45 research outputs found
Quantum Phase Transition in a Resonant Level Coupled to Interacting Leads
An interacting one-dimensional electron system, the Luttinger liquid, is
distinct from the "conventional" Fermi liquids formed by interacting electrons
in two and three dimensions. Some of its most spectacular properties are
revealed in the process of electron tunneling: as a function of the applied
bias or temperature the tunneling current demonstrates a non-trivial power-law
suppression. Here, we create a system which emulates tunneling in a Luttinger
liquid, by controlling the interaction of the tunneling electron with its
environment. We further replace a single tunneling barrier with a
double-barrier resonant level structure and investigate resonant tunneling
between Luttinger liquids. For the first time, we observe perfect transparency
of the resonant level embedded in the interacting environment, while the width
of the resonance tends to zero. We argue that this unique behavior results from
many-body physics of interacting electrons and signals the presence of a
quantum phase transition (QPT). In our samples many parameters, including the
interaction strength, can be precisely controlled; thus, we have created an
attractive model system for studying quantum critical phenomena in general. Our
work therefore has broadly reaching implications for understanding QPTs in more
complex systems, such as cold atoms and strongly correlated bulk materials.Comment: 11 pages total (main text + supplementary
Driven coherent oscillations of a single electron spin in a quantum dot
The ability to control the quantum state of a single electron spin in a
quantum dot is at the heart of recent developments towards a scalable
spin-based quantum computer. In combination with the recently demonstrated
exchange gate between two neighbouring spins, driven coherent single spin
rotations would permit universal quantum operations. Here, we report the
experimental realization of single electron spin rotations in a double quantum
dot. First, we apply a continuous-wave oscillating magnetic field, generated
on-chip, and observe electron spin resonance in spin-dependent transport
measurements through the two dots. Next, we coherently control the quantum
state of the electron spin by applying short bursts of the oscillating magnetic
field and observe about eight oscillations of the spin state (so-called Rabi
oscillations) during a microsecond burst. These results demonstrate the
feasibility of operating single-electron spins in a quantum dot as quantum
bits.Comment: Total 25 pages. 11 pages main text, 5 figures, 9 pages supplementary
materia
Hypothalamic Wnt signalling and its role in energy balance regulation
yesWnt signalling and its downstream effectors are well known for their roles in embryogenesis
and tumourigenesis, including the regulation of cell proliferation, survival and differentiation. In
the nervous system, Wnt signalling has been described mainly during embryonic development,
although accumulating evidence suggests that it also plays a major role in adult brain morphogenesis
and function. Studies have predominantly concentrated on memory formation in the
hippocampus, although recent data indicate that Wnt signalling is also critical for neuroendocrine
control of the developed hypothalamus, a brain centre that is key in energy balance regulation
and whose dysfunction is implicated in metabolic disorders such as type 2 diabetes and
obesity. Based on scattered findings that report the presence of Wnt molecules in the tanycytes
and ependymal cells lining the third ventricle and arcuate nucleus neurones of the hypothalamus,
their potential importance in key regions of food intake and body weight regulation has
been investigated in recent studies. The present review brings together current knowledge on
Wnt signalling in the hypothalamus of adult animals and discusses the evidence suggesting a
key role for members of the Wnt signalling family in glucose and energy balance regulation in
the hypothalamus in diet-induced and genetically obese (leptin deficient) mice. Aspects of Wnt
signalling in seasonal (photoperiod sensitive) rodents are also highlighted, given the recent evidence
indicating that the Wnt pathway in the hypothalamus is not only regulated by diet and
leptin, but also by photoperiod in seasonal animals, which is connected to natural adaptive
changes in food intake and body weight. Thus, Wnt signalling appears to be critical as a modulator
for normal functioning of the physiological state in the healthy adult brain, and is also
crucial for normal glucose and energy homeostasis where its dysregulation can lead to a range
of metabolic disorders
A lexicon of DNA modifications: their roles in embryo development and the germline
5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are thought to be solely associated with DNA damage. However, growing evidence indicates that some base modifications, namely 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxylcytosine (5caC), and N6-methadenine (6mA), may be of biological relevance, particularly during early stages of embryo development. Although abundance of these DNA modifications in eukaryotic genomes can be low, there are suggestions that they cooperate with other epigenetic markers to affect DNA-protein interactions, gene expression, defense of genome stability and epigenetic inheritance. Little is still known about their distribution in different tissues and their functions during key stages of the animal lifecycle. This review discusses current knowledge and future perspectives of these novel DNA modifications in the mammalian genome with a focus on their dynamic distribution during early embryonic development and their potential function in epigenetic inheritance through the germ line
Genome-wide methylation is modified by caloric restriction in<i> Daphnia magna</i>
Background
The degradation of epigenetic control with age is associated with progressive diseases of ageing, including cancers, immunodeficiency and diabetes. Reduced caloric intake slows the effects of ageing and age-related disease in vertebrates and invertebrates, a process potentially mediated by the impact of caloric restriction on epigenetic factors such as DNA methylation. We used whole genome bisulphite sequencing to study how DNA methylation patterns change with diet in a small invertebrate, the crustacean Daphnia magna. Daphnia show the classic response of longer life under caloric restriction (CR), and they reproduce clonally, which permits the study of epigenetic changes in the absence of genetic variation.
Results
Global cytosine followed by guanine (CpG) methylation was 0.7â0.9%, and there was no difference in overall methylation levels between normal and calorie restricted replicates. However, 333 differentially methylated regions (DMRs) were evident between the normally fed and CR replicates post-filtering. Of these 65% were hypomethylated in the CR group, and 35% were hypermethylated in the CR group.
Conclusions
Our results demonstrate an effect of CR on the genome-wide methylation profile. This adds to a growing body of research in Daphnia magna that demonstrate an epigenomic response to environmental stimuli. Specifically, gene Ontology (GO) term enrichment of genes associated with hyper and hypo-methylated DMRs showed significant enrichment for methylation and acyl-CoA dehydrogenase activity, which are linked to current understanding of their roles in CR in invertebrate model organisms
ÎČ-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis
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Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at âs = 13 TeV
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp â tH/A â ttÂŻc and pp â tH/A â ttÂŻu processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fbâ1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3
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Search for WâČ bosons decaying to a top and a bottom quark in leptonic final states in proton-proton collisions at = 13 TeV
A preprint version of the article is available at arXiv:2310.19893v1 [hep-ex], https://arxiv.org/abs/2310.19893v1 . Comments: Submitted to the Journal of High Energy Physics. All figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-012 (CMS Public Pages). Report number: CMS-B2G-20-012, CERN-EP-2023-213.A search for W' bosons decaying to a top and a bottom quark in final states including an electron or a muon is performed with the CMS detector at the LHC. The analyzed data correspond to an integrated luminosity of 138 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 Tev. Good agreement with the standard model expectation is observed and no evidence for the existence of the W' boson is found over the mass range examined. The largest observed deviation from the standard model expectation is found for a W' boson mass (mWâČ) hypothesis of 3.8 TeV with a relative decay width of 1%, with a local (global) significance of 2.6 (2.0) standard deviations. Upper limits on the production cross sections of W' bosons decaying to a top and a bottom quark are set. Left- and right-handed W' bosons with mWâČ below 3.9 and 4.3 TeV, respectively, are excluded at the 95% confidence level, under the assumption that the new particle has a narrow decay width. Limits are also set for relative decay widths up to 30%. These are the most stringent limits to date on this W' boson decay channel.SCOAP3
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Search for long-lived heavy neutral leptons with lepton flavour conserving or violating decays to a jet and a charged lepton
A preprint version of the article is available at arXiv:2312.07484v3 [hep-ex], https://arxiv.org/abs/2312.07484 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-013 (CMS Public Pages)A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2-20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fbâ1. A novel jet tagger, based on a deep neural network, has been developed to identify jets from an HNL decay using various features of the jet and its constituent particles. The network output can be used as a powerful discriminating tool to probe a broad range of HNL lifetimes and masses. Contributions from background processes are determined from data. No excess of events in data over the expected background is observed. Upper limits on the HNL production cross section are derived as functions of the HNL mass and the three coupling strengths VâN to each lepton generation â and presented as exclusion limits in the coupling-mass plane, as lower limits on the HNL lifetime, and on the HNL mass. In this search, the most stringent limit on the coupling strength is obtained for pure muon coupling scenarios; values of |VÎŒN|2 > 5 (4) Ă 10â7 are excluded for Dirac (Majorana) HNLs with a mass of 10 GeV at a confidence level of 95% that correspond to proper decay lengths of 17 (10) mm.SCOAP3