The influence of the Calbuco eruption on the 2015 Antarctic ozone hole in a fully coupled chemistry-climate model

Recent research has demonstrated that the concentrations of anthropogenic halocarbons have decreased in response to the worldwide phaseout of ozone depleting substances. Yet in 2015 the Antarctic ozone hole reached a historical record daily average size in October. Model simulations with specified dynamics and temperatures based on a reanalysis suggested that the record size was likely due to the eruption of Calbuco but did not allow for fully coupled dynamical or thermal feedbacks. We present simulations of the impact of the 2015 Calbuco eruption on the stratosphere using the Whole Atmosphere Community Climate Model with interactive dynamics and temperatures. Comparisons of the interactive and specified dynamics simulations indicate that chemical ozone depletion due to volcanic aerosols played a key role in establishing the record-sized ozone hole of October 2015. The analysis of an ensemble of interactive simulations with and without volcanic aerosols suggests that the forced response to the eruption of Calbuco was an increase in the size of the ozone hole by 4.5 × 10⁶ km²

Emergence of healing in the Antarctic ozone layer

Industrial chlorofluorocarbons that cause ozone depletion have been phased out under the Montreal Protocol. A chemically driven increase in polar ozone (or “healing”) is expected in response to this historic agreement. Observations and model calculations together indicate that healing of the Antarctic ozone layer has now begun to occur during the month of September. Fingerprints of September healing since 2000 include (i) increases in ozone column amounts, (ii) changes in the vertical profile of ozone concentration, and (iii) decreases in the areal extent of the ozone hole. Along with chemistry, dynamical and temperature changes have contributed to the healing but could represent feedbacks to chemistry. Volcanic eruptions have episodically interfered with healing, particularly during 2015, when a record October ozone hole occurred after the Calbuco eruption

Community Isolation Project

Introduction The authors of this summary are nursing students at Seattle Pacific University, and the project goal is focused on understanding feelings of isolation in elderly communities and whether fostering social activities, such as Bingo, would improve social interaction between residents in this community. For the past two years, the COVID-19 pandemic has altered various aspects of social interaction. From masking to social distancing, societal norms and expectations evolved in a manner that promoted isolation and minimal interaction to inhibit the spread of Covid infection between individuals. Of the general populace, the most vulnerable and at risk for infection are the elderly and those with comorbidities. Subsequently, older individuals are more at risk for rigid social isolation precautions due to the risk of infection, affecting many of the individuals in this group who live in community settings such as nursing homes and long-term care facilities. This project ultimately seeks to understand how older individuals might feel after participating in community activities with one another as well as assess for any feelings of depression and social isolation post pandemic.  Background The population worked with is a subsidized living community for individuals over the age of 62. The 200-plus unit apartment complex is located in North Seattle just off the Aurora business district. Social isolation and loneliness in older adults living in communities such as this is a growing concern especially since the pandemic showing upwards of 29% of the elderly population to report being lonely in the U.S. (Taylor, et al., 2018). Although it is hard to precisely measure social isolation and loneliness, the evidence that does exist shows there is an increased risk for dementia alone, by fifty percent, with links to an increase in cardiovascular disease, stroke, anxiety, depression, and suicide (CDC, 2021). More recent studies in populations of older adults residing in senior housing communities seem to experience higher levels of loneliness due to lower-income, being alone due to the death of a spouse/partner, having fewer confiding relationships, depression, and other significant comorbidities as mentioned, as compared to those living in conventional housing (Taylor, et al., 2018). This is attributed to having less contact with family and friends, social anxiety of meeting neighbors, and altogether feeling of not being supported (Taylor, et al., 2018). The COVID-19 pandemic added more barriers to social isolation and loneliness for the elderly due to early restrictions of in-person gatherings, recreational activities within the community, family gatherings being canceled, spiritual congregations canceled, and many deaths within the community, all adding to the sense of isolation, loneliness, and depression (Webb and Chen, 2021). As far as interventions to combat loneliness and social isolation, there have been many. It is difficult to analyze due to individual experience surrounding the issues (Fakoya et al., 2020). There is not a “one-size-fits all” standardization to address social isolation and loneliness in the elderly, showing that tailoring interventions to specific community and individual needs as being the best approach (Fakoya et al., 2020). Activities with Rationale When discussing what activities or events the project should center around, the team collaborated with the property manager at the senior living community to ensure the provided activity would be both fun and engaging for the residents, as well as beneficial and information-producing for our project and the property manager. After it was determined the project would center around targeting loneliness in elderly communities, an idea was landed on creating an event that would demonstrate the importance of connection and combat isolation. A transtheoretical model of change was used as the basis for this project. This change model states that behavior change takes place through the following stages: precontemplation, contemplation, preparation, action, maintenance, and termination. To measure this, pre- and post- surveys were filled out by residents to gather data to support the health promotion project’s claims. The project at the community included two Bingo days. The specific activity was determined through popular request by the residents who had mentioned playing and enjoying Bingo as a community in the past. A week prior to the first event, pre surveys were distributed asking the residents about their experience of isolation and/or loneliness if they had any. Residents were incentivized to attend the Bingo events with promised coffee, snacks, and small prizes for Bingo winners. Residents were even given a chance to be entered into a randomized drawing for a fifteen-dollar gift card to Sprouts, a local grocery store, which was conducted at the end of each Bingo day. After the events, those who participated in Bingo were then further encouraged to fill out post surveys. These surveys questioned how it felt to engage in the community and if their feelings or loneliness/isolation had changed in order to assess the impact the bingo event had on mood and affect. For the purposes of this project, it was important not only to gather information, but to model what having community events, such as Bingo, could look like and how they would positively impact the community. Outcomes To gain a better understanding of how the community felt regarding loneliness, isolation, and their willingness to participate in group activities, pre- and post-bingo surveys were provided utilizing the Likert scale. In return, 30 pre-surveys were returned from the community. Following the event, 30 post-surveys were filled out by the residents who participated in Bingo. After reviewing the results of the pre-surveys, it was concluded that the overall community often feels a sense of loneliness, but they have an ardent desire to participate in group activities. After 2 days of Bingo, residents who joined us were asked to fill out a post-survey to gauge if the group activity had any effect on them. In almost every single post activity survey received, residents answered that playing Bingo with their community positively impacted their mental health, they would play Bingo or attend another event again, and they found it easier to build relationships with their community members while engaging in Bingo together. The community engagement surveys revealed that group activities such as bingo led to an outcome of decreased loneliness and isolation. According to the data collected, hosting and facilitating social events, specifically for older adult populations, post pandemic, is extremely beneficial to mental health and overall wellness. Conclusion Although Covid has been around for two years now, it has proven to be very difficult to navigate, especially in community settings such as this subsidized living community. This pandemic has been exceptionally problematic as facilities search for a balance betweenl encouraging social activity, and also promoting physical safety from Covid-19. While preventing the spread of the virus is certainly a priority, mental health, arguably, is just as crucial to one\u27s well-being as their physical health. The surveys collected in this project revealed that while many individuals had a strong urge to engage in social activities, a sense of loneliness in the community still exists for many people. As mentioned in other studies, there’s no “correct” way to decrease feelings of isolation as the process of overcoming this sense of remoteness may be very specific to the community. Luckily, the staff at this site are very in tune with their population and they disclosed that Bingo is a popular activity among the residents. It was important that the activity was appropriate and engaging for people of all different backgrounds as the intent of the project was to foster community engagement and improve social interactions among the group. Overall, there was a great turnout of people at both the first and second Bingo events, further exemplifying the enthusiasm many individuals shared about wanting to be more engaged in the community. Because there was such a big turnout, the group had a few challenges to overcome. Firstly, accessibility and navigation within the conference room was a little tight the first time around which the group was able to overcome by rearranging tables to accommodate for walkers and wheelchairs. Secondly, while there was a provided space and Bingo set, the budget for prizes and snacks was also very limited which led to the group contributing personal funds to the project. Lastly, while the post-surveys offered great insight, they provided information on a very small percentage of the population. The results of the surveys are from the perspective of individuals who most likely often attend group activities, which ultimately skews the information as this may not accurately represent the entirety of the population at this senior community. For a more accurate representation of the community, there would need to be a larger sample number. The project proved to be successful as many of the residents answered in their post-surveys that the Bingo event decreased feelings of loneliness and isolation, therefore positively impacting their mental health. Many of the individuals also stated in their questionnaires that they would attend more Bingo events in the future. In addition, residents were also eager to suggest other fun group activities such as painting, gardening, picnics, and dances. Moving forward, it would be beneficial for future groups to try other activities in addition to Bingo. Different events may motivate social interaction from the individuals who don’t enjoy activities such as Bingo and would facilitate a feeling of excitement in anticipation for a communal gathering that is both entertaining and interactive. This health promotion project found Bingo to be a successful event in which participants were able to maintain a safe social distance, and engage together in a fun, community activity. References Fakoya, O., McCorry, N., & Donnelly, M. (2020). Loneliness and social isolation for older adults: A scoping review of reviews. BMC Public Health, 20(129). https://doi.org/10.1186/s12889-020-8251-6 Centers for Disease Control and Prevention (2021). Loneliness and social isolation linked to serious health conditions. (n.d.).  https://www.cdc.gov/aging/publications/features/lonely-older-adults.html#:~:text=A%20report%20from%20the%20National,considered%20to%20be%20socially%20isolated Taylor, H., Wang, Y., & Morrow-Howell, N. (2018). Loneliness in senior housing communities. Journal of Gerontological Social Work, 61(6), 623-639. https://doi.org/10.1080/01634372.2018.1478352 Webb, L., & Chen, C. (2021). The covid-19 pandemic\u27s impact on older adults\u27 mental health: Contributing factors, coping strategies, and opportunities for improvement. Int J Geriatr Psychiatry. https://doi.org:10.1002/gps.564

Emergence of healing in the Antarctic ozone layer

Industrial chlorofluorocarbons that cause ozone depletion have been phased out under the Montreal Protocol. A chemically driven increase in polar ozone (or “healing”) is expected in response to this historic agreement. Observations and model calculations together indicate that healing of the Antarctic ozone layer has now begun to occur during the month of September. Fingerprints of September healing since 2000 include (i) increases in ozone column amounts, (ii) changes in the vertical profile of ozone concentration, and (iii) decreases in the areal extent of the ozone hole. Along with chemistry, dynamical and temperature changes have contributed to the healing but could represent feedbacks to chemistry. Volcanic eruptions have episodically interfered with healing, particularly during 2015, when a record October ozone hole occurred after the Calbuco eruption.National Science Foundation (U.S.) (FESD Grant OCE-1338814)National Science Foundation (U.S.). Atmospheric Chemistry Program (Grant 1539972

ING116070: a study of the pharmacokinetics and antiviral activity of dolutegravir in cerebrospinal fluid in HIV-1-infected, antiretroviral therapy-naive subjects.

BackgroundDolutegravir (DTG), a once-daily, human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and antiviral activity in cerebrospinal fluid (CSF).MethodsING116070 is an ongoing, single-arm, open-label, multicenter study in antiretroviral therapy-naive, HIV-1-infected adults. Subjects received DTG (50 mg) plus abacavir/lamivudine (600/300 mg) once daily. The CSF and plasma (total and unbound) DTG concentrations were measured at weeks 2 and 16. The HIV-1 RNA levels were measured in CSF at baseline and weeks 2 and 16 and in plasma at baseline and weeks 2, 4, 8, 12, and 16.ResultsThirteen white men enrolled in the study; 2 withdrew prematurely, 1 because of a non-drug-related serious adverse event (pharyngitis) and 1 because of lack of treatment efficacy. The median DTG concentrations in CSF were 18 ng/mL (range, 4-23 ng/mL) at week 2 and 13 ng/mL (4-18 ng/mL) at week 16. Ratios of DTG CSF to total plasma concentration were similar to the unbound fraction of DTG in plasma. Median changes from baseline in CSF (n = 11) and plasma (n = 12) HIV-1 RNA were -3.42 and -3.04 log10 copies/mL, respectively. Nine of 11 subjects (82%) had plasma and CSF HIV-1 RNA levels <50 copies/mL and 10 of 11 (91%) had CSF HIV-1 RNA levels <2 copies/mL at week 16.ConclusionsThe DTG concentrations in CSF were similar to unbound plasma concentrations and exceeded the in vitro 50% inhibitory concentration for wild-type HIV (0.2 ng/mL), suggesting that DTG achieves therapeutic concentrations in the central nervous system. The HIV-1 RNA reductions were similar in CSF and plasma. Clinical Trials Registration. NCT01499199

The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis

Objective To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States

Observing the Impact of Calbuco Volcanic Aerosols on South Polar Ozone Depletion in 2015

The Southern Hemisphere Antarctic stratosphere experienced two noteworthy events in 2015: a significant injection of sulfur from the Calbuco volcanic eruption in Chile in April and a record-large Antarctic ozone hole in October and November. Here we quantify Calbuco's influence on stratospheric ozone depletion in austral spring 2015 using observations and an Earth system model. We analyze ozonesondes, as well as data from the Microwave Limb Sounder. We employ the Community Earth System Model, version 1, with the Whole Atmosphere Community Climate Model (WACCM) in a specified dynamics setup, which includes calculations of volcanic effects. The Cloud-Aerosol Lidar with Orthogonal Polarization data indicate enhanced volcanic liquid sulfate 532 nm backscatter values as far poleward as 68°S during October and November (in broad agreement with WACCM). Comparison of the location of the enhanced aerosols to ozone data supports the view that aerosols played a major role in increasing the ozone hole size, especially at pressure levels between 150 and 100 hPa. Ozonesonde vertical ozone profiles from the sites of Syowa, South Pole, and Neumayer display the lowest individual October or November measurements at 150 hPa since the 1991 Mount Pinatubo eruption period, with Davis showing similarly low values, but no available 1990 data. The analysis suggests that under the cold conditions ideal for ozone depletion, stratospheric volcanic aerosol particles from the moderate-magnitude eruption of Calbuco in 2015 greatly enhanced austral ozone depletion, particularly at 55–68°S, where liquid binary sulfate aerosols have a large influence on ozone concentrations

Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms

Exposure of human populations to ambient particulate matter (PM) air pollution significantly contributes to the mortality attributable to ischemic cardiovascular events. We reported that mice treated with intratracheally instilled PM develop a prothrombotic state that requires the release of IL-6 by alveolar macrophages. We sought to determine whether exposure of mice to PM increases the levels of PAI-1, a major regulator of thrombolysis, via a similar or distinct mechanism. mice but was absent in mice treated with etanercept, a TNF-α inhibitor. Treatment with etanercept did not prevent the PM-induced tendency toward thrombus formation.Mice exposed to inhaled PM exhibited a TNF-α-dependent increase in PAI-1 and an IL-6-dependent activation of coagulation. These results suggest that multiple mechanisms link PM-induced lung inflammation with the development of a prothrombotic state

Timing of glacial retreat in the Wicklow Mountains, Ireland, conditioned by glacier size and topography

This paper presents 170 Schmidt Hammer exposure ages from moraine boulders and glacially-sculpted bedrock to reveal the post-Last Glacial Maximum (LGM) history of the Wicklow Mountains, Ireland. These data suggest that large ice masses survived for 4-7 ka after retreat of the Irish Sea Ice Stream and were sustained by summit ice-fields until ~16.6 ka. Post-LGM retreat was dynamic, with re-advance moraines deposited in response to Heinrich Stadial 1. However, these events reflect short-term ice front oscillations (≤ 1 ka) during the long-term retreat phase. Retreat from re-advance positions was synchronous across the range and paced by climate, with time-progressive deglaciation from low to high elevation. In contrast, marked asynchroneity in the timing of Younger Dryas deglaciation is closely linked to snow redistribution and indicates that for small cirque glaciers (≤ 1 km2 ), topography can exert the primary control on glacier survival. This result has important implications for palaeoclimate econstructions as cirque glacier dynamics may be unrelated to climate. This is further complicated by post-depositional processes which can result in moraine ages (e.g. 10Be) which post-date retreat. Future palaeoclimate studies should prioritise cirque glaciers where snow contributing areas are small and where postdepositional disturbance is limited (matrix-poor, boulder-rich moraines)

Drosophila pericardial nephrocyte ultrastructure changes during ageing

Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial nephrocytes, which represent the majority of functional nephrocytes in larvae and adults, lack these characteristic features at the embryonic stage. During larval development, a subpopulation of the pericardial cells survives and matures into functional nephrocytes (PCNs) displaying a fully differentiated slit diaphragm and a labyrinth channel compartment. Likely the embryonic pericardial cells have primary functions other than ultrafiltration (e.g. in production and secretion of ECM constituents). We also show, for the first time, that PCNs in the adult fly undergo dramatic histological degeneration upon ageing. The slit diaphragms disappear, the labyrinth channel system degenerates and the lysosomal compartment becomes highly enriched with electron-dense material. When using nephrocytes as a model for genetic screening purposes or to investigate the specific role of genes involved in endocytosis, histological changes occurring upon ageing need to be taken into account when interpreting structural data