Effect of baselevel change on floodplain and fan sediment storage and ephemeral tributary channel morphology, Navarro River, California

Managed baselevel lowering in tributaries that emerge from small canyons onto forested floodplains affects floodplain and fan sediment storage and small ephemeral tributary channel morphology in the Navarro River basin, Mendocino Country, California, USA. Numerous small tributaries (drainage areas up to several square kilometres) flow through culverts under Highway 128 across the forested floodplain of the Navarro River and one of its major tributaries, the North Fork. Excavation significantly deepened and widened these small tributaries upstream and downstream of culverts under the highway following the 1997 flood (recurrence interval 12 years), that inundated both the floodplain and the highway and culvert system. The excavation lowered the local baselevel of the tributary systems within the floodplain. This field study documents the effect of the lowered baselevel on floodplain and fan sediment storage and ephemeral tributary channel morphology. Excavation created defined channels in the floodplain where no channels previously existed. Additionally, the excavation and baselevel change created steps, or knickpoints, that migrated headward and incised the upstream tributary channels. Tributary incision decreases the sediment storage potential of the fan and floodplain and reduces the residence time for storage of fine sediment. A reduction in fine sediment residence time degrades downstream habitat for anadromous fish and other aquatic organisms in the Navarro River. Large wood influences floodplain and small tributary channel morphology by forming steps and increases sediment residence time by trapping sediment in forested tributary-fan-floodplain systems. Although this field investigation is specific to the Navarro River basin, our findings linking culvert maintenance excavation to geomorphic processes may be extended to other roads on forested floodplains in the Pacific Northwest or other systems with roads on floodplains

Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1

To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized llamas were studied via deep sequencing analysis using broadly neutralizing monoclonal HCAbs as a guides. Distinct neutralizing antibody lineages were identified in each animal, including two defined by novel antibodies (as variable regions called VHH) identified by robotic screening of over 6000 clones. The combined application of five VHH against viruses from clades A, B, C and CRF_AG resulted in neutralization as potent as any of the VHH individually and a predicted 100% coverage with a median IC50 of 0.17 µg/ml for the panel of 60 viruses tested. Molecular analysis of the VHH repertoires of two sets of immunized animals showed that each neutralizing lineage was only observed following immunization, demonstrating that they were elicited de novo. Our results show that immunization can induce potent and broadly neutralizing antibodies in llamas with features similar to human antibodies and provide a framework to analyze the effectiveness of immunization protocols

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P <5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.Peer reviewe

Effect of baselevel change on floodplain and fan sediment storage and ephemeral tributary channel morphology, Navarro River, California

Managed baselevel lowering in tributaries that emerge from small canyons onto forested floodplains affects floodplain and fan sediment storage and small ephemeral tributary channel morphology in the Navarro River basin, Mendocino Country, California, USA. Numerous small tributaries (drainage areas up to several square kilometres) flow through culverts under Highway 128 across the forested floodplain of the Navarro River and one of its major tributaries, the North Fork. Excavation significantly deepened and widened these small tributaries upstream and downstream of culverts under the highway following the 1997 flood (recurrence interval 12 years), that inundated both the floodplain and the highway and culvert system. The excavation lowered the local baselevel of the tributary systems within the floodplain. This field study documents the effect of the lowered baselevel on floodplain and fan sediment storage and ephemeral tributary channel morphology. Excavation created defined channels in the floodplain where no channels previously existed. Additionally, the excavation and baselevel change created steps, or knickpoints, that migrated headward and incised the upstream tributary channels. Tributary incision decreases the sediment storage potential of the fan and floodplain and reduces the residence time for storage of fine sediment. A reduction in fine sediment residence time degrades downstream habitat for anadromous fish and other aquatic organisms in the Navarro River. Large wood influences floodplain and small tributary channel morphology by forming steps and increases sediment residence time by trapping sediment in forested tributary-fan-floodplain systems. Although this field investigation is specific to the Navarro River basin, our findings linking culvert maintenance excavation to geomorphic processes may be extended to other roads on forested floodplains in the Pacific Northwest or other systems with roads on floodplains

y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk