Media Professionals’ Opinions about Interactive Visualizations of Political Polarization during Brazilian Presidential Campaigns on Twitter

Interactive data visualization techniques are an important way to obtain information from large datasets. Data journalism is an emerging area that strongly makes use of such techniques. In this work we investigate the relationship between journalists (and media professionals) in their job routine and data visualization, with the main goal of understanding if these professionals know and use data visualization tools in their job context, as well as if they consider these resources to be important. For this, we present the results of a survey made with journalists and media professionals to analyze how interactive visualizations could help them to get insight or knowledge of such data, and if their use may improve and support these professionals\u27 activities. The results indicate that visualization and data analysis tools are still not easily accessible by those professionals, and therefore still less influential than they could be. However, most participants considered data visualization a valuable resource in their news production routines. As a contribution, we also identified positive points and understanding gaps of visualizations, as well as the perception of journalists and media professionals about getting information from data visualization

Perfil clínico-epidemiológico e histológico do Câncer de Mama no estado da Bahia, no periodo entre 2011 e 2021

O câncer de mama é o segundo tipo de câncer mais incidente na população feminina do Brasil, sendo considerado um problema de saúde pública no Brasil e no mundo. Este estudo tem o objetivo de descrever o perfil clínico-epidemiológico e histológico do câncer de mama no estado da Bahia, no período de 2011 a 2021. Trata-se de um estudo ecológico, retrospectivo com abordagem quantitativa. Os dados foram coletados no site do Departamento de Informática do Sistema Único de Saúde (DataSUS), utilizando as plataformas do Sistema de Informação do Câncer de Mama (SISMAMA) do Sistema de Informação de Câncer (SISCAN), do período de 2011 a 2021, considerando o diagnóstico de lesão de caráter neoplásico maligno por exame histopatológico. Nesse período, foram realizados 20 224 exames histopatológicos na Bahia, sendo 7.070 positivos para malignidade. O câncer de mama foi predominante entre as mulheres (99,52%), com destaque para a faixa etária entre 50 e 54 anos (15,32%), e para pacientes com ensino fundamental incompleto (47,92%), em consonância com os estudos de Lages et al. (2018), e Figueiredo (2019). Esses dados indicam que o maior acesso à educação e à informação contribui para que os pacientes saibam a importância da prevenção do câncer de mama. Ademais, a maior parte das lesões foi identificada por exame clinico das mamas (64,21%), sendo as lesões em mama direita predominante (51,63%) em discordância com a maioria dos estudos. Quanto às características histológicas, a maioria foi determinada como carcinoma intraductal infiltrante (66,78%) de grau II (37,47%), padrões predominantes encontrados por outros autores. Observa-se que para redução do número de casos, os administradores públicos precisam desenvolver programas voltados à prevenção primária, incentivando a divulgação de sinais e sintomas sugestivos de câncer de mama e da necessidade de exame clínico das mamas e exames de imagem de rastreio

Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury

Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients. Mechanisms underlying reperfusion-associated injury include recruitment and activation of leukocytes and release of inflammatory mediators. In this study, we investigated the renal effects of acute administration of AVE0991, an agonist of Mas, the angiotensin-(1–7) receptor, the angiotensin-(1–7) receptor, in a murine model of renal I/R. Male C57BL/6 wild-type or Mas−/− mice were subjected to 30 min of bilateral ischemia and 24 h of reperfusion. Administration of AVE0991 promoted renoprotective effects, as seen by improvement of function, decreased tissue injury, prevention of local and remote leucocyte infiltration, and release of the chemokine, CXCL1. I/R injury was similar in WT and Mas−/− mice, suggesting that endogenous activation of this receptor does not control renal damage under baseline conditions. In conclusion, pharmacological interventions using Mas receptor agonists may represent a therapeutic opportunity for the treatment of renal I/R injury

Natural Products as Source of Potential Dengue Antivirals

Dengue is a neglected disease responsible for 22,000 deaths each year in areas where it is endemic. To date, there is no clinically approved dengue vaccine or antiviral for human beings, even though there have been great efforts to accomplish these goals. Several approaches have been used in the search for dengue antivirals such as screening of compounds against dengue virus enzymes and structure-based computational discovery. During the last decades, researchers have turned their attention to nature, trying to identify compounds that can be used as dengue antivirals. Nature represents a vast reservoir of substances that can be explored with the aim of discovering new leads that can be either used directly as pharmaceuticals or can serve as lead structures that can be optimized towards the development of new antiviral agents against dengue. In this review we describe an assortment of natural products that have been reported as possessing dengue antiviral activity. The natural products are organized into classes of substances. When appropriate, structure-activity relationships are outlined. The biological assays used to assess antiviral activity are briefly described

Habilidades perceptuais e linguísticas na aquisição de nomes e adjetivos

-O presente trabalho insere-se em uma pesquisa acerca da identificação de nomes e adjetivos por crianças brasileiras durante o processo de aquisição do PB. Focaliza-se a relação semântica estabelecida pelo adjetivo, quando anteposto ou posposto ao nome. No português do Brasil (PB), a ordem canônica do SD complexo é Det + N + Adj, mas há a possibilidade da ordem inversa, Det + Adj + N. A anteposição do adjetivo em relação ao nome pode acarretar uma alteração de sentido (um amigo velho / um velho amigo) ou não (uma moça linda / uma linda moça). Investigamos se crianças em idade escolar percebem tal relação entre a posição do adjetivo e alteração semântica. Uma atividade experimental de produção eliciada é proposta com crianças entre 7 e 9 anos em que o experimentador conta histórias mostrando cenários que as descrevem. Ao final de cada história três pranchas com três respostas diferentes são apresentadas à criança para que ela escolha, a partir de seu entendimento, a melhor opção. Observa-se se a criança, na sua escolha, mantém ou não a diferença semântica causada pelo adjetivo anteposto ou posposto ao nome. Os resultados são analisados e discutidos, levando-se em conta um modelo psicolingüístico de aquisição da linguage

Aerobic training prevents changes in endothelium-dependent vasodilation of diabetic rats

O objetivo do presente estudo é verificar os efeitos do treinamento aeróbio sobre a reatividade vascular em artéria mesentérica de ratos diabéticos. Ratos Wistar foram divididos em três grupos: controle sedentário (CS), diabético sedentário (DS) e diabético treinado (DT). Alterações na reatividade vascular foram avaliadas após a última sessão de treinamento, por meio da obtenção de curvas concentração-resposta. Os testes t de Student ou análise de variância (ANOVA) de duas-vias, seguida do pós-teste de Bonferroni, foram realizados para avaliar a significância das diferenças entre as médias. Foi observada uma redução dos relaxamentos induzidos por acetilcolina no grupo DS (79,7 ± 3,0 %), quando comparado ao CS (98,8 ± 3,0) e uma manutenção dos valores normais no grupo DT (100,1 ± 5,3 %). Os resultados sugerem que o treinamento aeróbio é capaz de proporcionar efeitos benéficos na função vascular de ratos diabéticos

Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.  Methodology/Principal Findings: The T. rangeli haploid genome is ,24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heatshock proteins.  Conclusions/Significance: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Comparative Genomic Analysis of Human Fungal Pathogens Causing Paracoccidioidomycosis

Paracoccidioides is a fungal pathogen and the cause of paracoccidioidomycosis, a health-threatening human systemic mycosis endemic to Latin America. Infection by Paracoccidioides, a dimorphic fungus in the order Onygenales, is coupled with a thermally regulated transition from a soil-dwelling filamentous form to a yeast-like pathogenic form. To better understand the genetic basis of growth and pathogenicity in Paracoccidioides, we sequenced the genomes of two strains of Paracoccidioides brasiliensis (Pb03 and Pb18) and one strain of Paracoccidioides lutzii (Pb01). These genomes range in size from 29.1 Mb to 32.9 Mb and encode 7,610 to 8,130 genes. To enable genetic studies, we mapped 94% of the P. brasiliensis Pb18 assembly onto five chromosomes. We characterized gene family content across Onygenales and related fungi, and within Paracoccidioides we found expansions of the fungal-specific kinase family FunK1. Additionally, the Onygenales have lost many genes involved in carbohydrate metabolism and fewer genes involved in protein metabolism, resulting in a higher ratio of proteases to carbohydrate active enzymes in the Onygenales than their relatives. To determine if gene content correlated with growth on different substrates, we screened the non-pathogenic onygenale Uncinocarpus reesii, which has orthologs for 91% of Paracoccidioides metabolic genes, for growth on 190 carbon sources. U. reesii showed growth on a limited range of carbohydrates, primarily basic plant sugars and cell wall components; this suggests that Onygenales, including dimorphic fungi, can degrade cellulosic plant material in the soil. In addition, U. reesii grew on gelatin and a wide range of dipeptides and amino acids, indicating a preference for proteinaceous growth substrates over carbohydrates, which may enable these fungi to also degrade animal biomass. These capabilities for degrading plant and animal substrates suggest a duality in lifestyle that could enable pathogenic species of Onygenales to transfer from soil to animal hosts.National Institute of Allergy and Infectious Diseases (U.S.)National Institutes of Health. Department of Health and Human Services (contract HHSN266200400001C)National Institutes of Health. Department of Health and Human Services(contract HHSN2722009000018C)Brazil. National Council for Scientific and Technological Developmen