Strange Particles in Dense Matter and Kaon Condensates

We discuss the role of strangeness in dense matter and especially in neutron stars. The early (in density) introduction of hyperons found in many calculations is probably delayed by the decrease in vector mean field acting on the neutron. The decrease results from both conventional many-body rescattering effects and from the movement towards asymptotic freedom at high densities. Subthreshold $K^-$-meson production by the KaoS collaboration at GSI shows that the $K^-$-mass must be substantially lowered, by $\gtrsim$ 200 MeV at $\rho\sim 2\rho_0$. It is shown that explicit chiral symmetry breaking through the kaon mass may be responsible for $\Sigma^-$-nucleon and $\Xi^-$-nucleon scalar attraction being weaker than obtained by simple quark scaling. The normal mode of the strangeness minus, charge $e^-$, excitation is constructed as a linear combination of $K^-$-meson and $\Sigma^-$, neutron-hole state. Except for zero momentum, where the terms are unmixed the "kaesobar" is a linear combination of these two components.Comment: 10 pages, 8 postscript figures, Talk given at the International Conference on Hypernuclear and Strange Particle Physics (HYP97), Brookhaven Nat'l Lab., USA, October 13-18, 1997, to be published in Nucl. Phys.

Double Λ\Lambda Hypernuclei and the Nuclear Medium Effective ΛΛ\Lambda\Lambda Interaction

We fit the $^1 S_0 \Lambda\Lambda$ interaction in the nuclear medium to the masses of the experimentally known double-$\Lambda$ hypernuclei: $^{\phantom{6}6}_{\Lambda\Lambda}$He, $^{10}_{\Lambda\Lambda}$Be and $^{13}_{\Lambda\Lambda}$B. We derive this effective interaction from OBE J\"ulich $\Lambda\Lambda$-type potentials and using both Hartree-Fock and variational approaches. We find that the inclusion of $\Lambda\Lambda$ correlations in the variational scheme leads to significant differences and a better understanding of the dynamical features of the system. We investigate the sensitivity of the binding energies and the mesonic decay widths of the above double-$\Lambda$ hypernuclei to the $\omega \Lambda\Lambda$ coupling and the form factor at the $\sigma \Lambda\Lambda$ vertex. We also use this effective interaction to predict binding energies and pionic decay widths of heavier double-$\Lambda$ hypernuclei, not discovered yet. Finally, we discard the existence of $^1 S_0$ $\Lambda\Lambda$ bound states provided the $\Lambda\Lambda-\Xi N$ coupling can be neglected.Comment: 49 pages, LaTeX + 8 ps-figure file

Density dependent hadron field theory for hypernuclei

The Density Dependent Relativistic Hadron Field (DDRH) theory, previously introduced and applied to isospin nuclei, is extended to hypernuclei by including the octet hyperons. Infinite matter Dirac-Brueckner theory for octet baryons and the derivation of in-medium DDRH baryon-meson vertices is discussed. From the properties of Dirac-Brueckner interactions it is found that hyperon and nucleon self-energies and vertices are related by the ratios of free space coupling constants. This leads to simple scaling laws for the in-medium hyperon and nucleon vertices. The model is applied in relativistic DDRH mean-field calculations to singl$\Lambda nuclei. Free space N-Lambda T-matrix results are used for the scalar vertex. As the only free parameter the hyperon vector vertex scaling factor is adjusted to a selected set of hypernuclear data. Spectroscopic data of single Lambda hypernuclei over the full mass range are well described. The reduced Lambda spin-orbit splitting is reproduced and found to be related closely the medium dependence of scalar and vector interactions.Comment: 38 pages, 9 figure

Application of the density dependent hadron field theory to neutron star matter

The density dependent hadron field (DDRH) theory, previously applied to isospin nuclei and hypernuclei is used to describe $\beta$-stable matter and neutron stars under consideration of the complete baryon octet. The meson-hyperon vertices are derived from Dirac-Brueckner calculations of nuclear matter and extended to hyperons. We examine properties of density dependent interactions derived from the Bonn A and from the Groningen NN potential as well as phenomenological interactions. The consistent treatment of the density dependence introduces rearrangement terms in the expression for the baryon chemical potential. This leads to a more complex condition for the $\beta$-equilibrium compared to standard relativistic mean field (RMF) approaches. We find a strong dependence of the equation of state and the particle distribution on the choice of the vertex density dependence. Results for neutron star masses and radii are presented. We find a good agreement with other models for the maximum mass. Radii are smaller compared to RMF models and indicate a closer agreement with results of non-relativistic Brueckner calculations.Comment: 28 pages, 11 figure

Uso de habtats por pequenos mamíferos não-voadores no cerrado do Brasil central

Non-volant small mammals are organisms capable of yielding precise information on richness, abundance and species composition variations related to the use of habitats. The aim of this research was to compare these variations in Cerrado sensu stricto, Palm Forest, Gallery Forest and Rocky Field. From May 1999 to February 2000, we surveyed non-volant small mammals (hence small mammals) in Serra das Araras Ecological Station. We captured 218 individuals and recaptured 62 individuals, belonging to 21 taxa, 13 rodents and eight marsupials, in a total of 13200 trap-nights. Capture success was 1.7%. We observed higher richness of small mammals in forested areas (Gallery Forest and Palm Forest) than in open areas (Rocky Field and Cerrado sensu stricto). The Palm Forest had the highest richness of marsupials, possibly due to the quality of a specific niche. The Rocky Field had the smallest richness, but with very high abundance of few species, mainly Thrichomys pachyurus and Monodelphis domestica. Forest habitats had similar species composition. The open habitats, Cerrado sensu stricto and Rocky Field, had a distinct species composition between them, and also when compared to forested areas. Different species are exclusive or showed preference for specific habitats. The protection of horizontally heterogeneous biomes, such as Cerrado, has a fundamental importance to the maintenance of the regional diversity of the small mammal community of Central Brazil

Mesomorphic behaviour in copoly(ester-imide)s of poly(butylene-2,6-naphthalate) (PBN)

Copolycondensation of N,N’-bis(4-hydroxybutyl)-biphenyl-3,4,3',4'-tetracarboxylic diimide at 20 and 25 mol% with bis(4-hydroxybutyl)-2,6-naphthalate produces PBN-based copoly(ester-imide)s that not only crystallise but also form a (smectic) mesophase upon cooling from the melt. Incorporation of 25 mol% imide in PBN causes the glass transition temperature (measured by DSC) to rise from 51 to 74 °C, a significant increase relative to PBN. Furthermore, increased storage- (G'), loss- (G'') and elastic (E) moduli are observed for both copoly(ester-imide)s when compared to PBN itself. Structural analysis of the 20 mol% copolymer by X-ray powder and fibre diffraction, interfaced to computational modelling, suggests a crystal structure related to that of α-PBN, in space group P-1, with cell dimensions a = 4.74, b = 6.38, c = 14.45 Å, α = 106.1, β = 122.1, γ = 97.3°, ρ = 1.37 g cm-3

Review of nutrient actions on age-related macular degeneration

The actions of nutrients and related compounds on age-related macular degeneration (AMD) are explained in this review. The findings from 80 studies published since 2003 on the association between diet and supplements in AMD were reviewed. Antioxidants and other nutrients with an effect on AMD susceptibility include carotenoids (lutein and zeaxanthin, β-carotene), vitamins (vitamin A, E, C, D, B), mineral supplements (zinc, copper, selenium), dietary fatty acids [monounsaturated fatty acids, polyunsaturated fatty acids (PUFA both omega-3 PUFA and omega-6 PUFA), saturated fatty acids and cholesterol], and dietary carbohydrates. The literature revealed that many of these antioxidants and nutrients exert a protective role by functioning synergistically. Specifically, the use of dietary supplements with targeted actions can provide minimal benefits on the onset or progression of AMD; however, this does not appear to be particularly beneficial in healthy people. Furthermore, some supplements or nutrients have demonstrated discordant effects on AMD in some studies. Since intake of dietary supplements, as well as exposure to damaging environmental factors, is largely dependent on population habits (including dietary practices) and geographical localization, an overall healthy diet appears to be the best strategy in reducing the risk of developing AMD. As of now, the precise mechanism of action of certain nutrients in AMD prevention remains unclear. Thus, future studies are required to examine the effects that nutrients have on AMD and to determine which factors are most strongly correlated with reducing the risk of AMD or preventing its progression

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.

Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of intracellular proteins through the recruitment of E3 ligase complexes to non-native protein substrates. The catalytic mechanism of action of PROTACs represents an exciting new modality in drug discovery that offers several potential advantages over traditional small-molecule inhibitors, including the potential to deliver pharmacodynamic (PD) efficacy which extends beyond the detectable pharmacokinetic (PK) presence of the PROTAC, driven by the synthesis rate of the protein. Herein we report the identification and development of PROTACs that selectively degrade Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) and demonstrate in vivo degradation of endogenous RIPK2 in rats at low doses and extended PD that persists in the absence of detectable compound. This disconnect between PK and PD, when coupled with low nanomolar potency, offers the potential for low human doses and infrequent dosing regimens with PROTAC medicines

Macular and serum carotenoid concentrations in patients with malabsorption syndromes

The carotenoids lutein and zeaxanthin are believed to protect the human macula by absorbing blue light and quenching free radicals. Intestinal malabsorption syndromes such as celiac and Crohn’s disease are known to cause deficiencies of lipid-soluble nutrients. We hypothesized that subjects with nutrient malabsorption syndromes will demonstrate lower carotenoid levels in the macula and blood, and that these lower levels may correlate with early-onset maculopathy. Resonance Raman spectrographic (RRS) measurements of macular carotenoid levels were collected from subjects with and without a history of malabsorption syndromes. Carotenoids were extracted from serum and analyzed by high performance liquid chromatography (HPLC). Subjects with malabsorption (n = 22) had 37% lower levels of macular carotenoids on average versus controls (n = 25, P < 0.001). Malabsorption was not associated with decreased serum carotenoid levels. Convincing signs of early maculopathy were not observed. We conclude that intestinal malabsorption results in lower macular carotenoid levels

Genetic structure of sigmodontine rodents (Cricetidae) along an altitudinal gradient of the Atlantic Rain Forest in southern Brazil

The population genetic structure of two sympatric species of sigmodontine rodents (Oligoryzomys nigripes and Euryoryzomys russatus) was examined for mitochondrial DNA (mtDNA) sequence haplotypes of the control region. Samples were taken from three localities in the Atlantic Rain Forest in southern Brazil, along an altitudinal gradient with different types of habitat. In both species there was no genetic structure throughout their distribution, although levels of genetic variability and gene flow were high