248 research outputs found
Blood prolactin depression in growing pigs fed sorghum ergot (Claviceps africana)
The toxicity of sorghum ergot (Claviceps africana) was assessed in young pigs over 28 days. Forty-eight pigs of both sexes and 2 breeds (Large White and Duroc) were allocated across 6 grower diets, balanced for fibre and predicted digestible energy, and containing 0, 0.3, 0.6, 1.3, 2.5, or 5% ergot sclerotia [the 5% sclerotia diet contained 70 mg alkaloids/kg (>90% dihydroergosine)]. Blood samples taken on Days 0 and 28 were analysed for prolactin and clinical, biochemical, and haematological indices of health. Feed consumption and liveweight were individually monitored. There were no clinical signs of illness attributable to ergotism in the pigs. Blood prolactin concentrations were significantly depressed in pigs receiving 9 mg alkaloids/kg (0.6% sclerotia) and by >80% in pigs receiving 35 and 70 mg alkaloids/kg, clearly indicating a potential to interfere with lactation in sows. Reductions in feed intake and poor feed conversion were observed over the first 7 days with >9 mg alkaloids/kg, but some tolerance developed later. Feed refusal was more pronounced for pigs of the Duroc breed. Over the full trial period, growth was reduced by about 30% in pigs receiving 70 mg alkaloids/kg, as a result of poor feed intake and feed conversion. Digestible energy of diets containing ergot was later found to be lower than predicted, which contributed to this result
Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons
The influx of calcium ions into the dendritic spines through the
N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for
various forms of synaptic plasticity. In this paper, the authors calculate
analytically the mean values of the calcium transients elicited by a spiking
neuron undergoing a simple model of ionic currents and back-propagating action
potentials. The relative variability of these transients, due to the stochastic
nature of synaptic transmission, is further considered using a simple Markov
model of NMDA receptos. One finds that both the mean value and the variability
depend on the timing between pre- and postsynaptic action-potentials. These
results could have implications on the expected form of synaptic-plasticity
curve and can form a basis for a unified theory of spike time-dependent, and
rate based plasticity.Comment: 14 pages, 10 figures. A few changes in section IV and addition of a
new figur
Iron and Nickel spectral opacity calculations in conditions relevant for pulsating stellar envelopes and experiments
Seismology of stars is strongly developing. To address this question we have
formed an international collaboration OPAC to perform specific experimental
measurements, compare opacity calculations and improve the opacity calculations
in the stellar codes [1]. We consider the following opacity codes: SCO,
CASSANDRA, STA, OPAS, LEDCOP, OP, SCO-RCG. Their comparison has shown large
differences for Fe and Ni in equivalent conditions of envelopes of type II
supernova precursors, temperatures between 15 and 40 eV and densities of a few
mg/cm3 [2, 3, 4]. LEDCOP, OPAS, SCO-RCG structure codes and STA give similar
results and differ from OP ones for the lower temperatures and for spectral
interval values [3]. In this work we discuss the role of Configuration
Interaction (CI) and the influence of the number of used configurations. We
present and include in the opacity code comparisons new HULLAC-v9 calculations
[5, 6] that include full CI. To illustrate the importance of this effect we
compare different CI approximations (modes) available in HULLAC-v9 [7]. These
results are compared to previous predictions and to experimental data.
Differences with OP results are discussed.Comment: 4 pages, 3 figures, conference Inertial Fusion Sciences and
Applications, Bordeaux, 12th to 16th September 2011; EPJ web of Conferences
201
Recent Advances in Modeling Stellar Interiors
Advances in stellar interior modeling are being driven by new data from
large-scale surveys and high-precision photometric and spectroscopic
observations. Here we focus on single stars in normal evolutionary phases; we
will not discuss the many advances in modeling star formation, interacting
binaries, supernovae, or neutron stars. We review briefly: 1) updates to input
physics of stellar models; 2) progress in two and three-dimensional evolution
and hydrodynamic models; 3) insights from oscillation data used to infer
stellar interior structure and validate model predictions (asteroseismology).
We close by highlighting a few outstanding problems, e.g., the driving
mechanisms for hybrid gamma Dor/delta Sct star pulsations, the cause of giant
eruptions seen in luminous blue variables such as eta Car and P Cyg, and the
solar abundance problem.Comment: Proceedings for invited talk at conference High Energy Density
Laboratory Astrophysics 2010, Caltech, March 2010, submitted for special
issue of Astrophysics and Space Science; 7 pages; 5 figure
Argon K-shell and bound-free emission from OMEGA direct-drive implosion cores
We discuss calculations of synthetic spectra for the interpretation and analysis of K-shell and bound-free emission from argon-doped deuterium-filled OMEGA direct-drive implosion cores. The spectra are computed using a model that considers collisional-radiative atomic kinetics, continuum-lowering, detailed Stark-broadened line shapes, line overlapping, and radiation transport effects. The photon energy range covers the moderately optically thick n = 3 → n = 1 and n = 4 → n = 1 line transitions in He- and H-like Ar, their associated satellite lines in Li- and He-like Ar, and several radiative recombination edges. At the high-densities characteristic of implosion cores, the radiative recombination edges substantially shift to lower energies thus overlapping with several line transitions. We discuss the application of the spectra to spectroscopic analysis of doped implosion core
HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus
Hyperpolarisation-activated (Ih) currents are considered
important for dendritic integration, synaptic transmission,
setting membrane potential and rhythmic action potential (AP) discharge in neurons of the central nervous system. Hyperpolarisation-activated cyclic nucleotide-gated
(HCN) channels underlie these currents and are composed
of homo- and hetero-tetramers of HCN channel subunits
(HCN1–4), which confer distinct biophysical properties on
the channel. Despite understanding the structure–function
relationships of HCN channels with different subunit stoichiometry, our knowledge of their expression in defined neuronal populations remains limited. Recently, we have shownthat HCN subunit expression is a feature of a specific population of dorsal horn interneurons that exhibit high-frequency AP discharge. Here we expand on this observation
and use neuroanatomical markers to first identify well-characterised neuronal populations in the lumbar spinal cord
and hippocampus and subsequently determine whether
HCN4 expression correlates with high-frequency AP discharge
in these populations. In the spinal cord, HCN4 is
expressed in several putative inhibitory interneuron populations including parvalbumin (PV)-expressing islet cells (84.1%; SD: ±2.87), in addition to all putative Renshaw cells and Ia inhibitory interneurons. Similarly, virtually all PVexpressing cells in the hippocampal CA1 subfield (93.5%;±3.40) and the dentate gyrus (90.9%; ±6.38) also express HCN4. This HCN4 expression profile in inhibitory interneurons mirrors both the prevalence of Ih sub-threshold currents and high-frequency AP discharge. Our findings indicate that HCN4 subunits are expressed in several populations of spinal and hippocampal interneurons, which are known to express both Ih sub-threshold currents and exhibit high-frequency AP discharge. As HCN channel function plays a critical role in pain perception, learning and memory,and sleep as well as the pathogenesis of several neurologicaldiseases, these findings provide important insights into the identity and neurochemical status of cells that could underlie such conditions
Radiative properties of stellar plasmas and open challenges
The lifetime of solar-like stars, the envelope structure of more massive
stars, and stellar acoustic frequencies largely depend on the radiative
properties of the stellar plasma. Up to now, these complex quantities have been
estimated only theoretically. The development of the powerful tools of helio-
and astero- seismology has made it possible to gain insights on the interiors
of stars. Consequently, increased emphasis is now placed on knowledge of the
monochromatic opacity coefficients. Here we review how these radiative
properties play a role, and where they are most important. We then concentrate
specifically on the envelopes of Cephei variable stars. We discuss the
dispersion of eight different theoretical estimates of the monochromatic
opacity spectrum and the challenges we need to face to check these calculations
experimentally.Comment: 6 pages, 5 figures, in press (conference HEDLA 2010
Q
The Qweak experiment, which took data at Jefferson Lab in the period 2010 - 2012, will precisely determine the weak charge of the proton by measuring the parity-violating asymmetry in elastic e-p scattering at 1.1 GeV using a longitudinally polarized electron beam and a liquid hydrogen target at a low momentum transfer of Q2 = 0.025 (GeV/c)2. The weak charge of the proton is predicted by the Standard Model and any significant deviation would indicate physics beyond the Standard Model. The technical challenges and experimental apparatus for measuring the weak charge of the proton will be discussed, as well as the method of extracting the weak charge of the proton. The results from a small subset of the data, that has been published, will also be presented. Furthermore an update will be given of the current status of the data analysis
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