Tibial Artery Calcification as a Marker of Amputation Risk in Patients With Peripheral Arterial Disease

ObjectivesThe purpose of this study was to evaluate the relationship between calcification in tibial arteries, the degree of limb ischemia, and the near-term risk of amputation.BackgroundDetermining the amputation risk in patients with peripheral arterial disease (PAD) remains difficult. Developing new measures to identify patients who are at high risk for amputation would allow for targeted interventions and focused trials aimed at limb preservation.MethodsTwo hundred twenty-nine patients underwent evaluation by history, arterial Doppler, and multislice computed tomography of the lower extremities. We then explored the relationship between a tibial artery calcification (TAC), traditional risk factors for PAD, limb status at presentation, and near-term amputation risk.ResultsIncreased age and traditional atherosclerosis risk factors were associated with higher TAC scores. Patients with critical limb ischemia had the highest TAC scores, and increasing TAC scores were associated with worsening levels of limb ischemia in ordinal regression analysis. Receiver-operator characteristic analysis suggested that the TAC score predicted amputation better than the ankle-brachial index (ABI). Symptomatic patients with a TAC score greater than 400 had a significantly increased risk of amputation. In Cox regression analysis, there was a strong association between the TAC score and the risk of major amputation that remained after adjustment for traditional risk factors and the ABI.ConclusionsIn patients presenting with PAD, the TAC score is associated with the stage of disease and it identifies those who are at high risk for amputation better than traditional risk factors and an abnormal ABI

Review of recent experimental progresses in Foundations of Quantum Mechanics and Quantum Information obtained in Parametric Down Conversion Experiments at IENGF

We review some recent experimental progresses concerning Foundations of Quantum Mechanics and Quantum Information obtained in Quantum Optics Laboratory "Carlo Novero" at IENGF. More in details, after a short presentation of our polarization entangled photons source (based on precise superposition of two Type I PDC emission) and of the results obtained with it, we describe an innovative double slit experiment where two degenerate photons produced by PDC are sent each to a specific slit. Beyond representing an interesting example of relation between visibility of interference and "welcher weg" knowledge, this configuration has been suggested for testing de Broglie-Bohm theory against Standard Quantum Mechanics. Our results perfectly fit SQM results, but disagree with dBB predictions. Then, we discuss a recent experiment addressed to clarify the issue of which wave-particle observables are really to be considered when discussing wave particle duality. This experiments realises the Agarwal et al. theoretical proposal, overcoming limitations of a former experiment. Finally, we hint to the realization of a high-intensity high-spectral-selected PDC source to be used for quantum information studies

Abstinence-only-until-marriage : An Updated review of U.S. policies and programs and their impact

Adolescence is marked by the emergence of human sexuality, sexual identity and the initiation of intimate relations; within this context, abstinence from sexual intercourse can be a healthy choice. However, programs that promote abstinence-only-until-marriage (AOUM) or sexual risk avoidance (SRA), are scientifically and ethically problematic and—as such—have been widely rejected by medical and public health professionals. Although abstinence is theoretically effective, in actual practice, intentions to abstain from sexual activity often fail. Given a rising age at first marriage around the world, a rapidly declining percentage of young people remain abstinent until marriage. Promotion of AOUM policies by the United States (U.S.) government has undermined sexuality education in the U.S. and in U.S. foreign aid programs; funding for AOUM continues in the U.S. The weight of scientific evidence finds that AOUM programs are not effective in delaying initiation of sexual intercourse or changing other sexual risk behaviors. AOUM programs, as defined by U.S. federal funding requirements, inherently withhold information about human sexuality and may provide medically inaccurate and stigmatizing information. Thus, AOUM programs threaten fundamental human rights to health, information, and life. Young people need access to accurate and comprehensive sexual health information to protect their health and lives

Dark energy survey year 1 results: calibration of redMaGiC redshift distributions in DES and SDSS from cross-correlations

FINEP - FINANCIADORA DE ESTUDOS E PROJETOSFAPERJ - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIROCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOMCTIC - MINISTÉRIO DA CIÊNCIA, TECNOLOGIA, INOVAÇÕES E COMUNICAÇÕESWe present calibrations of the redshift distributions of redMaGiC galaxies in the Dark Energy Survey Year 1 (DES Y1) and Sloan Digital Sky Survey (SDSS) DR8 data. These results determine the priors of the redshift distribution of redMaGiC galaxies, which were used for galaxy clustering measurements and as lenses for galaxy-galaxy lensing measurements in DES Y1 cosmological analyses. We empirically determine the bias in redMaGiC photometric redshift estimates using angular cross-correlations with Baryon Oscillation Spectroscopic Survey (BOSS) galaxies. For DES, we calibrate a single-parameter redshift bias in three photometric redshift bins: z is an element of [0.15, 0.3], [0.3,0.45], and [0.45,0.6]. Our best-fit results in each bin give photometric redshift biases of vertical bar Delta z vertical bar < 0.01. To further test the redMaGiC algorithm, we apply our calibration procedure to SDSS redMaGiC galaxies, where the statistical precision of the cross-correlation measurement is much higher due to a greater overlap with BOSS galaxies. For SDSS, we also find best-fit results of vertical bar Delta z vertical bar < 0.01. We compare our results to other analyses of redMaGiC photometric redshifts.481224272443FINEP - FINANCIADORA DE ESTUDOS E PROJETOSFAPERJ - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIROCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOMCTIC - MINISTÉRIO DA CIÊNCIA, TECNOLOGIA, INOVAÇÕES E COMUNICAÇÕESFINEP - FINANCIADORA DE ESTUDOS E PROJETOSFAPERJ - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIROCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOMCTIC - MINISTÉRIO DA CIÊNCIA, TECNOLOGIA, INOVAÇÕES E COMUNICAÇÕESSem informaçãoSem informaçãoSem informaçãoSem informaçãoAgências de fomento estrangeiras apoiaram essa pesquisa, mais informações acesse artig

Particularistic and system trust in family businesses: the role of family influence

Research on how trust develops and why it matters in family businesses is in development. Our study investigates the emergence and the evolution of trust in family business leaders. Drawing on the New Systems Theory, we also examine the impact of family influence on trust. Multiple semi‐structured interviews were performed in three Chinese family businesses. Results suggest that relationship‐based particularistic trust prevails at the start‐up stage because of the void of governance mechanisms. As businesses grow, particularistic trust gradually gives way to institution‐based system trust. Evidence further indicates high family influence catalyzes particularistic trust initially and restricts system trust subsequently

Ethnomedicinal plant knowledge and practice of the Oromo ethnic group in southwestern Ethiopia

An ethnomedicinal study was conducted to document the indigenous medicinal plant knowledge and use by traditional healers in southwestern Ethiopia from December 2005 to November 2006. Data were collected from 45 randomly selected traditional healers using semi-structured interviews and observations. Sixty-seven ethnomedicinal plant species used by traditional healers to manage 51 different human ailments were identified and documented. Healers' indigenous knowledge was positively correlated with their reported age but not with their educational level. High degree of consensus was observed among traditional healers in treating tumor (locally known as Tanacha), rabies (Dhukuba Seree) and insect bite (Hadhaa). The use of more than one species was significantly cited for remedy preparations. The reported abundance of the ethnomedicinal plant species varied significantly with respect to the presence of multiple uses of the reported species. Our results showed that ethnomedicinal plant species used by healers are under serious threat due to several factors, which indicates the need for urgent attention towards their conservation and sustainable utilization

Swift observations of GRB050904: the most distant cosmic explosion ever observed

Swift discovered the high redshift (z=6.29) GRB050904 with the Burst Alert Telescope (BAT) and began observing with its narrow field instruments 161 s after the burst onset. This gamma-ray burst is the most distant cosmic explosion ever observed. Because of its high redshift, the X-ray Telescope (XRT) and BAT simultaneous observations provide 4 orders of magnitude of spectral coverage (0.2-150 keV; 1.4-1090 keV in the source rest frame) at a very early source-frame time (22 s). GRB050904 was a long, multi-peaked, bright GRB with strong variability during its entire evolution. The light curve observed by the XRT is characterized by the presence of a long flaring activity lasting up to 1-2 hours after the burst onset in the burst rest frame, with no evidence of a smooth power-law decay following the prompt emission as seen in other GRBs. However, the BAT tail extrapolated to the XRT band joins the XRT early light curve and the overall behavior resembles that of a very long GRB prompt. The spectral energy distribution softens with time, with the photon index decreasing from -1.2 during the BAT observation to -1.9 at the end of the XRT observation. The dips of the late X-ray flares may be consistent with an underlying X-ray emission arising from the forward shock and with the properties of the optical afterglow reported by Tagliaferri et al. (2005b). We interpret the BAT and XRT data as a single continuous observation of the prompt emission from a very long GRB. The peculiarities observed in GRB050904 could be due to its origin within one of the first star-forming regions in the Universe; very low metallicities of the progenitor at these epochs may provide an explanation.Comment: 9 pages, 2 table, 6 figures, accepted for publication on A&