21 fg/g (0.013 - 0.240 Bq/kg) with a mean value of 11.46 fg/g (0.098 Bq/kg) and a median value of 10.835 fg/g (0.093 Bq/kg). The isotopic and activity concentrations ratios of 238Pu/239Pu, 240Pu/239Pu, and 238Pu/239+240Pu can be used to identify the source. The main isotope ratios of 238Pu/239Pu in Qatari soils is (3.33 ± 1.02) x 10-4. A reported global and Chernobyl fallouts isotope ratio of 238Pu/239Pu are 1.77 x 10-4 and 4.3 x 10-3, respectively. The main isotope ratio of 240Pu/239Pu in Qatari soils is 0.1749 ± 0.0211. A reported global and Chernobyl fallouts isotope ratios of 240Pu/239Pu are 0.18-0.19 and 0.34-0.57, respectively. The average isotopic and activity ratios of 238Pu/239,240Pu in Qatari soils are (2.856 ± 0.881) x 10-4 and 0.0505 ± 0.0032, respectively. The activity ratio 238Pu/239+240Pu in releases from nuclear fuel reprocessing plants, nuclear tests, weapons grade, and Chernobyl fallout are about 0.25, 0.026, 0.014 and 0.47, respectively. Accordingly, it is difficult to identify the source, but it may be due to the contribution of more than one source. The most probable sources are both Chernobyl fallout of Pu isotopes and several decades of fallout Pu accumulation due to nuclear weapons testing. Novel Aspect New data base was established for the concentration and isotope ratios of Pu isotopes (238Pu, 239Pu, and 240Pu) in Qatar topsoil.qscienc

Stages of change and health-related quality of life among employees of an institution

Background Transtheoretical Model of change has been used successfully in promoting behaviour change. Objective To examine the relationships between health-related quality of life (HRQoL) scores with the stages of change of adequate physical activity and fruit and vegetables intake. Design This was a cross-sectional study conducted among employees of the main campus and Engineering campus of Universiti Sains Malaysia (USM) during October 2009 and March 2010. Main variables studied: Data on physical activity and fruit and vegetable intake was collected using the WHO STEPS instrument for chronic disease risk factors surveillance. The Short Form-12 health survey (SF-12) was used to gather information on participants' HRQoL. The current stages of change are measured using the measures developed by the Pro-Change Behaviour Systems Incorporation. Statistical analysis: One way ANOVA and its non-parametric equivalent Kruskal-Wallis were used to compare the differences between SF-12 scores with the stages of change. Results A total of 144 employees were included in this analysis. A large proportion of the participants reported inadequate fruits and vegetable intake (92.3%) and physical activity (84.6%). Mean physical and mental component scores of SF-12 were 50.39 (SD = 7.69) and 49.73 (SD = 8.64) respectively. Overall, there was no statistical significant difference in the SF-12 domains scores with regards to the stages of change for both the risk factors. Conclusions There were some evidence of positive relationship between stages of change of physical activity and fruit and vegetable intake with SF-12 scores. Further studies need to be conducted to confirm this association.Scopu

Appraisal of a high protein distiller’s dried grain (DDG) in diets for European sea bass, Dicentrarchus labrax fingerlings on growth performance, haematological status and related gut histology

High protein distiller's dried grains (HP‐DDG) are co‐products of ethanol production that uses prefractionation technology. An 8‐week growth trial was conducted to investigate the effect of partial replacement of soybean meal (SBM) by three levels of HP‐DDG (30%, 40% and 50%) on growth performance, physiological parameters and histological changes of the intestine of European sea bass, Dicentrarchus labrax. The results indicated that an increased dietary level of HP‐DDG of more than 30% significantly increases growth performance and improved the FCR of sea bass. In addition, replacement of SBM by HP‐DDG enhanced feed intake efficiency and the health status of fish. Haematology and serum biochemistry (haemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs), packed cell volume (PCV %) and humeral immune parameters including total protein, albumin, globulin, cholesterol, lysozyme activity and total antioxidant capacity significantly increased with increase HP‐DDG inclusion levels. The findings of this study indicated that HP‐DDG is a good complementary protein source for inclusion aquaculture diets and levels above 30% as a replacement of SBM did not compromise growth performance and physiological parameters of sea bass while enhancing some important indices of health status in this species

Glycoprotein isolated from eurycoma longifolia (Tongkat Ali) is capable of boosting testosterone levels in leydig cells

Eurycoma longifolia (Tongkat Ali) is renowned for its aphrodisiac potential, and its active constituent has been presumed to be a protein and more likely a glycosylated protein. In this study, the ability of the glycoprotein to increase testosterone hormone levels was investigated. The dried root powder of the plant was extracted using water under reflux. The protein fraction was separated using size-exclusion chromatography and subjected to SDS-PAGE analysis. Thereafter the protein fraction was isolated from its glycoprotein using a lectin column. Finally, TM-3 Leydig cells were treated with the isolated glycoprotein fraction (50 µg/mL). The extraction yielded 14.3% w/w protein and the SDS PAGE analysis showed a single band at approximately 20 kDa. Treatment of TM-3 Leydig cells with the glycoprotein fraction for 72 hours demonstrated an increase in testosterone levels by almost 100% (0.36 ± 0.03 nmol/L) in comparison to the untreated cells (0.18 ± 0.05 nmol/L). The findings suggested that the glycoprotein in E. longifolia root can be easily isolated because its sugar moiety can bind to a lectin affinity column. Moreover, this glycoprotein was shown to have testosterone-boosting activity. These findings identified the glycoprotein as the bioactive constituent associated with its aphrodisiac properties

Qualitative grading of aortic regurgitation: a pilot study comparing CMR 4D flow and echocardiography

Over the past 10 years there has been intense research in the development of volumetric visualization of intracardiac flow by cardiac magnetic resonance (CMR). This volumetric time resolved technique called CMR 4D flow imaging has several advantages over standard CMR. It offers anatomical, functional and flow information in a single free-breathing, ten-minute acquisition. However, the data obtained is large and its processing requires dedicated software. We evaluated a cloud-based application package that combines volumetric data correction and visualization of CMR 4D flow data, and assessed its accuracy for the detection and grading of aortic valve regurgitation using transthoracic echocardiography as reference. Between June 2014 and January 2015, patients planned for clinical CMR were consecutively approached to undergo the supplementary CMR 4D flow acquisition. Fifty four patients (median age 39 years, 32 males) were included. Detection and grading of the aortic valve regurgitation using CMR 4D flow imaging were evaluated against transthoracic echocardiography. The agreement between 4D flow CMR and transthoracic echocardiography for grading of aortic valve regurgitation was good (κ = 0.73). To identify relevant, more than mild aortic valve regurgitation, CMR 4D flow imaging had a sensitivity of 100 % and specificity of 98 %. Aortic regurgitation can be well visualized, in a similar manner as transthoracic echocardiography, when using CMR 4D flow imaging

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia:a Multinational Point Prevalence Study of Hospitalised Patients

Pseudornonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients

Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050

Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached$8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total,$40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this,$13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and$1.4 billion was repurposed from existing health projects. $3.1 billion (22.4$2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7$1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe