The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Direct synthesis of self-assembled ferrite/carbon hybrid nanosheets for high performance lithium-ion battery anodes

Extensive applications of rechargeable lithium-ion batteries (LIBs) to various portable electronic devices and hybrid electric vehicles result in the increasing demand for the development of electrode materials with improved electrochemical performance including high energy, power density, and excellent cyclability, while maintaining low production cost. Here, we present a direct synthesis of ferrite/carbon hybrid nanosheets for high performance lithium-ion battery anodes. Uniform-sized ferrite nanocrystals and carbon materials were synthesized simultaneously through a single heating procedure using metal-oleate complex as the precursors for both ferrite and carbon. 2-D nanostructures were obtained by using sodium sulfate salt powder as a sacrificial template. The 2-D ferrite/carbon nanocomposites exhibited excellent cycling stability and rate performance derived from 2-D nanostructural characteristics. The synthetic procedure is simple, inexpensive, and scalable for mass production, and the highly ordered 2-D structure of these nanocomposites has great potential for many future applications.

Effects of Alkaline-Reduced Water on Exercise-Induced Oxidative Stress and Fatigue in Young Male Healthy Adults

Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after intense exercise. The participants were divided into two groups, wherein they consumed either purified water (PW group) or ARW (ARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water. The serum levels of oxidative stress markers and fatigue markers were determined. The results showed that ROS (p < 0.01) and NO levels (p < 0.001) were significantly decreased after ARW intake, and the reduction was more pronounced than that in the PW group. Interestingly, the increase in GPx and MDA levels was mediated by ARW intake (both p < 0.05) after exercise. The levels of fatigue markers, such as lactate (p < 0.001), lactate dehydrogenase (p < 0.001), and phosphate (p < 0.001), were significantly reduced in both groups, with ARW intervention showing more decreased markers. The correlation analysis results showed that ARW may help maintain homeostatic conditions for ROS, antioxidant systems, and fatigue markers. These findings indicate that ARW consumption is effective in reducing oxidative stress and fatigue following exhaustive exercise and that ARW could be used as an antioxidant and anti-fatigue supplement after exhaustive physical exercise

Direct Synthesis of Self-Assembled Ferrite/Carbon Hybrid Nanosheets for High Performance Lithium-Ion Battery Anodes

Extensive applications of rechargeable lithium-ion batteries (LIBs) to various portable electronic devices and hybrid electric vehicles result in the increasing demand for the development of electrode materials with improved electrochemical performance including high energy, power density, and excellent cyclability, while maintaining low production cost. Here, we present a direct synthesis of ferrite/carbon hybrid nanosheets for high performance lithium-ion battery anodes. Uniform-sized ferrite nanocrystals and carbon materials were synthesized simultaneously through a single heating procedure using metal–oleate complex as the precursors for both ferrite and carbon. 2-D nanostructures were obtained by using sodium sulfate salt powder as a sacrificial template. The 2-D ferrite/carbon nanocomposites exhibited excellent cycling stability and rate performance derived from 2-D nanostructural characteristics. The synthetic procedure is simple, inexpensive, and scalable for mass production, and the highly ordered 2-D structure of these nanocomposites has great potential for many future applications

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.

Cell fate commitment is driven by dynamic changes in chromatin architecture and activity of lineage-specific transcription factors (TFs). The chromatin assembly factor-1 (CAF-1) is a histone chaperone that regulates chromatin architecture by facilitating nucleosome assembly during DNA replication. Accumulating evidence supports a substantial role of CAF-1 in cell fate maintenance, but the mechanisms by which CAF-1 restricts lineage choice remain poorly understood. Here, we investigate how CAF-1 influences chromatin dynamics and TF activity during lineage differentiation. We show that CAF-1 suppression triggers rapid differentiation of myeloid stem and progenitor cells into a mixed lineage state. We find that CAF-1 sustains lineage fidelity by controlling chromatin accessibility at specific loci, and limiting the binding of ELF1 TF at newly-accessible diverging regulatory elements. Together, our findings decipher key traits of chromatin accessibility that sustain lineage integrity and point to a powerful strategy for dissecting transcriptional circuits central to cell fate commitment

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

AbstractCell fate commitment is driven by dynamic changes in chromatin architecture and activity of lineage-specific transcription factors (TFs). The chromatin assembly factor-1 (CAF-1) is a histone chaperone that regulates chromatin architecture by facilitating nucleosome assembly during DNA replication. Accumulating evidence supports a substantial role of CAF-1 in cell fate maintenance, but the mechanisms by which CAF-1 restricts lineage choice remain poorly understood. Here, we investigate how CAF-1 influences chromatin dynamics and TF activity during lineage differentiation. We show that CAF-1 suppression triggers rapid differentiation of myeloid stem and progenitor cells into a mixed lineage state. We find that CAF-1 sustains lineage fidelity by controlling chromatin accessibility at specific loci, and limiting the binding of ELF1 TF at newly-accessible diverging regulatory elements. Together, our findings decipher key traits of chromatin accessibility that sustain lineage integrity and point to a powerful strategy for dissecting transcriptional circuits central to cell fate commitment.</jats:p