A Report of Nausea and Vomiting with Discontinuation of Chronic Use of Salvia divinorum

Introduction. This is the first reported case of gastrointestinal symptoms associated with withdrawal after chronic use of this substance. Case Presentation. A 51-year-old Caucasian woman was referred to a hospital with a 3-day history of nausea, vomiting, diarrhea, and abdominal discomfort. She reported no sick family members or contact with anyone who was ill. She did report smoking 3–5 cigarettes of the herb “Salvia” consistently for 3-4 months and quit approximately 48 hours before symptoms appeared. Her use of the herb had been consistent; she smoked several cigarettes each day. Laboratory results were essentially normal including the white blood cell count. She received symptomatic treatment and was released after one day. Discussion. Salvinorin A, a kappa-opioid receptor agonist, is the major active ingredient of S. divinorum. The unique opioid properties of this herb may explain its ability to cause changes in intestinal transit time. Conclusion. A 51-year-old woman possibly developed gastrointestinal manifestations suggestive of withdrawal from Salvia divinorum after smoking the substance consistently for 3 to 4 months. The widespread use of this herb will make the potential for withdrawal syndromes more commonplace

Thermal Analysis of a Metallic Wing Glove for a Mach-8 Boundary-Layer Experiment

A metallic 'glove' structure has been built and attached to the wing of the Pegasus(trademark) space booster. An experiment on the upper surface of the glove has been designed to help validate boundary-layer stability codes in a free-flight environment. Three-dimensional thermal analyses have been performed to ensure that the glove structure design would be within allowable temperature limits in the experiment test section of the upper skin of the glove. Temperature results obtained from the design-case analysis show a peak temperature at the leading edge of 490 F. For the upper surface of the glove, approximately 3 in. back from the leading edge, temperature calculations indicate transition occurs at approximately 45 sec into the flight profile. A worst-case heating analysis has also been performed to ensure that the glove structure would not have any detrimental effects on the primary objective of the Pegasus a launch. A peak temperature of 805 F has been calculated on the leading edge of the glove structure. The temperatures predicted from the design case are well within the temperature limits of the glove structure, and the worst-case heating analysis temperature results are acceptable for the mission objectives

Developing a Culturally Proficient Intervention for Young African American Men in Drug Court: Examining Feasibility and Estimating an Effect Size for Habilitation Empowerment Accountability Therapy (HEAT)

African American males between 18 and 29 years of age are substantially less likely than many other participants to graduate successfully from drug court. Unsuccessful termination from drug court can have serious repercussions for these young men, including possible incarceration and negative collateral consequences associated with having a criminal record. This article reports preliminary results from two pilot studies that examined the feasibility of implementing a culturally proficient intervention for young African American men in drug court, and estimated an effect size for the intervention in improving treatment retention and reducing termination rates. Results confirmed that participants with serious criminal and substance use histories were willing and able to complete the lengthy 9-month curriculum, were satisfied with the intervention, and graduated from drug court at substantially higher rates than are commonly observed in this at-risk population. A sufficient basis has been established to justify the effort and expense of examining this intervention — Habilitation Empowerment Accountability Therapy (HEAT) — in fully powered randomized controlled trials

Gut microbiome of the Hadza hunter-gatherers

Human gut microbiota directly influences health and provides an extra means of adaptive potential to different lifestyles. To explore variation in gut microbiota and to understand how these bacteria may have co-evolved with humans, here we investigate the phylogenetic diversity and metabolite production of the gut microbiota from a community of human hunter-gatherers, the Hadza of Tanzania. We show that the Hadza have higher levels of microbial richness and biodiversity than Italian urban controls. Further comparisons with two rural farming African groups illustrate other features unique to Hadza that can be linked to a foraging lifestyle. These include absence of Bifidobacterium and differences in microbial composition between the sexes that probably reflect sexual division of labour. Furthermore, enrichment in Prevotella, Treponema and unclassified Bacteroidetes, as well as a peculiar arrangement of Clostridiales taxa, may enhance the Hadza’s ability to digest and extract valuable nutrition from fibrous plant foods

Research Progress Reports, 1962. Fruit and Vegetable Processing and Technology Division, Department of Horticulture.

Tomato variety evaluation for processing, 1962 / W. A. Gould, J. R. Geisman and Wade Schulte -- Evaluation of snap bean varieties for processing, 1962 / Wilbur A. Gould -- Handling and holding studies of mechanically harvested tomatoes. 1. Processed product quality / W. A. Gould, W. D. Bash, J. R. Geisman, D. E. Yingst, G. A. Marlowe and W. N. Brown -- Handling and holding studies of mechanically harvested tomatoes. 2. Spore counts / Winston D. Bash and W. A. Gould -- Handling and holding studies of mechanically harvested tomatoes. 3. pH / Winston D. Bash and W. A. Gould -- Handling and holding studies of mechanically harvested tomatoes. 4. Chlorine residuals / Donald E. Yingst and W. A. Gould -- Removal of insects and residues from sweet corn by washing techniques / J. R. Geisman and W. A. Gould -- Removal of pesticides and radioactive fallout from fruits and vegetables / J. R. Geisman, R. P. Blackmore, R. W. Hirzel and W. S. Stinson -- The effect of apple variety and browning prevention treatments during preparation on the quality of frozen apple pies / D. Robert Davis and James F. Gallander -- Effect of three tomato peeling methods on efficiency and product quality / Wade A. Schulte and W. A. Gould -- Effects of cooling rates on vacuum of canned pumpkin / Winston D. Bash -- New flavors for sauerkraut / J. R. Geisman and Robert Reyda -- Flavor of tomato juice / Wilbur A. Gould, Natholyn Dalton and John Hal Johnson -- Fruit juice blends offer a promising new field for apple cider / D. Robert Davi

Numerical simulations of shocks encountering clumpy regions

We present numerical simulations of the adiabatic interaction of a shock with a clumpy region containing many individual clouds. Our work incorporates a sub-grid turbulence model which for the first time makes this investigation feasible. We vary the Mach number of the shock, the density contrast of the clouds, and the ratio of total cloud mass to inter-cloud mass within the clumpy region. Cloud material becomes incorporated into the flow. This "mass-loading" reduces the Mach number of the shock, and leads to the formation of a dense shell. In cases in which the mass-loading is sufficient the flow slows enough that the shock degenerates into a wave. The interaction evolves through up to four stages: initially the shock decelerates; then its speed is nearly constant; next the shock accelerates as it leaves the clumpy region; finally it moves at a constant speed close to its initial speed. Turbulence is generated in the post-shock flow as the shock sweeps through the clumpy region. Clouds exposed to turbulence can be destroyed more rapidly than a similar cloud in an "isolated" environment. The lifetime of a downstream cloud decreases with increasing cloud-to-intercloud mass ratio. We briefly discuss the significance of these results for starburst superwinds and galaxy evolution.Comment: 17 pages, 19 figures, accepted for publication in MNRA

Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal alpha-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition

PMCID: PMC3534021This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Star forming dwarf galaxies

Star forming dwarf galaxies (SFDGs) have a high gas content and low metallicities, reminiscent of the basic entities in hierarchical galaxy formation scenarios. In the young universe they probably also played a major role in the cosmic reionization. Their abundant presence in the local volume and their youthful character make them ideal objects for detailed studies of the initial stellar mass function (IMF), fundamental star formation processes and its feedback to the interstellar medium. Occasionally we witness SFDGs involved in extreme starbursts, giving rise to strongly elevated production of super star clusters and global superwinds, mechanisms yet to be explored in more detail. SFDGs is the initial state of all dwarf galaxies and the relation to the environment provides us with a key to how different types of dwarf galaxies are emerging. In this review we will put the emphasis on the exotic starburst phase, as it seems less important for present day galaxy evolution but perhaps fundamental in the initial phase of galaxy formation.Comment: To appear in JENAM Symposium "Dwarf Galaxies: Keys to Galaxy Formation and Evolution", P. Papaderos, G. Hensler, S. Recchi (eds.). Lisbon, September 2010, Springer Verlag, in pres

6-m Telescope Spectroscopic Observations of The Bubble Complex in NGC 6946

We describe the results of a long-slit spectroscopic study of an unusual star complex in the nearby spiral galaxy NGC 6946 using the SAO 6-m telescope and the Keck 10-m telescope. The complex resembles a circular bubble 600 pc in diameter with a young super star cluster (SSC) near the center. The kinematics of ionized gas is studied through Ha emission with several slit positions. Position-velocity diagrams show two distinct features with high speed motions. One is an irregularly shaped region to the east of the SSC, 270 pc in size, in which most of the Ha emission is blue shifted by 120 km/s, and another is a 350 pc shell centered on the SSC with positive and negative velocity shifts of 60 km/s. Balmer and HeI absorption lines in the SSC give an age of 12-13 Myr, which is consistent with the photometric age but significantly older than the kinematic ages of the high speed regions. The energetics of the SSC and its interaction with the environment are considered. The expansion energies exceed 10^52 ergs, but the power outputs from winds and supernova in the SSC are large enough to account for this. The intensities of Balmer, [NII], and [SII] emission lines within and around the complex indicate that shock excitation makes a significant contribution to the emission from the most energetic region.Comment: LaTeX, 11 pages and 11 GIF files in tar-archive with figures. A&A, accepted 16.05.2002. Full A&A version of the paper is available via http://precise.sao.ru/Laboratory/Publications/2002/NGC6946.ps.g