Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition

Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex

Combination of self-organization mechanisms to enhance service discovery in open systems

Decentralized systems have emerged as an alternative to centralized approaches for dealing with dynamic requirements in new business models. These systems should provide mechanisms that contribute to flexibility and facilitate adaptation to changes in the environment. In this paper, we present two self-organization mechanisms for a decentralized service discovery system in order to improve its performance. These mechanisms are based on local actions of agents that only consider local information about queries they forward during the discovery process. The self-organization actions are chosen by each agent individually when the agent considers them to be appropriate. The actions are: remaining in the system, leaving the system, cloning, and changing structural relations with other agents. We have evaluated each self-organization mechanism separately but also the combination of the two as the environmental conditions in the service demand change. The results show that the proposed self-organization mechanisms considerably improve the performance of the service discovery systemDel Val Noguera, E.; Rebollo Pedruelo, M.; Botti Navarro, VJ. (2014). Combination of self-organization mechanisms to enhance service discovery in open systems. Information Sciences. 279:138-162. doi:10.1016/j.ins.2014.03.109S13816227

Current trends in drug metabolism and pharmacokinetics.

Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication. In this review we provided an overview of recent research on PK with focus on the following aspects: (1) an update on drug-metabolizing enzymes and transporters in the determination of PK, as well as advances in xenobiotic receptors and noncoding RNAs (ncRNAs) in the modulation of PK, providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy; (2) current status and trends in assessing drug-drug interactions, especially interactions between drugs and herbs, between drugs and therapeutic biologics, and microbiota-mediated interactions; (3) advances in understanding the effects of diseases on PK, particularly changes in metabolizing enzymes and transporters with disease progression; (4) trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies; (5) emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes, especially non-P450s. Existing challenges and perspectives on future directions are discussed, and may stimulate the development of new research models, technologies, and strategies towards the development of better drugs and improved clinical practice

Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition

Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex