Second Guessing in Perceptual Decision-Making.

Human subjects of both sexes were asked to make a perceptual decision between multiple directions of visual motion. In addition to reporting a primary choice, they also had to report a second guess, indicating which of the remaining options they would rather bet on, assuming that they got their primary choice wrong. The second guess was clearly informed by the amounts of sensory evidence that were provided for the different options. A single computational integration-to-threshold model, based on the assumption that the second guess is determined by the rank ordering of accumulated evidence at or shortly after the time of the decision, was able to explain the distribution of primary choices, associated response times, and the distribution of second guesses. This suggests that the decision-maker has access to how well supported unchosen options are by the sensory evidence.SIGNIFICANCE STATEMENT Perceptual decisions require conversion of sensory evidence into a discrete choice. Computational models based on the accumulation of evidence to a decision threshold can explain the distribution of choices and associated decision times. Subjects are also able to report the level of confidence in their decision. Here we show that, when making decisions between more than two alternatives, the decision-maker can even report a second guess that is clearly informed by the sensory evidence. These second guesses show a distribution that is consistent with subjects having access to how much sensory evidence was accumulated for the unchosen options. The decision-maker therefore has knowledge about the outcome of the decision process that goes beyond just the choice and an associated confidence

A New Composite Restorative Based on a Hydrophobic Matrix

A hydrophobic restorative composite based on a fluorocarbon analog of an alkyl methacrylate and a bisphenol adduct was formulated into a one-paste system, which polymerized in the presence of blue light. Physical, mechanical, and water-related properties were determined. High contact angles and low water sorption were shown by the experimental composite. Capillary penetration of oral fluids around restorations, therefore, could be prevented in the presence of this highly hydrophobic surface. The physical and mechanical properties of the experimental composite were either comparable to or somewhat less favorable than commercial Bis-GMA composites.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67042/2/10.1177_00220345790580100401.pd

Calibrating Galaxy Redshifts Using Absorption by the Surrounding Intergalactic Medium

Rest-frame UV spectral lines of star-forming galaxies are systematically offset from the galaxies' systemic redshifts, probably because of large-scale outflows. We calibrate galaxy redshifts measured from rest-frame UV lines by utilizing the fact that the mean HI Ly-alpha absorption profiles around the galaxies, as seen in spectra of background objects, must be symmetric with respect to the true galaxy redshifts if the galaxies are oriented randomly with respect to the lines of sight to the background objects. We use 15 QSOs at z~2.5-3 and more than 600 foreground galaxies with spectroscopic redshifts at z~1.9-2.5. All galaxies are within 2 Mpc proper from the lines of sight to the background QSOs. We find that LyA emission and ISM absorption redshifts require systematic shifts of v_LyA=-295(+35)(-35) km/s and v_ISM=145(+70)(-35) km/s. Assuming a Gaussian distribution, we put 1-sigma upper limits on possible random redshift offsets of <220 km/s for LyA and <420 km/s for ISM redshifts. For the small subset (<10%) of galaxies for which near-IR spectra have been obtained, we can compare our results to direct measurements based on nebular emission lines which we confirm to mark the systemic redshifts. While our v_ISM agrees with the direct measurements, our v_LyA is significantly smaller. However, when we apply our method to the near-IR subsample which is characterized by slightly different selection effects, the best-fit velocity offset comes into agreement with the direct measurement. This confirms the validity of our approach, and implies that no single number appropriately describes the whole population of galaxies, in line with the observation that the line offset depends on galaxy spectral morphology. This method provides accurate redshift calibrations and will enable studies of circumgalactic matter around galaxies for which rest-frame optical observations are not available.Comment: 7 pages, 3 figures, accepted for publication in MNRA

Prospects of Stellar Abundance Studies from Near-IR Spectra Observed with the E-ELT

In 2006 ESO Council authorized a Phase B study of a European AO-telescope with a 42 m segmented primary with a 5-mirror design, the E-ELT. Several reports and working groups have already presented science cases for an E-ELT, specifically exploiting the new capabilities of such a large telescope. One of the aims of the design has been to find a balance in the performances between an E-ELT and the James Webb Space Telescope, JWST. Apart from the larger photon-collecting area, the strengths of the former is the higher attainable spatial and spectral resolutions. The E-ELT AO system will have an optimal performance in the near-IR, which makes it specially advantageous. High-resolution spectroscopy in the near-infrared has, however, not been discussed much. This paper aims at filling that gap, by specifically discussing spectroscopy of stellar (mainly red giant), photospheric abundances. Based on studies in the literature of stellar abundances, at the needed medium to high spectral resolutions in the near-infrared (0.8-2.4 microns), I will try to extrapolate published results to the performance of the E-ELT and explore what could be done at the E-ELT in this field. A discussion on what instrument characteristics that would be needed for stellar abundance analyses in the near-IR will be given.Comment: Accepted for publication in Astronomische Nachrichten, A

The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis

YesChemerin is an adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism, and has been hypothesized as a link between obesity and type II diabetes. In humans affected by obesity, chemerin gene expression in peripheral tissues and circulating levels are elevated. In mice, plasma levels of chemerin are upregulated by high-fat feeding and gain and loss of function studies show an association of chemerin with body weight, food intake and glucose homeostasis. Therefore, chemerin is an important blood-borne mediator that, amongst its other functions, controls appetite and body weight. Almost all studies of chemerin to date have focused on its release from adipose tissue and its effects on peripheral tissues with the central effects largely overlooked. To demonstrate a central role of chemerin, we manipulated chemerin signaling in the hypothalamus, a brain region associated with appetite regulation, using pharmacological and genetic manipulation approaches. Firstly, the selective chemerin receptor CMKLR1 antagonist α-NETA was administered i.c.v. to rats to test for an acute physiological effect. Secondly, we designed a short-hairpin-RNA (shRNA) lentivirus construct targeting expression of CMKLR1. This shRNA construct, or a control construct was injected bilaterally into the arcuate nucleus of male Sprague Dawley rats on high-fat diet (45%). After surgery, rats were maintained on high-fat diet for 2 weeks and then switched to chow diet for a further 2 weeks. We found a significant weight loss acutely and inhibition of weight gain chronically. This difference became apparent after diet switch in arcuate nucleus-CMKLR1 knockdown rats. This was not accompanied by a difference in blood glucose levels. Interestingly, appetite-regulating neuropeptides remained unaltered, however, we found a significant reduction of the inflammatory marker TNF-α suggesting reduced expression of CMKLR1 protects from high-fat diet induced neuroinflammation. In white and brown adipose tissue, mRNA expression of chemerin, its receptors and markers of adipogenesis, lipogenesis and brown adipocyte activation remained unchanged confirming that the effects are driven by the brain. Our behavioral analyses suggest that knockdown of CMKLR1 had an impact on object recognition. Our data demonstrate that CMKLR1 is functionally important for the central effects of chemerin on body weight regulation and neuroinflammation.This work was funded in part by the Academy of Medical Sciences, the Wellcome Trust, the Government of Business, Energy and Industrial Strategy and the British Heart Foundation and Diabetes United Kingdom [SBF004/1063] (GH), the Society for Endocrinology Equipment Grant (GH, RD), the University of Bradford (GH, KP, SK) and Nottingham Trent University (RD)

Experimental Infection of North American Birds with the New York 1999 Strain of West Nile Virus

To evaluate transmission dynamics, we exposed 25 bird species to West Nile virus (WNV) by infectious mosquito bite. We monitored viremia titers, clinical outcome, WNV shedding (cloacal and oral), seroconversion, virus persistence in organs, and susceptibility to oral and contact transmission. Passeriform and charadriiform birds were more reservoir competent (a derivation of viremia data) than other species tested. The five most competent species were passerines: Blue Jay (Cyanocitta cristata), Common Grackle (Quiscalus quiscula), House Finch (Carpodacus mexicanus), American Crow (Corvus brachyrhynchos), and House Sparrow (Passer domesticus). Death occurred in eight species. Cloacal shedding of WNV was observed in 17 of 24 species, and oral shedding in 12 of 14 species. We observed contact transmission among four species and oral in five species. Persistent WNV infections were found in tissues of 16 surviving birds. Our observations shed light on transmission ecology of WNV and will benefit surveillance and control programs

Alligators as West Nile Virus Amplifiers

Juvenile alligators may help transmit West Nile virus in some areas

Comparison of Argentinean Saint Louis Encephalitis Virus Non-Epidemic and Epidemic Strain Infections in an Avian Model

St. Louis encephalitis virus (SLEV, Flavivirus, Flaviviridae) is an emerging mosquito-borne pathogen in South America, with human SLEV encephalitis cases reported in Argentina and Brazil. Genotype III strains of SLEV were isolated from Culex quinquefasciatus mosquitoes in Cordoba, Argentina in 2005, during the largest SLEV outbreak ever reported in South America. The present study tested the hypothesis that the recent, epidemic SLEV strain exhibits greater virulence in birds as compared with a non-epidemic genotype III strain isolated from mosquitoes in Santa Fe Province 27 years earlier. The observed differences in infection parameters between adult House sparrows (Passer domesticus) that were needle-inoculated with either the epidemic or historic SLEV strain were not statistically significant. However, only the House sparrows that were infected with the epidemic strain achieved infectious-level viremia titers sufficient to infect Cx. spp. mosquitoes vectors. Furthermore, the vertebrate reservoir competence index values indicated an approximately 3-fold increase in amplification potential of House sparrows infected with the epidemic strain when pre-existing flavivirus-reactive antibodies were present, suggesting the possibility that antibody-dependent enhancement may increase the risk of avian-amplified transmission of SLEV in South America