Estimating local records for Northern and Central Italy from a sparse secular temperature network and from 1961–1990 climatologies

The paper presents monthly 30-arc-second-resolution Northern and Central Italy temperature climatologies and discusses the procedure we adopt to superimpose the information of temperature secular records onto these climatologies. The climatologies are obtained by means of a step-wise linear regression method which aims at determining the temperature dependence on geographical and morphological variables. Such a method is applied to a database of about 800 monthly 1961–1990 temperature normals. In the first regression (temperature vs. elevation) the recorded data are considered; the further regressions concern the residuals obtained after taking into account the effect of each variable, in order of importance. An estimated secular anomaly record can be obtained for each point of the climatology grid by means of a distance-weighted average of the temperature anomaly records of the stations surrounding the grid point

Un juego que de(s)borde: una intervención psicoanalítica en la escuela

En esta ponencia nos ocuparemos de presentar una intervención en una escuela primaria. Dicho pedido de intervención, proviene de la institución y sus actores: docentes, Equipo de Orientación Escolar (EOE) y directivos, para tratar el malestar que genera las manifestaciones súbitas de violencia de un niño de doce años, tanto con pares como con algunos docentes. Por otro lado, asistimos en este caso, a lazos familiares poco disponibles para el niño. La intervención, en esta oportunidad, es doble: por un lado, se realiza un taller lúdico en el aula, con los alumnos y la docente responsable; por otro, se realizan algunas entrevistas con el equipo de orientación. Estas últimas son de suma importancia, en la medida en que muestran en acto al EOE soluciones que ellos mismos implementan sin saberlo o que podrían comenzar a implementar, en general a partir del uso del juego como algo transicional entre la posición del niño que produce malestar y una nueva posición posible. El abordaje del síntoma escolar muestra una de las posibilidades del Psicoanálisis aplicado (Rubinstein, 2003), la de intervenir en territorio, a pesar de su extraterritorialidad (Lacan, 1955).Lectura de la demanda e intervención del síntoma en instituciones educativas: perspectivas en extensión universitariaFacultad de Psicologí

Un juego que de(s)borde: una intervención psicoanalítica en la escuela

En esta ponencia nos ocuparemos de presentar una intervención en una escuela primaria. Dicho pedido de intervención, proviene de la institución y sus actores: docentes, Equipo de Orientación Escolar (EOE) y directivos, para tratar el malestar que genera las manifestaciones súbitas de violencia de un niño de doce años, tanto con pares como con algunos docentes. Por otro lado, asistimos en este caso, a lazos familiares poco disponibles para el niño. La intervención, en esta oportunidad, es doble: por un lado, se realiza un taller lúdico en el aula, con los alumnos y la docente responsable; por otro, se realizan algunas entrevistas con el equipo de orientación. Estas últimas son de suma importancia, en la medida en que muestran en acto al EOE soluciones que ellos mismos implementan sin saberlo o que podrían comenzar a implementar, en general a partir del uso del juego como algo transicional entre la posición del niño que produce malestar y una nueva posición posible. El abordaje del síntoma escolar muestra una de las posibilidades del Psicoanálisis aplicado (Rubinstein, 2003), la de intervenir en territorio, a pesar de su extraterritorialidad (Lacan, 1955).Lectura de la demanda e intervención del síntoma en instituciones educativas: perspectivas en extensión universitariaFacultad de Psicologí

Un juego que de(s)borde: una intervención psicoanalítica en la escuela

En esta ponencia nos ocuparemos de presentar una intervención en una escuela primaria. Dicho pedido de intervención, proviene de la institución y sus actores: docentes, Equipo de Orientación Escolar (EOE) y directivos, para tratar el malestar que genera las manifestaciones súbitas de violencia de un niño de doce años, tanto con pares como con algunos docentes. Por otro lado, asistimos en este caso, a lazos familiares poco disponibles para el niño. La intervención, en esta oportunidad, es doble: por un lado, se realiza un taller lúdico en el aula, con los alumnos y la docente responsable; por otro, se realizan algunas entrevistas con el equipo de orientación. Estas últimas son de suma importancia, en la medida en que muestran en acto al EOE soluciones que ellos mismos implementan sin saberlo o que podrían comenzar a implementar, en general a partir del uso del juego como algo transicional entre la posición del niño que produce malestar y una nueva posición posible. El abordaje del síntoma escolar muestra una de las posibilidades del Psicoanálisis aplicado (Rubinstein, 2003), la de intervenir en territorio, a pesar de su extraterritorialidad (Lacan, 1955).Lectura de la demanda e intervención del síntoma en instituciones educativas: perspectivas en extensión universitariaFacultad de Psicologí

Exosomal chaperones and miRNAs in gliomagenesis: State-of-art and theranostics perspectives

Gliomas have poor prognosis no matter the treatment applied, remaining an unmet clinical need. As background for a substantial change in this situation, this review will focus on the following points: (i) the steady progress in establishing the role of molecular chaperones in carcinogenesis; (ii) the recent advances in the knowledge of miRNAs in regulating gene expression, including genes involved in carcinogenesis and genes encoding chaperones; and (iii) the findings about exosomes and their cargo released by tumor cells. We would like to trigger a discussion about the involvement of exosomal chaperones and miRNAs in gliomagenesis. Chaperones may be either targets for therapy, due to their tumor-promoting activity, or therapeutic agents, due to their antitumor growth activity. Thus, chaperones may well represent a Janus-faced approach against tumors. This review focuses on extracellular chaperones as part of exosomes’ cargo, because of their potential as a new tool for the diagnosis and management of gliomas. Moreover, since exosomes transport chaperones and miRNAs (the latter possibly related to chaperone gene expression in the recipient cell), and probably deliver their cargo in the recipient cells, a new area of investigation is now open, which is bound to generate significant advances in the understanding and treatment of gliomas

Cross section measurements of 155,157Gd(n, γ) induced by thermal and epithermal neutrons

© SIF, Springer-Verlag GmbH Germany, part of Springer Nature 2019Neutron capture cross section measurements on 155Gd and 157Gd were performed using the time-of-flight technique at the n_TOF facility at CERN on isotopically enriched samples. The measurements were carried out in the n_TOF experimental area EAR1, at 185 m from the neutron source, with an array of 4 C6D6 liquid scintillation detectors. At a neutron kinetic energy of 0.0253 eV, capture cross sections of 62.2(2.2) and 239.8(8.4) kilobarn have been derived for 155Gd and 157Gd, respectively, with up to 6% deviation relative to values presently reported in nuclear data libraries, but consistent with those values within 1.6 standard deviations. A resonance shape analysis has been performed in the resolved resonance region up to 181 eV and 307 eV, respectively for 155Gd and 157Gd, where on average, resonance parameters have been found in good agreement with evaluations. Above these energies and up to 1 keV, the observed resonance-like structure of the cross section has been analysed and characterised. From a statistical analysis of the observed neutron resonances we deduced: neutron strength function of 2. 01 (28) × 10 - 4 and 2. 17 (41) × 10 - 4; average total radiative width of 106.8(14) meV and 101.1(20) meV and s-wave resonance spacing 1.6(2) eV and 4.8(5) eV for n + 155Gd and n + 157Gd systems, respectively.Peer reviewedFinal Accepted Versio

The 33S(n,α)30Si cross section measurement at n-TOF-EAR2 (CERN) : From 0.01 eV to the resonance region

The 33S(n,α)30Si cross section measurement, using 10B(n,α) as reference, at the n-TOF Experimental Area 2 (EAR2) facility at CERN is presented. Data from 0.01 eV to 100 keV are provided and, for the first time, the cross section is measured in the range from 0.01 eV to 10 keV. These data may be used for a future evaluation of the cross section because present evaluations exhibit large discrepancies. The 33S(n,α)30Si reaction is of interest in medical physics because of its possible use as a cooperative target to boron in Neutron Capture Therapy (NCT)

Measurement of the Ge 70 (n,γ) cross section up to 300 keV at the CERN n-TOF facility

©2019 American Physical Society.Neutron capture data on intermediate mass nuclei are of key importance to nucleosynthesis in the weak component of the slow neutron capture processes, which occurs in massive stars. The (n,γ) cross section on Ge70, which is mainly produced in the s process, was measured at the neutron time-of-flight facility n-TOF at CERN. Resonance capture kernels were determined up to 40 keV neutron energy and average cross sections up to 300 keV. Stellar cross sections were calculated from kT=5 keV to kT=100 keV and are in very good agreement with a previous measurement by Walter and Beer (1985) and recent evaluations. Average cross sections are in agreement with Walter and Beer (1985) over most of the neutron energy range covered, while they are systematically smaller for neutron energies above 150 keV. We have calculated isotopic abundances produced in s-process environments in a 25 solar mass star for two initial metallicities (below solar and close to solar). While the low metallicity model reproduces best the solar system germanium isotopic abundances, the close to solar model shows a good global match to solar system abundances in the range of mass numbers A=60-80.Peer reviewedFinal Published versio

High-accuracy determination of the neutron flux in the new experimental area n_TOF-EAR2 at CERN

A new high flux experimental area has recently become operational at the n_TOF facility at CERN. This new measuring station, n_TOF-EAR2, is placed at the end of a vertical beam line at a distance of approximately 20m from the spallation target. The characterization of the neutron beam, in terms of flux, spatial profile and resolution function, is of crucial importance for the feasibility study and data analysis of all measurements to be performed in the new area. In this paper, the measurement of the neutron flux, performed with different solid-state and gaseous detection systems, and using three neutron-converting reactions considered standard in different energy regions is reported. The results of the various measurements have been combined, yielding an evaluated neutron energy distribution in a wide energy range, from 2meV to 100MeV, with an accuracy ranging from 2%, at low energy, to 6% in the high-energy region. In addition, an absolute normalization of the n_TOF-EAR2 neutron flux has been obtained by means of an activation measurement performed with 197Au foils in the beam.Peer reviewe

Time-of-flight and activation experiments on 147Pm and 171Tm for astrophysics

The neutron capture cross section of several key unstable isotopes acting as branching points in the s-process are crucial for stellar nucleosynthesis studies, but they are very challenging to measure due to the difficult production of sufficient sample material, the high activity of the resulting samples, and the actual (n,γ) measurement, for which high neutron fluxes and effective background rejection capabilities are required. As part of a new program to measure some of these important branching points, radioactive targets of 147Pm and 171Tm have been produced by irradiation of stable isotopes at the ILL high flux reactor. Neutron capture on 146Nd and 170Er at the reactor was followed by beta decay and the resulting matrix was purified via radiochemical separation at PSI. The radioactive targets have been used for time-of-flight measurements at the CERN n-TOF facility using the 19 and 185 m beam lines during 2014 and 2015. The capture cascades were detected using a set of four C6D6 scintillators, allowing to observe the associated neutron capture resonances. The results presented in this work are the first ever determination of the resonance capture cross section of 147Pm and 171Tm. Activation experiments on the same 147Pm and 171Tm targets with a high-intensity 30 keV quasi-Maxwellian flux of neutrons will be performed using the SARAF accelerator and the Liquid-Lithium Target (LiLiT) in order to extract the corresponding Maxwellian Average Cross Section (MACS). The status of these experiments and preliminary results will be presented and discussed as well