Use of Innovative Fabrics to Sewing Work Clothes

При производстве рабочей одежды используются натуральные, синтетические и смесовые ткани. Натуральные ткани хорошо пропускают воздух, гигиеничные, не вызывают раздражения, не накапливают статическое электричество, но уступают синтетике по износостойкости, прочности и устойчивости к загрязнениям. Синтетические ткани эластичны, долговечны, легко стираются, но у них есть свои недостатки - они плохо пропускают воздух, не комфортные при высокой температуре, могут вызывать раздражение кожи. Самые популярные ткани для изготовления спецодежды - смесовые. Материал нужно выбирать для определенных условий. Материал, который отвечает всем требованиям, предъявляемым к спецодежде сварщика является базальтовая ткань, которая не воспламеняется, не горит, не подвергается коррозии, виброустойчива, обладает высокой химической стойкостью к щелочным и кислотным средам, рабочий диапазон температур от -250 °С до +700 °С, а также обладает долговечностью, высокой стойкостью к разложению и механическому износу.In the production of workwear, natural, synthetic and blended fabrics are used. Natural fabrics well pass air, hygienic, do not cause irritation, do not accumulate static electricity, but are inferior to synthetics in terms of wear resistance, strength and resistance to pollution. Synthetic fabrics are elastic, durable, easy to wash, but they have their drawbacks - they are poorly breathable, not comfortable at high temperatures, and can cause skin irritation. The most popular fabrics for the manufacture of workwear are blended. The material must be selected for certain conditions. The material that meets all the requirements for the workwear of the welder is basalt fabric, which is not ignited, does not burn, does not undergo corrosion, is vibration resistant, has high chemical resistance to alkaline and acidic media, operating temperature range from -250 °C to +700 °C, and also has durability, high resistance to decomposition and mechanical wear

Analysis of the Physical and Mechanical Properties of Basalt Clays

Рассмотрены вопросы комплексной оценки качества базальтовых полотен. Комплексно изучены физико-механические свойства базальтовых полотен. Проведены лабораторные анализы с целью определения их устойчивости на разрыв, растяжение и сжатие.The issues of a comprehensive assessment of the quality of basalt sheets are considered. The physical and mechanical properties of basalt sheets were comprehensively studied. Laboratory analyzes were carried out to determine their resistance to tearing, stretching and compression

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

Background: Endoplasmic reticulum (ER) lumenal protein thiol redox balance resists dramatic variation in unfolded protein load imposed by diverse physiological challenges including compromise in the key upstream oxidases. Lumenal calcium depletion, incurred during normal cell signaling, stands out as a notable exception to this resilience, promoting a rapid and reversible shift towards a more reducing poise. Calcium depletion induced ER redox alterations are relevant to physiological conditions associated with calcium signaling, such as the response of pancreatic cells to secretagogues and neuronal activity. The core components of the ER redox machinery are well characterized; however, the molecular basis for the calcium-depletion induced shift in redox balance is presently obscure. Results: In vitro, the core machinery for generating disulfides, consisting of ERO1 and the oxidizing protein disulfide isomerase, PDI1A, was indifferent to variation in calcium concentration within the physiological range. However, ER calcium depletion in vivo led to a selective 2.5-fold decline in PDI1A mobility, whereas the mobility of the reducing PDI family member, ERdj5 was unaffected. In vivo, fluorescence resonance energy transfer measurements revealed that declining PDI1A mobility correlated with formation of a complex with the abundant ER chaperone calreticulin, whose mobility was also inhibited by calcium depletion and the calcium depletion-mediated reductive shift was attenuated in cells lacking calreticulin. Measurements with purified proteins confirmed that the PDI1A-calreticulin complex dissociated as Ca2+ concentrations approached those normally found in the ER lumen ([Ca2+] K-0.5max = 190 mu M). Conclusions: Our findings suggest that selective sequestration of PDI1A in a calcium depletion-mediated complex with the abundant chaperone calreticulin attenuates the effective concentration of this major lumenal thiol oxidant, providing a plausible and simple mechanism for the observed shift in ER lumenal redox poise upon physiological calcium depletion.Wellcome Trust [Wellcome 084812/Z/08/Z]; European Commission (EU FP7 Beta-Bat) [277713]; Fundacao para a Ciencia e Tecnologia, Portugal [PTDC/QUI-BIQ/119677/2010]info:eu-repo/semantics/publishedVersio

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

Most MPN patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells we developed a novel strategy (KISMET) which utilises the full range of kinase selectivity data available from each inhibitor and thus takes advantage of off-target noise that limits conventional siRNA or inhibitor screens. KISMET successfully identified known essential kinases in haematopoietic and non-haematopoietic cell lines and identified the MAPK pathway as required for growth of the CALR-mutated MARIMO cells. Expression of mutant CALR in murine or human haematopoietic cell lines was accompanied by MPL-dependent activation of MAPK signalling, and MPN patients with CALR mutations showed increased MAPK activity in CD34-cells, platelets and megakaryocytes. Although CALR mutations resulted in protein instability and proteosomal degradation, mutant CALR was able to enhance megakaryopoiesis and pro-platelet production from human CD34+ progenitors. These data link aberrant MAPK activation to the MPN phenotype and identify it as a potential therapeutic target in CALR-mutant positive MPNs.Leukemia accepted article preview online, 14 October 2016. doi:10.1038/leu.2016.280.Work in the Green lab is supported by Leukemia and Lymphoma Research, Cancer Research UK, the NIHR Cambridge Biomedical Research Centre, the Cambridge Experimental Cancer Medicine Centre and the Leukemia & Lymphoma Society of America. WW is supported by the Austrian Science Foundation (J 3578-B21). CGA is supported by Kay Kendall Leukaemia Fund clinical research fellowship. UM is supported by a Cancer Research UK Clinician Scientist Fellowship. Work in the Huntly lab is supported by the European Research Council, the MRC (UK), Bloodwise, the Cambridge NIHR funded BRC, KKLF and a WT/MRC Stem Cell centre grant. Work in the Green and Huntly Labs is supported by core support grants by the Wellcome Trust to the Cambridge Institute for Medical Research (100140/z/12/z) and Wellcome Trust-MRC Cambridge Stem Cell Institute (097922/Z/11/Z)

CMS physics technical design report : Addendum on high density QCD with heavy ions

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