1,049 research outputs found
External and intrinsic anchoring in nematic liquid crystals: A Monte Carlo study
We present a Monte Carlo study of external surface anchoring in nematic cells
with partially disordered solid substrates, as well as of intrinsic anchoring
at free nematic interfaces. The simulations are based on the simple hexagonal
lattice model with a spatially anisotropic intermolecular potential. We
estimate the corresponding extrapolation length by imposing an elastic
deformation in a hybrid cell-like nematic sample. Our estimates for
increase with increasing surface disorder and are essentially
temperature--independent. Experimental values of are approached only when
both the coupling of nematic molecules with the substrate and the anisotropy of
nematic--nematic interactions are weak.Comment: Revisions primarily in section I
Dynamic Changes in High-Sensitivity Cardiac Troponin I in Response to Anthracycline-Based Chemotherapy
Aims:
Treatment advances have improved cancer-related outcomes and shifted interest towards minimising long-term iatrogenic complications, particularly chemotherapy-related cardiotoxicity. High-sensitivity cardiac troponin I (hs-cTnI) assays accurately quantify very low concentrations of plasma troponin and enable early detection of cardiomyocyte injury prior to the development of myocardial dysfunction. The profile of hs-cTnI in response to anthracycline-based treatment has not previously been described.
Materials and methods:
This was a multicentre prospective observational cohort study. Female patients with newly diagnosed invasive breast cancer scheduled to receive anthracycline-based (epirubicin) chemotherapy were recruited. Blood sampling was carried out before and 24 h after each cycle. Hs-cTnI concentrations were measured using the Abbott ARCHITECTSTAT assay.
Results:
We recruited 78 women with a median (interquartile range) age of 52 (49â61) years. The median baseline troponin concentration was 1 (1â4) ng/l and the median cumulative epirubicin dose was 394 (300â405) mg/m2. Following an initial 33% fall 24 h after anthracycline dosing (P < 0.001), hs-cTnI concentrations increased by a median of 50% (P < 0.001) with each successive treatment cycle. In total, 45 patients had troponin measured immediately before the sixth treatment cycle, 21 (46.6%) of whom had hs-cTnI concentrations â„16 ng/l, indicating myocardial injury. Plasma hs-cTnI concentrations before the second treatment cycle were a strong predictor of subsequent myocardial injury.
Conclusions:
Cardiotoxicity arising from anthracycline therapy is detectable in the earliest stages of breast cancer treatment and is cumulative with each treatment cycle. This injury is most reliably determined from blood sampling carried out before rather than after each treatment cycle
Running Backwards: Consequences of Current HIV Incidence Rates for the Next Generation of Black MSM in the United States
Black men who have sex with men (MSM) in the United States are disproportionately impacted by HIV. To better understand this public health problem, we reviewed the literature to calculate an estimate of HIV incidence among Black MSM. We used this rate to model HIV prevalence over time within a simulated cohort, which we subsequently compared to prevalence from community-based samples. We searched all databases accessible through PubMed, and Conference on Retroviruses and Opportunistic Infections abstracts for HIV incidence estimates among Black MSM. Summary HIV incidence rates and 95 % confidence intervals (CIs) were calculated using random effects models. Using the average incidence rate, we modeled HIV prevalence within a simulated cohort of Black MSM (who were all HIV-negative at the start) from ages 18 through 40. Based on five incidence rates totaling 2898 Black MSM, the weighted mean incidence was 4.16 % per year (95 % CI 2.76â5.56). Using this annual incidence rate, our model predicted that 39.94 % of Black MSM within the simulated cohort would be HIV-positive by age 30, and 60.73 % by 40. Projections were similar to HIV prevalence found in community-based samples of Black MSM. High HIV prevalence will persist across the life-course among Black MSM, unless effective prevention and treatment efforts are increased to substantially reduce HIV transmission among this underserved and marginalized population
Two-loop corrections to the decay rate of parapositronium
Order corrections to the decay rate of parapositronium are
calculated. A QED scattering calculation of the amplitude for electron-positron
annihilation into two photons at threshold is combined with the technique of
effective field theory to determine an NRQED Hamiltonian, which is then used in
a bound state calculation to determine the decay rate. Our result for the
two-loop correction is in units of times the
lowest order rate. This is consistent with but more precise than the result
of a previous calculation.Comment: 26 pages, 7 figure
Low mass fraction impregnation with graphene oxide (GO) enhances thermo-physical properties of paraffin for heat storage applications
Whereas previous researchers analyzed the thermal behavior of paraffin waxes impregnated with graphene oxide nanoparticles (P-GONP) at high mass fraction ( > 1%), this paper analyzes behavior and stability at only 0.3% mass fraction. GONP was prepared by Hummerâs method. The morphology was studied using scanning electron microscope (SEM), transmission electron microscope (TEM), X-Ray diffraction (XRD) and Fourier Transformation-Infrared (FT-IR) Spectrometer and the thermal properties were measured using laser flash analyser (LFA), differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA) and thermal cycling. LFA showed a 101.2% and 94.5% increase in the thermal conductivity of P-GONP compared to pure paraffin (P) in solid and liquid state respectively. Melting and solidifying temperatures and latent heat were found to be 63.5, 59 °C & 102 kJ/kg and 57.5, 56 °C & 64.7 kJ/kg for P and P-GONP respectively. Thermal cycling over 4000 cycles showed that P-GONP was 27% more stable than P. The latent heat was 64.7 kJ/kg, a 36.5% deterioration compared to virgin paraffin. Compared against higher mass fraction impregnation, lower mass fraction P-GONP was found to have almost equivalent thermo-physical properties (namely thermal conductivity, melting and solidifying characteristics, thermo-chemical stability and reliability) while providing considerable cost saving
The Value of Information for Populations in Varying Environments
The notion of information pervades informal descriptions of biological
systems, but formal treatments face the problem of defining a quantitative
measure of information rooted in a concept of fitness, which is itself an
elusive notion. Here, we present a model of population dynamics where this
problem is amenable to a mathematical analysis. In the limit where any
information about future environmental variations is common to the members of
the population, our model is equivalent to known models of financial
investment. In this case, the population can be interpreted as a portfolio of
financial assets and previous analyses have shown that a key quantity of
Shannon's communication theory, the mutual information, sets a fundamental
limit on the value of information. We show that this bound can be violated when
accounting for features that are irrelevant in finance but inherent to
biological systems, such as the stochasticity present at the individual level.
This leads us to generalize the measures of uncertainty and information usually
encountered in information theory
Anthropogenic alteration of nutrient supply increases the global freshwater carbon sink
Lakes have a disproportionate effect on the global carbon (C) cycle relative to their area, mediating C transfer from land to atmosphere, and burying organic-C in their sediments. The magnitude and temporal variability of C burial is, however, poorly constrained, and the degree to which humans have influenced lake C cycling through landscape alteration has not been systematically assessed. Here, we report global and biome specific trajectories of lake C sequestration based on 516 lakes and show that some lake C burial rates (i.e., those in tropical forest and grassland biomes) have quadrupled over the last 100 years. Global lake C-sequestration (~0.12 Pg year-1) has increased by ~72 Tg year-1 since 1900, offsetting 20% of annual CO2 freshwater emissions rising to ~30% if reservoirs are included and contributing to the residual continental C sink. Nutrient availability explains ~70% of the observed increase, while rising temperatures have a minimal effect
Large-angle production of charged pions by 3 GeV/c - 12.9 GeV/c protons on beryllium, aluminium and lead targets
Measurements of the double-differential production cross-section
in the range of momentum 100 \MeVc \leq p < 800 \MeVc and angle 0.35 \rad
\leq \theta < 2.15 \rad in proton--beryllium, proton--aluminium and
proton--lead collisions are presented. The data were taken with the HARP
detector in the T9 beam line of the CERN PS. The pions were produced by proton
beams in a momentum range from 3 \GeVc to 12.9 \GeVc hitting a target with a
thickness of 5% of a nuclear interaction length. The tracking and
identification of the produced particles was performed using a small-radius
cylindrical time projection chamber (TPC) placed inside a solenoidal magnet.
Incident particles were identified by an elaborate system of beam detectors.
Results are obtained for the double-differential cross-sections at six incident
proton beam momenta (3 \GeVc, 5 \GeVc, 8 \GeVc, 8.9 \GeVc (Be only), 12 \GeVc
and 12.9 \GeVc (Al only)) and compared to previously available data
Discovery of a first-in-class small molecule antagonist against the adrenomedullin-2 receptor: structureâactivity relationships and optimization
Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) together with one of three accessory proteins known as receptor activity-modifying proteins (RAMPs). CLR/RAMP1 forms a CGRP receptor, CLR/RAMP2 forms an adrenomedullin-1 (AM1) receptor, and CLR/RAMP3 forms an adrenomedullin-2 (AM2) receptor. The CTR/RAMP complexes form three distinct amylin receptors. While the selective blockade of AM2 receptors would be therapeutically valuable, inhibition of AM1 receptors would cause clinically unacceptable increased blood pressure. We report here a systematic study of structureâactivity relationships that has led to the development of first-in-class AM2 receptor antagonists. These compounds exhibit therapeutically valuable properties with 1000-fold selectivity over the AM1 receptor. These results highlight the therapeutic potential of AM2 antagonists
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