Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.

Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time

High Energy Physics

This proposal is for the continuation of the High Energy Physics Program at the University of California, Riverside. In 1990, we will concentrate on analysis of LEP data from the OPAL detector. We expect to record 10{sup 5} Z`s by the end of 1989 and 10{sup 6} in 1990. This data will be used to measure the number of quark-lepton families in the universe. In the second half of 1990 we will also be occupied with the installation of the D-Zero detector in the Tevatron Collider and the preparation of software for the 1991 run. A new initiative made possible by generous university support is a laboratory for detector development at UCR. The focus will be on silicon strip tracking detectors both for the D-Zero upgrade and for SSC physics. The theory program will pursue further various mass-generating radiative mechanisms for understanding small quark and lepton masses as well as some novel phenomenological aspects of supersymmetry

High Energy Physics

Hadron collider studies will focus on: (i) the search for the top quark with the newly installed D0 detector at the Fermilab Tevatron collider, (ii) the upgrade of the D0 detector to match the new main injector luminosity and (iii) R&D on silicon microstrip tracking devices for the SSC. High statistics studies of Z{sup 0} decay will continue with the OPAL detector at LEP. These studies will include a direct measurement of Z decay to neutrinos, the search for Higgs and heavy quark decays of Z. Preparations for the Large Scintillation Neutrino Detector (LSND) to measure neutrino oscillations at LAMPF will focus on data acquisition and testing of photomultiplier tubes. In the theoretical area E. Ma will concentrate on mass-generating radiative mechanisms for light quarks and leptons in renormalizable gauge field theories. J. Wudka`s program includes a detailed investigation of the magnetic-flip approach to the solar neutrino

Distortion of the acoustic peaks in the CMBR due to a primordial magnetic field

In this paper we study the effect of a magnetic field on the fluctuation spectrum of the cosmic microwave background. We find that upcoming measurements might give interesting bounds on large scale magnetic fields in the early Universe. If the effects are seen, it might be possible to establish the presence of different fields in different patches of the sky. Absence of any effect, will provide by one order of magnitude a better limit for a primordial field, now given by nucleosynthesis.Comment: 10 pages, 2 .ps figures included, extra reference added and typographical errors correcte

Active-active and active-sterile neutrino oscillation solutions to the atmospheric neutrino anomaly

We perform a fit to the full data set corresponding to 33.3 kt-yr of data of the Super-Kamiokande experiment as well as to all other experiments in order to compare the two most likely solutions to the atmospheric neutrino anomaly in terms of oscillations in the $\nu_\mu \to \nu_\tau$ and $\nu_\mu \to \nu_s$ channels. Using state-of-the-art atmospheric neutrino fluxes we have determined the allowed regions of oscillation parameters for both channels. We find that the $\Delta m^2$ values for the active-sterile oscillations (both for positive and negative $\Delta m^2$) are higher than for the $\nu_\mu \to \nu_\tau$ case, and that the increased Super-Kamiokande sample slightly favours $\nu_\mu \to \nu_\tau$ oscillations over oscillations into a sterile species $\nu_s$, $\nu_\mu \to \nu_s$, and disfavours $\nu_\mu \to \nu_e$. We also give the zenith angle distributions predicted for the best fit points in each of the possible oscillation channels. Finally we compare our determinations of the atmospheric neutrino oscillation parameters with the expected sensitivities of future long-baseline experiments K2K, MINOS, ICARUS, OPERA and NOE.Comment: Updated to 535 days of Super-Kamiokande and corresponding modifications in the discussion and figures. Some References adde

Limits on Active-Sterile Neutrino Mixing and the Primordial Deuterium Abundance

Studies of limits on active-sterile neutrino mixing derived from big bang nucleosynthesis considerations are extended to consider the dependance of these constraints on the primordial deuterium abundance. This study is motivated by recent measurements of D/H in quasar absorption systems, which at present yield discordant results. Limits on active-sterile mixing are somewhat relaxed for high D/H. For low D/H ($\approx 2 \times 10^{-5}$), no active-sterile neutrino mixing is allowed by currently popular upper limits on the primordial $^4$He abundance $Y$. For such low primordial D/H values, the observational inference of active-sterile neutrino mixing by upcoming solar neutrino experiments would imply that $Y$ has been systematically underestimated, unless there is new physics not included in standard BBN.Comment: 10 pages + 2 figures, uses revtex macros, submitted to Phys. Rev. D. Corrected figure captions and an added referenc

Neutrino Decay as an Explanation of Atmospheric Neutrino Observations

We show that the observed zenith angle dependence of the atmospheric neutrinos can be accounted for by neutrino decay. Furthermore, it is possible to account for all neutrino anomalies with just three flavors.Comment: 4 pages, 1 figur

When is a Publishing Business Truly ‘Global’? An Analysis of a Routledge Case Study with Reference to Ohmae’s Theory of Globalization

This study first reviews the writing of the management theorist Kenichi Ohmae, before assessing the potential application of his theory of global commercial maturation to the strategies adopted by the academic publishing company, Routledge, and its precursor imprints between 1960 and 2013. Based on the analysis of interviews carried out between 2011 and 2013 and supporting document analysis, the paper concludes that, with some caveats, the stages of globalization identified by Ohmae are of considerable explanatory value for students and analysts of global publishing as well as offering strategic insights to managers of academic publishing houses

Models of Light Singlet Fermion and Neutrino Phenomenology

We suggest that a singlet fermion $S$ exists beyond the standard see-saw structure. It mixes with light neutrinos via interactions with the right-handed neutrino components, so that \n_e \to S conversion solves the solar neutrino problem. Supersymmetry endowed with R-symmetry is shown to give a natural framework for existence, mass scale and mixing ($\sin^22\th_{es} \sim (0.1-1.5)\cdot 10^{-2}$) of such a fermion. Models with an approximate horizontal symmetry are constructed, which embed the fermion $S$ and explain simultaneously solar, atmospheric, hot dark matter problems as well as may predict the oscillation \bar{\n}_\m \to \bar{\n}_e in the region of sensitivity of KARMEN and LSND experiments.Comment: 14 pages, latex, no figure

Light Gravitinos as Mixed Dark Matter

In theories with a gauge-mediated mechanism of supersymmetry breaking the gravitino is likely to be the lightest superparticle and, hence, a candidate for dark matter. We show that the decay of the next-to-lightest superparticle into a gravitino can yield a non-thermal population of gravitinos which behave as a hot dark matter component. Together with the warm component, which is provided by the population of gravitinos of thermal origin, they can give rise to viable schemes of mixed dark matter. This realization has some specific and testable features both in particle physics and astrophysics. We outline under which conditions the mechanism remains viable even when R parity is broken.Comment: 18 pages, LaTeX, no figur