18 research outputs found
La jĂĄcara en el siglo XVII : literatura y mĂșsica entre las fuentes escritas y la tradiciĂłn oral
[ES]El trabajo examina el origen y la etimologĂa del concepto de âjĂĄcaraâ. Tras reseñar los distintos significados, estudia la estructura de su esquema musical durante los siglos XVII y XVIII. Para ello analiza las fuentes musicales y literarias de la Ă©poca.[EN]The paper reviews the origin and etymology of the concept of "jĂĄcara". After outlining the different meanings, it studies the structure of its musical pattern during the seventeenth and eighteenth centuries. In order to achieve it, the work analyzes the musical and literary sources of that times
Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis
Metabolic syndrome (MetS) is one of the most important medical problems around the world. Identification of patient ' s singular characteristic could help to reduce the clinical impact and facilitate individualized management. This study aimed to categorize MetS patients using phenotypical and clinical variables habitually collected during health check-ups of individuals considered to have high cardiovascular risk. The selected markers to categorize MetS participants included anthropometric variables as well as clinical data, biochemical parameters and prescribed pharmacological treatment. An exploratory factor analysis was carried out with a subsequent hierarchical cluster analysis using the z-scores from factor analysis. The first step identified three different factors. The first was determined by hypercholesterolemia and associated treatments, the second factor exhibited glycemic disorders and accompanying treatments and the third factor was characterized by hepatic enzymes. Subsequently four clusters of patients were identified, where cluster 1 was characterized by glucose disorders and treatments, cluster 2 presented mild MetS, cluster 3 presented exacerbated levels of hepatic enzymes and cluster 4 highlighted cholesterol and its associated treatments Interestingly, the liver status related cluster was characterized by higher protein consumption and cluster 4 with low polyunsaturated fatty acid intake. This research emphasized the potential clinical relevance of hepatic impairments in addition to MetS traditional characterization for precision and personalized management of MetS patients
Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)
Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease -free survival. Methods: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected. Results: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95 % CI: 22.2-56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0.179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0.895). Conclusion: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection
Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)
Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients. Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical characteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected. Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metastases' resection was 87.35 months (ICR: 1.51-332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13-78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13-3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22-4.86], p 0.01). Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the performance of a total pancreatectomy in order to improve survival. (C) 2021 The Authors. Published by Elsevier Ltd
CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative
Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research
I Congresso Ibero-Americano de Bibliotecas Escolares
Actas de la primera ediciĂłn del I Congreso Iberoamericano de Bibliotecas Escolares, CIBES 2015, organizado por la Universidad Carlos III de Madrid (España), la Universidad Estatal Paulista (Brasil) y el Ayuntamiento de Getafe (España). Celebrado: 21 - 23 de octubre de 2015 en la Universidad Estatal Paulista (MarĂlia) y 26 - 28 de octubre de 2015 en la Universidad Carlos III de Madrid (Getafe)Universidad Carlos III de Madrid (España)Universidad Estatal Paulista (Brasil)Ayuntamiento de Getafe (España)Dimensiones y visiones de la biblioteca escolar en una EducaciĂłn por competencias: la
necesidad de una polĂtica estratĂ©gica / Miguel Ăngel Marzal. -- Getafe ciudad educadora,
lectora y escritora: Bibliotecas escolares / Lourdes Muñoz Santiuste. -- Presente y
futuro: biblioteca escolar-CREA y proyectos interdisciplinares / Rosa PiquĂn. -- Cultura
en informaciĂłn: un reto esencial de la biblioteca escolar / MĂłnica BarĂł. -- Bibliotecas
escolares de Galicia: un mundo de oportunidades a favor de la EducaciĂłn / Cristina Novoa.
-- 10 años de la Red de Bibliotecas Escolares de Extremadura (REBEX) / Casildo MacĂas
Pereira. -- Biblioteca Escolar y uso Ă©tico de la informaciĂłn para una Cultura de Paz / Ana
Barrero TĂscar. -- DinamizaciĂłn de la Biblioteca Escolar Plumita durante el curso escolar
2014/15 / MarĂa Antonia Cano Cañada. -- Experiencia de la creaciĂłn de una biblioteca
escolar / Susana Santos MartĂn. -- Grupo cooperativo Bibliotecas escolares en Red-Albacete
/ José Manuel Garrido Argandoña y Eva Leal Scasso. -- La BCREA "Juan Leiva". El fomento de
la lectura desde la web social / Andrés Pulido Villar. -- Proceso de implantación de una
herramienta de autoevaluaciĂłn en la red de bibliotecas escolares de Extremadura (REBEX) /
Casildo MacĂas Pereira. -- La biblioteca escolar: abriendo fronteras / Lorena VerĂłnica
Cabrera Orellana. -- O programa RBE e a avaliaçao das bibliotecas escolares: melhoria,
desenvolvimiento e innovaçao / Elsa Conde. -- Profesional de BiblioteconomĂa y
DocumentaciĂłn: esencial en la plantilla de la escuela / Pilar del Campo Puerta. -- Una
mirada activa al proceso educativo desde la biblioteca escolar / MarĂa JesĂșs Fontela
FernĂĄndez . -- Con otra mirada "La ilustraciĂłn como vehĂculo de comunicaciĂłn y aprendizaje
en las bibliotecas escolares" / Pablo Jurado SĂĄnchez-GalĂĄn. -- Fingertips. Recriar a
biblioteca escolar na sala de aula / Rui Alfonso Mateus. -- Hablemos de libros. CĂłmo
transformar una clase de literatura en una comunidad de interpretaciĂłn de textos /
Francisco CĂ©sar DĂaz Rey. -- InclusiĂłn social de familias inmigrantes a travĂ©s de un
programa de aprendizaje de la lengua castellana / Ana Carmen Tolino FernĂĄndez-Henarejos.
-- O desenvolvimento de atividades de mediação de leitura em biblioteca escolar: o caso da
biblioteca da Escola Sesc de Ensino MĂ©dio / Vagner Amaro. -- La biblioteca escolar.
Proceso de enseñanza-aprendizaje de padres a hijos / Ana Carmen Tolino Fernåndez-
Henarejos. -- Leo con y para los demĂĄs / Ismael FernĂĄndez FernĂĄndez, Ana MarĂa Moreno
Vicente y Ana Beatriz Vicente PĂ©rez. -- Nanas y arrullo. PoesĂa a la deriva / Bernardo
Fuentes Navarrete y Carlos GarcĂa-Romeral PĂ©rez. -- GestiĂłn y evaluaciĂłn de servicios
bibliotecarios para personas con dislexia: una biblioteca escolar inclusiva desde una
perspectiva internacional / Carmen Jorge GarcĂa-Reyes. -- Sueños lectores compartidos
hechos realidad: la biblioteca escolar del C.E.I.P-S.E.S-A.A âLA PAZâ de Albacete / Ana
Rosa Cabañero Tobarra, Juan Manuel HerrĂĄez, Eva Leal Scasso, MarĂa MarĂn SĂĄnchez, Ana
BelĂ©n Medrano MartĂnez y MarĂa JosĂ© Nortes RuipĂ©rez. -- El programa biblioteca escuela en
Civican. La literatura como elemento motivador para la alfabetizaciĂłn informacional /
Villar Arellano Yanguas. -- La competencia digital en el diseño curricular: desde la
biblioteca al aula / Felicidad Campal GarcĂa. -- O deselvomimento da pesquisa escolar por
meio da competĂȘncia em informaçao / Luciane de FĂĄtima Cavalcante Beckman y Marta Leandro
da Mata. -- Proyecto escolar de investigación documental "Te pillé leyendo" / José Manuel
Garrido Argandoña. -- Aprender com a Biblioteca Escolar: formar para as literacias / Paula
Correia y Isabel Mendinhos. -- SucediĂł en el siglo XX / MarĂa Antonia Becerra MontalbĂĄn,
Ăngel BernabĂ© Muñoz y SofĂa Vaz Romero. -- El Club de lectura en la nube / BelĂ©n Benito
BlĂĄzquez y Ana OrdĂĄs GarcĂa. -- Promover a leitura e a escrita na era digital:
prĂĄcticas nas bibliotecas escolares / MarĂa Raquel Ramos. -- A biblioteca escolar e o
desafĂo da interculturalidade: o projeto Ser + cidadao / MarĂa da Conceição TomĂ©. --
Cuando la competencia digital encontrĂł a la alfabetizaciĂłn informacional o Mucho ruido y
pocas nueces / Felicidad Campal GarcĂa. -- Hora de ler, un programa para el fomento de la
lectura en contexto educativo / Cristina Novoa. -- HĂĄbitos de lectura para las
competencias en informaciĂłn y alfabetizaciĂłn en informaciĂłn en bibliotecas escolares de
Puerto Rico / Karen Denise Centeno Casillas. -- Repositorios digitales en las bibliotecas
escolares andaluzas: situaciĂłn, modelos y herramientas para su creaciĂłn / Dolores Olmos
Olmos y Andrés Pulido Villar. -- Trabajando las competencias clave con las aventuras de
Mozarito en Extremadura / MarĂa Teresa Carballosa GonzĂĄlez y MarĂa Esther Nieto Vidal. --
AnĂĄlisis de modelos de evaluaciĂłn de la web de la biblioteca escolar / RaĂșl Cremades
GarcĂa. -- EmociĂłnate con las historias: El bosque de las emociones e historias con mucho
teatro / Esther Luis PĂ©rez y Ana MarĂa Peromingo FernĂĄndez. -- Biblioteca escolar de
innovaciĂłn y continuaciĂłn / E. MarĂa Guerrero Palacios y Silvia Mora RamĂrez. -- Uso de
estĂĄndares y licencias para la creaciĂłn y difusiĂłn de contenidos en las bibliotecas
escolares / José Luis Barreiro Cebey. -- La biblioteca escolar digital móvil / Javier
FernĂĄndez Delgado. -- Uso de aplicaciones mĂłviles para el desarrollo de
la competencia lingĂŒĂstica. Proyecto Hansel App Gretel / Dolores Olmos Olmos. -- A memĂłria
e a mediação segundo Vigotski / Leda Maria AraĂșjo, Patricia Celia Santana, Sueli Bortolin
y Leticia Gorri Molina. -- Bibliotecas escolares como tema de estudo dos alunos de
graduação em blioteconomia do Instituto de Ensino Superior da FUNLEC: estado da arte /
Tiago Pereira Nocera y Rodrigo Pereira. -- AçÔes de mediação da leitura e da informação
em bibliotecas escolares: um olhar sobre as bibliotecas dos Colégios de Aplicação /
Tatyanne Christina Gonçalves Ferreira Valdez y Alberto Calil JĂșnior. -- Mediação
pedagĂłgica numa biblioteca de escola pĂșblica em Londrina / Rovilson JosĂ© da Silva, Teba
Silva Yllana y Sueli Bortolin. -- Utilização de categorias por cores em sistema de
biblioteca voltado ao pĂșblico infanto-juvenil / Liliana Giusti Serra. -- Atividades de
ensino dos atos de leitura com crianças em risco social / Adriana Naomi Fukushima da Silva
y Dagoberto Buim Arena. -- Biblioteca escolar: espaço de significados entre
alunos, professores e bibliotecĂĄrios / Rodrigo Barbosa Paulo, Marisa Xavier, Helen Castro
Casarin y Creuza Barbaroto. -- A Biblioteca Escolar no Contexto da Legislação e
do Processo Educativo / Eliane Lourdes da Silva Moro, Francisca Rosaline Leite Mota y
Raimundo Martins de Lima. -- O jornal impresso como fonte de informação: a importùncia da
formação de leitores crĂticos / Mariana PĂcaro Cerigatto. -- Bibliotecas escolares no
estado do Rio Grande do Sul: a trajetĂłria de realização dos fĂłruns gaĂșchos pela melhoria
das bibliotecas escolares / Eliane Lourdes da Silva Moro y Lizandra Brasil Estabel. -- O
acesso Ă informação dos usuĂĄrios surdos na biblioteca escolar / AndrĂ© LuĂs OnĂłrio
Coneglian y Mayara Melo Santana. -- Aprendizagem coletiva de bibliotecĂĄrios e a
competĂȘncia de pesquisa dos docentes: o caso do Instituto Federal do EspĂrito Santo /
Maristela Almeida Mercandeli Rodrigues y Beatriz Quiroz Villardi. -- Biblioteca escolar:
atores, parĂąmetros e competĂȘncias / Mavi Galante Mancera DallÂŽAcqua Carvalho y Claudio
Marcondes de Castro Filho. -- Estratégias de aprendizagem de escrita no
Ensino Fundamental II / Ărika Christina Kohle. -- BebĂȘs e livros: leitura nas bebetecas.
Kenia Adriana de Aquino Modesto Silva, Juliane Francischeti Martins Motoyama y Renata
Junqueira de Souza. -- Pråticas alternativas para organização de acervos nos espaços de
leitura em ambientes escolares / Luciana Souza Gracioso, Ariovaldo Alves,
DĂ©bora Nascimento, Suelen Redondo, Tainara Torika Kiri de Castro, Elizabete Angelon y
Eduardo Barbosa. -- ReflexÔes sobre a modelagem e criação de uma Rede Virtual de Leitores
para Bibliotecas Escolares / Carla Floriana Martins y Raoni Guerra RajĂŁo. -- Biblioteca
escolar: espaço de formação leitora? / Silvana Ferreira de Souza Balsan y Renata
Junqueira de Souza. -- âSe a Biblioteca Escolar Ă© minha mĂŁe, o Google Ă© meu paiâ:
representaçÔes da relação entre Biblioteca Escolar e Google no imaginårio de
alunos do ensino técnico / Adriana Bogliolo Sirihal-Duarte, Maria L. Amorim Antunes y
Raquel Miranda Vilela Paiva. -- Desafios e propostas para a universalização das
bibliotecas escolares no Brasil e na Espanha / Rodrigo Pereira, Daniela Spudeit y Fernanda
de Sales. -- Bibliotecårio educador: possibilidades de atuação no contexto da biblioteca
escolar / André Carlos da Silva, Valéria Martin Valls y Mariana de Paula Silva. -- Uma ONG
para Bibliotecas Escolares : estratégia para ampliar a igualdade e capacidade de acesso
e uso da informação e educação escolar de qualidade / Suelen Camilo Ferreira y Luciana de
Souza Gracioso. -- O aluno com deficĂȘncia: o papel do bibliotecĂĄrio na disponibilidade de
recursos acessĂveis na biblioteca escolar / Adriano de Sales Coelho, Rosilene de Melo
Oliveira y Marcos Pastana Santos. -- Biblioteca digital virtual e o uso do tablete: uma
possibilidade de construção de novas pråticas de leitura na escola / Barbara Cibelli da
Silva Monteagudo y Dagoberto Buim Arena. -- A importùncia da biblioteca na educação de
crianças de 0 a 3 anos / Yngrid Karolline Mendonça Costa y Cyntia Graziella Guizelim
SimÔes Girotto. -- Comportamento Informacional de adolescentes: a relação com bibliotecas
e escolas / Nelson Sebastian Silva-Jerez y Helen de Castro S. Casarin
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
La mirada y la comida: Un ejercicio de antropologĂa visual acerca de prĂĄcticas alimenticias en Colombia
Hablamos entonces del comer como una experiencia que nos condiciona permanentemente como individuos, como sociedad, omo seres culturales y espirituales. El cocinar y el comer entendidos como conocimiento, herencia y sabidurĂa, pertenecientes a un grupo de personas, que hace parte de su cotidianidad, que se transfiere y que muta con el paso del tiempo, tiene un altĂsimo valor identificador, por lo que su culto y la continuidad de sus prĂĄcticas son elementales para la fijaciĂłn de la identidad cultural y la memoria colectiva de cualquier grupo social, sea una familia, una comunidad, un pueblo, una regiĂłn o un paĂs
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells.
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK), Akt, and 5'AMP-activated protein kinase (AMPK) leading to autophagy and apoptosis induced by sorafenib. Sorafenib induced early (3-12âhr) ER stress characterized by an increase of Ser51 P-eIF2α/eIF2α, C/EBP homologous protein (CHOP), IRE1α, and sXBP1, but a decrease of activating transcription factor 6 expression, overall temporally associated with the increase of Thr183,Tyr185 P-JNK1/2/JNK1/2, Thr172 P-AMPKα, Ser413 P-Foxo3a, Thr308 P-AKt/AKt and Thr32 P-Foxo3a/Foxo3a ratios, and reduction of Ser2481 P-mammalian target of rapamycin (mTOR)/mTOR and protein translation. This pattern was related to a transient increase of tBid, Bim EL , Beclin-1, Bcl-xL, Bcl-2, autophagy markers, and reduction of myeloid cell leukemia-1 (Mcl-1) expression. The progressive increase of CHOP expression, and reduction of Thr308 P-AKt/AKt and Ser473 P-AKt/AKt ratios were associated with the reduction of autophagic flux and an additional upregulation of Bim EL expression and caspase-3 activity (24âhr). Small interfering-RNA (si-RNA) assays showed that Bim, but not Bak and Bax, was involved in the induction of caspase-3 in sorafenib-treated HepG2 cells. Sorafenib increased autophagic and apoptotic markers in tumor-derived xenograft model. In conclusion, the early sorafenib-induced ER stress and regulation of JNK and AMPK-dependent signaling were related to the induction of survival autophagic process. The sustained drug treatment induced a progressive increase of ER stress and PERK-CHOP-dependent rise of Bim EL , which was associated with the shift from autophagy to apoptosis. The kinetic of Bim EL expression profile might also be related to the tight balance between AKt- and AMPK-related signaling leading to Foxo3a-dependent BIM EL upregulation