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Mitochondrial translation is required for sustained killing by cytotoxic T cells.
T cell receptor activation of naïve CD8+ T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an increased reliance on glycolysis upon acquisition of effector function, we found an essential requirement for mitochondria in target cell–killing. Acute mitochondrial depletion in USP30 (ubiquitin carboxyl-terminal hydrolase 30)–deficient CTLs markedly diminished killing capacity, although motility, signaling, and secretion were all intact. Unexpectedly, the mitochondrial requirement was linked to mitochondrial translation, inhibition of which impaired CTL killing. Impaired mitochondrial translation triggered attenuated cytosolic translation, precluded replenishment of secreted killing effectors, and reduced the capacity of CTLs to carry out sustained killing. Thus, mitochondria emerge as a previously unappreciated homeostatic regulator of protein translation required for serial CTL killing
Metastability, negative specific heat and weak mixing in classical long-range many-rotator system
We perform a molecular dynamical study of the isolated classical
Hamiltonian , known to
exhibit a second order phase transition, being disordered for and ordered otherwise ( total energy
and ). We focus
on the nonextensive case and observe that, for , a
basin of attraction exists for the initial conditions for which the system
quickly relaxes onto a longstanding metastable state (whose duration presumably
diverges with like ) which eventually crosses over to the
microcanonical Boltzmann-Gibbs stable state. The temperature associated with
the (scaled) average kinetic energy per particle is lower in the metastable
state than in the stable one. It is exhibited for the first time that the
appropriately scaled maximal Lyapunov exponent
, where, for all values of ,
numerically coincides with {\it one third} of its value for , hence
decreases from 1/9 to zero when increases from zero to unity,
remaining zero thereafter. This new and simple {\it connection between
anomalies above and below the critical point} reinforces the nonextensive
universality scenario.Comment: 9 pages and 4 PS figure
Nonextensivity of the cyclic Lattice Lotka Volterra model
We numerically show that the Lattice Lotka-Volterra model, when realized on a
square lattice support, gives rise to a {\it finite} production, per unit time,
of the nonextensive entropy . This finiteness only occurs for for the growth mode
(growing droplet), and for for the one (growing stripe). This
strong evidence of nonextensivity is consistent with the spontaneous emergence
of local domains of identical particles with fractal boundaries and competing
interactions. Such direct evidence is for the first time exhibited for a
many-body system which, at the mean field level, is conservative.Comment: Latex, 6 pages, 5 figure
Infográficos versus Materiais de Aprendizagem Tradicionais: uma Investigação Empírica
Infográfico é um tipo popular de visualização de informação que utiliza deapelo visual para tornar a transmissão de informação rápida e efetiva. No entanto, ainda existem poucos trabalhos empíricos que investiguem sua interferência no processo de aprendizagem e interação com as características estilos de aprendizagem e satisfação. Nesse contexto, este trabalho teve como objetivo avaliar a eficácia dos infográficos em comparação com os materiais de aprendizagem tradicionais (gráfico e texto). Para isso, foi executado um experimento com 54 alunos de graduação. Os alunos foram distribuídos entre os três tipos de materiais e avaliados em relação ao aprendizado, retenção de conhecimento e satisfação pessoal. Os resultados mostraram que os infográficos foram tão bons para a aprendizagem e retenção de conhecimento quanto os materiais tradicionais
Recent developments in planet migration theory
Planetary migration is the process by which a forming planet undergoes a
drift of its semi-major axis caused by the tidal interaction with its parent
protoplanetary disc. One of the key quantities to assess the migration of
embedded planets is the tidal torque between the disc and planet, which has two
components: the Lindblad torque and the corotation torque. We review the latest
results on both torque components for planets on circular orbits, with a
special emphasis on the various processes that give rise to additional, large
components of the corotation torque, and those contributing to the saturation
of this torque. These additional components of the corotation torque could help
address the shortcomings that have recently been exposed by models of planet
population syntheses. We also review recent results concerning the migration of
giant planets that carve gaps in the disc (type II migration) and the migration
of sub-giant planets that open partial gaps in massive discs (type III
migration).Comment: 52 pages, 18 figures. Review article to be published in "Tidal
effects in Astronomy and Astrophysics", Lecture Notes in Physic
Planetary population synthesis
In stellar astrophysics, the technique of population synthesis has been
successfully used for several decades. For planets, it is in contrast still a
young method which only became important in recent years because of the rapid
increase of the number of known extrasolar planets, and the associated growth
of statistical observational constraints. With planetary population synthesis,
the theory of planet formation and evolution can be put to the test against
these constraints. In this review of planetary population synthesis, we first
briefly list key observational constraints. Then, the work flow in the method
and its two main components are presented, namely global end-to-end models that
predict planetary system properties directly from protoplanetary disk
properties and probability distributions for these initial conditions. An
overview of various population synthesis models in the literature is given. The
sub-models for the physical processes considered in global models are
described: the evolution of the protoplanetary disk, the planets' accretion of
solids and gas, orbital migration, and N-body interactions among concurrently
growing protoplanets. Next, typical population synthesis results are
illustrated in the form of new syntheses obtained with the latest generation of
the Bern model. Planetary formation tracks, the distribution of planets in the
mass-distance and radius-distance plane, the planetary mass function, and the
distributions of planetary radii, semimajor axes, and luminosities are shown,
linked to underlying physical processes, and compared with their observational
counterparts. We finish by highlighting the most important predictions made by
population synthesis models and discuss the lessons learned from these
predictions - both those later observationally confirmed and those rejected.Comment: 47 pages, 12 figures. Invited review accepted for publication in the
'Handbook of Exoplanets', planet formation section, section editor: Ralph
Pudritz, Springer reference works, Juan Antonio Belmonte and Hans Deeg, Ed
High prevalence of methicillin resistance and PVL genes among <i>Staphylococcus aureus</i> isolates from the nares and skin lesions of pediatric patients with atopic dermatitis
Staphylococcus aureus is highly prevalent among patients with atopic dermatitis (AD), and this pathogen may trigger and aggravate AD lesions. The aim of this study was to determine the prevalence of S. aureus in the nares of pediatric subjects and verify the phenotypic and molecular characteristics of the isolates in pediatric patients with AD. Isolates were tested for antimicrobial susceptibility, SCCmec typing, and Panton-Valentine Leukocidin (PVL) genes. Lineages were determined by pulsed-field gel electrophoresis and multilocus sequence typing (MLST). AD severity was assessed with the Scoring Atopic Dermatitis (SCORAD) index. Among 106 patients, 90 (85%) presented S. aureus isolates in their nares, and 8 also presented the pathogen in their skin infections. Two patients had two positive lesions, making a total of 10 S. aureus isolates from skin infections. Methicillin-resistant S. aureus (MRSA) was detected in 24 (26.6%) patients, and PVL genes were identified in 21 (23.3%), including 6 (75%) of the 8 patients with skin lesions but mainly in patients with severe and moderate SCORAD values (P=0.0095). All 24 MRSA isolates were susceptible to trimethoprim/sulfamethoxazole, while 8 isolates had a minimum inhibitory concentration (MIC) to mupirocin >1024 μg/mL. High lineage diversity was found among the isolates including USA1100/ST30, USA400/ST1, USA800/ST5, ST83, ST188, ST718, ST1635, and ST2791. There was a high prevalence of MRSA and PVL genes among the isolates recovered in this study. PVL genes were found mostly among patients with severe and moderate SCORAD values. These findings can help clinicians improve the therapies and strategies for the management of pediatric patients with AD
Extrasolar planet population synthesis IV. Correlations with disk metallicity, mass and lifetime
Context. This is the fourth paper in a series showing the results of planet
population synthesis calculations.
Aims. Our goal in this paper is to systematically study the effects of
important disk properties, namely disk metallicity, mass and lifetime on
fundamental planetary properties.
Methods. For a large number of protoplanetary disks we calculate a population
of planets with our core accretion formation model including planet migration
and disk evolution.
Results. We find a large number of correlations: Regarding the planetary
initial mass function, metallicity, disk mass and disk lifetime have different
roles: For high [Fe/H], giant planets are more frequent. For high disk masses,
giant planets are more massive. For long disk lifetimes, giant planets are both
more frequent and massive. At low metallicities, very massive giant planets
cannot form, but otherwise giant planet mass and metallicity are uncorrelated.
In contrast, planet masses and disk gas masses are correlated. The sweet spot
for giant planet formation is at 5 AU. In- and outside this distance, higher
planetesimals surface densities are necessary. Low metallicities can be
compensated by high disk masses, and vice versa, but not ad infinitum. At low
metallicities, giant planets only form outside the ice line, while at high
metallicities, giant planet formation occurs throughout the disk. The extent of
migration increases with disk mass and lifetime and usually decreases with
metallicity. No clear correlation of metallicity and the semimajor axis of
giant planets exists because in low [Fe/H] disks, planets start further out,
but migrate more, whereas for high [Fe/H] they start further in, but migrate
less. Close-in low mass planets have a lower mean metallicity than Hot
Jupiters.
Conclusions. The properties of protoplanetary disks are decisive for the
properties of planets, and leave many imprints.Comment: 23 pages, 16 figures. Accepted for A&
The `Friction' of Vacuum, and other Fluctuation-Induced Forces
The static Casimir effect describes an attractive force between two
conducting plates, due to quantum fluctuations of the electromagnetic (EM)
field in the intervening space. {\it Thermal fluctuations} of correlated fluids
(such as critical mixtures, super-fluids, liquid crystals, or electrolytes) are
also modified by the boundaries, resulting in finite-size corrections at
criticality, and additional forces that effect wetting and layering phenomena.
Modified fluctuations of the EM field can also account for the `van der Waals'
interaction between conducting spheres, and have analogs in the
fluctuation--induced interactions between inclusions on a membrane. We employ a
path integral formalism to study these phenomena for boundaries of arbitrary
shape. This allows us to examine the many unexpected phenomena of the dynamic
Casimir effect due to moving boundaries. With the inclusion of quantum
fluctuations, the EM vacuum behaves essentially as a complex fluid, and
modifies the motion of objects through it. In particular, from the mechanical
response function of the EM vacuum, we extract a plethora of interesting
results, the most notable being: (i) The effective mass of a plate depends on
its shape, and becomes anisotropic. (ii) There is dissipation and damping of
the motion, again dependent upon shape and direction of motion, due to emission
of photons. (iii) There is a continuous spectrum of resonant cavity modes that
can be excited by the motion of the (neutral) boundaries.Comment: RevTex, 2 ps figures included. The presentation is completely
revised, and new sections are adde
Itineration of the Internet over Nonequilibrium Stationary States in Tsallis Statistics
The cumulative probability distribution of sparseness time interval in the
Internet is studied by the method of data analysis. Round-trip time between a
local host and a destination host through ten odd routers is measured using the
Ping Command, i.e., doing echo experiment. It is found that the data are well
described by the q-exponential destributions, which maximize the Tsallis
entropy indexed by q less or larger than unity. The network is observed to
itinerate over a series of the nonequilibrium stationary states characterized
by Tsallis statistics.Comment: 15 pages, 5 figure
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