Seamless 5G Multi-Hop Connectivity Architecture and Trials for Maritime Applications

This paper provides a study of the different alternatives that are being considered in the 5G-ROUTES project to establish seamless 5G connectivity in a maritime environment both from an architectural point of view and also from the definition of field trials to evaluate the performance and dependability of the proposed solution. As expected, the main challenge in providing 5G connectivity on the sea is to provide coverage over large areas of open water. Thus, as a starting point, this paper presents a measurement campaign that was conducted to assess the current coverage in the Baltic Sea, which concluded that the current terrestrial networks cannot guarantee sufficient coverage. Next, the solution architecture and trials proposed by 5G-ROUTES are described, which are based on the integration of satellite and leading-edge multi-hop connectivity in 5G networks. Utilizing satellite backhaul can potentially overcome the connectivity challenge from the terrestrial domain to the maritime domain, while multi-hop connectivity ensures that coverage is extended among the different ships that are navigating the sea. Furthermore, this paper describes how the project will evaluate, in field trials tailored to this maritime environment, common connectivity key performance indicators (KPIs) such as latency, throughput, availability and reliability. This paper concludes by providing a vision for applying the obtained results and insights to maritime transportation and other remote areas where the deployment of a suitable 5G infrastructure may be challenging or costly. The findings will be used to guide the design of future 5G networks for marine applications and to identify the most effective methods for providing secure and dependable communication in a maritime setting

5G Cross-Border Operation for Connected and Automated Mobility: Challenges and Solutions

The vision of cooperative, connected and automated mobility (CCAM) across Europe can only be realized when harmonized solutions that support cross-border traffic exist. The possibility of providing CCAM services along different countries when vehicles drive across various national borders has a huge innovative business potential. However, the seamless provision of connectivity and the uninterrupted delivery of services along borders also poses interesting technical challenges. The situation is particularly innovative given the multi-country, multi-operator, multi-telco-vendor, and multi-car-manufacturer scenario of any cross-border layout. This paper introduces the challenges associated to a cross-border deployment of communication technologies through the analysis of three use cases: tele-operated driving, high-definition map generation and distribution for autonomous vehicles, and anticipated cooperative collision avoidance. Furthermore, a set of 5G solutions have been identified to ensure that CCAM services can be supported efficiently in cross-border scenarios. Faster handover of a data connection from one operator to another, generalized inter-mobile edge computing (MEC) coordination, and quality of service (QoS) prediction are some of the solutions that have been introduced to reduce the uncertainties of a real 5G cross-border deployment

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n similar to 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n similar to 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders