Pens, print, and pixels : gendered writing and the epistolary genre in transitional eras.

This dissertation proposes a retheorization of rhetorical genres, media, and modes, with a particular emphasis on how this interrelationship reinstantiates and/or subverts deeply entrenched power dynamics over time. Current scholarship often depicts genres and media in a one-to-one relationship that obscures the intricate ways rhetorical genres and media rely on one another to enable (or hinder) writers’ participation in particular discourse communities. This project primarily focuses on gendered power and analyzes letters—a traditionally feminized genre—in three distinct time periods marked by media transition. Specifically, I explore ways women employ genre and media affordances together to assume positions of greater authority and examine how texts mediate who can exercise power. The first chapter reviews scholarship on rhetorical genre theory, media studies, and multimodal composition and introduces a new theoretical model. The first case focuses on Renaissance women’s manuscript letterwriting in the Bagot family collection (Chapter Two). The second case examines Samuel Richardson’s gendered epistolary writing in his vernacular letters, printed manuals, and fiction (Chapter Three). Finally, Chapter Four examines epistolary conventions of social media posts in Pantsuit Nation. Using these cases, I drew conclusions about how genres and media can continue to exclude and/or promote certain writers’ voices in and over time—even when the genres and media appear more accessible and inclusive. The project emphasizes how genres and media influence our lives and enable us to make space for ourselves in the world. Genres and media shape each other in recurrent, dynamic processes through their modal affordances and respond to the social and cultural exigencies of a particular moment. As a field committed to inclusivity and the study of power in language, we must retheorize the dynamic processes involved in writing platforms if we are to empower students and other writers and citizens with whom we work

Cancer Stem Cells in the Screening of Anticancer Drugs for Central Nervous System Tumors

There is a growing need (in the medical field) to design personalized therapy for cancer patients. Decades of cancer research have found no silver bullet that can cure all or even most patients. This study evaluated four patients affected by central nervous system (CNS) tumors (Ependymoma and Glioblastoma), and found that tumors with the same histology had unique responses to treatment. Each sample presented different levels of heterogeneity in expressed biomarkers and responded to drugs at varying levels. Oncologists conventionally treat cancer patients with drugs tested in large clinical trials. However, often patients do not experience positive outcomes following treatments with standardof- care first line drugs and oncologists need to treat them with a different second-line anticancer therapy that is chosen empirically. This study was designed to find a way to better predict patient’s response to chemotherapeutic drugs. The focus of this study was on Central Nervous System (CNS) tumors because of their limited response to anticancer drugs and their low survival rate. The uniqueness of this study revealed that each patient’s tumor had different drug sensitivities and that screening for multiple drugs may increase the chance of finding a drug from which the patient would have the most benefit. More importantly this study evaluated the Cancer Stem-Like Cell (CSLC) population sensitivity to these drugs. This subpopulation is responsible for initiation and maintenance of the tumor and is known to be resistant to chemotherapy drugs. Dr. Claudio’s laboratory developed a test capable of determining the cytotoxic drug to which cancer cells and CSLCs of an individual tumor are most responsive. In the future this procedure may focus the treatment of CNS patients to drugs effective against their particular tumor allowing them to have better outcomes with fewer detrimental side effects

Re-engineering the computer services help desk

The goal of this project is to re-engineer the Help Desk at USC into a cohesive group that will assist Computer Services to support the instructional mission of the University, provide the core services for the University IT infrastructure, provide excellent customer service, develop the human resources within our organization, support the operations and continual improvement of the institution, and encourage efficient use of computing and networking among departments

Observations on acoustic emissions from a line contact compressed into the plastic region

Some observations from acoustic emissions recorded during a yield test of a bearing raceway compressed into plasticity using a rolling element are presented. The general objective of the study is to establish whether there is enough evidence of the onset of sub-surface plasticity in the acoustic emissions signature. It is discussed here how acoustic emissions monitoring during compression could indicate the onset of subsurface plasticity as a precursor to damage propagation to the surface. Some comparisons are drawn between the acoustic emissions activity levels and time-frequency response during elastic deformation and at yield loads

Mesoporous stilbene-based lanthanide metal organic frameworks: synthesis, photoluminescence and radioluminescence characteristics

Mesoporous non-interpenetrating stilbene-based lanthanide metal organic frameworks exhibits photo and radioluminescence behavior.</p

Unified Topological Inference for Brain Networks in Temporal Lobe Epilepsy Using the Wasserstein Distance

Persistent homology can extract hidden topological signals present in brain networks. Persistent homology summarizes the changes of topological structures over multiple different scales called filtrations. Doing so detect hidden topological signals that persist over multiple scales. However, a key obstacle of applying persistent homology to brain network studies has always been the lack of coherent statistical inference framework. To address this problem, we present a unified topological inference framework based on the Wasserstein distance. Our approach has no explicit models and distributional assumptions. The inference is performed in a completely data driven fashion. The method is applied to the resting-state functional magnetic resonance images (rs-fMRI) of the temporal lobe epilepsy patients collected at two different sites: University of Wisconsin-Madison and the Medical College of Wisconsin. However, the topological method is robust to variations due to sex and acquisition, and thus there is no need to account for sex and site as categorical nuisance covariates. We are able to localize brain regions that contribute the most to topological differences. We made MATLAB package available at https://github.com/laplcebeltrami/dynamicTDA that was used to perform all the analysis in this study

The Lantern, 2009-2010

• I\u27m Pregnant. It\u27s Yours • The Nightmare • What Death Became After Cyparissus • Substances • Ain\u27t That a Man? • Portrait • The 100th Chemo • Looking into Her Toy Box with a Lover • They Used to Talk About Burning Cities • MESSAGE: Absence for Allen Ginsberg • Lunch with Candide • Behold! Man of Unbelief! Behold! • Dream #1 Final Strophe • Patience (Things You Will Discover) • Four Years • He Falls Like Leaves • The Quilt • Ariel (Turning Tricks at Fisherman\u27s Wharf, Monterey, California) • Extranjera • The Taste of Morning • Fear of Glory • The Rum Bottle\u27s Fortune • While Thinking of What to Write • Dying in Spring • Tutte le Eta di Firenze • Token • A House Grows Into Itself • Gravity • Father with the Skyy • He Says He Dreams of Me • Myth • Sun-Veins and Wishbones • Attempts at Bravery • One Boy in Four Parts • Blacktop Rollin\u27 • Getting My Feet Wet • The Long Ride After Ending • Wet Tongues and Sweaty Cotton • Norman Bates is My Mother • Sims Trek • Tomorrow Comes Today • The Writer\u27s Process • This Too Was Real • Venus from the Waves • Shark • Monday\u27s Expectations • Recognition • The Black Shoes • Climax • Andrew • Bottles • Calle de Cusco • God in the Machine • The 26th of December • Lollipop Lollipop • When Dinosaurs Roamed the Earth • Meaning • Jeffrey • Looking • Jagged Edges • Fading Storm • Shoes • Cover Image: Death by Chocolatehttps://digitalcommons.ursinus.edu/lantern/1175/thumbnail.jp

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Concert recording 2016-11-15

[Track 1]. Subjugation. Connection [Track 2]. Captivation / Durgan Maxey -- [Track 3]. Fight / Bryce Owens -- [Track 4]. Overture to Stay / Joshua Bland -- [Track 5]. A cellist\u27s legacy. Part I [Track 6]. Part II / Eric Dreggors -- [Track 7]. Evening prayer / Robbie Baker -- [Track 8]. Elegy / Brandon Wade -- [Track 9]. The grotesques trio. Gargoyles [Track 10]. Chimera [Track 11]. Grotesques / Marissa Johnson -- [Track 12]. Crosshair / Joshua Bland -- [Track 13]. Nightwind sings / L. Coley Pitchford -- [Track 14]. Six reflections through poetry. Memories (Walt Whitman) [Track 15]. The musician\u27s wife (Weldon Kees) [Track 16]. The road not taken (Robert Frost) [Track 17]. Lessons (Whitman) [Track 18]. Stronger lessons (Whitman) [Track 19]. O me! O life! (Whitman) / Nick Vecchio -- [Tracks 20-21]. String quartet #1 / Jeremiah Flannery -- [Track 22]. Tides. Morning tide [Track 23]. Bore tide / Elizabeth Greener -- [Track 24]. Shepherd\u27s contemplation / Robbie Baker -- Green grass / arranged by Eva Martin -- [Track 25]. Urbe fracta est II. A prayer for Jerusalem / Joshua Bland

CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology

In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia