Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Numerical and experimental lateral vibration assessment of an in-service footbridge

This paper describes the experimental and numerical lateral vibration assessment of La Paz footbridge (LPF) as part of a research project of pedestrian structures located in Madrid. LPF is a cable-stayed structure with main span of 85m and total length of 127.8m. A preliminary analysis predicted a first lateral mode close to 0.9Hz, which is within the critical range and, consequently, a further analysis was required. The numerical assessment was performed in the frequency domain and the pedestrian action was defined using the HIVOSS guide. The experimental evaluation consisted in both the modal testing of the structure to validate the numerical model, and interaction pedestrian tests. The numerical model is in accordance with the tests and thus the footbridge dynamics is accurately determined. However, the interaction pedestrian tests are not sufficient to evaluate the LPF performance under dense traffic conditions.The authors acknowledge the financial support provided by the Spanish Ministry of Science, Innovation and Universities through the project SEED-SD (RTI2018-099639-B-I00)

Numerical and experimental lateral vibration assessment of an in-service footbridge

This paper describes the experimental and numerical lateral vibration assessment of La Paz footbridge (LPF) as part of a research project of pedestrian structures located in Madrid. LPF is a cable-stayed structure with main span of 85m and total length of 127.8m. A preliminary analysis predicted a first lateral mode close to 0.9Hz, which is within the critical range and, consequently, a further analysis was required. The numerical assessment was performed in the frequency domain and the pedestrian action was defined using the HIVOSS guide. The experimental evaluation consisted in both the modal testing of the structure to validate the numerical model, and interaction pedestrian tests. The numerical model is in accordance with the tests and thus the footbridge dynamics is accurately determined. However, the interaction pedestrian tests are not sufficient to evaluate the LPF performance under dense traffic conditions.The authors acknowledge the financial support provided by the Spanish Ministry of Science, Innovation and Universities through the project SEED-SD (RTI2018-099639-B-I00)

Toxicity assessment of cobalt ferrite nanoparticles on wheat plants

<p>Cobalt ferrite nanoparticles (NPs) have received increasing attention due to their widespread therapeutic and agricultural applicability. In the environmental field, dry powder- and ferrofluid-suspended cobalt ferrite NPs were found to be useful for removing heavy metals and metalloids from water, while diluted suspensions of cobalt ferrite NP have been promisingly applied in medicine. However, the potential toxicological implications of widespread exposure are still unknown. Since cobalt ferrite NPs are considered residual wastes of environmental or medical applications, plants may serve as a point-of-entry for engineered nanomaterials as a result of consumption of these plants. Thus, the aim of this study was to assess the effects of dry powder and fresh cobalt ferrite NP on wheat plants. Seven-day assays were conducted, using quartz sand as the plant growth substrate. The toxicity end points measured were seed germination, root and shoot lengths, total cobalt (Co) and iron (Fe) accumulation, photosynthetic pigment production, protein (PRT) production, and activities of catalase (CAT), ascorbate peroxidase (APX), and guaiacol peroxidase (GPX). Increasing total Co and Fe in plant tissues indicated that wheat plants were exposed to cobalt ferrite NP. Seed germination and shoot length were not sufficiently sensitive toxicity end points. The effective concentration (EC₅₀) that diminished root length of plants by 50% was 1963 mg/kg for fresh ferrite NPs and 5023 mg/kg for powder ferrite NP. Hence, fresh ferrite NPs were more toxic than powder NP. Plant stress was indicated by a significant decrease in photosynthetic pigments. CAT, APX, and GPX antioxidant enzymatic activity suggested the generation of reactive oxygen species and oxidative damage induced by cobalt ferrite NP. More studies are thus necessary to determine whether the benefits of using these NPs outweigh the risks.</p

Estudios sociales y administrativos en América Latina

Esta obra contiene la compilación de una serie de investigaciones latinoamericanas en las cuales se presenta los nuevos enfoques investigativos, metodológicos y cientificos. Para la generación de soluciones que contribuyan a la toma de decisiones en variables, sociales, economicas y administrativas en los diferentes contextos organizacionales. Además de estos elementos, en esta obra se presentan nuevas apuestas multidisciplinares cuanti-cualitativas en las cuales se destacan la ingeniería, derecho entre otros.

Science with the Cherenkov Telescope Array

The Cherenkov Telescope Array, CTA, will be the major global observatory forvery high energy gamma-ray astronomy over the next decade and beyond. Thescientific potential of CTA is extremely broad: from understanding the role ofrelativistic cosmic particles to the search for dark matter. CTA is an explorerof the extreme universe, probing environments from the immediate neighbourhoodof black holes to cosmic voids on the largest scales. Covering a huge range inphoton energy from 20 GeV to 300 TeV, CTA will improve on all aspects ofperformance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to providefull sky coverage and will hence maximize the potential for the rarestphenomena such as very nearby supernovae, gamma-ray bursts or gravitationalwave transients. With 99 telescopes on the southern site and 19 telescopes onthe northern site, flexible operation will be possible, with sub-arraysavailable for specific tasks. CTA will have important synergies with many ofthe new generation of major astronomical and astroparticle observatories.Multi-wavelength and multi-messenger approaches combining CTA data with thosefrom other instruments will lead to a deeper understanding of the broad-bandnon-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory,with all data available on a public archive after a pre-defined proprietaryperiod. Scientists from institutions worldwide have combined together to formthe CTA Consortium. This Consortium has prepared a proposal for a CoreProgramme of highly motivated observations. The programme, encompassingapproximately 40% of the available observing time over the first ten years ofCTA operation, is made up of individual Key Science Projects (KSPs), which arepresented in this document

Deep underground neutrino experiment (DUNE) near detector conceptual design report

The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents. © 2021 by the authors. Licensee MDPI, Basel, Switzerland