21 research outputs found

    Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

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    Five insights from the Global Burden of Disease Study 2019

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    The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe

    Impact of Spinal Cord Injury

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    Although medical advances have greatly improved the prognosis for people who sustain spinal cord injury, it remains a major social and health-care problem. There are estimated 10,000–12,000 spinal cord injuries every year in the USA alone. More than a quarter of a million Americans are currently living with spinal cord injury, with many millions more worldwide. The cost of managing the care of patients with spinal cord injury is approximately $4 billion per year. The majority of spinal cord injury victims are young adults. Of them, more than 80% are men. As a result, young males constitute the largest part of this patient population. Reproductive function is essential for men with spinal cord injury, but unfortunately, less than 10% of them can father children without medical assistance. Infertility in male patients with spinal cord injury results from a combination of erectile dysfunction, ejaculatory dysfunction, and poor semen quality. As a result of advancements in assisted ejaculation techniques including electroejaculation and high-amplitude penile vibratory stimulation, semen can be safely obtained from nearly all men with spinal cord injury without resorting to surgical procedures; however, semen quality is poor in the majority of cases. Research indicates that inflammation contributes to this problem. Treating abnormal inflammatory processes may hold promise for improving semen quality in men with spinal cord injury
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