2,105 research outputs found
Glatiramer acetate treatment does not modify the clinical course of (NZB × BXSB)F1 lupus murine model
Glatiramer acetate (GA, copolymer-1, Copaxone®), a therapy approved for treatment of multiple sclerosis (MS), prevents and reverses experimental autoimmune encephalomyelitis, the animal model of MS. In central nervous system autoimmune disease, GA is thought to act through modulation of antigen-presenting cells, such as monocytes, mediating an antigen-independent Th2 shift and development of FoxP3+ regulatory T cells. Recent reports indicate that GA may also be effective in models of other autoimmune diseases such as uveoretinitis, inflammatory bowel disease and graft rejection. To date, the potential effect of GA in lupus animal models has not been described. (NZB × BXSB)F1, male mice bearing Y-linked autoimmune acceleration , is a lupus-prone mouse model which is associated with a monocytosis accelerating disease progression. These mice were treated with GA before disease onset until death and both mortality rate and biological parameters were assessed to investigate whether GA may be beneficial in this spontaneous model of systemic lupus erythematosus. GA exerted no beneficial effect on the median survival after up to 7 months of treatment. Humoral and cellular parameters used as markers for lupus progression, such as anti-chromatin, anti-double-stranded DNA and anti-erythrocytes antibodies, hematocrit and monocytosis, were similarly unchanged. Our study demonstrates that GA has no significant effect on the progression of the (NZB × BXSB)F1 lupus-prone animal model. These results reinforce the hypothesis that GA may exert its beneficial effect in some specific autoimmune diseases onl
Pancreatic intraductal papillary mucinous neoplasm associated colloid carcinoma
Funding Information: Acknowledgments: Special thanks to Celso Matos, MD/PhD, for assistance with manuscrip preparation. The authors received no financial support for the publication of this article. Publisher Copyright: © 2021Colloid carcinomas are rare pancreatic tumors characterized by the presence of mucin pools with scarce malignant cells. Most of these neoplasms arise from intestinal-type intraductal papillary mucinous neoplasms (IPMNs). We report a case of a 77-year-old male patient who presented with weight loss, asthenia, lumbar pain and diabetes. Imaging studies revealed a mixed-type IPMN with high-risk features and a possible invasive component. The patient underwent surgical resection and the histology confirmed an invasive colloid carcinoma of the pancreas associated with an intestinal-type IPMN. Although invasive ductal and colloid carcinomas may look similar on imaging studies, its distinction is important because the latter have a better prognosis.publishersversionpublishe
Parton distributions from deep-inelastic-scattering data
We perform the analysis of existing light-targets deep-inelastic-scattering
(DIS) data in the leading-order (LO), next-to-leading-order (NLO), and
next-to-next-to-leading-order (NNLO) QCD approximations and extract PDFs
simultaneously with the value of the strong coupling constant and
the high-twist contribution to the structure functions. The main theoretical
uncertainties and experimental uncertainties due to all sources of experimental
errors in data are estimated, the latter generally dominate for the obtained
PDFs. The uncertainty in Higgs boson production cross section due to errors in
PDFs is % for the LHC and varies from 2% to 10% for the Fermilab
collider under variation of the Higgs boson mass from to . For the -boson production cross section the uncertainty is % for the both colliders. The value of is obtained, while the high-twist terms do
not vanish up to the NNLO as required by comparison to data
The SOAR Gravitational Arc Survey - I: Survey overview and photometric catalogs
We present the first results of the SOAR (Southern Astrophysical Research)
Gravitational Arc Survey (SOGRAS). The survey imaged 47 clusters in two
redshift intervals centered at and , targeting the richest
clusters in each interval. Images were obtained in the , and
bands using the SOAR Optical Imager (SOI), with a median seeing of 0.83, 0.76
and 0.71 arcsec, respectively, in these filters. Most of the survey clusters
are located within the Sloan Digital Sky Survey (SDSS) Stripe 82 region and all
of them are in the SDSS footprint. Photometric calibration was therefore
performed using SDSS stars located in our SOI fields. We reached for galaxies
in all fields the detection limits of , and for a signal-to-noise ratio (S/N) = 3. As a by-product of the image
processing, we generated a source catalogue with 19760 entries, the vast
majority of which are galaxies, where we list their positions, magnitudes and
shape parameters. We compared our galaxy shape measurements to those of local
galaxies and concluded that they were not strongly affected by seeing. From the
catalogue data, we are able to identify a red sequence of galaxies in most
clusters in the lower range. We found 16 gravitational arc candidates
around 8 clusters in our sample. They tend to be bluer than the central
galaxies in the lensing cluster. A preliminary analysis indicates that of the clusters have arcs around them, with a possible indication of a
larger efficiency associated to the high- systems when compared to the
low- ones. Deeper follow-up images with Gemini strengthen the case for the
strong lensing nature of the candidates found in this survey.Comment: 17 pages, 11 figures (most of them multi-panel) MNRAS (2013
Impact of Higher Order and Soft Gluon Corrections on the Extraction of Higher Twist Effects in DIS
The impact of recently calculated next-to-next-to-leading order QCD
corrections and soft gluon resummations on the extraction of higher twist
contributions to the deep-inelastic structure function F_2 is studied using the
BCDMS and SLAC data. It is demonstrated to which extent the need for higher
twist terms is diminishing due to these higher order effects in the kinematical
region, 0.35 \le x \le 0.85 and Q^2>1.2 GeV^2, investigated. In addition,
theoretical uncertainties in the extraction of higher twist contributions are
discussed, and comparisons to results obtained previously are made.Comment: 16 pages, 3 figure
Exploring the Impact of the HOMO–LUMO Gap on Molecular Thermoelectric Properties: A Comparative Study of Conjugated Aromatic, Quinoidal, and Donor–Acceptor Core Systems
Thermoelectric materials have garnered significant interest for their potential to efficiently convert waste heat into electrical energy at room temperature without moving parts or harmful emissions. This study investigated the impact of the HOMO–LUMO (H-L) gap on the thermoelectric properties of three distinct classes of organic compounds: conjugated aromatics (isoindigos (IIGs)), quinoidal molecules (benzodipyrrolidones (BDPs)), and donor–acceptor systems (bis(pyrrol-2-yl)squaraines (BPSs)). These compounds were chosen for their structural simplicity and linear π-conjugated conductance paths, which promote high electrical conductance and minimize complications from quantum interference. Single-molecule thermoelectric measurements revealed that despite their low H-L gaps, the Seebeck coefficients of these compounds remain low. The alignment of the frontier orbitals relative to the Fermi energy was found to play a crucial role in determining the Seebeck coefficients, as exemplified by the BDP compounds. Theoretical calculations support these findings and suggest that anchor group selection could further enhance the thermoelectric behavior of these types of molecules
Influence of parental healthy-eating attitudes and nutritional knowledge on nutritional adequacy and diet quality among preschoolers: the SENDO project
Parental nutrition knowledge and attitudes play a fundamental role in their children's food knowledge. However, little is known about their influence on their children's diet quality and micronutrient intake. Thus, we aimed to assess the association of parental nutrition knowledge and healthy-eating attitudes with their children's adherence to the Mediterranean dietary pattern and micronutrient adequacy. Parental healthy-eating attitudes and knowledge of the quality of their child's diet as well as anthropometric, lifestyle, and nutrient intake characteristics were recorded with a basal questionnaire that included a 140-item-food frequency-questionnaire. A total of 287 pre-school children were included in the analyses. Intake adequacy was defined using the Estimated Average Requirements (EAR) cut-off point method. We developed a parental nutrition knowledge and healthy-eating attitudes scores and evaluated whether they were independently associated with 1) children's inadequate intake (probability of failing to meet 3 EAR) of micronutrients, using logistic regression analyses, and 2) children's diet quality (adherence to the Mediterranean Diet according to a Mediterranean Diet Quality Index for children and adolescents, the KIDMED index), using multiple linear regression models. A higher score in the parental healthy-eating attitudes score was associated with lower risk of failing to meet 3 EAR compared with the reference category (odds ratio (OR): 0.3; 95% confidence interval (CI) 0.12-0.95; p for trend: 0.037) and a higher adherence to the Mediterranean diet in the most adjusted model ( coefficient: 0.34; 95% CI 0.01-0.67; p for trend: 0.045). Our results suggest a positive association of parental healthy-eating attitudes with nutritional adequacy and diet quality in a sample of Spanish preschoolers. Public health strategies should focus on encouraging parental healthy-eating attitudes rather than simply educating parents on what to feed their children, recognizing the important influence of parental behavior on children's practices
Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection
Additional file 3: Table S2. Clinical Study Participant Characteristics
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