Approximation to the theory of affinities to manage the problems of the groupping process

New economic and enterprise needs have increased the interest and utility of the methods of the grouping process based on the theory of uncertainty. A fuzzy grouping (clustering) process is a key phase of knowledge acquisition and reduction complexity regarding different groups of objects. Here, we considered some elements of the theory of affinities and uncertain pretopology that form a significant support tool for a fuzzy clustering process. A Galois lattice is introduced in order to provide a clearer vision of the results. We made an homogeneous grouping process of the economic regions of Russian Federation and Ukraine. The obtained results gave us a large panorama of a regional economic situation of two countries as well as the key guidelines for the decision-making. The mathematical method is very sensible to any changes the regional economy can have. We gave an alternative method of the grouping process under uncertainty

Photodynamic opening of the blood-brain barrier using different photosensitizers in mice

In a series of previous studies, we demonstrated that the photodynamic therapy (PDT), as a widely used tool for treatment of glioblastoma multiforme (GBM), also site-specifically opens the blood-brain barrier (BBB) in PDT-dose and age-related manner via reversible disorganization of the tight junction machinery. To develop the effective protocol of PDT-opening of the BBB, here we answer the question of what kind of photosensitizer (PS) is the most effective for the BBB opening. We studied the PDT-opening of the BBB in healthy mice using commercial photosensitizers (PSs) such as 5-aminolevulenic acid (5-ALA), aluminum phthalocyanine disulfonate (AlPcS), zinc phthalocyanine (ZnPc) and new synthetized PSs such as galactose functionalized ZnPc (GalZnPc). The spectrofluorimetric assay of Evans Blue albumin complex (EBAC) leakage and 3-D confocal imaging of FITC-dextran 70 kDa (FITCD) extravasation clearly shows a revisable and dose depended PDT-opening of the BBB toEBACand FITCD associated with a decrease in presence of tight junction (TJ) in the vascular endothelium. The PDT effects on the BBB permeability, TJ expression and the fluorescent signal from the brain tissues are more pronounced in PDT-GalZnPc vs. PDT-5-ALA/AlPcS/ZnPc. These pre-clinical data are the first important informative platform for an optimization of the PDT protocol in the light of new knowledge about PDT-opening of the BBB for drug brain delivery and for the therapy of brain diseases. © 2019 by the authors

Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases

UHMWPE/SBA-15 nanocomposites synthesized by in situ polymerization

Different nanocomposites have been attained by in situ polymerization based on ultra-high molecular weight polyethylene (UHMWPE) and mesoporous SBA-15, this silica being used for immobilization of the FI catalyst bis [N-(3-tert-butylsalicylidene)-2,3,4,5,6-pentafluoroanilinato] titanium (IV) dichloride and as filler as well. Two distinct approaches have been selected for supporting the FI catalyst on the SBA-15 prior polymerization. A study on polymerization activity of this catalyst has been performed under homogenous conditions and upon heterogenization. A study of the effect of presence of mesoporous particles and of the immobilization method is also carried out. Moreover, the thermal characterization, phase transitions and mechanical response of some pristine UHMWPEs and UHMWPE/SBA-15 materials have been carried out. Relationships with variations on molar mass, impregnation method of catalyst and final SBA-15 content have been established

Photostimulation of extravasation of beta-amyloid through the model of blood-brain barrier

Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Photostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier

Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system.Russian Science FoundationRussian Foundation for Fundamental InvestigationsPeer Reviewe

Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer's disease

In this pilot study, we analyzed effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm2) on clearance of beta-amyloid (Aβ) from the mouse brain. The immunohistochemical and confocal data clearly demonstrate the significant reduction of deposition of Aβ plaques in mice after tPBM vs. untreated animals. The behavior tests showed that tPBM improved the cognitive, memory and neurological status of mice with Alzheimer’s disease (AD). Using of our original method based on optical coherence tomography (OCT) analysis of clearance of gold nanorods (GNRs) from the brain, we proposed possible mechanism underlying tPBM-stimulating effects on clearance of Aβ via the lymphatic system of the brain and the neck. These results open breakthrough strategies for a non-pharmacological therapy of Alzheimer’s disease and clearly demonstrate that tPBM might be a promising therapeutic target for preventing or delaying Alzheimer’s disease

Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic "smart"delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas

Koncepcja denizenship w Europie: studia na przypadku Turcji, Szwecji i Polsce.

W niniejszej pracy omówiono kwestie imigracji i znaczenia obywatelstwa z punktu widzenia prawnego i społecznego. Będę argumentowała, że europejska denicjatura zacząła szybko się rozwijać pod wpływem globalnego kryzysu gospodarczego w 2008 r. i eskalacji kryzysu uchodźców, który jest skutkiem syryjskiego konfliktu zbrojnego. W pierwszym rozdziale omówię dwa typy obywatelstwa: prawny i kulturowy. Następnie przeanalizuję, jak podwójne obywatelstwo ewoluowało, aby stać się mechanizmem rozwoju denicjatury. Przedstawię także, że różnica między cudzoziemcami a obywatelami staje się nieistotna na poziomie kulturowym i prawnym. Aby zilustrować ogólną różnorodność Europy, trzy poniższe rozdziały przedstawiają porównawczą analizę stosowania denitencjarności w studiach przypadków Szwecji, Turcji i Polski. W pierwszej części każdego rozdziału przedstawiam ilościowe opracowanie statystyk i polityki imigracyjnej, dostarczonych przez organizacje pozarządowe i rządowe, aby zbadać prawny aspekt imigracji. Drugi podrozdział każdego rozdziału omawiaja perspektywy kulturowe imigracji poprzez krytyczną analizę źródeł akademickich i dokumentów prawnych. W ostatnim rozdziale przedstawiono wnioski ze studiów przypadków. Zawiera on również wniosek o prawdopodobieństwie istnienia denitencjarności w danych studiach przypadków, a także zalecenia dotyczące przyszłego rozwoju denitencjarnego w państwach europejskich.This research paper discusses immigration and the meaning of citizenship from the legal and social perspectives. I will argue that European denizenship has started to rapidly develop under the influence of the global economic crisis of 2008 and the escalation of the refugee crisis as a result of the Syrian military conflict. In the first chapter I identify two types of citizenship: legal and cultural. Then, I analyze how dual citizenship evolved to become a mechanism for denizenship’s development, while the difference between the aliens and nationals becomes insignificant on both cultural and legal levels. To illustrate the general diversity of Europe, the three following chapters present a comparative analysis of the application of denizenship in case studies of Sweden, Turkey and Poland. In the first section of each chapter, I present a quantitative study of immigration statistics and policies provided by the NGOs and governmental sources in order to examine the legal aspect of immigration. The second subsection of each chapter I discuss the cultural outlook of immigration by critically analyzing academic sources and legal documents. The last chapter shows the findings from the case studies and provides the conclusion on the likelihood of existence of denizenship in the given case studies as well as recommendations on the future possible development of denizenship in European states

Procrastination phenomenon in individual and team sports athletes’ activity

The modern world imposes strict conditions on people in various types of activities. A huge amount of processed information, tight timelines and other factors may cause people’s inability to cope with their tasks. Thus, there is a popular habit to put off the work without thinking about the consequences. This trait called procrastination is inherent to a million people all over the world. The problem of procrastination is just beginning to develop in Russia. Nowadays lots of foreign research and foreign questionnaires are being translated and approbated. The aim of this research is to identify the level of athletes’ procrastination, and define the differences of procrastination patterns in individual and team sports athletes. Also we want to study the relationship between procrastination and athletes’ personal characteristics such as extroversion, neuroticism, control over the actions, motivation to success, anxiety, time perspective and decision-making style (coping), and also indicators of state anxiety using a sample of individual athletes (boxing, unarmed self-defence, judo, karate, kickboxing, wrestling, taekwondo) and teams (hockey, football, volleyball). Correlation analysis shows structural differences of procrastination manifestations in different types of sport. Regression analysis shows that in athletes of individual sports (model: p = 0,002, adjusted R2 = 0,368) there is only one significant predictor of procrastination - the negative past (p = 0,007, β = 0,495). The negative past (p = 0,003, β = 0,463), the control over the planning of the action (p = 0,05, β = -0.220) and the monitoring of the implementation of the action (p = 0,003, β = -0,465) are the predictors of procrastination in team sports (model: p = 0,002, adjusred R2 = 0,368)