166 research outputs found
Directional orientation of reproductive tissue of Eulychnia breviflora (Cactaceae) in the hyperarid Atacama Desert
- Author
- A Westheld
- C Tinoco-Ojanguren
- D MartĂnez-Moreno
- DM Figueroa-Castro
- E Barrera De la
- G Bell
- GN Geller
- GN Geller
- GS Watson
- HH Piña
- I Aguilar-Gastellum
- J Ehleringer
- JA Rech
- JA Zavala-Hurtado
- JE Bowers
- JL LeĂłn de la Luz
- JN Holland
- JR Cooley
- K Nishiizumi
- KV Mardia
- L. Scott Baggett
- Lorgio E. Aguilera
- M Lenzi
- M VĂĄzquez-SĂĄnchez
- MC Mandujano
- ME McIntosh
- MF Herce
- MV Thompson
- N Palleiro
- P Cereceda
- P Cereceda
- PL Valverde
- PS Nobel
- PW Rundel
- R Börgel
- R Garreaud
- RA Fischer
- RG Maliva
- SD Smith
- SD Warren
- Steven D. Warren
- TH Kunz
- TJ Dunai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
- Abad Rd
- Abe T
- Abroug F
- Adams Jc
- Adamsson Ro
- Adolfsson A
- Aguilar Rz
- Aguirre Js
- Aguirre-Bermeo H
- Aisa Tm
- Aisiku I
- Ajetunmobi Oo
- Aker M
- Akyol Oo
- Al Dorzi Hm
- Al Jabbary As
- Albaiceta Gm
- Albarrak Mm
- Albiero D
- Alda Rs
- Alejandro Rv
- Alexander P
- Algaba Ă
- Aliaga Fa
- Alisasis Au
- Allan Rm
- Allue Rm
- Almekhlafi G
- Alonso Jg
- Altaf W
- Alvarez Am
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen Fh
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli Mm
- AntĂŽnio Acp
- Aoki N
- Appelberg H
- Arabi Y
- Arabi Ym
- Arabi Ym
- Araujo Am
- Arizmendi A
- Arnal Jm
- Artiga Mjd
- Artigas A
- Ascoli A
- Au Sm
- Avila Le
- Azad R
- Azevedo Lc
- Baboi L
- Badie Jc
- Bailey Im
- Bailey Mb
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed Vm
- Barberet G
- Baron Rm
- Baronia Ak
- Barratt-Due A
- Barros Fm
- Barros Nc
- Batra H
- Battle Ce
- Bauer Pr
- Beck E
- Beck O
- Bedreag Oh
- Beegle Sh
- Beitler Jr
- Bellani G
- Bellani Giacomo
- Beloncle F
- Benslama A
- Beraldo Do
- Berkelmans F
- Besset Sl
- Bettini Lr
- Beuret P
- Bezzi Mg
- Bhardwaj Vk
- Bhowmick K
- Biehler J
- Bihari S
- Biondi Rs
- Biscione Rr
- Bisso Mc
- Black Cs
- Blakeman Tc
- Blanco J
- Bolon S
- Borello Sa
- Borotto Ee
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw Mj
- Boyd O
- Boyle Andrew J.
- Bramall J
- Braschi A
- Braschi A
- Brazzi L
- Breen Dm
- Briquet A
- Brito Va
- Brizuela M
- Broman Lm
- Brown Sm
- Browne Ts
- Bruhn Scar
- Brunettini B
- Bruns Mm
- Buensuseso Ja
- Bugedo G
- Buise Mp
- Bulpa Pa
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw Aj
- Burtin P
- Buzancais G
- BĂ©duneau G
- Camsooksai J
- Cani A
- Carbayo-Gorriz C
- Cardonnet Lp
- Careless Jp
- Carpentier D
- Carreño Ng
- Carteaux G
- Casalena P
- Casement J
- Castro Ag
- Castro S
- Catorze Nt
- Cazorla-Barranquero Fg
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato Vi
- Cervantes Mr
- Cesar Ps
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau Sk
- Chelly J
- Chen K
- Chena A
- Cheng Mp
- Chiche Jd
- Chouchene I
- Choudry S
- Christiansen A
- Cimic N
- Cinnella G
- Cirone R
- CitalĂĄn Je
- Claraco-Vega Lm
- Clarkson K
- Clarkson Kp
- Claverias L
- Cohen Je
- Cole Jm
- Collins Dv
- Collyer T
- Colombo R
- Combaux Dm
- Combes A
- Constantin Jm
- Conti S
- Cooper R
- Coppadoro A
- Corneci De
- Cortegiani A
- Cortez Ca
- Coxo Cm
- Cracchiolo An
- Cranshaw Jh
- Crapelli G
- Crouch Dr
- Crouch Dr
- Crova Pj
- Csabi P
- Curley G
- Curto Eg
- Daldin J
- Dangers L
- Daniel F.
- Danin Pe
- Daubin C
- Daviaud F
- Davies Kg
- Dawson H
- De Cima-Iglesias S
- De Gordoa Lo
- De Haro C
- De Pablo R
- de Prost N
- Dean Mn
- Deane Adam M.
- Declercq Pm
- Dector D
- Dector Dm
- Deicas A
- Del Carmen Lorente M
- Dellamonica J
- Dellera C
- Delsing A
- Demirkiran O
- Demoule A
- Dempsey G
- Dendane T
- Depuydt P
- Depuydt P
- Derman Ss
- Di Tomasso Nn
- Di Yd
- Diaz-Rodriguez E
- Dive Am
- Dixit Sb
- do Vale Fernandes A
- Dolva Ms
- Donnelly A
- Dowling At
- Doyen D
- Dres M
- Dreyer Kr
- Dreyer Kr
- Dunne Es
- Dupont H
- Duranteau J
- Dwyer R
- DĂ©mpaire G
- Ebeid A
- Elatrous S
- Elisabet Gm
- Elkhayari M
- Ellis He
- Elmasri M
- Erbabacan E
- Eriksson Ke
- Estenssoro E
- Esteve F
- Estilita Jm
- Estrella Cr
- Ezzouine H
- Fan E
- Fartoukh M
- Faruq Mo
- FarĂas Pa
- Fawkes Da
- Ferguson A
- Ferguson Nd
- Fernandez Am
- Fernandez Ro
- Fierro Jm
- Floris L
- Follin A
- Fontenele Dc
- Formenti P
- Forteza C
- Fossali T
- Foti G
- Franco N
- Francois Gm
- França Ag
- Frati E
- Frendl G
- Frigyik Ad
- Fusari M
- Futami S
- Gally J
- Ganesan D
- Gao Y
- Gao Yn
- Garcia Ph
- Gazenkampf Aa
- Gelée B
- George Fg
- Ghazi M
- Gianinetto H
- Giarratano A
- Gillis S
- Girgin Nk
- Gjedsted J
- Glietsch R
- Goldgran-Toledano D
- Goligher Ec
- Gomaa D
- Gomaa D
- Gomersall C
- Gomes Rm
- Gomez Pe
- Gomez-Flores Ss
- Gonzalez Dr
- Gonzalez M
- GonzĂĄlez Rojas Ma
- GonzĂĄlez Rm
- GonzĂĄlez-Salamanca Ă
- Gonçalves Ch
- Goodson Jc
- Gordo F
- Gosselin Rj
- Goubaux B
- Graziani R
- Grelon F
- Griffin Ro
- Grigoriev E
- Grijalba Cq
- Grissom Ck
- Gritsan Ai
- Grubissich N
- Gueret Rm
- Gurjar M
- Guttormsen Ab
- Guérin C
- GĂłmez Pra
- Hacking Dj
- Haddad Y
- Hadfield D
- Hagan Sj
- Han H
- Han Y
- Hang Ay
- Hanlon Gc
- Harasawa T
- Harrois A
- Hashemian Sm
- Hashemian Sm
- Hashida T
- He Z
- Hedlund L
- Heidari F
- Heines Sj
- Helleberg J
- Henderson G
- Herbrecht Je
- Hermosa C
- Hessell Rj
- Heunks Lm
- Heunks Lm
- Higashijima U
- Hirata A
- Holzgraefe B
- Honda H
- Honrubia T
- Hopf Hf
- Hopkins P
- Hormis Ap
- Hou Pc
- Hou Sk
- Hua Mx
- Huang Qq
- Huang Xb
- Huerta Fp
- Huff Ng
- Humphreys Sk
- Hunt A
- Hurtado J
- Hurtado J
- Hurtado J
- Hutchison Ra
- Hutton Pj
- Ibañez-Santacruz M
- Ichikado K
- Ilutovich S
- Imai H
- Imma Vp
- Imperio Mc
- Inskip Dm
- Ioannou N
- Iotti Ga
- Irvine Da
- Ismail D
- Ismail M
- Ito F
- Izawa M
- Jaafar Rf
- Jakubowska K
- Jamaati H
- Jarquin-Badiola Yd
- Jassal M
- Javeed A
- JhaMatthew Thomas Rr
- Jiang L
- Jibaja M
- Jimenez Ag
- Jochmans S
- Jog Sa
- John Trinder T
- Jovanovic B
- Judy C
- Jurado Mt
- Kadaba V
- Kajtor I
- Kakar V
- Kalaitzis E
- Kalkoff M
- Kamel G
- Kameyama Y
- Kamoun S
- Kander T
- Kannan Sg
- Kashif W
- Kashiwa Y
- Kedelv H
- Kennedy B
- Khebbeb S
- Kheir F
- Kheir Fm
- Kimura H
- Kiourtzieva Ev
- Kitch Bt
- Klasen F
- Knapman Km
- Knoll J
- Knowles S
- Koh Y
- Kol Mr
- Kong J
- Koyama K
- KraĂler J
- Krstevski A
- Kulkarni S
- Kumar A
- Kurahashi K
- Kusumoto K
- Laake Jh
- Laake Jh
- Labarca Ef
- Laffey J
- Laffey John G.
- Lamb Kd
- Lanspa Mj
- Larsson A
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- Le Moal C
- Lebbinck H
- Lee J
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- Leemann-Refondini C
- Lemiale V
- Lemus Js
- Leon Yoshido Hh
- Li B
- Li Q
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- Li W
- Li X
- Li Xl
- Li Y
- Li Yy
- Li-Xin Z
- Liew Ky
- Ling Ll
- Liu H
- Liu J
- Liu Jl
- Liu L
- Llano M
- Llinares Moya Dd
- Lohner R
- Loiacono Fa
- Lombardo A
- Lopez-Delgado Jc
- Lora Fs
- Lora P
- Lorente Ja
- Losada Ep
- Lovazzano P
- Lu W
- Lu Y
- Luis Pse
- Luo X
- Lynch Jm
- LĂłpez-Messa Jb
- Maazouzi W
- Macfadyen R
- Macfie Cc
- Madotto Fabiana
- Maeyama Hn
- Maghrabi Ka
- Magret M
- Mahto Hl
- Mancebo J
- Manoharan V
- Marcos Dp
- Marcu A
- Marin J
- Marin Mc
- Martinez Ft
- Martinho Am
- Marum Sm
- Massa Ev
- Mataloun S
- Matamis D
- Matsumoto S
- Mattei A
- May Mm
- Mcarthur C
- Mcauley
- Mcauley D
- Mcauley Df
- Mccalman Kh
- Mckechnie S
- Mckee R
- Mckenna Te
- Mcleod A
- Mcnamee L
- Mcnamee L
- Meaney Ea
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- Mehta S
- Mejia Fjf
- Mellis C
- Memon M
- Mercat A
- Mesar T
- Mesar T
- Messias Am
- Messika J
- Meybohm P
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- Millar Rt
- Miller Jj
- Miller Rr
- Mirabella L
- Mizuguchi I
- Mochizuki K
- Mohr Nm
- Mojoli F
- Mojoli F
- Moles Si
- Molin A
- Montanha Gm
- Monteiro Jm
- Montero La
- Montes Oscanoa Fa
- Monti G
- Montini Lm
- Moock M
- Morin Ak
- Mortaza S
- Morton A
- Mouloudi Ek
- Mukkera Sr
- Mustafa Gm
- Muthuchellappan R
- MĂĄca J
- Nagy Eo
- Nakamura T
- Namih M
- Nassar AP Jr
- Nasu M
- Navalpotro Mab
- Navarra L
- Navarro G
- Neal J
- Negoita Si
- Newby L
- Nichol A
- Nielsen J
- Nielsen J
- Niimi D
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- Nin N
- Nishikawa E
- Nitta K
- Nobrega D
- Noremark Kal
- Nunes Sl
- Nunomiya S
- Nutt C
- Nuñez E
- Nygren I
- O'Croinin D
- O'Kane Cecilia M.
- O'Muircheartaigh Ac
- Occhipinti G
- Oetting Tw
- Ogino Y
- Oikonomou Ma
- Okane Sc
- Okuda N
- Oldroyd Mg
- Olga Mf
- Oliveira Bs
- Oneill O
- Ortiz Ca
- Osman Em
- Oss P
- Ouanes I
- Ourailogloy V
- Owens Rl
- Ozcelik M
- Palaniswamy V
- Palma Dm
- Palmese S
- Palo Je
- Panarello G
- Papanikolaou Mn
- Papavasilopoulou Tg
- Papazian L
- Papurica M
- Para Lh
- Parhar K
- Parotto M
- Pasanting-Lim Rab
- Patjanasoontorn B
- Patroniti N
- Pattarino Pti
- Pecci E
- Pellegrini Ca
- Pelletier N
- Pellicer Am
- Penuelas O
- Pereira Cs
- Perez Cp
- Perez Mp
- Persson L
- Pesenti Antonio
- Pg Hj Ismail Dmab
- Pham T
- Pham T
- Pham TĂ i
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- Philippe M
- Piacentini Ea
- Pillai S
- Pintado Mc
- Piquilloud L
- Piquilloud L
- Piras C
- Pittini G
- Plotnikow Ga
- Poblano M
- Poli Mm
- Pota V
- Pozo Nc
- Pozzi M
- Preez Pd
- Prieto-GonzĂĄlez M
- Pronovost A
- Protti A
- Qin B
- Qin J
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- Qiu H
- Raaijmakers M
- Rabboni F
- Rafael Si
- Raimondi F
- Raj As
- Ramakrishnan N
- Ramesh Vj
- Ramirez-Alfaro Cm
- Ramirez-Gutierrez A
- Rampinelli Am
- Ranero Jl
- Raponi F
- Recio Nn
- Reschreiter H
- Reske Aw
- Reuter D
- Reynolds C
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- Rialp G
- Richecoeur Jr
- Ricome S
- Rigaud Jp
- Rigshopitalet
- Rinia M
- Rios F
- Riss Kc
- Rittayamai N
- Roberts Bl
- Robine A
- Robles Jb
- Roche-Campo F
- Rodgers Hj
- Rodriguez Ll
- Rodriguez R
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- Roser Tp
- Rossi A
- Roux D
- Rugonfalvi S
- Ruiz Sr
- Ruiz-Aguilar Al
- Rylander Cc
- Ryosuke S
- Sabelnikovs O
- Sable Sd
- Saenz Mg
- Saez Aa
- Sagar Sv
- Saito K
- Saito S
- Salahuddin N
- Salas Je
- Sales Vm
- Samkaoui N
- Sanchez Rj
- Sanchez-Hurtado La
- Sanchez-Medina Jr
- Sandesc D
- Santoli Fl
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- Savioli M
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- Schiavone V
- Schiavoni L
- Schiöler F
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- Seasman C
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- Serra C
- Serra Im
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- Shindhe S
- Shinn Iii Jo
- Shiozaki K
- Silesky Jimenez Ji
- Silesky J
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- Simon P
- Simonis Fd
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- SjĂžbĂž BĂ„
- Sklienka P
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- Solis-Quesada Je
- Sottiaux T
- Souissi Ab
- Spadaro S
- Srinivasa L
- Stamou Ee
- Staudinger T
- Stephenson L
- Stewart R
- Stigler W
- Strauch U
- Sula H
- Sun R
- Surbatovic M
- Suzuki H
- Symmonds S
- Synclair J
- Szakmany T
- SĂĄnchez Rm
- SĂĄnchez-Ballesteros J
- SĂžreide E
- Tabhan E
- Tabhan Ee
- Tainter C
- Takaba A
- Takada T
- Takagi S
- Tallet Alfonso Aa
- Tan Bc
- Tanaka H
- Tang R
- Tapponnier R
- Tarantino F
- Temprano S
- Terzi N
- Thibault S
- Thompson B. Taylor
- Thompson Mm
- Tibblin Ao
- Tinnirello A
- Tiribelli N
- Todeschini M
- Tomescu Dr
- Toribio Dp
- Toth-Tarsoly P
- Treanor N
- Trinidad Oa
- Tulaimat A
- Twohey L
- Uchiyama A
- Ueda T
- Ueno K
- Umbrello M
- Unnikrishnan R
- Uppalapati A
- Van Haren F
- Van Wezel Hm
- Vargas Mp
- Vascotto Er
- Vasquez Dn
- Vega Ld
- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez Aj
- Villamagua Bg
- Villar V
- Virgilio Cg
- Vitale Mn
- Volta Ca
- Wang C
- Wang Hx
- Wang Sh
- Wang W
- Warren J
- Watanabe E
- Watt P
- Welters Id
- Wenham T
- Wessbergh J
- Whitehead C
- Willett El
- Williams Aj
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- Wittebole X
- Wong Hs
- Woods Pw
- Wrathall Dw
- Wrigge H
- Wu Yq
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- Yamaguchi O
- Yamaji Y
- Yao Q
- Ye Zl
- Yeatts Dj
- Yu R
- Yu T
- Yu W
- Yumha Js
- Yuste Lj
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- Zacharowski Kd
- Zani G
- Zantua Ks
- Zazu A
- Zeggwagh Aa
- Zeggwagh Aa
- Zein So
- Zender Ho
- Zhai Z
- Zhang F
- Zhang Xy
- Zhao H
- Zhao J
- Zhao Xy
- Zheng R
- Zhou Fc
- Zhou S
- Zhu Bh
- Zhu Wh
- Zogheib Eh
- Ăamendys-Silva Sa
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Ben Souissi A
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
- Brochard L.
- Broman LM
- Brown SM
- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw AJ
- Burtin P
- Buzancais G
- BĂ©duneau G
- Camsooksai J
- Canestrini S
- Cani A
- Carbayo-Gorriz C
- Cardonnet LP
- Careless JP
- Carpentier D
- Carreño NG
- Carteaux G
- Casalena P
- Casement J
- Castro AG
- Castro S
- Catorze NT
- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
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- Gelée B
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- Glietsch R
- Goldgran-Toledano D
- Goligher E. C.
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- Gomaa D
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- GonzĂĄlez-Salamanca Ă
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- Uchiyama A
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- Unnikrishnan R
- Uppalapati A
- van Haren F
- van Haren F.
- Van Wezel HM
- Vargas MP
- Vascotto ER
- Vasquez DN
- Vega LD
- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez AJ
- Villamagua BG
- Villar V
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- Woods PW
- Wrathall DW
- Wrigge H
- Wrigge H
- Wrigge H.
- Wu YQ
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- Yamaji Y
- Yao Q
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- Yeatts DJ
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- Yumha JS
- Yuste LJ
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- Zacharowsk KD
- Zani G
- Zantua KS
- Zazu A
- Zeggwagh AA
- Zeggwagh AA
- Zein SO
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- Zhai Z
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- Zhu WH
- Zogheib EH
- Ăamendys-Silva SA
- Ănal N
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabim YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
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- Battle CE
- Bauer PR
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- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
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- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
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- Besset SL
- Bettini LR
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- Biondi RS
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- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato VI
- Cervantes MR
- Cesar PS
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau SK
- Chelly J
- Chen K
- Chena A
- Cheng MP
- Chiche JD
- Chile SC
- Chouchene I
- Choudry S
- Cimic N
- Cinnella G
- Cirone R
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- Claraco-Vega LM
- Clarkson K
- Clarkson KP
- Claverias L
- Cohen JE
- Cole JM
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- Collyer T
- Colombo R
- Combaux DM
- Combes A
- Conti S
- Cooper R
- Coppadoro A
- Corneci DE
- Cortegiani A
- Cortez CA
- Coxo CM
- Cracchiolo AN
- Cranshaw JH
- Crapelli G
- Crouch DR
- Crova PJ
- Csabi P
- Curley G
- Curto EG
- Daldin J
- Dangers L
- Danin PE
- Daubin C
- Daviaud F
- Davies KG
- Dawson H
- de Cima-Iglesias S
- de Gordoa LO
- de Haro C
- de Pablo R
- de Prost N
- Dean MN
- Declercq PM
- Dector D
- Dector DM
- Deicas A
- Del Carmen Lorente M
- Dellamonica J
- Dellera C
- Delsing A
- Demirkiran O
- Demoule A
- Dempsey G
- Dendane T
- Depuydt P
- Depuydt P
- Derman SS
- Di Tomasso NN
- Di YD
- Diaz-Rodriguez E
- Dive AM
- Dixit SB
- do Vale Fernandes A
- Dolva MS
- Donnelly A
- Dowling AT
- Doyen D
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- Dreyer KR
- Dunne ES
- Dupont H
- Duranteau J
- Dwyer R
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- Elisabet GM
- Elkhayari M
- Ellis HE
- Elmasri M
- Erbabacan E
- Eriksson KE
- Esteban A
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- Esteve F
- Estilita JM
- Estrella CR
- Ezzouine H
- Fan E
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- Fawkes DA
- Ferguson A
- Ferguson ND
- Fernandez AM
- Fernandez RO
- Fierro JM
- Floris L
- Fontenele DC
- Formenti P
- Forteza C
- Fossali T
- Foti G
- Franco N
- Francois GM
- França AG
- Frati E
- Frendl G
- Frigyik AD
- Fusari M
- Futami S
- Gally J
- Ganesan D
- Gao Y
- Gao YN
- Garcia PH
- Gattinoni L
- Gazenkampf AA
- Gelée B
- General H
- George FG
- Ghazi M
- Gianinetto H
- Giarratano A
- Gillis S
- Girgin NK
- Gjedsted J
- Glietsch R
- Goldgran-Toledano D
- Goligher EC
- Gomaa D
- Gomaa D
- Gomes RM
- Gomez PE
- Gomez-Flores SS
- Gonzalez DR
- Gonzalez M
- GonzĂĄlez RM
- GonzĂĄlez Rojas MA
- GonzĂĄlez-Salamanca Ă
- Gonçalves CH
- Goodson JC
- Gordo F
- Gosselin RJ
- Goubaux B
- Graziani R
- Grelon F
- Griffin R
- Grigoriev E
- Grijalba CQ
- Grissom CK
- Gritsan AI
- Grubissich N
- Gueret RM
- Gurjar M
- Guttormsen AB
- Guérin C
- GĂłmez PRA
- Hacking DJ
- Haddad Y
- Hadfield D
- Hagan SJ
- Han H
- Han Y
- Hang AY
- Hanlon GC
- Harasawa T
- Harrois A
- Hashemian SM
- Hashemian SM
- Hashida T
- He Z
- Hedlund L
- Heidari F
- Heines SJ
- Helleberg J
- Henderson G
- Herbrecht JE
- Hermosa C
- Hessell RJ
- Heunks LM
- Higashijima U
- Hirata A
- Holzgraefe B
- Honda H
- Honrubia T
- Hopf HF
- Hopkins P
- Hormis AP
- Hou PC
- Hou SK
- Hraiech S
- Hua MX
- Huang QQ
- Huang XB
- Huerta FP
- Huff NG
- Humphreys SK
- Hunt A
- Hurtado J
- Hutchison RA
- Hutton PJ
- Ibañez-Santacruz M
- Ichikado K
- Ilutovich S
- Imai H
- Imma VP
- Imperio MC
- Insaurralde CS
- Inskip DM
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
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- Ălvarez FernĂĄndez A
- Ăsterberg K
- Ăzçelik Ă
- Ć irokĂœ J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
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- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
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- Capiluppi P
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- Carrillo Montoya CA
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- Cornelis T
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Observation of a New Excited Beauty Strange Baryon Decaying to Îb- Ï+Ï-
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- Ăzçelik Ă
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Îb-Ï+Ï- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Îb- is reconstructed via its decays to J/ÏÎ- and J/ÏÎK-. A narrow resonance, labeled Îb(6100)-, is observed at a Îb-Ï+Ï- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Îb-) MeV, where the last uncertainty reflects the precision of the Îb- baryon mass. The upper limit on the Îb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Îb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Îc baryon states, the new Îb(6100)- resonance and its decay sequence are consistent with the orbitally excited Îb- baryon, with spin and parity quantum numbers JP=3/2-
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of Ï Leptons in pp collisions at sqrt[s]=13ââTeV
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the Ï lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13ââTeV and corresponding to an integrated luminosity of 138ââfb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two Ï leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Measurement of the inclusive and differential WZ production cross sections, polarization angles, and triple gauge couplings in pp collisions at âs = 13 TeV
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- Aarrestad T. K.
- Aarup Petersen H.
- Abbaneo D.
- Abbiendi G.
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- Zorbilmez C.
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- Zou R.
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- Zygala L.
- Ălvarez FernĂĄndez A.
- Ăzçelik Ă.
- Publication venue
- Scuola Internazionale Superiore di Studi Avanzati
- Publication date
- 12/08/2022
- Field of study
The associated production of a W and a Z boson is studied in final states with multiple leptons produced in proton-proton (pp) collisions at a centre-of-mass energy of 13 TeV using 137 fbâ1 of data collected with the CMS detector at the LHC. A measurement of the total inclusive production cross section yields Ïtot(pp â WZ) = 50.6 ± 0.8 (stat) ± 1.5 (syst) ± 1.1 (lumi) ± 0.5 (theo) pb. Measurements of the fiducial and differential cross sections for several key observables are also performed in all the final-state lepton flavour and charge compositions with a total of three charged leptons, which can be electrons or muons. All results are compared with theoretical predictions computed up to next-to-next-to-leading order in quantum chromodynamics plus next-to-leading or- der in electroweak theory and for various sets of parton distribution functions. The results include direct measurements of the charge asymmetry and the W and Z vector boson polarization. The first observation of longitudinally polarized W bosons in WZ production is reported. Anomalous gauge couplings are searched for, leading to new constraints on beyond-the-standard-model contributions to the WZ triple gauge coupling
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