08/28/1947 Letter from Lewiston Playgrounds

Letter from Pauline Marcous, Playground Director of Lewiston Playgrounds, to Louis-Philippe Gagné.https://digitalcommons.usm.maine.edu/fac-lpg-1947-07-09/1027/thumbnail.jp

Developing a Bioreactor for Biaxial Mechanical Testing and Conditioning of Vascular Tissue

Cardiovascular diseases are known to be one of the major causes of death around the world. One of the major causes of cardiovascular disease is arterial malfunction. Arteries malfunction when they experience chronic perturbations in their local environment above normal levels. Hence, we developed a bioreactor system in order to study the effect of chronic changes in the arterial global parameters (axial force, luminal pressure, and flow rate) on the behavior of local parameters (circumferential stress, axial stress, and flow induced shear stress). The bioreactor system was designed to (i) perform biaxial mechanical testing, (ii) incorporate, for the first time, the outer pressure as a fourth global parameter, (iii) independently control flow rate, transmural pressure (inner pressure minus outer pressure), and axial force, (iv) continuously monitor the change in arterial geometry, and (v) automatically reach/maintain constant level of user defined target values for mean axial and circumferential stress. The bioreactor system was capable of performing inflation Extension tests at axial stretch ratios of 1.2, 1.4, and 1.6 for a porcine renal artery at a pressure range from 10 to 180 mmHg. The bioreactor system was also capable of achieving target values of circumferential stress (5, 10, 15, and 20 kPa) with a tolerance of 10% at a constant level of axial stress (100 kPa) and vice versa; 60, 100, 140, and 180 kPa axial stress at constant circumferential stress of 5 kPa. A 95% Confidence Level was used to remove outliers form the collected data points

Philosophy, Out of Bounds: The Method and Mysticism of Simone Weil

The purpose of this study is exposition on the themes of method and mysticism in the work of Simone Weil. Nearly a decade before the onset of her first mystical experience, Weil developed a method to be rigorously applied in daily philosophical reflection. She outlines this method in her dissertation on Descartes (1929-1930). I examine the question of how Weil applied method to philosophical reflection on her mystical experiences (onset 1938-1939). I analyze Weil’s mystical experiences as a type of transformative experience in L. A. Paul’s strict sense of the term. On Paul’s view, an experience is transformative if it is both epistemically and personally transformative. An experience is epistemically transformative if the only way to know what it is like to have it is to have it yourself. An experience is personally transformative if it changes your point of view, including your core preferences (Paul, 2014). I present a thought experiment and textual evidence to motivate the claim that Weil’s mystical experiences meet Paul’s conditions for transformative experience. I then propose two epistemological facts that can be revealed by philosophical reflection on mystical experience. First, it is possible to read meaning erroneously in the appearances of things. Second, it is possible to come to hold to the certainty of a conviction for reasons that elude the intellect. My findings suggest that Weil’s late views on philosophy accommodate these two epistemological constraints, thereby demonstrating a possible connection between Weil’s mystical experiences and her mature views on the nature, scope, and proper method of philosophy. However, my preliminary findings also suggest that Weil’s early work on method may have anticipated these epistemological obstacles prior to the onset of her first mystical experience. Thus, further exposition of Weil’s method is needed to support or elucidate the claim (Rozelle-Stone and Davis, 2021) that Weil’s epistemology underwent significant changes because of her mystical experiences

Impacto de la formalización en la rentabilidad en mypes de abarrotes de Puno

La investigación tuvo como objetivo determinar si la formalización influye en la rentabilidad de las Mypes de abarrotes de Puno, 2022. La metodología que se uso fue de tipo básico con un enfoque cuantitativo, descriptivo-causal, la muestra fue de 39 Mypes, también se aplicó un instrumento denominado cuestionario. Para los resultados se evidenciaron en función a tablas con sus correspondientes interpretaciones. Llegando a la conclusión, la medición de chi – cuadrada indica que 2= 8.322a ≥ 2 = 7.815 por lo tanto es mayor la Chi cuadrada calculada a la Chi cuadrada tabulada, ello en dirección de corroborar la hipótesis, en donde se evidencia el valor de significancia que es 0.040; en la cual los resultados señalan que, el 31% de los encuestados mencionan que la formalización se encuentra en un nivel medio mientras que la rentabilidad es regular. Mientras que para el objetivo específico 1, se demostró la medición de chi – cuadrada indica que 2= 8.433a ≥ 2 = 7.815 por lo tanto es mayor la Chi cuadrada calculada a la Chi cuadrada tabulada, ello en dirección de corroborar la hipótesis, en donde se evidencia el valor de significancia que es 0.011

Inhibition of Staphylococcus aureus growth in fresh calf minced meat using low density Polyethylene films package promoted by titanium dioxide and zinc oxide nanoparticles

Antibacterial properties of TiO2, ZnO as well as mixed TiO2-ZnO nanoparticles coated low density polyethylene films on Staphylococcus aureus PTCC1112 were investigated. Bactericidal efficiency of 0.5, 1 and 2 Wt% for TiO2 and ZnO nanoparticles and also 1 Wt% mixed TiO2-ZnO nanoparticles with TiO2:ZnO ratios of 25:75, 50:50 and 75:25 were tested under UV and fluorescent lights exposure at two different states: films alone (Direct effect) and fresh calf minced meat packed inside the films. ZnO nanoparticle showed good antibacterial properties against Staphylococcus aureus PTCC1112. Maximum CFU reduction of 99.59% and 97.07% were obtained using 2 and 1 Wt% ZnO nanoparticle coated LDPE film under UV light for films alone as well as 62.43% and 59.57% for fresh calf minced meat packed. The best antibacterial functionalities of 96.25% and 77.11% CFU reduction were recorded for 1 Wt% TiO2 nanoparticle coated LDPE films in the presence of UV light at direct contact with bacteria and fresh calf minced meat packed, respectively. In the case of mixed TiO2-ZnO, maximum CFU reductions of 98.37% and 97.84% were obtained using 50:50 ratio of TiO2: ZnO nanoparticles at the presence of UV light for direct effect and fresh calf minced meat packed, respectively. 2 Wt% ZnO nanoparticle as well as 1 Wt% mixed TiO2-ZnO nanoparticles in ratio of 50:50 coated LDPE films were identified as the best case to improve shelf life and prevent Staphylococcus aureus PTCC1112 growth in fresh calf minced meat

Carolyn Mitchell McCully Correspondence

Entries include a typed biographical letter from McCully, a newspaper clipping, and correspondence following the posthumous publication of McCully\u27s poems with the Farmington Public Library, family, and friends

The Pine Needle, May 1947

Libraries and archives collect materials from different cultures and time periods to preserve and make available the historical record. As a result, materials such as those presented here may reflect sexist, misogynistic, abusive, racist, or discriminatory attitudes or actions that some may find disturbing, harmful, or difficult to view. Both a humor and literary magazine, The Pine Needle was a University of Maine student-produced periodical that began publication in the fall of 1946, the first post-World War II semester that saw GIs returning to campus. The Needle reflected an edginess and rebellion not found in previous student publications. While past student publications relied on euphemisms for alcohol and dating on campus, The Needle openly promoted the sexualization of co-eds and the use of drugs, tobacco, and alcohol by students who experienced war. In response to Alumni complaints that The Needle was ...filled with sex and drinking, the University Publications Committee instituted stricter controls. In this issue, the editorial staff announce that starting in Fall 1947, the publication would publish only four issues of the magazine each year—Fall, Christmas, Spring, and Graduation among other changes. Cover art for this issue is an unsigned ink illustration of chatting university students lined up outside a shop bearing a sign that reads Jifty Cleaners-Dyers. Signs in the shop window reads We Specialize in Grass Stains. 24 Hour Service

Fundamental challenges in designing a collaborative travel app

The growing capabilities of smartphones have opened up new opportunities for travel coordination and transport is a fertile area for app development. One stream of development is apps that enable collaborative travel, either in the form of lift sharing or collaborative shopping, but despite growing interest from governmental agencies, there is little evidence of the efficacy of such apps. Based on trials of purpose built travel collaboration apps, deployed in tourism, urban and rural residential communities, and logistics, this paper analyses the fundamental challenges facing users adopting such travel apps. The findings suggest that transport practitioners, policy makers and app developers need to better understand the challenges associated with attracting users, the use of incentives and the types of communities most appropriate to implement collaborative travel concepts using such approaches. Also, how the users’ sense of time pressure and the issues around reciprocal exchange can impact on their long-term success and wider adoption

Implementing smartphone enabled collaborative travel: Routes to success in the tourism domain.

Smartphone technology can help identify current and anticipate future patterns of behaviour and, with its social networking capabilities, allow users to imagine and organise collaborative travel opportunities, such as lift share. This has led to the development of collaborative apps designed to enable activities like lift sharing. Such apps require new norms of behaviour to establish a user base and research has yet to address the socio-cultural barriers to both the use of this technology to organise travel and the sharing of personal space that collaborative travel entails. This paper reports the findings of a study which designed, built and tested a collaborative travel app in the tourism domain. Data derived from exploratory interviews, post-trial interviews and a questionnaire reveal that user age and extent of mobile engagement play a less significant role than expected, while other aspects of the social exchange, notably social tie strength, trust and obligations play a more marked role. A conceptual framework and discussion of strategies to address these barriers provides insight into appropriate contexts and routes for implementation of collaborative travel apps

A community effort in SARS-CoV-2 drug discovery.

peer reviewedThe COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the "Billion molecules against Covid-19 challenge", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.R-AGR-3826 - COVID19-14715687-CovScreen (01/06/2020 - 31/01/2021) - GLAAB Enric