Fórmulas para la innovación en la docencia universitaria

Ficha técnica:  Beatriz Peña Acuña (Coord.) Visión Libros  Madrid, 2014  496

Desarrollo de una metodología de monitoreo predictivo de procesos en un sistema de manufactura auto-organizado

Este proyecto tiene como objetivo desarrollar una metodología que permita introducir un modelo predictivo en un sistema de manufactura flexible auto-organizado, permitiendo que dicho sistema pueda tomar mejores decisiones. Teniendo en cuenta la competitividad actual de los mercados productivos, y los cada vez mayores requerimientos técnicos en los productos de manufactura, el desarrollo de mejoras de diversos tipos de sistemas de producción es necesario. Adicionalmente, tomar decisiones oportunas y acertadas en procesos en marcha permite generar mejores resultados en diversos indicadores como los tiempos de ejecución del proceso y una adecuada respuesta ante posibles perturbaciones. Esto permite mejorar la eficiencia del sistema. Por otro lado, el análisis de datos, y herramientas propias de la ingeniería industrial a través de la minería de procesos permitirá desarrollar una metodología que permita la implementación de un modelo predictivo de procesos en un sistema de manufactura flexible auto-organizado simulado basado en la celda de manufactura AIP - PRIMECA ubicada en la Universidad de Valenciennes (Francia). Herramientas de la minería de procesos tales como Apromore, Nírdizati, ProM serán usadas como base para el desarrollo de la metodología y su implementación en el sistema simulado. Se espera que con la implementación de la metodología el sistema sea más eficiente.The objective of this project is to develop a methodology that allows the introduction of a predictive model in a flexible self-organized manufacturing system, allowing the system to make better decisions. Taking into consideraron current competitivity in productive markets and, the higher requirements in manufactured producís, the development of improvements of various types of production systems is necessary. Additionally, taking oportune and accurate decisión in ongoing processes allows to generate better results in various indicators such as the execution time of process and an adequate response to possible perturbations. This allows to improve the efficiency of the system. On the other hand, data analysis and industrial engineering tools through process mining, will allow to develop a methodology that permits the implementation of a predictive model of processes in a simulated flexible self-organized manufacturing system based on the manufacturing cell AIP - PRIMECA located in Valenciennes Université (France). Process mining tools such as Apromore, Nirdizati, ProM will be used as a basis for the development of the methodology and its implementation in the simulated system. It is expected that with the implementation of the methodology, the system will be more efficient.Ingeniero (a) IndustrialPregrad

INFLUÊNCIA DO GÊNERO, NÍVEL EDUCACIONAL E PRÁTICA DESPORTIVA DOS PAIS NOS HÁBITOS ESPORTIVOS DAS CRIANÇAS EM IDADE ESCOLAR

The importance of parents in the physical activity of their children during adolescence has been previously established, but few studies have determined which are the most important variables. This study analyzes the influence of gender stereotypes, educational level, and the level of parents’ sports practice on their children’s practice. The sample included 965 adolescents and 1,599 parents from the Region of Murcia. The results showed differences in the sports practice of the adolescents when considering the educational level of their mothers, the physical activity carried out by the fathers on male children, the frequency of practice of the mothers for female children and gender stereotypes of the mothers. It found that gender stereotypes and parents’ educational level influenced adolescents’ sports practice.La importancia de los padres en la actividad física de sus hijos durante la adolescencia ha sido constatada previamente, pero pocos estudios han establecido cuáles son las variables más determinantes. El objetivo del presente estudio fue analizar las diferencias en la práctica deportiva de los adolescentes según el nivel educativo, el nivel de práctica deportiva y los estereotipos de género de sus progenitores. La muestra estuvo compuesta por 965 adolescentes y 1599 progenitores de la Región de Murcia. Los resultados mostraron diferencias en la práctica deportiva de los adolescentes al considerar el nivel educativo de las madres, la actividad física realizada por los padres para los varones, la frecuencia de práctica de las madres para las mujeres y los estereotipos de género de las madres. Como conclusiones, señalar que los estereotipos de género y el nivel educativo de los progenitores influyeron en la práctica deportiva de los adolescentes.  A importância dos pais na atividade física dos seus filhos durante a adolescência foi previamente afirmada, mas poucos estudos determinaram quais são as variáveis mais determinantes. O objetivo do presente estudo foi analisar a influência dos estereótipos de gênero, o nível educacional e o nível de prática desportiva dos pais sobre a prática desportiva dos seus filhos. A amostra foi composta por 965 adolescentes e 1599 pais da Região de Múrcia. Os resultados mostraram diferenças na prática desportiva dos adolescentes ao considerar o nível educacional das mães, a atividade física realizada pelos pais para os homens, a frequência da prática das mães para as mulheres e os estereótipos de gênero das mães. Como conclusões, é de notar que os estereótipos de gênero e o nível de educação dos pais influenciaram a prática do desporto pelos adolescentes.

Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Samples were collected in 9 regions. A pol fragment was amplified from plasma RNA or blood-extracted DNA. Phylogenetic analyses were performed via maximum likelihood, including database sequences of the same genetic forms as the identified clusters. Times and locations of the most recent common ancestors (MRCA) of clusters were estimated with a Bayesian method. Five large non-subtype B clusters associated with MSM were identified. The largest one, of F1 subtype, was reported previously. The other four were of CRF02_AG (CRF02_1; n = 115) and subtypes A1 (A1_1; n = 66), F1 (F1_3; n = 36), and C (C_7; n = 17). Most individuals belonging to them had been diagnosed of HIV-1 infection in the last 10 years. Each cluster comprised viruses from 3 to 8 Spanish regions and also comprised or was related to viruses from other countries: CRF02_1 comprised a Japanese subcluster and viruses from 8 other countries from Western Europe, Asia, and South America; A1_1 comprised viruses from Portugal, United Kingom, and United States, and was related to the A1 strain circulating in Greece, Albania and Cyprus; F1_3 was related to viruses from Romania; and C_7 comprised viruses from Portugal and was related to a virus from Mozambique. A subcluster within CRF02_1 was associated with heterosexual transmission. Near full-length genomes of each cluster were of uniform genetic form. Times of MRCAs of CRF02_1, A1_1, F1_3, and C_7 were estimated around 1986, 1989, 2013, and 1983, respectively. MRCA locations for CRF02_1 and A1_1 were uncertain (however initial expansions in Spain in Madrid and Vigo, respectively, were estimated) and were most probable in Bilbao, Spain, for F1_3 and Portugal for C_7. These results show that the HIV-1 epidemic among MSM in Spain is becoming increasingly diverse through the expansion of diverse non-subtype B clusters, comprising or related to viruses circulating in other countries.This work was funded through Acción Estratégica en Salud Intramural (AESI), Instituto de Salud Carlos III, project “Estudios sobre vigilancia epidemiológica molecular del VIH-1 en España,” PI16CIII/00033; Red de Investigación en SIDA (RIS), Instituto de Salud Carlos III, Subdirección General de Evaluación y Fondo Europeo de Desarrollo Regional (FEDER), Plan Nacional I+D+I, project RD16ISCIII/0002/0004; scientific agreements with Consellería de Sanidade, Government of Galicia (MVI 1004/16) and Osakidetza-Servicio Vasco de Salud, Government of Basque Country (MVI 1001/16); European Research Infrastructures for Poverty Related Diseases (EURIPRED). Seventh Framework Program: FP7-Capacities-infrastructures-2012-1, grant agreement 312661; and Dirección General de Farmacia, Ministerio de Sanidad, Servicios Sociales e Igualdad, Government of Spain (grant EC11-272).S

Moringa oleifera leaf supplementation as a glycemic control strategy in subjects with prediabetes

This article belongs to the Section Phytochemicals and Human Health.Moringa oleifera (MO) is a multipurpose plant with a high polyphenol content, which is being increasingly consumed to lessen the risk of chronic metabolic diseases such as Type 2 diabetes; however, scientific evidence from clinical trials is scarce. A double-blind, randomized, placebo-controlled, parallel group intervention study with MO leaves as a food supplement was conducted in subjects with prediabetes. They consumed six daily capsules of MO dry leaf powder (2400 mg/day) (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Glycemia, appetite-controlling hormones and gut microbiota composition were studied. ANCOVA with the fixed factor “treatment” and the basal value as covariate was used to compare the change score between the groups. The results showed significant differences between groups in the rate of change of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c), which showed opposite directions during the intervention, decreasing in MO and increasing in PLC. No different change scores were found between the groups in microbiota, hepatic and renal function markers or the appetite-controlling hormones measured. In conclusion, MO supplementation resulted in favorable changes in glycaemia markers compared to placebo in the subjects with prediabetes studied, suggesting that MO might act as a natural antihyperglycemic agent.This article is part of the R + D + i Project AGL2017-86044-C2-1-R, funded by CIN/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”.Peer reviewe

Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients

Background Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. In this study, we aimed to describe the safety and effectiveness of erenumab, galcanezumab and fremanezumab in migraine patients over 65 years old in real-life. Methods In this observational real-life study, a retrospective analysis of prospectively collected data from 18 different headache units in Spain was performed. Migraine patients who started treatment with any anti-CGRP monoclonal antibody after the age of 65 years were included. Primary endpoints were reduction in monthly migraine days after 6 months of treatment and the presence of adverse effects. Secondary endpoints were reductions in headache and medication intake frequencies by months 3 and 6, response rates, changes in patient-reported outcomes and reasons for discontinuation. As a subanalysis, reduction in monthly migraine days and proportion of adverse effects were also compared among the three monoclonal antibodies. Results A total of 162 patients were included, median age 68 years (range 65-87), 74.1% women. 42% had dyslipidaemia, 40.3% hypertension, 8% diabetes, and 6.2% previous cardiovascular ischaemic disease. The reduction in monthly migraine days at month 6 was 10.17.3 days. A total of 25.3% of patients presented adverse effects, all of them mild, with only two cases of blood pressure increase. Headache and medication intake frequencies were significantly reduced, and patient-reported outcomes were improved. The proportions of responders were 68%, 57%, 33% and 9% for reductions in monthly migraine days >= 30%,>= 50%,>= 75% and 100%, respectively. A total of 72.8% of patients continued with the treatment after 6 months. The reduction in migraine days was similar for the different anti-CGRP treatments, but fewer adverse effects were detected with fremanezumab (7.7%). Conclusions Anti-CGRP mAbs are safe and effective treatments in migraine patients over 65 years old in real-life clinical practice

The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

Altres ajuts: We thank CERCA Program/Generalitat de Catalunya for their institutional support. This work was also supported by the Fundació La Marató de TV3, grant number #20131610 (S.G.), the AECC-Junta de Barcelona (S.G.), the Fundación Científica de la AECC under grant GCB13131578DEÁ (O.M.T.), the Health and Science Departments of the Catalan Government (Gen-eralitat de Catalunya). C.O.-M. is a pre-doctoral fellow funded by the Basque Government (PRE_2013_1_1009).One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types together with its antisense transcribed pseudogene RPSAP52. RPSAP52 is abundantly present in the cytoplasm, where it interacts with the RNA binding protein IGF2BP2/IMP2, facilitating its binding to mRNA targets, promoting their translation by mediating their recruitment on polysomes and enhancing proliferative and self-renewal pathways. Notably, downregulation of RPSAP52 impairs the balance between the oncogene LIN28B and the tumor suppressor let-7 family of miRNAs, inhibits cellular proliferation and migration in vitro and slows down tumor growth in vivo. In addition, high levels of RPSAP52 in patient samples associate with a worse prognosis in sarcomas. Overall, we reveal the roles of a transcribed pseudogene that may display properties of an oncofetal master regulator in human cancers

Desarrollo de los perfiles profesionales del egresado en historia y ciencias de la música a través del emprendimiento creativo: investigación, educación y gestión cultural

Memoria ID-116. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Puesta en marcha del Doble Grado Internacional en Derecho UCM - Sorbona en el marco de la alianza europea de universidades UNA EUROPA

Implementación de mejoras que potencien el Doble Grado Internacional en Derecho impartido conjuntamente entre la UCM y la Universidad de la Sorbona y que esta doble titulación internacional refuerce el papel de la UCM en la alianza europea UNA EUROP

Unraveling the effect of silent, intronic and missense mutations on VWF splicing : contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to the identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7437G>A) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of three mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that four of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease. identifier:02869074