3,872 research outputs found
Antegrade selective cerebral perfusion in patients with "bovine aortic arch": is it easier?
[No abstract available
The Halo Occupation Distribution of Active Galactic Nuclei
Using a fully cosmological hydrodynamic simulation that self-consistently
incorporates the growth and feedback of supermassive black holes and the
physics of galaxy formation, we examine the effects of environmental factors
(e.g., local gas density, black hole feedback) on the halo occupation
distribution of low luminosity active galactic nuclei (AGN). We decompose the
mean occupation function into central and satellite contribution and compute
the conditional luminosity functions (CLF). The CLF of the central AGN follows
a log-normal distribution with the mean increasing and scatter decreasing with
increasing redshifts. We analyze the light curves of individual AGN and show
that the peak luminosity of the AGN has a tighter correlation with halo mass
compared to instantaneous luminosity. We also compute the CLF of satellite AGN
at a given central AGN luminosity. We do not see any significant correlation
between the number of satellites with the luminosity of the central AGN at a
fixed halo mass. We also show that for a sample of AGN with luminosity above
10^42 ergs/s the mean occupation function can be modeled as a softened step
function for central AGN and a power law for the satellite population. The
radial distribution of AGN inside halos follows a power law at all redshifts
with a mean index of -2.33 +/- 0.08. Incorporating the environmental dependence
of supermassive black hole accretion and feedback, our formalism provides a
theoretical tool for interpreting current and future measurements of AGN
clustering.Comment: 14 pages, 11 figures, 2 Tables (Matches the MNRAS accepted version
Multi-scale initial conditions for cosmological simulations
We discuss a new algorithm to generate multi-scale initial conditions with
multiple levels of refinements for cosmological "zoom-in" simulations. The
method uses an adaptive convolution of Gaussian white noise with a real space
transfer function kernel together with an adaptive multi-grid Poisson solver to
generate displacements and velocities following first (1LPT) or second order
Lagrangian perturbation theory (2LPT). The new algorithm achieves RMS relative
errors of order 10^(-4) for displacements and velocities in the refinement
region and thus improves in terms of errors by about two orders of magnitude
over previous approaches. In addition, errors are localized at coarse-fine
boundaries and do not suffer from Fourier-space induced interference ringing.
An optional hybrid multi-grid and Fast Fourier Transform (FFT) based scheme is
introduced which has identical Fourier space behaviour as traditional
approaches. Using a suite of re-simulations of a galaxy cluster halo our real
space based approach is found to reproduce correlation functions, density
profiles, key halo properties and subhalo abundances with per cent level
accuracy. Finally, we generalize our approach for two-component baryon and
dark-matter simulations and demonstrate that the power spectrum evolution is in
excellent agreement with linear perturbation theory. For initial baryon density
fields, it is suggested to use the local Lagrangian approximation in order to
generate a density field for mesh based codes that is consistent with
Lagrangian perturbation theory instead of the current practice of using the
Eulerian linearly scaled densities.Comment: 22 pages, 24 figures. MNRAS in press. Updated affiliation
The Star Formation History and Dust Content in the Far Outer Disc of M31
We present a detailed analysis of two fields located 26 kpc (~5 scalelengths)
from the centre of M31. One field samples the major axis populations--the Outer
Disc field--while the other is offset by ~18' and samples the Warp in the
stellar disc. The CMDs based on HST/ACS imaging reach old main-sequence
turn-offs (~12.5 Gyr). We apply the CMD-fitting technique to the Warp field to
reconstruct the star formation history (SFH). We find that after undergoing
roughly constant SF until about 4.5 Gyr ago, there was a rapid decline in
activity and then a ~1.5 Gyr lull, followed by a strong burst lasting 1.5 Gyr
and responsible for 25% of the total stellar mass in this field. This burst
appears to be accompanied by a decline in metallicity which could be a
signature of the inflow of metal-poor gas. The onset of the burst (~3 Gyr ago)
corresponds to the last close passage of M31 and M33 as predicted by detailed
N-body modelling, and may have been triggered by this event. We reprocess the
deep M33 outer disc field data of Barker et al. (2011) in order to compare
consistently-derived SFHs. This reveals a similar duration burst that is
exactly coeval with that seen in the M31 Warp field, lending further support to
the interaction hypothesis. The complex SFHs and the smoothly-varying
age-metallicity relations suggest that the stellar populations observed in the
far outer discs of both galaxies have largely formed in situ rather than
migrated from smaller galactocentric radii. The strong differential reddening
affecting the CMD of the Outer Disc field prevents derivation of the SFH.
Instead, we quantify this reddening and find that the fine-scale distribution
of dust precisely follows that of the HI gas. This indicates that the outer HI
disc of M31 contains a substantial amount of dust and therefore suggests
significant metal enrichment in these parts, consistent with inferences from
our CMD analysis.Comment: Abstract shortened. 17 pages, 12 figures (+ 6 pages & 5 figures in
Appendix). MNRAS, in pres
Which are the most reliable predictors of recurrence of atrial fibrillation after transcatheter ablation?: a meta-analysis.
Context: Transcatheter ablation of atrial fibrillation (AF) has undergone important development, with acceptable midterm results in terms of the safety and recurrence. A meta-analysis was performed to identify the periprocedural complications, midterm success rates and predictors of recurrence after AF ablation. Methods and results: 4357 patients with paroxysmal AF, 1083 with persistent AF and 1777 with long standing AF were included. The pooled analysis showed that there was an in-hospital complication rate of tamponade requiring drainage of 0.99% (0.44-1.54; CI 99%), stroke with neurological persistent impairment of 0.22% (0.04-0.47; CI 99%), and stroke without of 0.36% (0.03-0.70; CI 99%) After a follow up of 22 (13-28) months and 1.23 (1.19-1.5; CI 99%) procedures per patient, the AF recurrence rate was 31.20% (24.87-34.81; CI 99%). The persistent AF patients exhibited a greater risk of recurrence after the first ablation (OR 1.78 [1.14, 2.77] CI 99%), but a trend towards non significance was present in the patients with more than one procedure (OR 1.69 [0.95, 3.00] CI 99%). The most powerful predictors of an AF ablation failure in the overall population were a recurrence within 30-days (OR 4.30; 2.00-10.80), valvular AF (OR 5.20; 2.22-9.50) and a left atrium diameter of more than 50 mm (OR 5.10 2.00-12.90; all CI 95%). Conclusions: Persistent AF remains burdened from higher recurrence rates, however not so following redo-procedures. Three predictors, valvular AF, a left atrium diameter longer than 50 mm and recurrence within 30 days, could be appraised to drive selection of patients and therapeutic strategy. (C) 2012 Elsevier Ireland Ltd. All rights reserved
Self-Regulated Black Hole Growth via Momentum Deposition in Galaxy Merger Simulations
We perform hydrodynamical simulations of major galaxy mergers using new
methods for calculating the growth of massive black holes (BH) in galactic
nuclei and their impact on the surrounding galaxy. We model BH growth by
including a subgrid model for accretion produced by angular momentum transport
on unresolved scales. The impact of the BHs radiation on surrounding gas is
approximated by depositing momentum into the ambient gas, which produces an
outward force away from the BH. We argue that these phenomenological models for
BH growth and feedback better approximate the interaction between the BH and
dense gas in galaxies than previous models. We show that this physics leads to
self-regulated black hole growth: during the peak of activity, the accretion
rate onto the BH is largely determined by the physics of BH feedback, not the
subgrid accretion model. The BH significantly modifies the gas dynamics in the
galactic nucleus (< 300 pc), but does not generate large-scale galactic
outflows. Integrated over an entire galaxy merger, BH feedback has little
effect on the total number of stars formed, but is crucial for setting the BHs
mass.Comment: 5 pages, 3 figures; final version accepted by MNRAS Letters;
conclusions unchange
Nicotinic receptors
Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including depression, anxiety, schizophrenia and Parkinson’s disorders. There is also a great amount of evidence indicating that 5-HT signalling may affect the reinforcing properties of drugs of abuse by the interaction and modulation of dopamine (DA) function. This chapter is focused on one of the more addictive drugs, nicotine. It is widely recognised that the effects of nicotine are strongly associated with the stimulatory action it exhibits on mesolimbic DAergic function. We outline the role of 5-HT and its plethora of receptors, focusing on 5-HT2 subtypes with relation to their involvement in the neurobiology of nicotine addiction. We also explore the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT2C receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required.peer-reviewe
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Methylome reorganization during in vitro dedifferentiation and regeneration of Populus trichocarpa
Background: Cytosine DNA methylation (5mC) is an epigenetic modification that is important to genome stability and regulation of gene expression. Perturbations of 5mC have been implicated as a cause of phenotypic variation among plants regenerated through in vitro culture systems. However, the pattern of change in 5mC and its functional role with respect to gene expression, are poorly understood at the genome scale. A fuller understanding of how 5mC changes during in vitro manipulation may aid the development of methods for reducing or amplifying the mutagenic and epigenetic effects of in vitro culture and plant transformation.
Results: We investigated the in vitro methylome of the model tree species Populus trichocarpa in a system that mimics routine methods for regeneration and plant transformation in the genus Populus (poplar). Using methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq), we compared the methylomes of internode stem segments from micropropagated explants, dedifferentiated calli, and internodes from regenerated plants. We found that more than half (56%) of the methylated portion of the genome appeared to be differentially methylated among the three tissue types. Surprisingly, gene promoter methylation varied little among tissues, however, the percentage of body-methylated genes increased from 9% to 14% between explants and callus tissue, then decreased to 8% in regenerated internodes. Forty-five percent of differentially-methylated genes underwent transient methylation, becoming methylated in calli, and demethylated in regenerants. These genes were more frequent in chromosomal regions with higher gene density. Comparisons with an expression microarray dataset showed that genes methylated at both promoters and gene bodies had lower expression than genes that were unmethylated or only promoter-methylated in all three tissues. Four types of abundant transposable elements showed their highest levels of 5mC in regenerated internodes.
Conclusions: DNA methylation varies in a highly gene-and chromosome-differential manner during in vitro differentiation and regeneration. 5mC in redifferentiated tissues was not reset to that in original explants during the study period. Hypermethylation of gene bodies in dedifferentiated cells did not interfere with transcription, and may serve a protective role against activation of abundant transposable elements.Keywords: Jacq, Palm Elaeis guineensis, Expression analysis, Genome, Cytosine methylation, Arabidopsis cells, Somaclonal variation, Plants, Tissue culture, Gene
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