MOOCs in language education and professional teacher development: possibilities and potential

Massive Open Online Courses (MOOCs) developed from the traditions of distance and selfaccess learning, and are growing in popularity. As a new and exciting area of education, the potential of MOOCs to transform education by allowing free access to courses for anyone with the access to technology and the internet has potential for teachers and learners to benefit from the courses offered. In this short article, three different perspectives on using MOOCs in educational contexts within Japan are discussed. The first describes a collaborative project in which one of the authors participated in a MOOC alongside a group of language learners. In the next, individual students pursuing self-directed language learning chose MOOCs to meet their various goals of knowledge and skill development as they prepared to study abroad. Finally, this article considers the role of MOOCs in professional teacher development through the reflections from a teacher participant. All three discussions relate their ideas to the themes of possibility and potential, while considering practical issues for language learners and educators

Interventions to Promote More Effective Balance-Recovery Reactions in Industrial Settings: New Perspectives on Footwear and Handrails

“Change-in-support” balance-recovery reactions that involve rapid stepping or reaching movements play a critical role in preventing falls. Recent geriatrics studies have led to new interventions to improve ability to execute these reactions effectively. Some of these interventions have the potential to reduce fall risk for younger persons working in industrial settings. In this paper, we review research pertaining to two such interventions: 1) balance-enhancing footwear insoles designed to improve stepping reactions, and 2) proximity-triggered handrail cueing systems designed to improve reach-to-grasp reactions. The insole has a raised ridge around the perimeter that is intended to improve balance control by providing increased stimulation of sensory receptors on the footsole in situations where loss of balance may be imminent. The cueing system uses flashing lights and/or verbal prompts to attract attention to the handrail and ensure that the brain registers its location, thereby facilitating more rapid and accurate grasping of the rail if and when sudden loss of balance occurs. Results to date support the efficacy of both interventions in geriatric populations. There is also some evidence that these interventions may improve balance control in younger persons; however, further research is needed to confirm their efficacy in preventing falls in industrial settings

The effect of a concurrent cognitive task on cortical potentials evoked by unpredictable balance perturbations

BACKGROUND: Although previous studies suggest that postural control requires attention and other cognitive resources, the central mechanisms responsible for this relationship remain unclear. To address this issue, we examined the effects of altered attention on cortical activity and postural responses following mechanical perturbations to upright stance. We hypothesized that cortical activity would be attenuated but not delayed when mechanical perturbations were applied during a concurrent performance of a cognitive task (i.e. when attention was directed away from the perturbation). We also hypothesized that these cortical changes would be accompanied by alterations in the postural response, as evidenced by increases in the magnitude of anteroposterior (AP) centre of pressure (COP) peak displacements and tibialis anterior (TA) muscle activity. Healthy young adults (n = 7) were instructed to continuously track (cognitive task) or not track (control task) a randomly moving visual target using a hand-held joystick. During each of these conditions, unpredictable translations of a moving floor evoked cortical and postural responses. Scalp-recorded cortical activity, COP, and TA electromyographic (EMG) measures were collected. RESULTS: Results revealed a significant decrease in the magnitude of early cortical activity (the N1 response, the first negative peak after perturbation onset) during the tracking task compared to the control condition. More pronounced AP COP peak displacements and EMG magnitudes were also observed for the tracking task and were possibly related to changes in the N1 response. CONCLUSION: Based on previous notions that the N1 response represents sensory processing of the balance disturbance, we suggest that the attenuation of the N1 response is an important central mechanism that may provide insight into the relationship between attention and postural control

'It's a film' : medium specificity as textual gesture in Red road and The unloved

British cinema has long been intertwined with television. The buzzwords of the transition to digital media, 'convergence' and 'multi-platform delivery', have particular histories in the British context which can be grasped only through an understanding of the cultural, historical and institutional peculiarities of the British film and television industries. Central to this understanding must be two comparisons: first, the relative stability of television in the duopoly period (at its core, the licence-funded BBC) in contrast to the repeated boom and bust of the many different financial/industrial combinations which have comprised the film industry; and second, the cultural and historical connotations of 'film' and 'television'. All readers of this journal will be familiar – possibly over-familiar – with the notion that 'British cinema is alive and well and living on television'. At the end of the first decade of the twenty-first century, when 'the end of medium specificity' is much trumpeted, it might be useful to return to the historical imbrication of British film and television, to explore both the possibility that medium specificity may be more nationally specific than much contemporary theorisation suggests, and to consider some of the relationships between film and television manifest at a textual level in two recent films, Red Road (2006) and The Unloved (2009)

Enhancement of Omicron-specific immune responses following bivalent COVID-19 booster vaccination in patients with chronic lymphocytic leukaemia

No abstract available

A perturbation-based balance training program for older adults: study protocol for a randomised controlled trial

<p>Abstract</p> <p>Background</p> <p>Previous research investigating exercise as a means of falls prevention in older adults has shown mixed results. Lack of specificity of the intervention may be an important factor contributing to negative results. Change-in-support (CIS) balance reactions, which involve very rapid stepping or grasping movements of the limbs, play a critical role in preventing falls; hence, a training program that improves ability to execute effective CIS reactions could potentially have a profound effect in reducing risk of falling. This paper describes: 1) the development of a perturbation-based balance training program that targets specific previously-reported age-related impairments in CIS reactions, and 2) a study protocol to evaluate the efficacy of this new training program.</p> <p>Methods/Design</p> <p>The training program involves use of unpredictable, multi-directional moving-platform perturbations to evoke stepping and grasping reactions. Perturbation magnitude is gradually increased over the course of the 6-week program, and concurrent cognitive and movement tasks are included during later sessions. The program was developed in accordance with well-established principles of motor learning, such as individualisation, specificity, overload, adaptation-progression and variability. Specific goals are to reduce the frequency of multiple-step responses, reduce the frequency of collisions between the stepping foot and stance leg, and increase the speed of grasping reactions. A randomised control trial will be performed to evaluate the efficacy of the training program. A total of 30 community-dwelling older adults (age 64–80) with a recent history of instability or falling will be assigned to either the perturbation-based training or a control group (flexibility/relaxation training), using a stratified randomisation that controls for gender, age and baseline stepping/grasping performance. CIS reactions will be tested immediately before and after the six weeks of training, using platform perturbations as well as a distinctly different method of perturbation (waist pulls) in order to evaluate the generalisability of the training effects.</p> <p>Discussion</p> <p>This study will determine whether perturbation-based balance training can help to reverse specific age-related impairments in balance-recovery reactions. These results will help to guide the development of more effective falls prevention programs, which may ultimately lead to reduced health-care costs and enhanced mobility, independence and quality of life.</p

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Scientific art : the tetralogy of John Banville

The main thesis of this study is that John Banville's fictional scientific tetralogy makes an aesthetically challenging attempt to fuse renewed popular notions of science and scientific figures with renewed artistic forms. Banville is most interested in the creative mind of the scientist, astronomer, or mathematician, his life and times in Doctor Copernicus (1976) and Kepler (1981), and his modern day influence in The Newton Letter (1982) and Mefisto (1986). The novelist's writing is a movement of the subjective into what has normally been regarded as the objective domain of science. Chapter one gives a critical overview of the present state of Banville scholarship. It reveals that despite his focus on scientists, the novelist rarely invites more than narrow literary approaches. Chapter two discusses the cultural context of relations between science and literature. The theories of Gerald Holton on scientific history, of Arthur Koestler on creativity, and of Thomas Kuhn on paradigm change are shown to be germane to Banville's tetralogy. These theories support the general methodology throughout the dissertation. Chapter three examines the creation of the scientific genius Doctor Copernicus. In particular, the following areas are examined: the scientist's boyhood; the influences of his family, friends and colleagues; the link between science and public policy; the scientist's living and working conditions; and the scientist's thematic presuppositions. Chapter four continues the exploration of the social and artistic process of science with regard to the astronomer Kepler. This chapter's discussion of the brotherhood of science, astrology, physicalization, religion and dreams inevitably raises questions about the role of the scientist in society and how his ideas are developed. Chapter five reveals the importance of the extra—scientific factors that go into the composition of any purportedly objective science. In The Newton Letter, both the great English scientist and his Irish biographer seem to suffer from similar paradigm shifts. Chapter six on Mefisto argues that recent scientific theory, including the science of chaos, informs the work, particularly with regard to the notions of symmetry and asymmetry. Chapter seven concludes by advancing the argument that Banville's work is a much needed contribution to Irish culture, which has tended to ignore the social potential of science.Arts, Faculty ofEnglish, Department ofGraduat

The Big Top on Screen : Towards a Genealogy of Circus Cinema

[Delivered as a conference paper at the Film Studies Association of Canada annual conference at UBC on June 5th, 2019]Arts, Faculty ofTheatre and Film, Department ofUnreviewedFacult