Understanding the dynamics of a coastal lagoon: Drivers, exchanges, state of the environment, consequences and responses

At present, many coastal ecosystems worldwide are highly affected by anthropic activities. La Mancha lagoon, in the state of Veracruz, Mexico, is an important ecosystem due to the wide array of ecosystem services that it provides. In this paper, an analysis of the environmental balances of the lagoon is outlined, using the Drivers, Exchanges, State of the Environment, Consequences and Responses (DESCR) tool. The methodological framework considers the interrelationships between the natural systems and the forces of change that alter the performance of the natural environment, in order to provide an overview of actions that may reduce negative consequences. The study area has been impacted by anthropic development, such as changes in land use for agricultural and livestock activities, loss of mangroves due to logging and modifications, carried out by local fishermen, to the natural hydrodynamics of the lagoon that alter the salinity and affect the ecosystem dynamics. Following analysis of the area, using the DESCR tool, the responses proposed include long-term environmental impact evaluation, with the aim of preserving the local coastal ecosystems

Translation Initiation Factor AteIF(iso)4E Is Involved in Selective mRNA Translation in Arabidopsis Thaliana Seedlings

One of the most regulated steps of translation initiation is the recruitment of mRNA by the translation machinery. In eukaryotes, this step is mediated by the 5′end cap-binding factor eIF4E bound to the bridge protein eIF4G and forming the eIF4F complex. In plants, different isoforms of eIF4E and eIF4G form the antigenically distinct eIF4F and eIF(iso)4F complexes proposed to mediate selective translation. Using a microarray analysis of polyribosome- and non-polyribosome-purified mRNAs from 15 day-old Arabidopsis thaliana wild type [WT] and eIF(iso)4E knockout mutant [(iso)4E-1] seedlings we found 79 transcripts shifted from polyribosomes toward non-polyribosomes, and 47 mRNAs with the opposite behavior in the knockout mutant. The translationally decreased mRNAs were overrepresented in root-preferentially expressed genes and proteins from the endomembrane system, including several transporters such as the phosphate transporter PHOSPHATE1 (PHO1), Sucrose transporter 3 (SUC3), ABC transporter-like with ATPase activity (MRP11) and five electron transporters, as well as signal transduction-, protein modification- and transcription-related proteins. Under normal growth conditions, eIF(iso)4E expression under the constitutive promoter 35 S enhanced the polyribosomal recruitment of PHO1 supporting its translational preference for eIF(iso)4E. Furthermore, under phosphate deficiency, the PHO1 protein increased in the eIF(iso)4E overexpressing plants and decreased in the knockout mutant as compared to wild type. In addition, the knockout mutant had larger root, whereas the 35 S directed expression of eIF(iso)4E caused shorter root under normal growth conditions, but not under phosphate deficiency. These results indicate that selective translation mediated by eIF(iso)4E is relevant for Arabidopsis root development under normal growth conditions

Evaluación de la implementación del protocolo de manejo de catéteres a permanencia : Estudio descriptivo transversal a realizarse con los enfermeros de la Unidad de Oncohematología y Trasplante de Médula Ósea del Hospital Italiano de Córdoba, durante el segundo semestre del 2022

El siguiente proyecto de investigación ha sido elaborado a raíz del escenario actual y de las funciones que cumplen en sus ámbitos laborales las autoras, haciendo hincapié en la capacitación y evaluación del avance de los aprendices no solo desde una base fundamentada en lo científico sino con especial énfasis en lograr obtener datos a futuro que certifiquen la relación directa entre las buenas prácticas y los beneficios que se pudieran obtener a posterior. Este es un trabajo que se enmarca en el contexto de una institución de salud de la ciudad de Córdoba, siendo el Hospital Italiano y su Unidad de Oncohematología y Trasplante de Medula Ósea el establecimiento elegido para llevar adelante la evaluación respecto a la implementación de protocolos en el manejo de catéteres a permanencia. La misma será efectuada durante el segundo semestre del año 2022. Para realizar la investigación se tuvo en cuenta a los miembros del personal asistencial de dicha unidad, quienes fueron auditados en cuanto a la realización del manejo de los accesos venosos centrales a permanencia, mediante el instrumento de grilla de observación, tomando como variable central la evaluación de la implementación del protocolo y considerando como sus dos dimensiones principales la técnica de conexión de catéter y el cambio de tubuladuras en CAP. Esta temática es fundamental, debido a que, desde la perspectiva profesional y experiencial recabada de cada una de las autoras de este escrito, se ha podido advertir la trascendencia de continuar monitoreando los protocolos que en reiteradas ocasiones caen en la monotonía y entran en la escala de la subestimación, la indiferencia o el descuido. Por lo tanto, trabajar rigurosamente y profesionalizar o formalizar, no solamente la existencia del protocolo, sino el hecho de hacerlo cumplir y fundamentarlo desde lo científico, se considera de una índole y espectro trascendental para continuar en el camino de las buenas prácticas orientadas a promover el aumento de la calidad y seguridad en la asistencia al paciente y su familia.Fil: Bravo, Valeria Yanina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Enfermería; Argentina.Fil: Luque, Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Enfermería; Argentina.Fil: Segura Martínez, Ámbar. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Enfermería; Argentina.Fil: Silva Ullua, Yamina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Enfermería; Argentina

Tratamiento con fludrocortisona en una paciente con cerebro perdedor de sal asociado a meningitis por criptococosis

Introducción: el cerebro perdedor de sal (CPS) es un síndrome de etiología confusa, responsable de un trastorno hidroelectrolítico de hiponatremia hipovolémica significativa, descrito en pacientes con afección del sistema nervioso central (SNC) por traumas o infecciones. Objetivo: describir el caso de una paciente con CPS de presentación atípica, quien requirió fludrocortisona como opción novedosa en su tratamiento. Presentación del caso: mujer de 65 años que ingresó a urgencias por alteración en estado de conciencia, hiponatremia severa y signos vitales estables. No cursó con diarrea, emesis o fiebre. Se sospechó de síndrome de secreción inadecuada de hormona antidiurética (SIADH) y se manejó con restricción hídrica que empeoró la hiponatremia. Tras identificar hemoconcentración y poliuria se orientó el diagnóstico a CPS, lo que dirigió a tratamiento con solución hipertónica complementado con fludrocortisona, esencial para alcanzar niveles de seguridad. Finalmente, se realizó una punción lumbar que confirmó meningitis por criptococosis como origen del síndrome. Discusión y conclusión: el CPS tiene una presentación inusual y este caso demuestra que el tratamiento con fludrocortisona es útil para casos refractarios de origen infeccioso

Fully automatic landmarking of 2D photographs identifies novel genetic loci influencing facial features

We report a genome-wide association study for facial features in > 6,000 Latin Americans. We placed 106 landmarks on 2D frontal photographs using the cloud service platform Face++. After Procrustes superposition, genome-wide association testing was performed for 301 inter-landmark distances. We detected nominally significant association (P-value < 5×10− 8) for 42 genome regions. Of these, 9 regions have been previously reported in GWAS of facial features. In follow-up analyses, we replicated 26 of the 33 novel regions (in East Asians or Europeans). The replicated regions include 1q32.3, 3q21.1, 8p11.21, 10p11.1, and 22q12.1, all comprising strong candidate genes involved in craniofacial development. Furthermore, the 1q32.3 region shows evidence of introgression from archaic humans. These results provide novel biological insights into facial variation and establish that automatic landmarking of standard 2D photographs is a simple and informative approach for the genetic analysis of facial variation, suitable for the rapid analysis of large population samples.- Introduction - Results And Discussion -- Study sample and phenotyping -- Trait/covariate correlation and heritability -- Overview of GWAS results and integration with the literature -- Follow-up of genomic regions newly associated with facial features: Replication in two human cohorts -- Follow-up of genomic regions newly associated with facial features: effects in the mouse -- Genome annotations at associated loci - Conclusion - Methods -- Study subjects -- Genotype data -- Phenotyping -- Statistical genetic analysis -- Interaction of EDAR with other genes -- Expression analysis for significant SNPs -- Detection of archaic introgression near ATF3 and association with facial features -- Annotation of SNPs in FUMA -- Shape GWAS in outbred mic

Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes

Sea urchins are emblematic models in developmental biology and display several characteristics that set them apart from other deuterostomes. To uncover the genomic cues that may underlie these specificities, we generated a chromosome-scale genome assembly for the sea urchin Paracentrotus lividus and an extensive gene expression and epigenetic profiles of its embryonic development. We found that, unlike vertebrates, sea urchins retained ancestral chromosomal linkages but underwent very fast intrachromosomal gene order mixing. We identified a burst of gene duplication in the echinoid lineage and showed that some of these expanded genes have been recruited in novel structures (water vascular system, Aristotle's lantern, and skeletogenic micromere lineage). Finally, we identified gene-regulatory modules conserved between sea urchins and chordates. Our results suggest that gene-regulatory networks controlling development can be conserved despite extensive gene order rearrangement

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.Instituto Multidisciplinario de Biología Celula

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.Instituto Multidisciplinario de Biología Celula

Juntos reforzando tus dientes

En la actualidad se acepta que el flúor tópico en pequeñas cantidades a lo largo de la vida, es la forma más conveniente de prevención junto a una correcta técnica de cepillado. Este proyecto pretende valorar y aplicar los recursos humanos, materiales, físicos y educativos, disponibles en el Centro de APS Club El Carmen Berisso, como así también en el Centro de APS de Lisandro Olmos para mantener y elevar los niveles de salud bucal. Consideramos importante a la hora de llevar a cabo este proyecto, la atención primaria de la salud bucal y la concientización de la prevención reforzando al huésped, a través de talleres y charlas sobre técnicas de higiene oral e importancia de la topicación con Flúor a las comunidades, brindando herramientas e información que permitan implementar la prevención de enfermedadesFacultad de Odontologí

Can the intake of antiparasitic secondary metabolites explain the low prevalence of hemoparasites among wild Psittaciformes?

Background: Parasites can exert selection pressure on their hosts through effects on survival, on reproductive success, on sexually selected ornament, with important ecological and evolutionary consequences, such as changes in population viability. Consequently, hemoparasites have become the focus of recent avian studies. Infection varies significantly among taxa. Various factors might explain the differences in infection among taxa, including habitat, climate, host density, the presence of vectors, life history and immune defence. Feeding behaviour can also be relevant both through increased exposure to vectors and consumption of secondary metabolites with preventative or therapeutic effects that can reduce parasite load. However, the latter has been little investigated. Psittaciformes (parrots and cockatoos) are a good model to investigate these topics, as they are known to use biological control against ectoparasites and to feed on toxic food. We investigated the presence of avian malaria parasites (Plasmodium), intracellular haemosporidians (Haemoproteus, Leucocytozoon), unicellular flagellate protozoans (Trypanosoma) and microfilariae in 19 Psittaciformes species from a range of habitats in the Indo-Malayan, Australasian and Neotropical regions. We gathered additional data on hemoparasites in wild Psittaciformes from the literature. We considered factors that may control the presence of hemoparasites in the Psittaciformes, compiling information on diet, habitat, and climate. Furthermore, we investigated the role of diet in providing antiparasitic secondary metabolites that could be used as self-medication to reduce parasite load. Results: We found hemoparasites in only two of 19 species sampled. Among them, all species that consume at least one food item known for its secondary metabolites with antimalarial, trypanocidal or general antiparasitic properties, were free from hemoparasites. In contrast, the infected parrots do not consume food items with antimalarial or even general antiparasitic properties. We found that the two infected species in this study consumed omnivorous diets. When we combined our data with data from studies previously investigating blood parasites in wild parrots, the positive relationship between omnivorous diets and hemoparasite infestation was confirmed. Individuals from open habitats were less infected than those from forests. Conclusions: The consumption of food items known for their secondary metabolites with antimalarial, trypanocidal or general antiparasitic properties, as well as the higher proportion of infected species among omnivorous parrots, could explain the low prevalence of hemoparasites reported in many vertebrates