La langue dans la langue. Ce que c’est que l’Anglais de Stéphane Mallarmé

Après sa nomination au lycée Fontanes (Condorcet), Mallarmé commence une carrière d'écrivain pédagogique qui couvrira une dizaine d'années. De 1875 à 1885, il rédige, prépare ou présente à son éditeur Truchy-Leroy plus de huit manuscrits, sans compter les manuels qu'il aura la charge de réviser et de corriger. Deux de ces ouvrages seulement paraîtront du vivant de l'auteur ( les Mots anglais , les Dieux antiques ). Nous commentons ici l'un des inédits: Ce que c'est que lAnglais . Abrégé des Mots anglais, ce manuel fait partie d'un ensemble qui constitue un cours complet. Le poète donne ici des aperçus sur l'histoire et la structure du langage qui trouveront place plus tard dans les grands articles de1892-95, ultimement réécrits et publiés dans Divagations (1897).After receiving a teaching position at the Lycée Fontanes, Mallarmé embarked on a career as an educational writer for a period of about ten years. From 1875 to 1885, he submitted more than eight of his own manuscripts to his publisher Truchy-Leroy, as well as all the other manuals he had to read and revise. Only two of those works les Mots anglais and les Dieux antiques were published in his lifetime. One of the unpublished manuscripts, entitled Ce que c'est que l'Anglais, is an abridged version of les Mots anglaisand forms one part of a larger complete course of English. In it, the author makes a brief survey of the history and structure of the English language

Banques de données électroniques et histoire du livre : le cas de l\u27histoire de l\u27édition littéraire au Québec

Colloque: Vers une nouvelle érudition : numérisation et recherche en histoire du livre, Rencontres Jacques Cartier, Lyon, décembre 1999

Vers une nouvelle érudition : numérisation et recherche en histoire du livre

En décembre 1999, à l\u27Enssib, s’est déroulé le colloque "Vers une nouvelle érudition : numérisation et recherche en histoire du livre", organisé dans le cadre des 12e Entretiens du Centre Jacques Cartier sous la responsabilité de Dominique Varry (enssib), Annie Charon (école nationale des chartes) et Guylaine Baudry (Université de Montréal)

Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region

<p>Abstract</p> <p>Background</p> <p>Duffy blood group polymorphisms are important in areas where <it>Plasmodium vivax </it>predominates, because this molecule acts as a receptor for this protozoan. In the present study, Duffy blood group genotyping in <it>P. vivax </it>malaria patients from four different Brazilian endemic areas is reported, exploring significant associations between blood group variants and susceptibility or resistance to malaria.</p> <p>Methods</p> <p>The <it>P. vivax </it>identification was determined by non-genotypic and genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP in 330 blood donors and 312 malaria patients from four Brazilian Amazon areas. In order to assess the variables significance and to obtain independence among the proportions, the Fisher's exact test was used.</p> <p>Results</p> <p>The data show a high frequency of the <it>FYA/FYB </it>genotype, followed by <it>FYB/FYB, FYA/FYA</it>, <it>FYA/FYB-33 </it>and <it>FYB/FYB-33</it>. Low frequencies were detected for the <it>FYA/FY</it>^<it>X</it>, <it>FYB/FY</it>^<it>X</it>, <it>FYX/FY</it>^{<it>X </it>}and <it>FYB-33/FYB-33 </it>genotypes. Negative Duffy genotype (<it>FYB-33/FYB-33</it>) was found in both groups: individuals infected and non-infected (blood donors). No individual carried the <it>FY</it>^<it>X</it><it>/FYB-33 </it>genotype. Some of the Duffy genotypes frequencies showed significant differences between donors and malaria patients.</p> <p>Conclusion</p> <p>The obtained data suggest that individuals with the <it>FYA/FYB </it>genotype have higher susceptibility to malaria. The presence of the <it>FYB-33 </it>allele may be a selective advantage in the population, reducing the rate of infection by <it>P. vivax </it>in this region. Additional efforts may contribute to better elucidate the physiopathologic differences in this parasite/host relationship in regions endemic for <it>P. vivax </it>malaria, in particular the Brazilian Amazon region.</p

Designed Metal-ATCUN Derivatives: Redox- and Non-redox-Based Applications Relevant for Chemistry, Biology, and Medicine

UID/QUI/50006/2019The designed "ATCUN'' motif (amino-terminal copper and nickel binding site) is a replica of naturally occurring ATCUN site found in many proteins/peptides, and an attractive platform for multiple applications, which include nucleases, proteases, spectroscopic probes, imaging, and small molecule activation. ATCUN motifs are engineered at periphery by conjugation to recombinant proteins, peptides, fluorophores, or recognition domains through chemically or genetically, fulfilling the needs of various biological relevance and a wide range of practical usages. This chemistry has witnessed significant growth over the last few decades and several interesting ATCUN derivatives have been described. The redox role of the ATCUN moieties is also an important aspect to be considered. The redox potential of designed M-ATCUN derivatives is modulated by judicious choice of amino acid (including stereochemistry, charge, and position) that ultimately leads to the catalytic efficiency. In this context, a wide range of M-ATCUN derivatives have been designed purposefully for various redox- and non-redox-based applications, including spectroscopic probes, target-based catalytic metallodrugs, inhibition of amyloid-beta toxicity, and telomere shortening, enzyme inactivation, biomolecules stitching or modification, next-generation antibiotic, and small molecule activation.publishersversionpublishe