Horizon 2020 EuPRAXIA design study

The Horizon 2020 Project EuPRAXIA ("European Plasma Research Accelerator with eXcellence In Applications") is preparing a conceptual design report of a highly compact and cost-effective European facility with multi-GeV electron beams using plasma as the acceleration medium. The accelerator facility will be based on a laser and/or a beam driven plasma acceleration approach and will be used for photon science, high-energy physics (HEP) detector tests, and other applications such as compact X-ray sources for medical imaging or material processing. EuPRAXIA started in November 2015 and will deliver the design report in October 2019. EuPRAXIA aims to be included on the ESFRI roadmap in 2020

EuPRAXIA - A compact, cost-efficient particle and radiation source

Plasma accelerators present one of the most suitable candidates for the development of more compact particle acceleration technologies, yet they still lag behind radiofrequency (RF)-based devices when it comes to beam quality, control, stability and power efficiency. The Horizon 2020-funded project EuPRAXIA ("European Plasma Research Accelerator with eXcellence In Applications") aims to overcome the first three of these hurdles by developing a conceptual design for a first international user facility based on plasma acceleration. In this paper we report on the main features, simulation studies and potential applications of this future research infrastructure

EuPRAXIA - A Compact, Cost-Efficient Particle and Radiation Source

Plasma accelerators present one of the most suitable candidates for the development of more compact particle acceleration technologies, yet they still lag behind radiofrequency (RF)-based devices when it comes to beam quality, control, stability and power efficiency. The Horizon 2020-funded project EuPRAXIA (“European Plasma Research Accelerator with eXcellence In Applications”) aims to overcome the first three of these hurdles by developing a conceptual design for a first international user facility based on plasma acceleration. In this paper we report on the main features, simulation studies and potential applications of this future research infrastructure

Étude et implantation de l'Observatoire Astronomique TAROT (traitement des données, ordonnancement dynamique des observations, gestion et contrôle du téléscope, détection des contreparties optiques des sursauts gamma cosmiques)

Le Télescope à Action Rapide pour les Objets Transitoires (TAROT) est un observatoire complètement automatisé, depuis les opérations de calibration de début de nuit, jusqu'au traitement et la sauvegarde des données. Concrètement, il n'y a aucune présence humaine lors des opérations de TAROT, soit localement soit à distance. TAROT est capable de pointer tout point du ciel en moins de trois secondes et d'effectuer un suivi d'au moins 5 minutes sans "bougé" sensible. Son objectif principal est la détection des contreparties optiques des sursauts gamma cosmiques (alertes) auquel s'ajoute l'observation de nombreuses sources célestes selon les demandes des astronomes. L'objectif de cette thèse était de mettre au point la chaîne de traitement automatique de ce téléscope. Aussi, un progiciel spécifique, le MAJORDOME a été étudié et implanté afin d'optimiser l'agencement des observations. Il est capable de fournir à tout moment au contrôle la meilleure observation possible, compte tenu de la position de l'objet sur le ciel, de sa priorité et des contraintes fournies par l'observateur. En cas d'interruption, dûe à l'apparition d'une alerte reçue au travers du réseau Internet ou du mauvais temps, l'emploi du temps est recalculé y compris au cours de la nuit. Ce logiciel entièrement autonome est la clef de voûte de notre observatoire. Il constitue à ce titre l'un des résultats les plus novateurs de cette thèse. Un autre aspect important de ce travail est le traitement automatique des données, qui permet dans les minutes suivant l'observation de connaître les objets détectés et/ou variables. Compte tenu des 400 images de 8Mo qui sont prises en moyenne chaque nuit, le traitement des images fait appel à des méthodes robustes et rapides afin de dépuiller les 3 Go de données nocturnes produites par TAROT. En résumé, nous avons doté TAROT, instrument certes modeste par ses dimensions, d'opérations, d'exploitations et de traitements inconnusjusqu'alors en astronomie.TOULOUSE-ENSEEIHT (315552331) / SudocSudocFranceF

Criminaliteit als sociaal leerproces: een toetsing van de differentiële-associatietheorie in de versie van K-D. Opp

Geriatrics in primary car

Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies

Chronic diseases are diseases of long duration and slow progression. Major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, rheumatologic diseases and mental health) represent the predominant health problem of the Century. The prevention and control of NCDs are the priority of the World Health Organization 2008 Action Plan, the United Nations 2010 Resolution and the European Union 2010 Council. The novel trend for the management of NCDs is evolving towards integrative, holistic approaches. NCDs are intertwined with ageing. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has prioritised NCDs. To tackle them in their totality in order to reduce their burden and societal impact, it is proposed that NCDs should be considered as a single expression of disease with different risk factors and entities. An innovative integrated health system built around systems medicine and strategic partnerships is proposed to combat NCDs. It includes (i) understanding the social, economic, environmental, genetic determinants, as well as the molecular and cellular mechanisms underlying NCDs; (ii) primary care and practice-based interprofessional collaboration; (iii) carefully phenotyped patients; (iv) development of unbiased and accurate biomarkers for comorbidities, severity and follow up of patients; (v) socio-economic science; (vi) development of guidelines; (vii) training; and (viii) policy decisions. The results could be applicable to all countries and adapted to local needs, economy and health systems. This paper reviews the complexity of NCDs intertwined with ageing. It gives an overview of the problem and proposes two practical examples of systems medicine (MeDALL) applied to allergy and to NCD co-morbidities (MACVIA-LR, Reference Site of the European Innovation Partnership on Active and Healthy Ageing)