Structural ambiguity of the Chinese version of the hospital anxiety and depression scale in patients with coronary heart disease

Background The Hospital Anxiety and Depression Scale (HADS) is a widely used screening tool designed as a case detector for clinically relevant anxiety and depression. Recent studies of the HADS in coronary heart disease (CHD) patients in European countries suggest it comprises three, rather than two, underlying sub-scale dimensions. The factor structure of the Chinese version of the HADS was evaluated in patients with CHD in mainland China. Methods Confirmatory factor analysis (CFA) was conducted on self-report HADS forms from 154 Chinese CHD patients. Results Little difference was observed in model fit between best performing three-factor and two-factor models. Conclusion The current observations are inconsistent with recent studies highlighting a dominant underlying tri-dimensional structure to the HADS in CHD patients. The Chinese version of the HADS may perform differently to European language versions of the instrument in patients with CHD

Analysis and prediction of VH/VL packing in antibodies

The packing of VH and VL domains in antibodies can vary, influencing the topography of the antigen-combining site. However, until recently, this has largely been ignored in modelling antibody structure. We present an analysis of the degree of variability observed in known structures together with a machine-learning approach to predict the packing angle. A neural network was trained on sets of interface residues and a genetic algorithm designed to perform ‘feature selection' to define which sets of interface residues could be used most successfully to perform the prediction. While this training procedure was very computationally intensive, prediction is performed in a matter of seconds. Thus, not only do we provide a rapid method for predicting the packing angle, but also we define a set of residues that may be important in antibody humanization in order to obtain the correct binding site topograph

The effect of SU-8 patterned surfaces on the response of the quartz crystal microbalance

In this work we present data showing the effect of patterning layers of SU-8 photoresist on a quartz crystal microbalance (QCM) and subsequent chemical treatment to increase their hydrophobicity. Patterns with 5 mu m diameter pillars spaced every 10 mu m have been fabricated with heights of 3, 5 and 10 mu m in addition to equivalent thickness flat layers. Contact angle measurements have been made before and after the hydrophobic chemical treatment. The change in resonant frequency of the QCM has been investigated as the surfaces were submerged in solutions of water/PEG with changing viscosity-density product

Electrospinning of ultra-thin polymer fibers

The electrospinning technique was used to spin ultra-thin fibers from several polymer/solvent systems. The diameter of the electrospun fibers ranged from 16 nm to 2 μm. The morphology of these fibers was investigated with an atomic force microscope (AFM) and an optical microscope. Polyethylene oxide) (PEO) dissolved in water or chloroform was studied in greater detail. PEO fibers spun from aqueous solution show a “beads on a string” morphology. An AFM study showed that the surface of these fibers is highly ordered. The “beads on a string” morphology can be avoided if PEO is spun from solution in chloroform; the resulting fibers show a lamellar morphology. Polyvinylalcohol (PVA) dissolved in water and cellulose acetate dissolved in acetone were additional polymer/solvent systems which were investigated. Furthermore, the electrospinning process was studied: different experimental lay-outs were tested, electrostatic fields were simulated, and voltage - current characteristics of the electrospinning process were recorded

Yang-Mills Action from Open Superstring Field Theory

We calculate the effective action for nonabelian gauge bosons up to quartic order using WZW-like open superstring field theory. After including level zero and level one contributions, we obtain with 75% accuracy the Yang-Mills quartic term. We then prove that the complete effective action reproduces the exact Yang-Mills quartic term by analytically performing a summation over the intermediate massive states.Comment: 10 page

Quality of Life in a Mixed Ethnic Population after Myocardial Infarction

Background: Although South Asian people are a significant ethnic group at increased risk of coronary heart disease and high mortality rates and experience greater delays with respect to diagnosis, referral and treatment, comparatively little is known about their quality of life during recovery from a myocardial infarction.Objectives: We sought to determine and compare the impact of ethnicity on quality of life after myocardial infarction (MI) in a mixed ethnic population (South Asian and white people) in the UK.Methods: A 2x2 mixed-group design with repeated measures on the second factor. The independent variables were ethnic group (white/South Asian) and time since MI (2 weeks/3 months). The dependent variables were the subscale scores on the Short-Form 36-item health survey (SF-36) and the Hospital Anxiety and Depression Scale (HADS).Results: At 2 weeks, significant differences were observed between groups on 5 of the 8 SF-36 subscale domain scores, with the white group reporting higher quality of life. Significant improvement in reported quality of life occurred in both groups over time on all domains of the SF-36, except bodily pain. There was a significantly greater improvement in favour of the white group for the role-physical domain. There was no significant difference between groups in terms of anxiety or depression at 2 weeks. Both groups showed a significant reduction in anxiety and depression by 3 months, but the degree of reduction was not significantly different between them. At 3 months, there was no significant difference between groups in terms of anxiety scores, but the South Asian group scored significantly higher on the depression scale.Conclusions: South Asian people have significantly poorer quality of life than white people after MI. While both groups showed improvement over time, South Asian people reported significantly less improvement in physical role function and were more depressed at 3 months. Identifying the factors accounting for such differences is important to develop models of care for delivering the most effective and culturally-sensitive interventions to this group

Controlling anomalous stresses in soft field-responsive systems

We report a new phenomenon occurring in field-responsive suspensions: shear-induced anomalous stresses. Competition between a rotating field and a shear flow originates a multiplicity of anomalous stress behaviors in suspensions of bounded dimers constituted by induced dipoles. The great variety of stress regimes includes non-monotonous behaviors, multi-resonances, negative viscosity effect and blockades. The reversibility of the transitions between the different regimes and the self-similarity of the stresses make this phenomenon controllable and therefore applicable to modify macroscopic properties of soft condensed matter phasesComment: 5 pages, 6 figures, submitted to PR

PMH40 How do Patients Describe Their Depression? - Incorporating the Patient's Voice Into Instrument Development

Letter from CGIAR Chairman Ismail Serageldin to CGIAR heads of delegation, board chairs, center directors and the TAC chairman and secretariat, leading up to ICW94. Serageldin described the work of various ad hoc and standing bodies in preparation for International Centers Week 1994 and the Ministerial-level Meeting being planned for early 1995. He also announced that as a result of additional funding by donors and matching funds from the World Bank, the 1994 core program was fully funded

Reconstruction of the Primordial Power Spectrum by Direct Inversion

We introduce a new method for reconstructing the primordial power spectrum, $P(k)$, directly from observations of the Cosmic Microwave Background (CMB). We employ Singular Value Decomposition (SVD) to invert the radiation perturbation transfer function. The degeneracy of the multipole $\ell$ to wavenumber $k$ linear mapping is thus reduced. This enables the inversion to be carried out at each point along a Monte Carlo Markov Chain (MCMC) exploration of the combined $P(k)$ and cosmological parameter space. We present best--fit $P(k)$ obtained with this method along with other cosmological parameters.Comment: 23 pages, 9 figure

The extended empirical process test for non-Gaussianity in the CMB, with an application to non-Gaussian inflationary models

In (Hansen et al. 2002) we presented a new approach for measuring non-Gaussianity of the Cosmic Microwave Background (CMB) anisotropy pattern, based on the multivariate empirical distribution function of the spherical harmonics a_lm of a CMB map. The present paper builds upon the same ideas and proposes several improvements and extensions. More precisely, we exploit the additional information on the random phases of the a_lm to provide further tests based on the empirical distribution function. Also we take advantage of the effect of rotations in improving the power of our procedures. The suggested tests are implemented on physically motivated models of non-Gaussian fields; Monte-Carlo simulations suggest that this approach may be very promising in the analysis of non-Gaussianity generated by non-standard models of inflation. We address also some experimentally meaningful situations, such as the presence of instrumental noise and a galactic cut in the map.Comment: 15 pages, 6 figures, submitted to Phys. Rev.