Adiabatic quantum trajectories in engineered reservoirs

We analyze the efficiency of protocols for adiabatic quantum state transfer assisted by an engineered reservoir. The target dynamics is a quantum trajectory in the Hilbert space and is the fixed point of a time-dependent master equation. We specialize to quantum state transfer in a qubit and determine the optimal schedule for a class of time-dependent Lindblad equations. The speed limit on state transfer is extracted from a physical model of a qubit coupled to a reservoir, from which the Lindblad equation is derived in the Born-Markov limit. Our analysis shows that the resulting efficiency is comparable to the efficiency of the optimal unitary dynamics. Numerical studies indicate that reservoir-engineered protocols could outperform unitary protocols outside the regime of the Born-Markov master equation, namely, when correlations between the qubit and reservoir become relevant. Our study contributes to the theory of shortcuts to adiabaticity for open quantum systems and to the toolbox of protocols of the NISQ era.Comment: 14+7 pages, 7 figure

Evidence for the formation of comet 67P/Churyumov-Gerasimenko through gravitational collapse of a bound clump of pebbles

The processes that led to the formation of the planetary bodies in the Solar System are still not fully understood. Using the results obtained with the comprehensive suite of instruments on-board ESA’s Rosetta mission, we present evidence that comet 67P/Churyumov-Gerasimenko likely formed through the gentle gravitational collapse of a bound clump of mm-sized dust aggregates (“pebbles”), intermixed with microscopic ice particles. This formation scenario leads to a cometary make-up that is simultaneously compatible with the global porosity, homogeneity, tensile strength, thermal inertia, vertical temperature profiles, sizes and porosities of emitted dust, and the steep increase in water-vapour production rate with decreasing heliocentric distance, measured by the instruments on-board the Rosetta spacecraft and the Philae lander. Our findings suggest that the pebbles observed to be abundant in protoplanetary discs around young stars provide the building material for comets and other minor bodies

In Vitro and In Vivo Human Herpesvirus 8 Infection of Placenta

Herpesvirus infection of placenta may be harmful in pregnancy leading to disorders in fetal growth, premature delivery, miscarriage, or major congenital abnormalities. Although a correlation between human herpesvirus 8 (HHV-8) infection and abortion or low birth weight in children has been suggested, and rare cases of in utero or perinatal HHV-8 transmission have been documented, no direct evidence of HHV-8 infection of placenta has yet been reported. The aim of this study was to evaluate the in vitro and in vivo susceptibility of placental cells to HHV-8 infection. Short-term infection assays were performed on placental chorionic villi isolated from term placentae. Qualitative and quantitative HHV-8 detection were performed by PCR and real-time PCR, and HHV-8 proteins were analyzed by immunohistochemistry. Term placenta samples from HHV-8-seropositive women were analyzed for the presence of HHV-8 DNA and antigens. In vitro infected histocultures showed increasing amounts of HHV-8 DNA in tissues and supernatants; cyto- and syncitiotrophoblasts, as well as endothelial cells, expressed latent and lytic viral antigens. Increased apoptotic phenomena were visualized by the terminal deoxynucleotidyl transferase-mediated deoxyuridine nick end-labeling method in infected histocultures. Ex vivo, HHV-8 DNA and a latent viral antigen were detected in placenta samples from HHV-8-seropositive women. These findings demonstrate that HHV-8, like other human herpesviruses, may infect placental cells in vitro and in vivo, thus providing evidence that this phenomenon might influence vertical transmission and pregnancy outcome in HHV-8-infected women

Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer

Background: Contrast enhanced ultrasound (CEUS) is an imaging technique which appeared on the market around the year 2000 and proposed for the detection of liver metastases in gastrointestinal cancer patients, a setting in which accurate staging plays a significant role in the choice of treatment. Methods: A total of 109 patients with colorectal (n = 92)or gastric cancer prospectively underwent computed tomography (CT) scan and conventional US evaluation followed by real time CEUS. A diagnosis of metastases was made by CT or, for lesions not visibile at CT, the diagnosis was achieved by histopathology or by a malignant behavior during follow-up. Results: Of 109 patients, 65 were found to have metastases at presentation. CEUS improved sensitivity in metastatic livers from 76.9% of patients (US) to 95.4% (p < 0.01), while CT scan reached 90.8% (p = n.s. vs CEUS, p < 0.01 vs US). CEUS and CT were more sensitive than US also for detection of single lesions (87 with US, 122 with CEUS, 113 with CT). In 15 patients (13.8%), CEUS revealed more metastases than CT, while CT revealed more metastases than CEUS in 9 patients (8.2%) (p = n.s.). Conclusion: CEUS is more sensitive than conventional US in the detection of liver metastases and could be usefully employed in the staging of patients with gastrointestinal cancer. Findings at CEUS and CT appear to be complementary in achieving maximum sensitivity. © 2007 Piscaglia et al; licensee BioMed Central Ltd

Terrestrial Very-Long-Baseline Atom Interferometry:Workshop Summary

This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions

Human herpesvirus 8 (HHV-8) “in vitro” infection of human placental histocultures

Most human Herpesvirus infect placental cells and may be harmful in pregnancy, leading to obstetrical and/or neonatal complications. Although a correlation between human herpesvirus 8 (HHV-8) infection and abortion or low birth weight in children has been reported [1,2] presently no information has been published regarding HHV-8 tropism for placenta

Double immunohistochemical staining for HHV-8 LANA antigens, CD31 and cytokeratin-7 in infected histocultures.

<p>(A) Double staining performed using peroxidase for the viral LANA protein (brown) and alkaline phosphatase for the vascular-associated CD31 marker (blue) showed coexpression of these proteins in endothelial cells (white arrow). (B) Double staining using peroxidase for LANA (brown) and alkaline phosphatase for cytokeratin-7 (blue) showed coexpression of these proteins in syncytiotrophoblasts (blue arrow). Original magnifications, ×100.</p

Immunofluorescence for detection of apoptotic cells.

<p>Immunofluorescence for qualitative detection of apoptotic cells in placental histocultures was performed by using the TUNEL assay. Apoptotic nuclei were more frequently evidenced in HHV-8-infected microexplants 48 h (A) and 72 h (B) after infection than in mock-infected microexplants 48 h (C) and 72 h (D) after mock infection. Original magnifications, ×40.</p