The Global Ant Biodiversity Informatics (GABI) database: synthesizing data on the geographic distribution of ant species (Hymenoptera: Formicidae)

The global distribution patterns of most vertebrate groups and several plant groups have been described and analyzed over the past few years, a development facilitated by the compilation of important databases. Similar efforts are needed for large insect groups that constitute he majority of global biodiversity. As a result of this lack of information, invertebrate taxa are often left out of both large-scale analyses of biodiversity patterns and large-scale efforts in conservation planning and prioritization. Here, we introduce the first comprehensive global database of ant species distributions, the Global Ant Biodiversity Informatics (GABI) database, based on the compilation of 1.72 million records extracted from over 8811 publications and 25 existing databases. We first present the main goals of the database, the methodology used to build the database, is well as its limitations and challenges. Then, we discuss how different fields of ant biology may benefit from utilizing this tool. Finally, we emphasize the importance of future participation of myrmecologists to improve the database and use it to identify and fill holes in our knowledge of ant biodiversity.published_or_final_versio

Taxonomic decomposition of the latitudinal gradient in species diversity of North American floras

Aim: To test the latitudinal gradient in plant species diversity for self-similarity across taxonomic scales and amongst taxa. Location: North America. Methods: We used species richness data from 245 local vascular plant floras to quantify the slope and shape of the latitudinal gradients in species diversity (LGSD) across all plant species as well as within each family and order. We calculated the contribution of each family and order to the empirical LGSD. Results: We observed the canonical LGSD when all plants were considered with floras at the lowest latitudes having, on average, 451 more species than floras at the highest latitudes. When considering slope alone, most orders and families showed the expected negative slope, but 31.7% of families and 27.7% of orders showed either no significant relationship between latitude and diversity or a reverse LGSD. Latitudinal patterns of family diversity account for at least 14% of this LGSD. Most orders and families did not show the negative slope and concave-down quadratic shape expected by the pattern for all plant species. A majority of families did not make a significant contribution in species to the LGSD with 53% of plant families contributing little to nothing to the overall gradient. Ten families accounted for more than 70% of the gradient. Two families, the Asteraceae and Fabaceae, contributed a third of the LGSD. Main Conclusions: The empirical LGSD we describe here is a consequence of a gradient in the number of families and diversification within relative few plant families. Macroecological studies typically aim to generate models that are general across taxa with the implicit assumption that the models are general within taxa. Our results strongly suggest that models of the latitudinal gradient in plant species richness that rely on environmental covariates (e.g. temperature, energy) are likely not general across plant taxa

Toward a theory for diversity gradients: the abundance–adaptation hypothesis

The abundance–adaptation hypothesis argues that taxa with more individuals and faster generation times will have more evolutionary ‘experiments’ allowing expansion into, and diversification within, novel habitats. Thus, as older taxa have produced more individuals over time, and smaller taxa have higher population sizes and faster generation times, the Latitudinal Diversity Gradients (LDGs) of these clades should show shallower slopes. We describe the LDGs for archaea, bacteria, fungi, invertebrates and trees from six North American forests. For three focal groups – bacteria, ants, and trees – older taxa had shallower LDG slopes than the more recent, terminal taxa. Across 12 orders of magnitude of body mass, LDG slopes were steeper in larger taxa. The slopes of LDGs vary systematically with body size and clade age, underscoring the non-canonical nature of LDGs. The steepest LDG slopes were found for the largest organisms while the smallest, from bacteria to small litter-soil invertebrates, have shallower- to zero-slope LDGs. If tropical niche conservatism is the failure of clades to adapt to, and diversify in temperate habitats, then the steep LDGs of chordates and plants likely arise from the decreased ability of clades with large individuals to adapt to the multiple challenges of extra-tropical life

Macroecology and macroevolution of the latitudinal diversity gradient in ants

published_or_final_versio

Temperature determines the diversity and structure of N2O-reducing microbial assemblages

Micro-organisms harbouring the nosZ gene convert N O to N and play a critical role in reducing global N O emissions. As higher denitrifier diversity can result in higher denitrification rates, here we aimed to understand the diversity, composition and spatial structure of N O-reducing microbial assemblages in forest soils across a large latitudinal and temperature gradient. We sequenced nosZ gene amplicons of 126 soil samples from six forests with mean annual soil temperatures (MAST) ranging from 3.7 to 25.3°C and tested predictions of the metabolic theory of ecology (MTE) and metabolic-niche theory (MNT). As predicted, α-diversity of nosZ communities increased with increasing MAST, within-site β-diversity decreased and two (pH and soil moisture) of the three niche widths examined were larger with increasing MAST. We calculated β-nearest taxon distance and Raup–Crick metric to quantify the relative influence of the assembly processes determining nosZ assemblage structure. Environmental selection was the primary process driving assemblage structure in all six forests. Homogenizing dispersal was also important at one site, which could be explained by the site's much lower variability in soil chemistry. We used canonical correspondence analysis and multiple regression on matrices to examine relationships between nosZ communities and environmental factors, and found that temperature and spatial distance were significant predictors of nosZ assemblage structure. Overall our results support both theories (MTE and MNT) tested, showing that higher temperatures are correlated with higher local diversity, wider niche breadths and lower within-site turnover rates. A plain language summary is available for this article. 2 2 2

Responsive Production in Manufacturing: A Modular Architecture

[EN] This paper proposes an architecture aiming at promoting the convergence of the physical and digital worlds, through CPS and IoT technologies, to accommodate more customized and higher quality products following Industry 4.0 concepts. The architecture combines concepts such as cyber-physical systems, decentralization, modularity and scalability aiming at responsive production. Combining these aspects with virtualization, contextualization, modeling and simulation capabilities it will enable self-adaptation, situational awareness and decentralized decision-making to answer dynamic market demands and support the design and reconfiguration of the manufacturing enterprise.The research leading to these results has received funding from the European Union H2020 project C2 NET (FoF-01-2014) nr 636909.Marques, M.; Agostinho, C.; Zacharewicz, G.; Poler, R.; Jardim-Goncalves, R. (2018). Responsive Production in Manufacturing: A Modular Architecture. Studies in Systems, Decision and Control. 140:231-254. https://doi.org/10.1007/978-3-319-78437-3_10S231254140European Commission: For a European Industrial Renaissance, Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions (2014)Hartmann, B., King, W.P., Narayanan, S.: Digital manufacturing: the revolution will be virtualized. McKinsey & Company (2015)European Forum for Manufacture: Driving Innovation and Growth in European Manufacturing (2015)European Factories of the Future Research Association (EFFRA): Factories of the Future: Multi-annual Roadmap for the Contractual PPP under the Horizon 2020 (2013)European Commission: Horizon 2020—Work Programme 2016–2017: 17. Cross-cutting Activities (2016)Schlaepfer, R.C., Koch, M., Merkofer, P.: Industry 4.0 challenges and solutions for the digital transformation and use of exponential technologies. Deloitte AG (2015)7iD: Industry 4.0. https://www.7id.com/technology/industry-4-0/ (2016)European Commission: Horizon 2020—Work Program 2016-2017—Cross-cutting Activities, 25 July 2016EFFRA: Factories of the Future: Multi-annual Roadmap for the Contractual PPP under the Horizon 2020 (2013)FInES Research Roadmap Task Force (2012)Jacinto, J.: Smart manufacturing? Industry 4.0? What’s it all about? Siements Totally Integrated Automation, Automation World & Design World (2014)Monostori, L.: Cyber-physical production systems: roots, expectations and R&D challenges. Procedia CIRP 17, 9–13 (2014)Adolphs, P.: RAMI 4.0—An architectural Model for Industrie 4.0. Platform Industrie 4.0 (2015)Collins, M.: Why America has a shortage of skilled workers. Industry Week (2015)Forbes, J., Naujok, N., Geissbauer, R., Vedso, J., Schrauf, S.: Industry 4.0: building the digital enterprise. PWC (2016)World Economic Forum Industrial Internet Survey (2014)Chen, D., Vernadat, F.B.: Enterprise interoperability: a standardisation view. Enterprise Inter- and Intra-Organizational Integration, Volume 108 of the series IFIP—The International Federation for Information Processing, pp. 273–282 (2003)Yan, L., Li, Z., Yuan, X.: Study on method-of-robust-multidisciplinary-design-collaborative-decision for product design. Inf. Technol. J. 8(4), 441–452 (2009)Ruiz Dominguez, G. A.: Caractérisation de l’activité de conception collaborative à distance: étude des effets de synchronisation cognitive (2005)Jung, J.J.: Reusing ontology mappings for query routing in semantic peer-to-peer environment. Inf. Sci. (2010). https://doi.org/10.1016/j.ins.2010.04.018Ranjan, R., Zhao, L., Wu, X., Liu, A., Quiroz, A., Parashar, M.: Peer-to-Peer Cloud Provisioning: Service Discovery and Load-Balancing. https://doi.org/10.1007/978-1-84996-241-4_12Agostinho, C., Pinto, P., Jardim-goncalves, R.: Dynamic adaptors to support model-driven interoperability and enhance sensing enterprise networks. In: 19th World Congress of the International Federation of Automatic Control (IFAC’14), Cape Town, South Africa (2014)Chen, D., Doumeingts, G., Vernadat, F.: Architectures for enterprise integration and interoperability: past, present and future. Comput. Ind. 59, 647–659 (2008). https://doi.org/10.1016/j.compind.2007.12.016Ducq, Y., Chen, D., Alix, T.: Principles of servitization and definition of an architecture for model driven service system engineering. In: 4th International IFIP Working Conference on Enterprise Interoperability (IWEI 2012), Harbin, China, 2012. https://doi.org/10.1007/978-3-642-33068-17_12Elvesæter, B., Hahn, A., Berre, A., Neple, T.: Towards an interoperability framework for model-driven development of software systems. In: 1st International Conference on Interoperability Enterprise Software and Applications. Springer. http://www.springerlink.com/index/L10NU4306N054T6G.pdf (2005)OMG: MDA Guide Version 1.0.1 (omg/2003-06-01), Object Management Group. http://www.omg.org/cgibin/doc?omg/03-06-01.pdf (2003)Agostinho, C., Ducq, Y., Zacharewicz, G., Sarraipa, J., Lampathaki, F., Poler, R., Jardim-Goncalves, R.: Towards a sustainable interoperability in networked enterprise information systems: trends of knowledge and model-driven technology. Comput. Ind. (2015). https://doi.org/10.1016/j.compind.2015.07.001Santucci, G., Martinez, C., Vlad-câlcic, D.: The sensing enterprise. In: FInES Work. FIA 2012, Aalborg, Denmark. http://www.theinternetofthings.eu/sites/default/files/%5Buser-name%5D/Sensing-enterprise.pdf (2012)Sriram, R.: Smart networked systems and societies: what will the future look like? In: IEEE IT Professional Conference (IT Pro). IEEE Computer Society (2014)Manyika, J., Chui, M., Brown, B., Bughin, J., Dobbs, R., Roxburgh, C., et al.: Big data: the next frontier for innovation, competition, and productivity. http://www.mckinsey.com/insights/business_technology/big_data_the_next_frontier_for_innovation (2011)Zacharewicz, G., Diallo, S., Ducq, Y., Agostinho, C., Jardim-Goncalves, R., Bazoun, H., Wang, Z., Doumeingts, G.: Model-based approaches for interoperability of next generation enterprise information systems: state of the art and future challenges. Inf. Syst. e-Bus. Manag. (2016). https://doi.org/10.1007/s10257-016-0317-8Jardim-Goncalves, R., Agostinho, C., Steiger-Garcao, A.: A reference model for sustainable interoperability in networked enterprises: towards the foundation of EI science base. Int. J. Comput. Integr. Manuf. 25(10) (2012). (Special Issue on Collaborative Manufacturing and Supply Chains). https://doi.org/10.1080/0951192x.2011.653831Schatsky, D., Muraskin, C.: Blockchain is coming to disrupt your industry. Deloitte (2015)Shi, J., Wan, J., Yan, H., Suo, H.: A survey of cyber-physical systems. In: International Conference on Wireless Communications and Signal Processing, pp. 1–6 (2011)Rajkumar, R.: Workshop report on foundations for innovation in cyber-physical systems. NIST. http://www.nist.gov/el/upload/CPS-WorkshopReport-1-30-13-Final.pdf/ (2013)Lee, J., Lapira, E., Yang, S. Kao, H.-A.: Predictive manufacturing system trends of next generation production systems. In: 11th IFAC Workshop on Intelligent Manufacturing Systems, vol. 11, issue 1, pp. 150–156 (2013)IDC: The digital universe of opportunities: rich data and increasing value of the internet of things. EMC Digital Universe. emc.com/collateral/analyst-reports/idc-digital-universe-2014.pdf . (2014)Baheti, R., Gill, H.: Cyber-physical systems. Impact Control Technol. 1–6 (2011)Lee, J., Bagheri, B., Kao, H.-A.: A cyber physical systems architecture for Industry 4.0-based manufacturing system. Manuf. Lett. 2015, 3, 18–23 (2014). https://doi.org/10.1016/j.mfglet.2014.12.001Bagheri, B., Lee, J.: Big future for cyber-physical manufacturing systems. Design World. http://www.designworldonline.com/big-future-for-cyber-physical-manufacturing-systems/ (2015)Lucke, D., Constantinescu, C., Westkämper, E.: Smart factory-a step towards the next generation of manufacturing. Manufacturing Systems and Technologies for the New Frontier, pp. 115–118. Springer, London (2008)Weiser, M.: The Computer for the 21st Century. Scientific American, Special Issue on Communications. Comput. Netw. (1991)Westkämper, E., Jendoubi, L., Eissele, M., Ertl, T.: Smart factory—bridging the gap between digital planning and reality. Manuf. Syst. 35(4), 307–314 (2006)Goryachev, A., Kozhevnikov, S., Kolbova, E., Kuznetsov, O., Simonova, E., Skobelev, P., Tsarev, A., Shepilov, Y.: Smart factory: intelligent system for workshop resource allocation, scheduling, optimization and controlling in real time. Adv. Mater. Res. 630, 508–513 (2012)Agostinho, C., Marques-Lucena, C., Sesana, M., Felic, A., Fischer, K., Rubattino, C., Sarraipa, J.: Osmosis process development for innovative product design and validation. 2015 ASME IMECE, Houston, USA (2015)Ko, J., Lee, B., Lee, K., Hong, S.G., Kim, N., Paek, J.: Sensor virtualization module: virtualizing IoT devices on mobile smartphones for effective sensor data management. Int. J. Distrib. Sens. Netw. (2015). https://doi.org/10.1155/2015/730762Guo, T., Papaioannou, T.G., Aberer, K.: Efficient indexing and query processing of model-view sensor data in the cloud. J. Big Data Res. 1, 52–65 (2014)Kumra, S., Sharma, L., Khanna, Y., Chattri, A.: Analysing an industrial automation pyramid and providing service oriented architecture. Int. J. Eng. Trends Technol. 3(5), 586–594 (2012)Endsley, M.: Design and evaluation for situational awareness enhancement. In: Proceedings of the Human Factors Society 32nd Annual Meeting. HFES, Santa Monica, pp. 97–10 (1988)Stanton, N.A., Chambers, P.R., Piggott, J.: Situational awareness and safety. Saf. Sci. 39(3), 189–204 (2001)Endsley, M.: Toward a theory of situation awareness in dynamic systems. Hum. Factors (The Journal of the Human Factors and Ergonomics Society) 37, 32–64 (1995)Bedny, G., Meister, D.: Theory of activity and situation awareness. Int. J. Cogn. Ergon. 3(1), 63–72 (1999)Smith, K., Hancock, P.A.: Situation awareness is adaptive, externally directed consciousness. Hum. Factors (The Journal of the Human Factors and Ergonomics Society) 37(1), 137–148 (1995)Ranganathan, A., Campbell, R.H.: An infrastructure for context-awareness based on first order logic. Pers. Ubiquit. Comput. 7(6), 353–364 (2003)Ning, K., Scholze, S., Marques, M., Campos, A, Neves-Silva, R. O’Sullivan, D.: A service oriented platform for context aware knowledge enhancing. In: 5th IFAC Conference on Management and Control of Production and Logistics (2010)Marques, M., Sucic, B., Vuk, T.: Context-based decision support for sustainable optimization of energy consumption. KES Trans. Sustain. Des. Manuf. 1(1), 899–910 (2014)Schneeweiss, C.: Distributed decision making in supply chain management. Int. J. Product. Econ. 84, 71–83 (2003)Alemany, M.M.E., Alarcón, F., Lario, F.C., Boj, J.J.: An application to support the temporal and spatial distributed decision-making process in supply chain collaborative planning. Comput. Ind. 62(5), 519–540 (2011). https://doi.org/10.1016/j.compind.2011.02.002Hong, I.H., Ammons, J.C., Realff, M.J.: Centralized versus decentralized decision-making for recycled material flows. Environ. Sci. Technol. 42(4), 1172–1177 (2008)Pibernik, R., Sucky, E.: An approach to inter-domain master planning in supply chains. Int. J. Product. Econ. 108, 200–212 (2007). https://doi.org/10.1016/j.ijpe.2006.12.010Lee, H., Whang, S.: Decentralized multi-echelon supply chains: incentives and information. Manag. Sci. 45(5), 633–640 (1999)Jung, H., Chen, F., Jeong, B.: Decentralized supply chain planning framework for third party logistics partnership. Comput. Ind. Eng. 55(2), 348–364 (2008). https://doi.org/10.1016/j.cie.2007.12.017Wang, K.-J., Chen, M.-J.: Cooperative capacity planning and resource allocation by mutual outsourcing using ant algorithm in a decentralized supply chain. Expert Syst. Appl. 36(2), 2831–2842 (2009)Simon, H.A.: The Science of the Artificial, 1st edn. MIT Press, Cambridge, Mass, (1969). (3rd ed. in 1996, MIT Press)Mesarovic, M.D., Masko, D., Takahara, Y.: Theory of Hierarchical Multilevel Systems. Academic Press, New York and London (1970)Camarinha-Matos, L.M., Afsarmanesh, H.J.: Collaborative networks: a new scientific discipline. J. Intell. Manuf. 16(4), 439–452 (2005)Popplewell, K., Stojanovic, N., Abecker, A., Apostolou, D., Mentzas, G., Harding, J.: Supporting adaptive enterprise collaboration through semantic knowledge services. In: Enterprise Interoperability Iii: New Challenges and Industrial Approaches, pp. 381–393 (2008). http://doi.org/10.1007/978-1-84800-221-0_30Agostinho, C., Ducq, Y., Zacharewicz, G., Sarraipa, J., Lampathaki, F., Jardim-Goncalves, R., Poler, R.: Towards a sustainable interoperability in networked enterprise information systems: trends of knowledge and model-driven technology. Accepted for Publication at Computers in Industry. http://doi.org/10.1016/j.compind.2015.07.001Agostinho, C., Jardim-Gonçalves, R.: Sustaining interoperability of networked liquid-sensing enterprises: a complex systems perspective. Annu. Rev. Control 39, 128–143 (2015). https://doi.org/10.1016/j.arcontrol.2015.03.012Weichhart, G., Molina, A., Chen, D., Whitman, L. E., Vernadat, F.: Challenges and current developments for sensing, smart and sustainable enterprise systems. Computers in Industry (2015). http://doi.org/10.1016/j.compind.2015.07.002Weichhart, G.: Supporting Interoperability for Chaotic and Complex Adaptive Enterprise Systems. On the Move to Meaningful Internet Systems: OTM 2013 Workshops. Confederated International Workshops: OTM Academy, OTM Industry Case Studies Program, ACM, EI2N, ISDE, META4eS, ORM, SeDeS, SINCOM, SMS, and SOMOCO 2013. Proceedings: LNCS 8186, 86–92. (2013). http://doi.org/10.1007/978-3-642-41033-8_14Truex, D.P., Baskerville, R., Klein, H.: Growing systems in emergent organizations. Mag. Commun. ACM CACM Homepage Arch. 42(8), 117–123 (1999)Weiberg, S.: Facilitating collaborative decision-making in six steps. International Association of Facilitators Annual Meeting, pp. 14–15 (1999)Delbecq, A.L., VandeVen, A.H.: A group process model for problem identification and program planning. J. Appl. Behav. Sci. 7, 466–492 (1971). https://doi.org/10.1177/002188637100700404Saaty, T.L.: The Analytic Hierarchy Process. McGraw-Hill, New York, USA (1980

Wnt-reporter expression pattern in the mouse intestine during homeostasis

<p>Abstract</p> <p>Background</p> <p>The canonical Wnt signaling pathway is a known regulator of cell proliferation during development and maintenance of the intestinal epithelium. Perturbations in this pathway lead to aberrant epithelial proliferation and intestinal cancer. In the mature intestine, proliferation is confined to the relatively quiescent stem cells and the rapidly cycling transient-amplifying cells in the intestinal crypts. Although the Wnt signal is believed to regulate all proliferating intestinal cells, surprisingly, this has not been thoroughly demonstrated. This important determination has implications on intestinal function, especially during epithelial expansion and regeneration, and warrants an extensive characterization of Wnt-activated cells.</p> <p>Methods</p> <p>To identify intestinal epithelial cells that actively receive a Wnt signal, we analyzed intestinal Wnt-reporter expression patterns in two different mouse lines using immunohistochemistry, enzymatic activity, <it>in situ </it>hybridization and qRT-PCR, then corroborated results with reporter-independent analyses. Wnt-receiving cells were further characterized for co-expression of proliferation markers, putative stem cell markers and cellular differentiation markers using an immunohistochemical approach. Finally, to demonstrate that Wnt-reporter mice have utility in detecting perturbations in intestinal Wnt signaling, the reporter response to gamma-irradiation was examined.</p> <p>Results</p> <p>Wnt-activated cells were primarily restricted to the base of the small intestinal and colonic crypts, and were highest in numbers in the proximal small intestine, decreasing in frequency in a gradient toward the large intestine. Interestingly, the majority of the Wnt-reporter-expressing cells did not overlap with the transient-amplifying cell population. Further, while Wnt-activated cells expressed the putative stem cell marker Musashi-1, they did not co-express DCAMKL-1 or cell differentiation markers. Finally, gamma-irradiation stimulated an increase in Wnt-activated intestinal crypt cells.</p> <p>Conclusion</p> <p>We show, for the first time, detailed characterization of the intestine from Wnt-reporter mice. Further, our data show that the majority of Wnt-receiving cells reside in the stem cell niche of the crypt base and do not extend into the proliferative transient-amplifying cell population. We also show that the Wnt-reporter mice can be used to detect changes in intestinal epithelial Wnt signaling upon physiologic injury. Our findings have an important impact on understanding the regulation of the intestinal stem cell hierarchy during homeostasis and in disease states.</p

NYESO-1/LAGE-1s and PRAME Are Targets for Antigen Specific T Cells in Chondrosarcoma following Treatment with 5-Aza-2-Deoxycitabine

Chondrosarcoma has no proven systemic option in the metastatic setting. The development of a non-cross-resistant strategy, such as cellular immunotherapy using antigen-specific T cells would be highly desirable. NY-ESO-1 and PRAME are members of the Cancer Testis Antigen (CTA) family that have been identified as promising targets for T cell therapy. LAGE-1 is a cancer testis antigen 90% homologous to NY-ESO-1, sharing the 157-165 A*0201 NY-ESO-1 epitope with its transcript variant, LAGE-1s. A number of CTA's have been induced using 5-Aza-2-Deoxycitabine (5-Aza-dC) in other cancers. We sought to evaluate the feasibility of targeting chondrosarcoma tumors using NY-ESO-1/LAGE-1s and PRAME specific T cells using 5-Aza-dC to induce antigen expression.We used 11 flash frozen tumors from the University of Washington tumor bank to test for the expression of NY-ESO-1, PRAME, LAGE-1s and LAGE-1L in chondrosarcoma tumors. Using four chondrosarcoma cell lines we tested the expression of these CTA's with and without 5-Aza-dC treatments. Finally, using NY-ESO-1/LAGE-1s and PRAME specific effectors that we generated from sarcoma patients, we evaluated the ability of these T cells to lyse A*0201 expressing chondrosarcoma cell lines in vitro both with and without 5-Aza-dC treatment.A minority (36%) of chondrosarcoma tumors expressed either NY-ESO-1 or LAGE-1s at >10% of our reference value and none expressed PRAME at that level. However, in all four of the chondrosarcoma cell lines tested, NY-ESO-1 and PRAME expression could be induced following treatment with 5-Aza-dC including in cell lines where expression was absent or barely detectable. Furthermore, NY-ESO-1/LAGE-1s and PRAME specific CD8+ effector T cells were able to specifically recognize and lyse A*0201 expressing chondrosarcoma cell lines following 5-Aza-dC treatment.These data suggest that adoptive immunotherapy in combination with 5-Aza-dC may be a potential strategy to treat unresectable or metastatic chondrosarcoma patients where no proven systemic therapies exist

Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal