Promoting global health innovation: On the need for global health care solutions in the spirit of the International Conference on Applied Science and Health (ICASH)

Not require

Exile Vol. XV No. 1

POETRY Haiku by John Anderson 2 It\u27s the looking in the mirror by Larry Faso 3 There is a voice in me by Larry Faso 15 We fight along time by Tracy Mac Nab 8 During the night by Tracy Mac Nab 8 Illusion by Phil Cockerille 10 Mexico City \u2759 by Keith McWalter 12 Summer Correspondence II by Lauren Shakely 13 America Sings to Herself and Doesn\u27t Hear by Lauren Shakely 15 eatin crawdads by Bob Martin 14 G. [unattributed*] 16 Finis Coronant Opus [unattributed*] 17 The Droplet Sea by Jeffrey R. Smith 17 The surrounding dismal forest by P. F. Galbraith 18 FICTION The Shadow in his mind by Cem Mehmet Kozlu 4-7 An Excerpt from a Novel in Progress by Dick Devine 19-22 ARTWORK AND ILLUSTRATIONS by Tom Robinson 2, 12, 16, 18 by Bob Tauber 3, 8, 15 by Tom King 7, 9, 13 by Ted Hall 11, 24 by Clare Conrad 14 Mislabeled Fall 196

Optimal relative timing of stance push-off and swing leg retraction

Abstract-Swing leg retraction, the backward rotation of the swing leg prior to heel-strike, is known to have several advantages in legged locomotion. To achieve this motion, a hip torque is required at the end of the swing phase to brake the forward rotation of the leg and/or accelerate its backward motion. In walking, pre-emptive push-off of the stance leg also occurs at the end of the swing, so its relative timing with late-swing retracting torque influences gait energetics. To find the best relative timing between the stance leg's pushoff force and the swing leg retraction torque, we calculate their work-based energetics in a simple bipedal model using impulsive approximations and with the aid of the so-called overlap parameter that quantifies the relative order and the percentage overlap of the push-off and retraction impulses. By minimizing the energetic cost of the gait, we found that it is energetically favorable to start with the push-off force, and postpone braking the leg swing until completely after the push-off (impulsive force/torque). The implication for the more realistic non-impulsive cases is to apply the retraction torque at the very end of the push-off before heel-strike. We show that the results are valid for many other bipedal models, for both periodic and aperiodic gaits, and regardless of the actuator efficiencies for positive and negative work

Hacia una Mejor Colaboración en la Educación de Estudiantes con Desordenes por Síndrome Alcohólico Fetal: Integrando las Voces de Profesores, Administradores, Cuidadores y Otros Profesionales

This exploratory study addresses the call for an increased presence of key stakeholders’perspectives in educational research involving students with Fetal Alcohol Spectrum Disorders (FASDs) (Duquette, Stodel, Fullarton, & Hagglund, 2006a). Specifically, greater understandings are necessary to support the educational success of students with FASDs. The analysis of 11 focus groups and 3 interviews with teachers, administrators, caregivers, and allied professionals (total n = 60) revealed three themes: fostering relationships, reframing practices, and accessing supports. These findings have important implications for the use of a qualitaitve approach in generating evidenced-based educational practices for stakeholders reflective of enhanced communication and collaboration that better meet the needs of students with FASDs.Este estudio exploratorio aborda la necesidad de una mayor presencia de las partes interesadas en la investigación educativa que implica a estudiantes con Desordenes por Síndrome Alcohólico Fetal (DSAF) (Duquette, Stodel, Fullarton, & Hagglund, 2006a). En concretoe, para un mayor entendimiento es necesario apoyar el éxito esolar de estudiantes con DSAF. En el análisis de 11grupos de discusión y 3 entrevistas con profesores, administradores, cuidadores y otros profesionales (total n = 60) se revelaron tres temas: relaciones de acogida, nuevas prácticas de referencia y acceso a ayudas. Estos resultados tienen importantes implicaciones para el uso de un enfoque cualitativo en la generación basada en evidencias sobre las prácticas educativas que reflejan una mayor comunicación y colaboración que mejor satisfagan las necesidades de los estudiantes con DSAF

Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen

MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Recently, some reports have shown that a limited number of mammalian microRNAs are also involved in anti-viral defense. In this study, the analysis of the hepatitis B virus (HBV) genome by the computer program MiRanda led to the identification of seven sites that are potential targets for human liver microRNAs. These sites were found to be clustered in a 995-bp segment within the viral polymerase ORF and the overlapping surface antigen ORF, and conserved among the most common HBV subtypes. The HBV genomic targets were then subjected to a validation test based on cultured hepatic cells (HepG2, HuH-7 and PLC/PRF/5) and luciferase reporter genes. In this test, one of the selected microRNAs, hsa-miR-125a-5p, was found to interact with the viral sequence and to suppress the reporter activity markedly. The microRNA was then shown to interfere with the viral translation, down-regulating the expression of the surface antigen. Overall, these results support the emerging concept that some mammalian microRNAs play a role in virus-host interaction. Furthermore, they provide the basis for the development of new strategies for anti-HBV intervention

Protecting Wild Land from Wind Farms in a Post-EU Scotland

Scotland is one of the places in Europe to have experienced significant wind farm development over recent years. Concern about impacts on wild land has resulted in legal challenges based on European Union (EU) law. This article analyses whether wild land can be protected from wind farms and the differences that the United Kingdom (UK) departure from the EU will make. It considers the concept of 'wild land' compared with 'wilderness', analyses the legal basis (if any) for wild land protection, and examines potential impacts from wind farms. It highlights the significance of EU environmental law, particularly nature conservation and environmental assessment law, and analyses recent Scottish jurisprudence that has applied this. The role of the European Commission and Court of Justice of the EU (CJEU) is emphasised as a key part of EU environmental law. The article asks whether relevant global and regional environmental agreements can effectively replace the content of the substantive law and context of the Commission and CJEU. Four environmental agreements and two related compliance procedures are briefly evaluated. The conclusion is that while EU law does not directly provide protection for wild land, it is considerably stronger than the international environmental agreements that may replace it

“Extreme" porn? The implications of a label

Despite its prevalence, the term ‘extreme’ has received little critical attention. ‘Extremity’ is routinely employed in ways that imply its meanings are self-evident. However, the adjective itself offers no such clarity. This article focuses on one particular use of the term – ‘extreme porn’ – in order to illustrate a broader set of concerns about the pitfalls of labelling. The label ‘extreme’ is typically employed as a substitute for engaging with the term’s supposed referents (here, pornographic content). In its contemporary usage, ‘extreme’ primarily refers to a set of context-dependent judgements rather than absolute standards or any specific properties the ‘extreme’ item is alleged to have. Concurrently then, the label ‘extreme’ carries a host of implicit values, and the presumption that the term’s meanings are ‘obvious’ obfuscates those values. In the case of ‘extreme porn’, this obfuscation is significant because it has facilitated the cultural and legal suppression of pornography

'Seeing through touch': the material world of visually impaired children

This article examines the changing material world of the visually impaired child and the ways in which this has been viewed and understood by scholars, philosophers, educators and other commentators over time. It describes and analyses tactile encounters as they have been planned for by educators, museum curators and others, from the Age of the Enlightenment until the present day. It takes as its starting point a recent blog that appeared online in 2011, which posted images from handling sessions for the visually impaired child, organized by John Alfred Charlton Deas from Sunderland Museum, England, between 1913-1926. It traces the provenance and development of ideas around 'seeing through touch', from the embossed books and maps and the printing machines for systems such as Braille in the nineteenth century to the theoretical and pedagogical developments which began to occur at the start of the twentieth century