Caracterización del contenido de metales de la fracción PM PM10 y evaluación del riesgo sobre la salud en un emplazamiento urbano de Elche

En este estudio se han tomado muestras de PM10 mediante un captador situado en el centro urbano de Elche y se ha determinado el contenido de metales de las mismas. En primer lugar, se ha llevado a cabo un análisis gravimétrico por el cual se ha determinado la concentración atmosférica de PM10. El siguiente paso ha sido el análisis de las muestras mediante un espectrómetro de Fluorescencia de Rayos X por Dispersión de Energía para obtener la concentración de los distintos metales presentes. Se ha trabajado en este estudio con K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn y Sr, ya que las concentraciones del resto de metales se encontraban por debajo del límite de detección para la mayoría de los días muestreados. A partir de los resultados obtenidos se ha evaluado la influencia de las intrusiones saharianas y el tráfico sobre la concentración de PM10 y los metales mencionados; se ha estudiado la variabilidad estacional de las mismas; y se ha seguido una metodología propuesta por la Agencia de Protección Medioambiental estadounidense para evaluar el riesgo que suponen para la salud las concentraciones medidas de metales en PM10.In this study, PM10 samples collected in the urban nuclei of Elche have been analyzed to determine the metal content. First, a gravimetric analysis to calculate PM10 concentration has been carried out. After the gravimetric analysis, samples have been analyzed with an Energy Dispersive X Ray Fluorescence spectrometer to obtain metal concentrations. In the present study, the levels of K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn and Sr have been evaluated. Other metals had concentrations under the detection limits for most of the days in the study period. From the results obtained, the influence of Saharan dust intrusions and traffic on PM10 and metal concentrations has been assessed. The seasonal variability of PM10 and metal concentrations has also been studied. Finally, the methodology proposed by the United States Environmental Protection Agency has been used to assess health risks associated with metals in PM10

Activated carbon from flash pyrolysis of eucalyptus residue

Forestry waste (eucalyptus sp) was converted into activated carbon by initial flash pyrolysis followed carbonization and CO2 activation. These residues were obtained from a pilot plant in Spain that produces biofuel, the biochar represented 10–15% in weight. It was observed that the highest activation was achieved at a temperature of 800 °C, the specific surface increased with time but, on the contrary, high loss of matter was observed. At 600 °C, although there was an important increase of the specific surface and the volume of micropores, at this temperature it was observed that the activation time was not an influential parameter. Finally, at 400 °C it was observed that the activation process was not very significant. Assessing the average pore diameter it was found that the lowest value corresponded to the activation temperature of 600 °C, which indicated the development of microporosity. When the activation temperature increase

Efecto del sexo sobre la calidad de la canal, de la carne y de la grasa de cerdos pesados

España es el primer país productor de jamón a escala mundial. La base animal de la producción de jamón y de otros productos elaborados son cerdos pesados que se sacrifican, generalmente, con pesos superiores a 105 kg. Dentro del escenario productivo del cerdo blanco mejorado, nuestro país cuenta con una Especialidad Tradicional Garantizada (ETG) denominada Jamón Serrano, una Denominación de Origen (Jamón y Paleta de Teruel) y una Indicación Geográfica Protegida (Jamón de Trévelez) amparadas por unas exigencias de calidad que no todos los animales satisfacen

Patrones de abundancia de la macrofauna asociada a macroalgas marinas a largo de la Península Ibérica

macroalgae were studied on a spatial scale along the Iberian Peninsula. Nineteen stations and four dominant algae were selected (intertidal zone: Corallina elongata and Asparagopsis armata; subtidal zone: Stypocaulon scoparium and Cladostephus spongiosus). Five environmental factors were also considered (seawater temperature, conductivity, dissolved oxygen, turbidity and pH). The Atlantic coast was characterized by lower temperature and conductivity as well as higher values of oxygen and turbidity than the Mediterranean coast. A total of 106274 macrofaunal specimens were sorted and examined (68% arthropods, 27% molluscs, 4% annelids and 1% echinoderms). Crustaceans were the dominant group in all the macroalgae (ca. 80% in C. elongata and A. armata, ca. 50% in S. scoparium and C. spongiosus) followed by molluscs, which were more abundant in the subtidal algae (ca. 40%) than in intertidal ones (ca.10%). Abundance patterns of macrofauna along the Iberian Peninsula were similar in the four studied algae. Most of crustaceans belonged to the order Amphipoda, which showed high densities (>1000 ind/1000 ml algae) along the whole Peninsula; isopods showed the highest abundances in the Atlantic, while tanaids, cumaceans and decapods were more abundant in the Mediterranean. Among molluscs, gasteropods showed highest abundances along the Atlantic coasts, whereas bivalves showed higher densities along the MediterraneanSe llevó a cabo un estudio espacial de los patrones de abundancia y distribución de la macrofauna asociada a macroalgas a lo largo de la Península Ibérica. Se seleccionaron 19 estaciones y 4 algas dominantes (zona intermareal: Corallina elongata y Asparagopsis armata; zona submareal: Stypocaulon scoparium y Cladostephus spongiosus). Se consideraron también cinco variables ambientales (temperatura del agua, conductividad, oxígeno disuelto, turbidez y pH). La costa atlántica se caracterizó por valores más bajos de temperatura y conductividad, y más altos de oxígeno y turbidez. Se examinaron 106274 individuos de la macrofauna (68% artrópodos, 27% moluscos, 4% anélidos y 1% equinodermos). Los crustáceos fueron dominantes en todas las macroalgas (alrededor del 80% en C. elongata y A. armata, y en torno al 50% en S. scoparium y C. spongiosus), seguidos por los moluscos, que fueron más abundantes en el submareal (40%) que en el intermareal (10%). Los patrones de abundancia de la macrofauna a lo largo de la Península Ibérica fueron similares en las cuatro algas estudiadas. La mayoría de los crustáceos pertenecieron al orden Amphipoda, que mostró densidades muy altas (>1000 ind/1000 ml alga) en toda la Península; los isópodos mostraron las mayores densidades en el Atlántico, mientras que los tanaidáceos, cumáceos y decápodos fueron más abundantes en el Mediterráneo. Entre los moluscos, los gasterópodos mostraron abundancias mayores en el Atlántico, mientras que los bivalvos dominaron en el Mediterráneo. Teniendo en cuenta que todas las estaciones seleccionadas no tenían influencia antrópica importante, los patrones de abundancia obtenidos podrían explicarse en base a diferencias naturales en la temperatura del agua, oxígeno, conductividad y turbidez, existiendo un gradiente transicional entre taxones de aguas más cálidas (del norte de Africa y del Mediterráneo) y taxones de aguas más frías (del Mar del Norte y el Ártico)

Recommendations for reporting equivalent black carbon (eBC) mass concentrations based on long-term pan-European in-situ observations

A reliable determination of equivalent black carbon (eBC) mass concentrations derived from filter absorption photometers (FAPs) measurements depends on the appropriate quantification of the mass absorption cross-section (MAC) for converting the absorption coefficient (babs) to eBC. This study investigates the spatial–temporal variability of the MAC obtained from simultaneous elemental carbon (EC) and babs measurements performed at 22 sites. We compared different methodologies for retrieving eBC integrating different options for calculating MAC including: locally derived, median value calculated from 22 sites, and site-specific rolling MAC. The eBC concentrations that underwent correction using these methods were identified as LeBC (local MAC), MeBC (median MAC), and ReBC (Rolling MAC) respectively. Pronounced differences (up to more than 50 %) were observed between eBC as directly provided by FAPs (NeBC; Nominal instrumental MAC) and ReBC due to the differences observed between the experimental and nominal MAC values. The median MAC was 7.8 ± 3.4 m2 g-1 from 12 aethalometers at 880 nm, and 10.6 ± 4.7 m2 g-1 from 10 MAAPs at 637 nm. The experimental MAC showed significant site and seasonal dependencies, with heterogeneous patterns between summer and winter in different regions. In addition, long-term trend analysis revealed statistically significant (s.s.) decreasing trends in EC. Interestingly, we showed that the corresponding corrected eBC trends are not independent of the way eBC is calculated due to the variability of MAC. NeBC and EC decreasing trends were consistent at sites with no significant trend in experimental MAC. Conversely, where MAC showed s.s. trend, the NeBC and EC trends were not consistent while ReBC concentration followed the same pattern as EC. These results underscore the importance of accounting for MAC variations when deriving eBC measurements from FAPs and emphasize the necessity of incorporating EC observations to constrain the uncertainty associated with eBC.</p

Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)

REIPI/INCREMENT-SOT Group.[Background] Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear.[Methods] We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively.[Results] Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes.[Conclusions] Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).This work was supported by: (1) Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases [RD16/0016/0001, RD16/0016/0002, REIPI RD16/0016/0008; RD16/0016/00010], co-financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligent Growth 2014-2020; (2) European Society of Clinical Microbiology and Infectious diseases Study Group for Infections in Compromised Hosts (ESGICH, grant to J.M.A.); (3) Sociedad Andaluza de Trasplante de Órgano Sólido (SATOT, grant to L.M.M.); (4) Research project PI16/01631 integrated into the Plan Estatal de I+D+I 2013-2016 and co-financed by the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and the Fondo Europeo de Desarrollo Regional (FEDER); (5) M.F.R. holds a research contract “Miguel Servet” (CP 18/00073) from ISCIII, Ministerio de Ciencia, Innovación y Universidades. The work was also supported by the following European Society of Clinical Microbiology and Infectious diseases (ESCMID) study groups: Infections in Compromised Hosts (ESGICH), Bloodstream Infections and Sepsis (ESGBIS) and Antimicrobial Resistance Surveillance (ESGARS).Peer reviewe

The polygenic basis of relapse after a first episode of schizophrenia

Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11–0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse

Adapting Agriculture to Climate Change: A Synopsis of Coordinated National Crop Wild Relative Seed Collecting Programs across Five Continents

The Adapting Agriculture to Climate Change Project set out to improve the diversity, quantity, and accessibility of germplasm collections of crop wild relatives (CWR). Between 2013 and 2018, partners in 25 countries, heirs to the globetrotting legacy of Nikolai Vavilov, undertook seed collecting expeditions targeting CWR of 28 crops of global significance for agriculture. Here, we describe the implementation of the 25 national collecting programs and present the key results. A total of 4587 unique seed samples from at least 355 CWR taxa were collected, conserved ex situ, safety duplicated in national and international genebanks, and made available through the Multilateral System (MLS) of the International Treaty on Plant Genetic Resources for Food and Agriculture (Plant Treaty). Collections of CWR were made for all 28 targeted crops. Potato and eggplant were the most collected genepools, although the greatest number of primary genepool collections were made for rice. Overall, alfalfa, Bambara groundnut, grass pea and wheat were the genepools for which targets were best achieved. Several of the newly collected samples have already been used in pre-breeding programs to adapt crops to future challenges.info:eu-repo/semantics/publishedVersio

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio