255 research outputs found
Swift/UVOT Photometry of the Planetary Nebula WeBo 1: Unmasking A Faint Hot Companion Star
We present an analysis of over 150 ks of data on the planetary nebula WeBo 1
(PN G135.6+01.0) obtained with the Swift Ultraviolet Optical Telescope (UVOT).
The central object of this nebula has previously been described as a late-type
K giant barium star with a possible hot companion, most likely a young
pre-white dwarf. UVOT photometry shows that while the optical photometry is
consistent with a large cool object, the near-ultraviolet (UV) photometry shows
far more UV flux than could be produced by any late-type object. Using model
stellar atmospheres and a comparison to UVOT photometry for the pre-white dwarf
PG 1159-035, we find that the companion has a temperature of at least 40,000 K
and a radius of, at most, 0.056 R_sun. While the temperature and radius are
consistent with a hot compact stellar remnant, they are lower and larger,
respectively, than expected for a typical young pre-white dwarf. This likely
indicates a deficiency in the assumed UV extinction curve. We find that higher
temperatures more consistent with expectations for a pre-white dwarf can be
derived if the foreground dust has a strong "blue bump" at 2175 AA and a lower
R_V. Our results demonstrate the ability of Swift to both uncover and
characterize hot hidden companion stars and to constrain the UV extinction
properties of foreground dust based solely on UVOT photometry.Comment: 26 pages, 9 figure, accepted to Astronomical Journa
Continuous bunch-by-bunch spectroscopic investigation of the micro-bunching instability
Electron accelerators and synchrotrons can be operated to provide short
emission pulses due to longitudinally compressed or sub-structured electron
bunches. Above a threshold current, the high charge density leads to the
micro-bunching instability and the formation of sub-structures on the bunch
shape. These time-varying sub-structures on bunches of picoseconds-long
duration lead to bursts of coherent synchrotron radiation in the terahertz
frequency range. Therefore, the spectral information in this range contains
valuable information about the bunch length, shape and sub-structures. Based on
the KAPTURE readout system, a 4-channel single-shot THz spectrometer capable of
recording 500 million spectra per second and streaming readout is presented.
First measurements of time-resolved spectra are compared to simulation results
of the Inovesa Vlasov-Fokker-Planck solver. The presented results lead to a
better understanding of the bursting dynamics especially above the
micro-bunching instability threshold.Comment: 12 pages, 11 figure
North Carolina Law Enforcement Assisted Diversion (LEAD): Considerations For Optimizing Eligibility and Referral
Solar thermoelectricity Via Advanced Latent Heat Storage
An aspect of the present disclosure is a system that includes a thermal valve having a first position and a second position, a heat transfer fluid, and an energy converter where, when in the first position, the thermal valve prevents the transfer of heat from the heat transfer fluid to the energy converter, and when in the second position, the thermal valve allows the transfer of heat from the heat transfer fluid to the energy converter, such that at least a portion of the heat transferred is converted to electricity by the energy converter
Dark Matter signals from Draco and Willman 1: Prospects for MAGIC II and CTA
The next generation of ground-based Imaging Air Cherenkov Telescopes (IACTs)
will play an important role in indirect dark matter searches. In this article,
we consider two particularly promising candidate sources for dark matter
annihilation signals, the nearby dwarf galaxies Draco and Willman 1, and study
the prospects of detecting such a signal for the soon-operating MAGIC II
telescope system as well as for the planned installation of CTA, taking special
care of describing the experimental features that affect the detectional
prospects. For the first time in such a study, we fully take into account the
effect of internal bremsstrahlung, which has recently been shown to
considerably enhance, in some cases, the gamma-ray flux at the high energies
where Atmospheric Cherenkov Telescopes operate, thus leading to significantly
harder annihilation spectra than traditionally considered. While the detection
of the spectral features introduced by internal bremsstrahlung would constitute
a smoking gun signature for dark matter annihilation, we find that for most
models the overall flux still remains at a level that will be challenging to
detect unless one adopts rather (though by no means overly) optimistic
astrophysical assumptions about the distribution of dark matter in the dwarfs.Comment: 10 pages, 4 figures, minor changes, matches the published version
(JCAP
Pomalidomide plus low-dose dexamethasone in patients with relapsed/refractory multiple myeloma and moderate renal impairment: a pooled analysis of three clinical trials
Renal impairment (RI) is a major comorbidity in patients with multiple myeloma (MM). Here we present the pooled safety and efficacy analysis of three clinical trials (MM-002, MM-003, and MM-010) of pomalidomide + low-dose dexamethasone (POM + LoDEX) in patients with moderate RI (creatinine clearance [CrCl] ≥ 30 to <60 mL/min) and without RI (≥ 60 mL/min). Trial protocols were approved by the institutional review board of each site involved. Patients with RI were older than patients without RI, although other baseline characteristics were similar. The dosing and safety profile of POM + LoDEX was similar across RI subgroups. Median overall response rate, progression-free survival, time to progression, and duration of response were not significantly different between RI subgroups. However, patients with vs. without RI had significantly shorter median overall survival (10.5 vs. 14.0 months, respectively; p = .004). This analysis demonstrates that POM + LoDEX is a safe and effective treatment for patients with moderate RI. The trials were registered at ClinicalTrials.gov as NCT00833833 (MM-002), NCT01311687 (MM-003), and NCT01712789 (MM-010) and at EudraCT as 2010-019820-30 (MM-003) and 2012-001888-78 (MM-010)
Single-subunit oligosaccharyltransferases of <i>Trypanosoma brucei </i>display different and predictable peptide acceptor specificities
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology
Regulation of Arpc3 by miRNA alters dendritic spine morphology
The Cooperation between hMena Overexpression and HER2 Signalling in Breast Cancer
hMena and the epithelial specific isoform hMena11a are actin cytoskeleton regulatory proteins belonging to the Ena/VASP family. EGF treatment of breast cancer cell lines upregulates hMena/hMena11a expression and phosphorylates hMena11a, suggesting cross-talk between the ErbB receptor family and hMena/hMena11a in breast cancer. The aim of this study was to determine whether the hMena/hMena11a overexpression cooperates with HER-2 signalling, thereby affecting the HER2 mitogenic activity in breast cancer. In a cohort of breast cancer tissue samples a significant correlation among hMena, HER2 overexpression, the proliferation index (high Ki67), and phosphorylated MAPK and AKT was found and among the molecular subtypes the highest frequency of hMena overexpressing tumors was found in the HER2 subtype. From a clinical viewpoint, concomitant overexpression of HER2 and hMena identifies a subgroup of breast cancer patients showing the worst prognosis, indicating that hMena overexpression adds prognostic information to HER2 overexpressing tumors. To identify a functional link between HER2 and hMena, we show here that HER2 transfection in MCF7 cells increased hMena/hMena11a expression and hMena11a phosphorylation. On the other hand, hMena/hMena11a knock-down reduced HER3, AKT and p44/42 MAPK phosphorylation and inhibited the EGF and NRG1-dependent HER2 phosphorylation and cell proliferation. Of functional significance, hMena/hMena11a knock-down reduced the mitogenic activity of EGF and NRG1. Collectively these data provide new insights into the relevance of hMena and hMena11a as downstream effectors of the ErbB receptor family which may represent a novel prognostic indicator in breast cancer progression, helping to stratify patients
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