Эрелзи® – биоаналог этанерцепта в лечении ревматических заболеваний и псориаза (резолюция Совета экспертов)

Introduction of biosimilars of biological disease-modifying antirheumatic drugs (bDMARs) into clinical practice has significantly expanded the availability of bDMARD therapy for a wide range of patients with chronic immuno-inflammatory diseases.In 2020, the first biosimilar etanercept Erelzi®, was registered in the Russian Federation. On May 22, 2021, an interdisciplinary Expert panel meeting was held on the use of Erelzi® for the treatment of rheumatic diseases and psoriasis. The leading Russian rheumatologists and dermatologists participated in this meeting. In the resolution of the Expert panel, it was stated that according data from randomized clinical trials and real clinical practice and due to low immunogenic potential of Erelzi, it can be used in initial therapy and in switching from other bDMARDs therapy in patients, who develop adverse reactions or face loss of their therapy effectiveness.Внедрение в клиническую практику биоаналогов генно-инженерных биологических препаратов (ГИБП) значительно расширило доступность генно-инженерной биологической терапии для широкого круга больных с хроническими иммуновоспалительными заболеваниями.В 2020 г. в Российской Федерации был зарегистрирован первый биоаналог этанерцепта – препарат Эрелзи®. 22 мая 2021 г. состоялось междисциплинарное заседание Совета экспертов, посвященное использованию Эрелзи® для лечения ревматических заболеваний и псориаза. В заседании участвовали ведущие российские ревматологи и дерматологи. В резолюции Совета экспертов зафиксировано, что низкий иммуногенный потенциал Эрелзи®, данные рандомизированных клинических исследований и реальной клинической практики, указывают на возможность использования этого препарата при инициации терапии и переключении пациентов с других ГИБП в случае потери их эффективности и/или развития нежелательных реакций

Endothelial function, regulation of angiogenesis and embryonic central hemodynamics in ART-conceived pregnancies

This study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, nј39) and normally conceived (control group, nј68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro-antiangiogenic factors balance and increase in vascular impedance in ART-conceived embryos

Опыт применения ингибитора интерферона I типа по программе раннего доступа для лечения резистентных форм системной красной волчанки

The article presents the results of treatment of patients with systemic lupus erythematosus (SLE), who, due to resistance to traditional regimens, for the first time in the Russian Federation were included in the early access program of the type I interferon inhibitor – anifrolumab. Clinical data and results of instrumental examinations of a patient with SLE on the background of 6-month therapy are presented.Представлен опыт лечения пациентов с системной красной волчанкой (СКВ), которые в связи с резистентностью к традиционным схемам впервые в Российской Федерации были включены в программу раннего доступа ингибитора интерферона I типа – анифролумаба. Приведены клинические данные и результаты инструментальных методов обследования на фоне 6-месячной терапии у пациентки с СКВ

Evaluation of myocardial damage in different types of rheumatoid arthritisduring disease-modifying antirheumatic drug or biological therapy (with infliximab)

Objective. To estimate the extent and pattern of myocardial damage in different types of rheumatoid arthritis (RA) during disease-modifying antirheumatic drug (DMARD) or biological therapy. Subjects and methods. Seventy-one patients with RA were examined; some of them received biological therapy with infliximab, while the others took DMARDs. A group of patients with incipient RA was also identified. B-type brain natriuretic peptide levels were estimated and electrocardiography, echocardiography (EchoCG), and cardiac magnetic resonance imaging (MRT) using the contrast medium Dotarem were conducted in all the patients. The follow-up totaled 6 months. A control examination was made at the moment of randomization and 6 months posttreatment. Results. Tn the bulk of patients, the level of B-type brain natriuretic peptide did not differ from the reference values, however, its lower level was observed in the incipient RA group, which was associated with the absence of cardiovascular diseases and with a younger age group. There were no negative EchoCG changes in myocardial viability values. Cardiac MRT demonstrated that the majority of patients had the similar changes that failed to affect myocardial kinetics and ejection fraction. These changes were not found in incipient RA patients without cardiovascular diseases. No improvement in myocardial viability was recorded in the patients receiving the biological therapy. Conclusion. Thus, cardiac MRT showed the similar changes that failed to affect myocardial kinetics and ejection fraction in patients with RA during both methotrexate and infliximab therapy

Успешное применение ингибитора интерлейкина17A (иксекизумаба) в лечении псориатического артрита

Psoriatic arthritis (PsA) is a chronic immune-mediated disease from a group of spondyloarthritis, which is characterized by damage to the musculoskeletal system with a wide range of different clinical manifestations and is usually associated with psoriasis. Activation of the interleukin (IL) 23/IL17 axis plays a key role in the pathogenesis of PsA and psoriasis. When non-steroidal and synthetic disease-modifying antirheumatic drugs are insufficiently effective, biological drugs are recommended. In recent years, there have been considerable advances in PsA treatment with tumor necrosis factor-α (IFN-α) inhibitors and IL-12/23 inhibitors. However, in some cases, this therapy fails to provide the desired effect and a search for new treatments for PsA seems to be an urgent task. The paper desctibes a clinical case demonstrating the efficacy of the IL17A inhibitor ixekizumab in a patient with high PsA activity and recurrent uveitis in both eyes. Ixekizumab therapy resulted in positive changes as the reduced severity of articular syndrome and psoriasis and normalization of acute phase parameters. Assessing the activity of PsA over time when using ixekizumab during a year showed an average decrease in ESR from 72 to 19 mm/h, in CRP from 162.1 to 0 mg/L, BSA from 51 to 0.25%, PASI from 43. 6 to 0, DAPSA from 78.2 to 2, ASDAS-SRB from 5.11 to 1.12, BASDAI from 4.85 to 1, BASFI from 5.3 to 0.7, BASMI from 5.0 to 2.6, MASES from 6 to 0, LEI from 2 to 0, SPARCC from 6 to 0, and NAPSI from 28 to 8. Thus, this clinical case is an example of successful treatment with the IL17 inhibitor ixekizumab for PsA with recurrent uveitis in the patient who has previously received three drugs from the TNFα group without any effect.Псориатический артрит (ПсА) представляет собой хроническое иммуноопосредованное заболевание из группы спондилоартритов, характеризующееся поражением опорно-двигательного аппарата с широким спектром различных клинических проявлений, обычно ассоциированное с псориазом. Основная роль в патогенезе ПсА и псориаза принадлежит активации оси интерлейкин (ИЛ) 23/ИЛ17. При недостаточной эффективности нестероидных и синтетических базисных противовоспалительных препаратов рекомендовано назначение генно-инженерных биологических препаратов. В последние годы достигнуты существенные успехи в лечении ПсА с использованием ингибиторов фактора некроза опухоли α (иФНОα) и ингибиторов ИЛ (иИЛ) 12/23. Однако в ряде случаев указанная терапия не дает желаемого эффекта, и поиск новых средств лечения ПсА представляется актуальной задачей. В статье приведено клиническое наблюдение, демонстрирующее эффективность иИЛ17А иксекизумаба (Талс) у пациента с высокой активностью ПсА и рецидивирующим увеитом обоих глаз. Терапия иксекизумабом привела к положительной динамике в виде уменьшения выраженности суставного синдрома и псориаза, нормализации острофазовых показателей. При оценке активности ПсА в динамике на фоне применения иксекизумаба в течение года отмечалось снижение СОЭ в среднем с 72 до 19 мм/ч, уровня СРБ с 162,1 до 0 мг/л, BSA с 51 до 0,25%, PASI с 43,6 до 0, DAPSA с 78,2 до 2, ASDAS-СРБ с 5,11 до 1,12, BASDAI с 4,85 до 1, BASFI с 5,3 до 0,7, BASMI с 5,0 до 2,6, MASES с 6 до 0, LEI с 2 до 0, SPARCC с 6 до 0, NAPSI с 28 до 8. Таким образом, данный клинический случай является примером успешного лечения иИЛ17 иксекизумабом ПсА с рецидивирующим увеитом у пациента, ранее получавшего без эффекта три препарата из группы иФНОα

Observation of two new Ξb−\Xi_b^- baryon resonances

Two structures are observed close to the kinematic threshold in the $\Xi_b^0 \pi^-$ mass spectrum in a sample of proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ recorded by the LHCb experiment. In the quark model, two baryonic resonances with quark content $bds$ are expected in this mass region: the spin-parity $J^P = \frac{1}{2}^+$ and $J^P=\frac{3}{2}^+$ states, denoted $\Xi_b^{\prime -}$ and $\Xi_b^{*-}$. Interpreting the structures as these resonances, we measure the mass differences and the width of the heavier state to be $m(\Xi_b^{\prime -}) - m(\Xi_b^0) - m(\pi^{-}) = 3.653 \pm 0.018 \pm 0.006$ MeV$/c^2$, $m(\Xi_b^{*-}) - m(\Xi_b^0) - m(\pi^{-}) = 23.96 \pm 0.12 \pm 0.06$ MeV$/c^2$, $\Gamma(\Xi_b^{*-}) = 1.65 \pm 0.31 \pm 0.10$ MeV, where the first and second uncertainties are statistical and systematic, respectively. The width of the lighter state is consistent with zero, and we place an upper limit of $\Gamma(\Xi_b^{\prime -}) < 0.08$ MeV at 95% confidence level. Relative production rates of these states are also reported.Comment: 17 pages, 2 figure

Differential branching fraction and angular analysis of the decay B0→K∗0μ+μ−

The angular distribution and differential branching fraction of the decay B 0→ K ∗0 μ + μ − are studied using a data sample, collected by the LHCb experiment in pp collisions at s√=7 TeV, corresponding to an integrated luminosity of 1.0 fb−1. Several angular observables are measured in bins of the dimuon invariant mass squared, q 2. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q20=4.9±0.9GeV2/c4 , where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions

Measurement of the relative rate of prompt χc0, χc1 and χc2 production at √s=7TeV

Prompt production of charmonium χc0, χc1 and χc2 mesons is studied using proton-proton collisions at the LHC at a centre-of-mass energy of √s=7TeV. The χc mesons are identified through their decay to J/ψγ, with J/ψ→μ+mu− using photons that converted in the detector. A data sample, corresponding to an integrated luminosity of 1.0fb−1 collected by the LHCb detector, is used to measure the relative prompt production rate of χc1 and χc2 in the rapidity range 2.0<y<4.5 as a function of the J/ψ transverse momentum from 3 to 20 GeV/c. First evidence for χc0 meson production at a hadron collider is also presented