A new model of innovation to foster entrepreneurship and employment in the FP

[EN] The Ministry of Education, Culture and Sport referred to in their action plans various measures to promote innovation in vocational training education, in line with the guidelines set by the European Parliament on "Europe 2020 strategy". In particular, the call for aid to projects of Innovation and Knowledge Transfer in vocational education system supports, among others, projects that facilitate the realization of innovative experiences between VET institutions, enterprises and entities, and projects that encourage entrepreneurial values of people, providing the framework, standards, and accompanying support needed to ensure their success. The Instituto de Biomecánica de Valencia (IBV) is actively involved in the projects SiempreFP and ComunicaFP supported by this announcement, providing technical expertise in people-driven innovation techniques.[ES] El Ministerio de Educación, Cultura y Deporte considera en sus planes de acción distintas medidas para propiciar la innovación en las Enseñanzas de Formación Profesional, en línea con las directrices marcadas por el Parlamento Europeo en la «Estrategia Europa 2020». En particular, la convocatoria de ayudas destinadas a la realización de proyectos de Innovación y Transferencia del Conocimiento en la formación profesional del sistema educativo apoya, entre otros tipos, proyectos que faciliten la realización de experiencias innovadoras entre centros de FP, empresas y entidades, y proyectos que estimulen los valores emprendedores de las personas, aportando el marco, las normas, el soporte y el acompañamiento necesarios para asegurar el éxito de los mismos. El Instituto de Biomecánica de Valencia (IBV) participa activamente en los proyectos ComunicaFP y SiempreFP apoyados por esta convocatoria, aportando su experiencia en técnicas de innovación orientada por las personas.A la Dirección General de Formación Profesional del Ministerio de Educación, Cultura y Deporte. Proyecto cofinanciado por el Fondo Social EuropeoPagan Castaño, P.; Guerrero Alonso, MA.; Lahuerta Martinez, R.; López Torres, M.; López Vicente, MA.; Garcia Bermell, C.; Campos Soriano, N.... (2012). Un nuevo modelo de innovación para fomentar el emprendimiento y el empleo en la FP. Revista de biomecánica. (58):75-80. http://hdl.handle.net/10251/38485S75805

Evaluation of unintended effects in the composition of tomatoes expressing a human immunoglobulin A against Rotavirus

The production of neutralizing immunoglobulin A (IgA) in edible fruits as a means of oral passive immunization is a promising strategy for the inexpensive treatment of mucosal diseases. This approach is based on the assumption that the edible status remains unaltered in the immunoglobulin-expressing fruit, and therefore extensive purification is not required for mucosal delivery. However, unintended effects associated with IgA expression such as toxic secondary metabolites and protein allergens cannot be dismissed a priori and need to be investigated. This paper describes a collection of independent transgenic tomato lines expressing a neutralizing human IgA against rotavirus, a mucosal pathogen producing severe diarrhea episodes. This collection was used to evaluate possible unintended effects associated with recombinant IgA expression. A comparative analysis of protein and secondary metabolite profiles using wild type lines and other commercial varieties failed to find unsafe features significantly associated with IgA expression. Preliminary, the data indicate that formulations derived from IgA tomatoes are as safe for consumption as equivalent formulations derived from wild type tomatoes.This work has been funded by Grant BIO2010-15384 from Plan Nacional I + D of the Spanish Ministry of Science. P.Juarez is the recipient of a FPU fellowship.Juárez Ortega, P.; Fernández Del Carmen, MA.; Rambla Nebot, JL.; Presa Castro, S.; Mico, A.; Granell Richart, A.; Orzáez Calatayud, DV. (2014). Evaluation of unintended effects in the composition of tomatoes expressing a human immunoglobulin A against Rotavirus. Journal of Agricultural and Food Chemistry. 62(32):8158-8168. https://doi.org/10.1021/jf502292gS81588168623

Evaluation of Unintended Effects in the Composition of Tomatoes Expressing a Human Immunoglobulin A against Rotavirus

The production of neutralizing immunoglobulin A (IgA) in edible fruits as a means of oral passive immunization is a promising strategy for the inexpensive treatment of mucosal diseases. This approach is based on the assumption that the edible status remains unaltered in the immunoglobulin-expressing fruit, and therefore extensive purification is not required for mucosal delivery. However, unintended effects associated with IgA expression such as toxic secondary metabolites and protein allergens cannot be dismissed a priori and need to be investigated. This paper describes a collection of independent transgenic tomato lines expressing a neutralizing human IgA against rotavirus, a mucosal pathogen producing severe diarrhea episodes. This collection was used to evaluate possible unintended effects associated with recombinant IgA expression. A comparative analysis of protein and secondary metabolite profiles using wild type lines and other commercial varieties failed to find unsafe features significantly associated with IgA expression. Preliminary, the data indicate that formulations derived from IgA tomatoes are as safe for consumption as equivalent formulations derived from wild type tomatoes

A Snapshot of the Emerging Tomato Genome Sequence

The genome of tomato (Solanum lycopersicum L.) is being sequenced by an international consortium of 10 countries (Korea, China, the United Kingdom, India, the Netherlands, France, Japan, Spain, Italy, and the United States) as part of the larger \u201cInternational Solanaceae Genome Project (SOL): Systems Approach to Diversity and Adaptation\u201d initiative. The tomato genome sequencing project uses an ordered bacterial artificial chromosome (BAC) approach to generate a high-quality tomato euchromatic genome sequence for use as a reference genome for the Solanaceae and euasterids. Sequence is deposited at GenBank and at the SOL Genomics Network (SGN). Currently, there are around 1000 BACs finished or in progress, representing more than a third of the projected euchromatic portion of the genome. An annotation effort is also underway by the International Tomato Annotation Group. The expected number of genes in the euchromatin is 3c40,000, based on an estimate from a preliminary annotation of 11% of finished sequence. Here, we present this first snapshot of the emerging tomato genome and its annotation, a short comparison with potato (Solanum tuberosum L.) sequence data, and the tools available for the researchers to exploit this new resource are also presented. In the future, whole-genome shotgun techniques will be combined with the BAC-by-BAC approach to cover the entire tomato genome. The high-quality reference euchromatic tomato sequence is expected to be near completion by 2010