Jet opening angles and gamma-ray brightness of AGN

We have investigated the differences in apparent opening angles between the parsec-scale jets of the active galactic nuclei (AGN) detected by the Fermi Large Area Telescope (LAT) during its first three months of operations and those of non-LAT-detected AGN. We used 15.4 GHz VLBA observations of sources from the 2 cm VLBA MOJAVE program, a subset of which comprise the statistically complete flux density limited MOJAVE sample. We determined the apparent opening angles by analyzing transverse jet profiles from the data in the image plane and by applying a model fitting technique to the data in the (u,v) plane. Both methods provided comparable opening angle estimates. The apparent opening angles of gamma-ray bright blazars are preferentially larger than those of gamma-ray weak sources. At the same time, we have found the two groups to have similar intrinsic opening angle distributions, based on a smaller subset of sources. This suggests that the jets in gamma-ray bright AGN are oriented at preferentially smaller angles to the line of sight resulting in a stronger relativistic beaming. The intrinsic jet opening angle and bulk flow Lorentz factor are found to be inversely proportional, as predicted by standard models of compact relativistic jets. If a gas dynamical jet acceleration model is assumed, the ratio of the initial pressure of the plasma in the core region P_0 to the external pressure P_ext lies within the range 1.1 to 34.6, with a best fit estimate of P_0/P_ext=2.Comment: 4 pages, 3 figures; accepted for publication in the A&A Letters; table in electronic form can be extracted from the preprint sourc

On the relation between AGN gamma-ray emission and parsec-scale radio jets

We have compared the radio emission from a sample of parsec-scale AGN jets as measured by the VLBA at 15 GHz, with their associated gamma-ray properties that are reported in the Fermi LAT 3-month bright source list. We find in our radio-selected sample that the gamma-ray photon flux correlates well with the quasi-simultaneously measured compact radio flux density. The LAT-detected jets in our radio-selected complete sample generally have higher compact radio flux densities, and their parsec-scale cores are brighter (i.e., have higher brightness temperature) than the jets in the LAT non-detected objects. This suggests that the jets of bright gamma-ray AGN have preferentially higher Doppler-boosting factors. In addition, AGN jets tend to be found in a more active radio state within several months from LAT-detection of their strong gamma-ray emission. This result becomes more pronounced for confirmed gamma-ray flaring sources. We identify the parsec-scale radio core as a likely location for both the gamma-ray and radio flares, which appear within typical timescales of up to a few months of each other.Comment: 5 pages, 5 figures, accepted for publication in the Astrophysical Journal Letters; title is changed, minor corrections of the text are mad

Bright AGN Source List from the First Three Months of the Fermi Large Area Telescope All-Sky Survey

The first three months of sky-survey operation with the Fermi Gamma Ray Space Telescope (Fermi) Large Area Telescope (LAT) reveals 132 bright sources at |b|>10 deg with test statistic greater than 100 (corresponding to about 10 sigma). Two methods, based on the CGRaBS, CRATES and BZCat catalogs, indicate high-confidence associations of 106 of these sources with known AGNs. This sample is referred to as the LAT Bright AGN Sample (LBAS). It contains two radio galaxies, namely Centaurus A and NGC 1275, and 104 blazars consisting of 57 flat spectrum radio quasars (FSRQs), 42 BL Lac objects, and 5 blazars with uncertain classification. Four new blazars were discovered on the basis of the LAT detections. Remarkably, the LBAS includes 10 high-energy peaked BL Lacs (HBLs), sources which were so far hard to detect in the GeV range. Another 10 lower-confidence associations are found. Only thirty three of the sources, plus two at |b|>10 deg, were previously detected with EGRET, probably due to the variable nature of these sources. The analysis of the gamma-ray properties of the LBAS sources reveals that the average GeV spectra of BL Lac objects are significantly harder than the spectra of FSRQs. No significant correlation between radio and peak gamma-ray fluxes is observed. Blazar log N - log S and luminosity functions are constructed to investigate the evolution of the different blazar classes, with positive evolution indicated for FSRQs but none for BLLacs. The contribution of LAT-blazars to the total extragalactic gamma-ray intensity is estimated.Comment: Submitted to ApJ. Not yet refereed. 61 pages, 26 figure

Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle

Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas HFHS diets are largely deleterious to the cardiovascular system. The reasons for this disparity are multifactorial and incompletely understood. We hypothesized that differences in redox adaptations following HFHS diet in comparison to exercise may underlie this disparity, particularly in mitochondria. Our objective in this study was to determine mechanisms by which heart and skeletal muscle (red gastrocnemius, RG) mitochondria experience differential redox adaptations to 12 weeks of HFHS diet and/or exercise training (Ex) in rats. Surprisingly, both HFHS feeding and Ex led to contrasting effects in heart and RG, in that mitochondrial H2O2 decreased in heart but increased in RG following both HFHS diet and Ex, in comparison to sedentary animals fed a control diet. These differences were determined to be due largely to increased antioxidant/anti-inflammatory enzymes in the heart following the HFHS diet, which did not occur in RG. Specifically, upregulation of mitochondrial thioredoxin reductase-2 occurred with both HFHS and Ex in the heart, but only with Ex in RG, and systematic evaluation of this enzyme revealed that it is critical for suppressing mitochondrial H2O2 during fatty acid oxidation. These findings are novel and important in that they illustrate the unique ability of the heart to adapt to oxidative stress imposed by HFHS diet, in part through upregulation of thioredoxin reductase-2. Furthermore, upregulation of thioredoxin reductase-2 plays a critical role in preserving the mitochondrial redox status in the heart and skeletal muscle with exercise.Funding from the National Institutes of Health, United State

New species of miniature fish from Marajó Island, Pará, Brazil, with comments on its relationships (Characiformes: Characidae)

A new miniature species of the family Characidae from Marajó Island, Pará State, Brazil is described and assigned to the genus Tyttobrycon. The new species can be distinguished from its congeners primarily by having multicuspid teeth on jaws, and additionally by having the combination of 5-7 premaxillary teeth, dorsal fin only with scattered melanophores and the presence of an adipose fin

MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo

Erratum: https://link.springer.com/article/10.1007/s10863-014-9597-1MuRF1 is a previously reported ubiquitin-ligase found in striated muscle that targets troponin I and myosin heavy chain for degradation. While MuRF1 has been reported to interact with mitochondrial substrates in yeast two-hybrid studies, no studies have identified MuRF1’s role in regulating mitochondrial function to date. In the present study, we measured cardiac mitochondrial function from isolated permeabilized muscle fibers in previously phenotyped MuRF1 transgenic and MuRF1−/− mouse models to determine the role of MuRF1 in intermediate energy metabolism and ROS production. We identified a significant decrease in reactive oxygen species production in cardiac muscle fibers from MuRF1 transgenic mice with increased α-MHC driven MuRF1 expression. Increased MuRF1 expression in ex vivo and in vitro experiments revealed no alterations in the respiratory chain complex I and II function. Working perfusion experiments on MuRF1 transgenic hearts demonstrated significant changes in glucose oxidation. This is an factual error as written; however, total oxygen consumption was decreased. This data provides evidence for MuRF1 as a novel regulator of cardiac ROS, offering another mechanism by which increased MuRF1 expression may be cardioprotective in ischemia reperfusion injury, in addition to its inhibition of apoptosis via proteasome-mediate degradation of c-Jun. The lack of mitochondrial function phenotype identified in MuRF1−/− hearts may be due to the overlapping interactions of MuRF1 and MuRF2 with energy regulating proteins found by yeast two-hybrid studies reported here, implying a duplicity in MuRF1 and MuRF2’s regulation of mitochondrial function.Funding support from Medical Research Council, United Kingdom; National Institutes of Health, United States; British Heart Foundation, United Kingdo

Variability of the blazar 4C 38.41 (B3 1633+382) from GHz frequencies to GeV energies

The quasar-type blazar 4C 38.41 (B3 1633+382) experienced a large outburst in 2011, which was detected throughout the entire electromagnetic spectrum. We present the results of low-energy multifrequency monitoring by the GASP project of the WEBT consortium and collaborators, as well as those of spectropolarimetric/spectrophotometric monitoring at the Steward Observatory. We also analyse high-energy observations of the Swift and Fermi satellites. In the optical-UV band, several results indicate that there is a contribution from a QSO-like emission component, in addition to both variable and polarised jet emission. The unpolarised emission component is likely thermal radiation from the accretion disc that dilutes the jet polarisation. We estimate its brightness to be R(QSO) ~ 17.85 - 18 and derive the intrinsic jet polarisation degree. We find no clear correlation between the optical and radio light curves, while the correlation between the optical and \gamma-ray flux apparently fades in time, likely because of an increasing optical to \gamma-ray flux ratio. As suggested for other blazars, the long-term variability of 4C 38.41 can be interpreted in terms of an inhomogeneous bent jet, where different emitting regions can change their alignment with respect to the line of sight, leading to variations in the Doppler factor \delta. Under the hypothesis that in the period 2008-2011 all the \gamma-ray and optical variability on a one-week timescale were due to changes in \delta, this would range between ~ 7 and ~ 21. If the variability were caused by changes in the viewing angle \theta\ only, then \theta\ would go from ~ 2.6 degr to ~ 5 degr. Variations in the viewing angle would also account for the dependence of the polarisation degree on the source brightness in the framework of a shock-in-jet model.Comment: 19 pages, 23 figures, in press for Astronomy and Astrophysic

Sex and the Single Cell. II. There Is a Time and Place for Sex

In both male and female Drosophila, only a subset of cells have the potential to sexually differentiate, making both males and females mosaics of sexually differentiated and sexually undifferentiated cells