Phonological development of Finnish speaking children at 3;6 and associations to previous and simultaneous lexical ability

Previous studies of Finnish children's phonological development focus mainly on children under 2;0. Earlier findings have suggested that phonological and lexical development are strongly associated at an early age. However, less is known about the longitudinal association. This study describes the phonological skills of Finnish-speaking children at 3;6 and compares them with early lexicon size at 2;0 and lexical ability at 3;6 (N = 67). The children's phonological development was measured using The Finnish Phonology Test. Lexical development was evaluated using the Finnish, long-form version of the Communicative Development Inventory at 2;0 and the Boston naming test at 3;6 At 3;6, all children mastered the vowels and diphthongs fully, and most of the children also mastered the consonants, with the exception of the phonemes/d/and/r/. Phonotactic skills had also been acquired well at this group level, although the word-medial and, especially, word-initial consonant clusters were still challenging. The percentage of phonemes correct was 95. Both paradigmatic and phonotactic skills at 3;6 were significantly associated with lexicon size at 2;0. In addition phonotactic skills correlated with naming ability at 3;6. Lexical development at 2;0 explained 21% of the variance in the phonological development at 3;6, whereas, the explaining value of simultaneous lexical skill was limited (9%). Present findings propose that associations between lexical and phonological skills weaken as phonological skills become more honed.Peer reviewe

Yhteistoimintaa ja yksilöllisiä valintoja kuntoutumisen polulla : Kelan työhönkuntoutuksen kehittämishankkeen tapaustutkimus

Tämä tutkimus on osa Kelan työhönkuntoutuksen kehittämishankkeeseen (TK2-hanke) kohdistunutta arviointitutkimusta, jonka tehtävä oli arvioida kuntoutusmallin toteutumista ja toimivuutta sekä sen vaikutuksia ja hyötyjä kuntoutujan, työpaikan, työterveyshuollon ja kuntoutuksen palvelutuottajan näkökulmista. Tapaustutkimuksen tavoite oli tuottaa tietoa kuntoutujan kuntoutus- ja kuntoutumisprosessista, sen sisällöstä ja etenemisestä sekä kuntoutumista edistävistä ja haittaavista mekanismeista. Monimenetelmällinen tapaustutkimus koski 11:tä kuntoutujaa. Siinä sovellettiin fenomenologista ajattelutapaa, realistisen arvioinnin käsitteitä ja vertailevan analyysin metodia. Tutkimuksessa oli moninäkökulmainen haastatteluaineisto sekä asiakirja- ja kyselyaineistot. Aineistojen analyysissä koottiin ensin kaikista aineistoista tutkimuskysymyksittäin tapauskuvaukset, ja toisessa vaiheessa tapauksia vertailtiin kuntoutujan työuraan liittyvien vaikutusten näkökulmasta. Toimijoiden yhteistoiminta edisti kuntoutumista. Kuntoutujan oman toimijuuden lisäksi keskeistä oli esimiehen tai työpaikan osallistuminen. Vaikutukset, jotka kytkeytyivät työhön ja työuraan, edellyttivät työpaikan ja esimiehen aktiivista osallistumista kuntoutusprosessiin. Kuntoutuksen tulokset rajoittuivat kuntoutujan omaan terveyteen ja hyvinvointiin, jos kuntoutumista edistävä mekanismi työpaikalla ja esimiestyössä ei toiminut. Työterveyshuollon aktiivinen kumppanuus edisti erityisesti osatyökykyisten kuntoutumista. TK2-malli vaikutti merkittävästi yksilön hyvinvointiin ja tuki työssä jatkamista, kun kuntoutujan toimijuutta tuettiin ja hän sai riittävästi tietoa tavoitteiden asettamista ja päätöksentekoa varten.25,00 euro

Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A

Screening of an in-house library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the 2-methylthiazole derivative 18, with an IC50 value of 3.4 ± 0.2 µM and promising selectivity. ABHD16A has been highlighted as a new target for in-flammation-mediated pain, although selective inhibitors of hABHD16A (human ABHD16A) have not yet been reported. Our study presents abietane-type diterpenoids as an attractive starting point for the design of selective ABHD16A inhibitors, which will contribute towards understanding the significance of hABHD16A inhibition in vivo

Study protocol: the effects of work-site exercise on the physical fitness and work-ability of older workers

BACKGROUND: Older workers have a higher rate and cost of injury than younger workers and with a rapidly ageing work force there is a need to identify strategies to address this problem. Older workers are less physically active and fit than younger workers and so have reduced work ability. The reduced work ability means they are more likely to be fatigued at work and so at greater risk of injury. Exercise could potentially assist this problem. Exercise training has been previously shown to improve fitness in older people however there has been no evaluation of workplace exercise program for older workers. We do not know if the programs are feasible and can improve the fitness and work ability of older workers. We have designed a randomised controlled trial to evaluate whether exercise improves fitness and perceived work-ability of older workers. METHODS/DESIGN: This paper describes the protocol for a trial examining the effects of a 12-week physical training program in workers over the age of 45. Participants will be randomized to an exercise or no-intervention control group. The primary outcomes are cardiorespiratory endurance, lifting capacity, upper and lower limb strength and perceived work-ability. DISCUSSION: This trial will test the feasibility of implementing a worksite-based exercise program as a means of improving the physical fitness and work-ability of older workers performing physically demanding work. If we demonstrate the feasibility of the program we will conduct a larger trial that additionally measures injury outcomes

Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis

Viral proteins are frequently multifunctional to accommodate the high density of information encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as Rhabdoviridae is one such example. Its primary function is virus assembly/budding but it is also involved in the switch from viral transcription to replication and the concomitant down regulation of host gene expression. In this study we undertook a search for potential rabies virus (RV) M protein's cellular partners. In a yeast two-hybrid screen the eIF3h subunit was identified as an M-interacting cellular factor, and the interaction was validated by co-immunoprecipitation and surface plasmon resonance assays. Upon expression in mammalian cell cultures, RV M protein was localized in early small ribosomal subunit fractions. Further, M protein added in trans inhibited in vitro translation on mRNA encompassing classical (Kozak-like) 5′-UTRs. Interestingly, translation of hepatitis C virus IRES-containing mRNA, which recruits eIF3 via a different noncanonical mechanism, was unaffected. Together, the data suggest that, as a complement to its functions in virus assembly/budding and regulation of viral transcription, RV M protein plays a role in inhibiting translation in virus-infected cells through a protein–protein interaction with the cellular translation machinery

A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy

Many men develop a rising PSA after initial therapy for prostate cancer. While some of these men will develop a local or metastatic recurrence that warrants further therapy, others will have no evidence of disease progression. We hypothesized that an expression biomarker panel can predict which men with a rising PSA would benefit from further therapy.A case-control design was used to test the association of gene expression with outcome. Systemic (SYS) progression cases were men post-prostatectomy who developed systemic progression within 5 years after PSA recurrence. PSA progression controls were matched men post-prostatectomy with PSA recurrence but no evidence of clinical progression within 5 years. Using expression arrays optimized for paraffin-embedded tissue RNA, 1021 cancer-related genes were evaluated-including 570 genes implicated in prostate cancer progression. Genes from 8 previously reported marker panels were included. A systemic progression model containing 17 genes was developed. This model generated an AUC of 0.88 (95% CI: 0.84-0.92). Similar AUCs were generated using 3 previously reported panels. In secondary analyses, the model predicted the endpoints of prostate cancer death (in SYS cases) and systemic progression beyond 5 years (in PSA controls) with hazard ratios 2.5 and 4.7, respectively (log-rank p-values of 0.0007 and 0.0005). Genes mapped to 8q24 were significantly enriched in the model.Specific gene expression patterns are significantly associated with systemic progression after PSA recurrence. The measurement of gene expression pattern may be useful for determining which men may benefit from additional therapy after PSA recurrence

The effects of the size and weight of a mobile device on an educational game

In this paper, we present an educational game for an iPhone and a Tablet PC. The main objective of the game was to reinforce children's knowledge about the water cycle. The game included different interaction forms like the touch screen and the accelerometer and combined AR mini-games with non-AR mini-games for better gameplay immersion. The main differences between the two devices were screen size and weight. A comparative study to check how these differences affect different aspects was carried out. Seventy-nine children from 8 to 10 years old participated in the study. From the results, we observed that the different characteristics (screen size and weight) of the devices did not influence the children's acquired knowledge, engagement, satisfaction, ease of use, or AR experience. There was only a statistically significant difference for the global score in which the iPhone was scored higher.We would like to highlight that the scores for the two devices and for all the questions were very high with means of over 4 (on a scale from 1 to 5). These positive results suggest that games of this kind could be appropriate educational games and that the mobile device used may not be a decisive factor. (C)2012 Elsevier Ltd. All rights reserved.This work was funded by the Spanish APRENDRA project (TIN2009-14319-C02). We would like to thank the following for their contributions: The "Escola d'Estiu" and especially Juan Cano, Miguelon Gimenez, and Javier Irimia. This work would not have been possible without their collaboration. Noemi Rando, Encarna Torres, Severino Gonzalez, M. Jose Vicent, Patricia Liminana, Tamara Aguilar, Alfonso Lopez, Yolanda Martinez, Enrique Daunis, M. Jose Martinez, and Eloy Hurtado for their help. The children's parents who signed the agreement to allow their children to participate in the study. The children who participated in the study. The ETSInf for letting us use its facilities during the testing phase.Furió Ferri, D.; González Gancedo, S.; Juan Lizandra, MC.; Seguí, I.; Costa, M. (2013). The effects of the size and weight of a mobile device on an educational game. Computers and Education. 64:24-41. https://doi.org/10.1016/j.compedu.2012.12.015S24416