9 research outputs found
NiII, CuII and ZnII complexes with a sterically hindered scorpionate ligand (TpmsPh) and catalytic application in the diasteroselective nitroaldol (Henry) reaction
- Author
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2014
- Field of study
The Ni-II and Zn-II complexes [MCl(Tpms(Ph))] (Tpms(Ph) = SO3C(pz(Ph))(3), pz = pyrazolyl; M = Ni 2 or Zn 3) and the Cu-II complex [CuCl(Tpms(Ph))(H2O)] (4) have been prepared by treatment of the lithium salt of the sterically demanding and coordination flexible tris(3-phenyl-1-pyrazolyl)methanesulfonate (Tpms(Ph))(-) (1) with the respective metal chlorides. The (Tpms(Ph))(-) ligand shows the N-3 or N2O coordination modes in 2 and 3 or in 4, respectively. Upon reaction of 2 and 3 with Ag(CF3SO3) in acetonitrile the complexes [M(Tpms(Ph))-(MeCN)](CF3SO3) (M = Ni 5 or Zn 6, respectively) were formed. The compounds were obtained in good yields and characterized by analytic and spectral (IR, H-1 and C-13{H-1} NMR, ESI-MS) data, density functional theory (DFT) methods and {for 4 and [(Bu4N)-Bu-n](Tpms(Ph)) (7), the tatter obtained upon Li+ replacement by [(Bu4N)-Bu-n](+) in Li(Tpms(Ph))} by single crystal X-ray diffraction analysis. The Zn-II and Cu-II complexes (3 and 4, respectively) act as efficient catalyst precursors for the diastereoselective nitroaldol reaction of benzaldehydes and nitroethane to the corresponding beta-nitroalkanols (up to 99% yield, at room temperature) with diastereoselectivity towards the formation of the anti isomer, whereas the Ni-II complex 2 only shows a modest catalytic activity
Ironporphyrin immobilized onto montmorillonite as a bimimetical model for azo dye oxidation
- Publication venue
- ELSEVIER SCI LTD
- Publication date
- Field of study
In this work, we studied the oxidation of the azo dye Disperse orange 3 (DO3) by hydrogen peroxide, catalyzed by 5,10,15, 20-tetrakis(4-N-methylpyridyl)porphyrin iron(III) chloride immobilized onto montmorillonite K10, FeP-K10. Results showed that the FeP-K10/H2O2 system is efficient for discoloration of the DO3 dye, especially at pH 3.0. The catalyst was shown to be relatively stable and could be recycled many times, leading to good yields. DO3 oxidation products were analyzed by gas chromatography and mass spectrometry, being 4-nitroaniline the main product. Tert-butylhydroperoxide and iodosylbenzene were also used as oxidants, giving rise to 4-nitroaniline as product too. The studied system is a good biomimetic model of oxidative enzymes, being a promising discoloring agent for azo dyes. (C) 2007 Elsevier Ltd. All rights reserved
A new role of AMP-activated protein kinase in regulating proliferation of mesenchymal stem cells
- Author
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- A. A. Lammertsma
- A. Akhmedov
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- A. Angelini
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- A. Berezin
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- A. Caporali
- A. Caporali
- A. Caporali
- A. Cardinali
- A. Carpi
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- A. Chester
- A. Coulter
- A. Cross
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- S. Kumar
- S. Lee
- S. Lemoine
- S. Lorain
- S. Marston
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- S. Schlossarek
- S. Schlossarek
- S. Seiler
- S. Seth
- S. Simrick
- S. Simsek
- S. Simsekyilmaz
- S. Steffens
- S. T. Aspenes
- S. Tisheva
- S. Trompet
- S. U. Oberdorf-Maass
- S. U. Y. Nikulina
- S. V. De Noronha
- S. Van Den Oever
- S. W. Schneider
- S. Wantha
- S. Weinert
- S. Z. Orosz
- S. Zoller
- S.-C. Lai
- T. A. B. Van Veen
- T. A. Berezina
- T. A. Kurak
- T. Benova
- T. Benova
- T. Brand
- T. Csont
- T. Desplantez
- T. Eschenhagen
- T. F. Bathen
- T. F. Luescher
- T. Forster
- T. Hryniewiecki
- T. J. Butler
- T. K. Tatiana Konovaleva
- T. Katova
- T. Katova
- T. N. Yenina
- T. N. Yenina
- T. Noll
- T. O. Usman
- T. Omland
- T. P. Collins
- T. P. Denisova
- T. Padro
- T. Padro
- T. Rzymski
- T. Szel
- T. Trenkwalder
- T. Uchikawa
- T. V. Statkevich
- T. Vladimirskaya
- T. Voit
- T. West
- T. Wieland
- T. Zaglia
- T. Zaglia
- T.-C. Kuan
- T.-C. Kuan
- T.-H. Yang
- U. C. Urszula Czech
- U. Ravens
- U. Siedlecka
- U. Stanzl
- U. Wisloff
- V. A. Kuznetcov
- V. A. Kuznetcov
- V. A. Olatunji
- V. Bodi
- V. Cachofeiro
- V. Dosenko
- V. Fressart
- V. J. A. Bourgonje
- V. J. A. Bourgonje
- V. J. Nijenhuis
- V. Khan
- V. Knezl
- V. Knezl
- V. Lahera
- V. Matchkov
- V. Muthurangu
- V. P. Ryabukho
- V. Parente
- V. Pelloux
- V. Regitz-Zagrosek
- V. Regitz-Zagrosek
- V. Seden
- V. Shulzhenko
- V. W. M. Van Hinsbergh
- V. Y. Hoymans
- W. Buczko
- W. E. Louch
- W. G. Daniel
- W. H. Van Gilst
- W. Husada
- W. J. Koch
- W. J. Koch
- W. J. Paulus
- W. J. Van Der Laarse
- W. J. Wijnen
- W. Kuzyniak
- W. Linke
- W. M. Blankesteijn
- W. R. Giles
- W. S. Speidl
- W. Schgoer
- W.-T. Wu
- X. Yin
- X. Yin
- Y. Ajiro
- Y. M. Pinto
- Y. Rudy
- Y. U. A. Yuricheva
- Y. Y. Wong
- Y. Yao
- Z. Gaciong
- Z. H. N. Kot
- Z. Husti
- Z. Papp
- Z. Pesevski
- Z. S. Kohajda
- Z. V. Varga
- Z. Vamos
- Z. Vucinic
- Z. Yassin
- Z. Yassin
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2012
- Field of study
Purpose: Natriuretic peptides (NPs) administered during early reperfusion are protective in models of myocardial infarction. A previous study examining the endogenous components of B-type natriuretic peptide (BNP) protection of reperfused myocardium, implicated both sarcolemmal (s) KATP and mitochondrial (m) KATP channels. The indirect evidence characterising the relationship between BNP signalling and KATP was obtained using sulphonylurea receptor inhibitors in a rat isolated heart model of ischaemia-reperfusion injury. Here we seek to further examine the relationship between NPs and sKATP openings using single channel electrophysiology. Given our previous findings and the overarching consensus that cardioprotective autacoids open KATP channels, it was hypothesised that NPs elicit sKATP opening.
Methods: Cardiomyocyte isolation. Left ventricular cardiomyocytes were isolated from male Sprague-Dawley rat hearts subjected to enzymatic digestion with Liberase Blendzyme DL. Cardiomyocytes were cultured overnight in Medium 199, prior to patch clamp. Single channel patch clamp. Single channel recordings at room temperature (22°C) were made from cell attached patches bathed in Na+ Locke, pH 7.2. The recording pipette contained high KCl (140 mM), pH 7.2. Recordings (45 sec) were made over a range of patch potentials (0, -30, -60, -90, -120 mV), in the absence (control) and in the presence of bath applied BNP (10, 100 nM and 1 µM), pinacidil (200 µM) or pinacidil vehicle (DMSO, 0.25%). Recordings were also made with BNP and pinacidil applied concomitantly. Data are mean ± S.E.M.
Results: The current voltage relationship of sKATP under control conditions was linear at –ve patch potentials, the mean conductance being 52.9 ± 1.8 pS (n = 18 hearts, n = 35 cells). Pinacidil caused a four fold increase in sKATP open probability compared to control. Mean channel conductance in the presence of pinacidil was 59.9 ± 1.9 pS (n = 16 hearts, n = 44 cells). Interestingly BNP at all concentrations had negligible effects on sKATP open probability and unitary conductance. However, BNP at all concentrations and patch potentials inhibited pinacidil induced sKATP openings, restoring channel open probability to baseline.
Conclusion: These data illustrate the inhibitory effect of NP signalling on sKATP function in the cardiomyocyte under normoxia. They are concordant with the inhibitory effect of atrial NP on KATP in the pancreatic beta cell, but are in apparent conflict with the current cardioprotection paradigm. However, differential effects on sKATP and mKATP and the effects of hypoxia-reoxygenation require further exploration
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Angelova Svetoslava V.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Arun Kg G.
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Atallah Dany V.
- Aufmuth Peter
- Aulbert Carsten
- Aultoneal K.
- Austin Corey
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barkett Kevin
- Barone Fabrizio
- Barr Bryan
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- Barta Daniel
- Bartlett Jeffrey
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- Bazzan Marco
- Beer Christian
- Bejger Michal
- Belahcene Imene
- Bell Angus S.
- Berger Beverly K.
- Bergmann Gerald
- Bero John J.
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Bhagwat Swetha
- Bhandare Rohan
- Bilenko Igor A.
- Billingsley Garilynn
- Billman Chris R.
- Birch Jeremy
- Birney Ross
- Birnholtz Ofek
- Biscans Sebastien
- Biscoveanu Sylvia
- Bisht Aparna
- Bitossi Massimiliano
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- Blackburn J.K.
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- Westphal Tobias
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- Willke Benno
- Wimmer Maximilian H.
- Winkler Walter
- Wipf Christopher C.
- Wittel Holger
- Woan Graham
- Woehler Janis
- Wofford Jared
- Wong K.W.K.
- Worden John
- Wright Jennifer L.
- Wu David S.
- Wysocki Daniel M.
- Xiao Sophia
- Yamamoto Hiro
- Yancey Cregg C.
- Yang Le
- Yap M.J.
- Yazback Maher
- Yu Hang
- Yu Haocun
- Yvert Michel
- Zadrożny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Sylvia J.
- Zhu Xingjiang J.
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceSpinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far
Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Afrough Mohammad
- Agarwal Bhanu
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Allen Bruce
- Allen Gabrielle
- Allocca Annalisa
- Almoubayyed Husni
- Altin Paul A.
- Amato A.
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Araya Melody C.
- Areeda Joseph S.
- Arnaud Nicolas
- Arun Kg G.
- Ascenzi Stefano
- Ashton Gregory
- Ast M.
- Aston Stuart M.
- Astone Pia
- Aufmuth Peter
- Aulbert Carsten
- AultONeal K.
- Avila-Alvarez A.
- Babak Stanislav
- Bacon Philippe
- Bader Maria K.M.
- Bae Sangwook
- Baker Paul T.
- Baldaccini Francesca
- Ballardin Giulio
- Ballmer Stefan W.
- Banagiri Sharan
- Barayoga Juan C.
- Barclay Sheena E.
- Barish Barry C.
- Barker David
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
- Bartos Imre
- Bassiri Riccardo
- Basti Andrea
- Batch James C.
- Baune Christoph
- Bawaj M.
- Bazzan Marco
- Beer Christian
- Bejger Michal
- Belahcene Imene
- Bell Angus S.
- Berger Beverly K.
- Bergmann Gerald
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Bhagwat Swetha
- Bhandare Rohan
- Bilenko Igor A.
- Billingsley Garilynn
- Billman Chris R.
- Birch Jeremy
- Birney Ross
- Birnholtz Ofek
- Biscans Sebastien
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- Willke Benno
- Wimmer Maximilian H.
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- Woan Graham
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- Worden John
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- Wu David S.
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- Zanolin Michele
- Zelenova Tatiana
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- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Xingjiang
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceDuring their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass 100 M⊙, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than 0.93 Gpc−3 yr−1 in comoving units at the 90% confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits
Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo
- Author
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adhikari Naresh
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Agarwal Deepali
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Ajith P.
- Akutsu Tomotada
- Albanesi Simone
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Anand Chandana
- Anand Shreya
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Ando Masaki
- Andrade Tomas
- Andres Nicolas
- Andrić Tomislav
- Angelova Svetoslava V.
- Ansoldi Stefano
- Antelis J.M.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Arai Koya
- Arai Yuya
- Araki Sakae
- Araya Akito
- Araya Melody C.
- Areeda Joseph S.
- Arellano Fabian E. Peña
- Aritomi Naoki
- Arnaud Nicolas
- Aronson Scott M.
- Arun Kg G.
- Arène Marc
- Asada Hideki
- Asali Yasmeen
- Ashton Gregory
- Aso Yoichi
- Assiduo Maria
- Aston Stuart M.
- Astone Pia
- Aubin Florian
- Austin Corey
- Babak Stanislav
- Badaracco Francesca
- Bader Maria K.M.
- Badger Charles
- Bae Sangwook
- Bae Y.
- Baer Anne M.
- Bagnasco Stefano
- Bai Yuntao
- Baiotti Luca
- Baird Jonathon
- Bajastani L.M. Daneshgaran
- Bajpai Rishabh
- Ball Matthew
- Ballardin Giulio
- Ballmer Stefan W.
- Balsamo Alexander
- Baltus Gregory
- Banagiri Sharan
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- Barbieri Claudio
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- Floden Erik
- Fong Heather
- Font J.A.
- Fornal Bartosz
- Forsyth Perry W.F.
- Franke Alexander
- Frasca Sergio
- Frasconi Franco
- Frederick Chase
- Freed Joshua P.
- Frei Zsolt
- Freise Andreas
- Frey Raymond
- Fritschel Peter
- Frolov Valery V.
- Fronzé Gabriele G.
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- Galaudage Shanika
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- Garaventa Barbara
- García-Núñez C.
- García-Quirós C.
- Garufi Fabio
- Gateley Bubba
- Gaudio Sergio
- Gayathri V.
- Ge G.-G.
- Gemme Gianluca
- Gennai Alberto
- George Jogy
- Gerberding Oliver
- Gergely Laszlo
- Gewecke Pascal
- Ghonge Sudarshan
- Ghosh Abhirup
- Ghosh Archisman
- Ghosh Shaon
- Ghosh Shrobana
- Giacomazzo Bruno
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- Gier Chalisa
- Giesler Matthew
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- Gissi F.
- Glanzer Jane
- Gleckl Amy E.
- Godwin Patrick
- Goetz Evan
- Goetz Ryan
- Gohlke Niklas
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- González Gabriela
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- GOSSELIN Matthieu
- Gouaty Romain
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- Grace Benjamin
- Grado Aniello
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- Wipf Christopher C.
- Wlodarczyk Tom
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- Xu W-R.
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- Yamamoto Hiro
- Yamamoto Kazuhiro
- Yamamoto Kohei
- Yamamoto Takahiro
- Yamashita Kanta
- Yamazaki Ryo
- Yang Fengwei W.
- Yang Le
- Yang Yang
- Yang Yi
- Yang Ziyan
- Yap M.J.
- Yeeles David W.
- Yelikar Anjali B.
- Ying Make
- Yokogawa Kazuya
- Yokoyama J.
- Yokozawa Takaaki
- Yoo Jooheon
- Yoshioka Toshiya
- Yu Hang
- Yu Haocun
- Yuzurihara Hirotaka
- Zadrożny Adam
- Zanolin Michele
- Zeidler Simon
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhan Mingsheng
- Zhang Hong
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhang Yanqi
- Zhao Chunnong
- Zhao Guoying
- Zhao Yue
- Zhao Yuhang
- Zhou Ruinan
- Zhou Zifan
- Zhu Xingjiang J.
- Zhu Z.-H.
- Zimmerman Aaron B.
- Zlochower Y.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'EDP Sciences'
- Publication date
- 01/01/2022
- Field of study
International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100−105 M⊙, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass ∼150 M⊙ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200 M⊙ and effective aligned spin 0.8 at 0.056 Gpc−3 yr−1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpc−3 yr−1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]† Deceased, August 2020
Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo
- Author
- David E.
- Jo F. J.
- Karl
- Loic
- Marc
- Nathan A.
- Romain
- Shreya
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- Van den Broeck Chris
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- Vinciguerra Serena
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- Vitale Salvatore
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- Willke Benno
- Winkler Walter
- Wipf Christopher C.
- Wittel Holger
- Woan Graham
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- Wofford Jared K.
- Wong Chun-fung
- Wright Jennifer L.
- Wu David S.
- Wysocki Daniel M.
- Xiao Liting
- y J.
- Yamamoto Hiro
- Yang Le
- Yang Yang
- Yang Ziyan
- Yap Min-jet J.
- Yazback Maher
- Yeeles David W.
- Yiqiu Ma
- Yu Hang
- Yu Haocun
- Yuen Shingheirobin
- Zadrozny Adam
- Zadrozny Adam K.
- Zanolin Michele
- Zelenova Tatiana
- Zendri Jean-pierre
- Zevin Michael
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhao Chunnong
- Zhao Guoying
- Zhou Minchuan
- Zhou Zifan
- Zhu Xingjiang J.
- Zimmerman Aaron B.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'Elsevier BV'
- Publication date
- 25/12/2019
- Field of study
Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-Gómez Ad
- Adarmes-Gómez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- Alarcón-Martín Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso María Dolores
- Alonso María Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- Antúnez Carmen
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- Auvinen Päivi
- Awaisa Ghazal
- Ayres Gayle
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- Wang Ruiqi
- Wang Yanbing
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- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
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- Au Alicia K
- Auberger Patrick
- Auner Holger W
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avalos Yenniffer
- Aveic Sanja
- Aveleira Celia Alexandra
- AvinWittenberg Tamar
- Aydin Yucel
- Ayton Scott
- Ayyadevara Srinivas
- Azzopardi Maria
- Baba Misuzu
- Backer Jonathan M
- Backues Steven K
- Bae Dong-Hun
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H
- Baek Ahruem
- Baek Seung-Hoon
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- Bagetta Giacinto
- Bagniewska-Zadworna Agnieszka
- Bai Hua
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- Bai Xiyuan
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- Bhattacharya Resham
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- Bhuiyan Md Shenuarin
- Bhutia Sujit Kumar
- Bi Lanrong
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- Biden Trevor J
- Bijian Krikor
- Billes Viktor A
- Binart Nadine
- Bincoletto Claudia
- Birgisdottir Asa B
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- Carra Serena
- Carrier Alice
- Carrier Lucie
- Carroll Bernadette
- Carter A Brent
- Carvalho Andreia Neves
- Casanova Magali
- Casas Caty
- Casas Josefina
- Cassioli Chiara
- Castillo Eliseo F
- Castillo Karen
- Castillo-Lluva Sonia
- Castoldi Francesca
- Castori Marco
- Castro Ariel F
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- Chakrabarti Oishee
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- Chen ChangShi
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- Chen Wei
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- Chen Xiong-Wen
- Chen Xu
- Chen Yan
- Chen Ye-Guang
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- Cheng Jun
- Cheng Shi-Yuan
- Cheng Wei
- Cheng Xiaodong
- Cheng Xiu-Tang
- Cheng Yiyun
- Cheng Zhiyong
- Cheong Heesun
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- Cherry Sara
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- Chiarelli Roberto
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- Choudhury Kamalika Roy
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- Chu Charleen T
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- Chung Hyewon
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- Chung So-Hyang
- Chung Yuen-Li
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- Comincini Sergio
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- Di Leo Luca
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- Falco Alberto
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- Fazeli Gholamreza
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- Guntur Anyonya R
- Guo Chuanyong
- Guo Chun
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- Hao Zijian
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- Harhaji-Trajkovic Ljubica
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- Horos Rastislav
- Hoshida Yujin
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- Irazoqui Javier E
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- Ishimwe Nestor
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- Jackson William T
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- Jewell Jenna L
- Ji Jing
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- Kalamvoki Maria
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- Kalinowski Danuta S
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- Kaminskyy Vitaliy O
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- Kanasaki Keizo
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- Kapuy Orsolya
- Karamouzis Michalis V
- Karim Md Razaul
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- Kawasaki Kiyoshi
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- Khandia Rekha
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- Khundadze Mukhran
- Killackey Samuel A
- Kim Dasol
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- Kirkin Vladimir
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- Korkmaz Gozde
- Korolchuk Viktor I
- Korsnes Monica Suarez
- Koskela Ali
- Kota Janaiah
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- Koukourakis Michael I
- Koustas Evangelos
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- Kozako Tomohiro
- Kraft Claudine
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- Kramer Helmut
- Krasnodembskaya Anna D
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- Kroemer Guido
- Ktistakis Nicholas T
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- Kuenen Sabine
- Kuerschner Lars
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- Kundu Mondira
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- Lee Yong-ho
- Lee Youngil
- Lefebvre Christophe
- Legouis Renaud
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- Lemus Leticia
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- Lenz Guido
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- Li Jing
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- Lin Qiong
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- Lin Su-Ju
- Lin Wenyu
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- Lin Yong
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- Lyamzaev Konstantin G
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- Vincent Olivier
- Vindis Cecile
- Viret Christophe
- Viscomi Maria Teresa
- Visnjic Dora
- Vitale Ilio
- Vocadlo David J
- Voitsekhovskaja Olga V
- Volonte Cinzia
- Volta Mattia
- Vomero Marta
- Von Haefen Clarissa
- Vooijs Marc A
- Voos Wolfgang
- Vucicevic Ljubica
- Wade-Martins Richard
- Waguri Satoshi
- Waite Kenrick A
- Wakatsuki Shuji
- Walker David W
- Walker Mark J
- Walker Simon A
- Walter Jochen
- Wandosell Francisco G
- Wang Bo
- Wang Chao-Yung
- Wang Chen
- Wang Chenran
- Wang Chenwei
- Wang Cun-Yu
- Wang Dong
- Wang Fangyang
- Wang Feng
- Wang Fengming
- Wang Guansong
- Wang Han
- Wang Hao
- Wang Hexiang
- Wang Hong-Gang
- Wang Jianrong
- Wang Jigang
- Wang Jiou
- Wang Jundong
- Wang Kui
- Wang Lianrong
- Wang Liming
- Wang Maggie Haitian
- Wang Meiqing
- Wang Nanbu
- Wang Peipei
- Wang Pengwei
- Wang Ping
- Wang Ping
- Wang Qing
- Wang Qing Jun
- Wang Qing Kenneth
- Wang Qiong A
- Wang Wen-Tao
- Wang Wuyang
- Wang Xinnan
- Wang Xuejun
- Wang Yan
- Wang Yanchang
- Wang Yanzhuang
- Wang YenYun
- Wang Yihua
- Wang Yipeng
- Wang Yu
- Wang Yuqi
- Wang Zhe
- Wang Zhenyu
- Wang Zhouguang
- Warnes Gary
- Warnsmann Verena
- Watada Hirotaka
- Watanabe Eizo
- Watchon Maxinne
- Weaver Timothy E
- Wegrzyn Grzegorz
- Wehman Ann M
- Wei Huafeng
- Wei Lei
- Wei Taotao
- Wei Yongjie
- Weiergraber Oliver H
- Weihl Conrad C
- Weindl Gunther
- Weiskirchen Ralf
- Wells Alan
- Wen Runxia H
- Wen Xin
- Werner Antonia
- Weykopf Beatrice
- Wheatley Sally P
- Whitton J Lindsay
- Whitworth Alexander J
- Wiktorska Katarzyna
- Wildenberg Manon E
- Wileman Tom
- Wilkinson Simon
- Willbold Dieter
- Williams Brett
- Williams Robin SB
- Williams Roger L
- Williamson Peter R
- Wilson Richard A
- Winner Beate
- Winsor Nathaniel J
- Witkin Steven S
- Wodrich Harald
- Woehlbier Ute
- Wollert Thomas
- Wong Esther
- Wong Jack Ho
- Wong Richard W
- Wong Vincent Kam Wai
- Wong W Wei-Lynn
- Wu An-Guo
- Wu Chengbiao
- Wu Jian
- Wu Junfang
- Wu Kenneth K
- Wu Min
- Wu Shan-Ying
- Wu Shengzhou
- Wu Shufang
- Wu ShuYan
- Wu William KK
- Wu Xiaohong
- Wu Xiaoqing
- Wu Yao-Wen
- Wu Yihua
- Xavier Ramnik J
- Xia Hongguang
- Xia Lixin
- Xia Zhengyuan
- Xiang Ge
- Xiang Jin
- Xiang Mingliang
- Xiang Wei
- Xiao Bin
- Xiao Guozhi
- Xiao Hengyi
- Xiao Hong-tao
- Xiao Jian
- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
- Ying Meidan
- Ying Zheng
- Yip Calvin K
- Yiu Stephanie Pei Tung
- Yoo Young H
- Yoshida Kiyotsugu
- Yoshii Saori R
- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field