Frictional contact analysis in a spherical roller bearing

Numerical analyses of the roller–raceway contact have been carried out in a spherical roller bearing using frictional contact models of different complexity. The models used in the study include an implementation of Kalker’s exact contact theory named CECT (Conformal Exact Contact Theory) and detailed Finite Element models. The adequacy of the more simplified contact solutions is assessed by contrasting them with the solutions obtained with the more comprehensive models. Additionally, the use of the exact contact theory, well known in the wheel–rail application, is demonstrated in contact mechanics analyses in rolling bearings, describing relevant details of its implementation for this application. Situations with different normal loads and friction levels have been analysed, and two distinct steady equilibrium configurations of the roller have been identified.J.B.-L., J.S., and E.G.V. gratefully acknowledge financial support from the European Horizon 2020 Joint Technology Initiative Shift2Rail through contracts 826255 and 101012456 (IN2TRACK2 and IN2TRACK3), from the Spanish Research Ministry MICINN/Economy and Competitiveness Ministry MINECO and MCI/AEI through contract PID2019-109483RB-I00, including funding by the FEDER-ERDF European Regional Development Fund, and from the Basque Government through IT1764-22

On the origin of the Galactic thin and thick discs, their abundance gradients and the diagnostic potential of their abundance ratios

Using a semi-analytical model of the evolution of the Milky Way, we show how secular evolution can create distinct overdensities in the phase space of various properties (e.g. age vs metallicity or abundance ratios vs age) corresponding to the thin and thick discs. In particular, we show how key properties of the Solar vicinity can be obtained by secular evolution, with no need for external or special events, like galaxy mergers or paucity in star formation. This concerns the long established double-branch behaviour of [alpha/Fe] vs metallicity and the recently found non-monotonic evolution of the stellar abundance gradient, evaluated at the birth radii of stars. We extend the discussion to other abundance ratios and we suggest a classification scheme, based on the nature of the corresponding yields (primary vs secondary or odd elements) and on the lifetimes of their sources (short-lived vs long-lived ones). The latter property is critical in determining the single- or double- branch behavior of an elementary abundance ratio in the Solar neighborhood. We underline the high diagnostic potential of this finding, which can help to separate clearly elements with sources evolving on different timescales and help determining the site of e.g. the r-process(es). We define the "abundance distance" between the thin and thick disc sequences as an important element for such a separation. We also show how the inside-out evolution of the Milky Way disc leads rather to a single-branch behavior in other disc regions.Comment: 20 pages, 16 figures, to appear in MNRA

Testing the Parentâ Adolescent Acculturation Discrepancy Hypothesis: A Fiveâ Wave Longitudinal Study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134121/1/jora12214.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134121/2/jora12214_am.pd

Evaluación de la conformidad. Proceso de certificación de los rones de Azcuba

La tradición en el cultivo de la caña de azúcar, cuenta con características y calidad que emanan de las condiciones geográficas y que en su conjunto proporcionan atributos organolépticos (es decir, que pueden ser percibidos a través de los sentidos) a los productos que derivan de ella Hoy más que nunca, la sociedad siente preocupaciones por los productos que compran en la medida que son diseñados, producidos, distribuidos y utilizados y los mercados insisten en diferenciar los productos, atendiendo a nuevos valores asociados al consumo. La industria del ron en AZCUBA, viene dando pasos firmes en lograr que sus productos sean reconocidos y para ello las empresas están trabajando en documentar, implementar y mantener sistemas de gestión de calidad que aseguren la conformidad de sus productos, que conjuntamente con el ensayo de tipo del producto a certificar, que deben ser realizados en laboratorios que cumplan los requisitos de competencia establecidos en la norma NC-ISO/IEC 17025:06 (2006), constituyen las dos evaluaciones cuyos resultados satisfactorios le permiten a dicho producto obtener la Marca Cubana de Conformidad. El objetivo de este trabajo, es que sirva de guía y orientación a aquellos productores que aún no han logrado la certificación de sus productos.Fil: Vasallo Sordo, M.C. Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar; Cuba.Fil: Blanco Carbajal, I. Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar; Cuba.Fil: Vega Batista, M. Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar; Cuba.Fil: Linares Reyes, A. Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar; Cuba.Fil: Lorenzo Izquierdo, M. Instituto Cubano de Investigaciones de los Derivados de la Caña de Azúcar; Cuba.Fil: Faillaci, S.M. Universidad Nacional de Córdoba. Instituto Superior de Estudios Ambientales; Argentina.Fil: Faillaci, S.M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Ciencia y Tecnología de los Alimentos; Argentina.Fil: Giordano, Jesús E. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Ciencia y Tecnología de los Alimentos; Argentina.Otras Ingenierías y Tecnología

Ozone Eliminates SARS-CoV-2 from Difficult-to-Clean Office Supplies and Clinical Equipment.

Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to cause profound health, economic, and social problems worldwide. The management and disinfection of materials used daily in health centers and common working environments have prompted concerns about the control of coronavirus disease 2019 (COVID-19) infection risk. Ozone is a powerful oxidizing agent that has been widely used in disinfection processes for decades. The aim of this study was to assess the optimal conditions of ozone treatment for the elimination of heat-inactivated SARS-CoV-2 from office supplies (personal computer monitors, keyboards, and computer mice) and clinical equipment (continuous positive airway pressure tubes and personal protective equipment) that are difficult to clean. (2) Methods: The office supplies and clinical equipment were contaminated in an area of 1 cm2 with 1 × 104 viral units of a heat-inactivated SARS-CoV-2 strain, then treated with ozone using two different ozone devices: a specifically designed ozonation chamber (for low–medium ozone concentrations over large volumes) and a clinical ozone generator (for high ozone concentrations over small volumes). SARS-CoV-2 gene detection was carried out using quantitative real-time polymerase chain reaction (RT-qPCR). (3) Results: At high ozone concentrations over small surfaces, the ozone eliminated SARS-CoV-2 RNA in short time periods—i.e., 10 min (at 4000 ppm) or less. The optimum ozone concentration over large volumes was 90 ppm for 120 min in ambient conditions (24 °C and 60–75% relative humidity). (4) Conclusions: This study showed that the appropriate ozone concentration and exposure time eliminated heat-inactivated SARS-CoV-2 RNA from the surfaces of different widely used clinical and office supplies, decreasing their risk of transmission, and improving their reutilization. Ozone may provide an additional tool to control the spread of the COVID-19 pandemic.TRUEInstituto de Salud Carlos III, Madrid, Spain, and by the European Regional Development Funds (FEDER)Fundación Canaria del Instituto de Investigación Sanitaria de Canarias (FIISC), Las PalmasFundación Mapfre Guanarteme, Las PalmasGobierno de Canarias, Las Palmaspu

Longitudinal Trajectories of Family Functioning Among Recent Immigrant Adolescents and Parents: Links With Adolescent and Parent Cultural Stress, Emotional Wellâ Being, and Behavioral Health

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148234/1/cdev12914.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148234/2/cdev12914_am.pd

Influence of family and friend smoking on intentions to smoke and smoking-related attitudes and refusal self-efficacy among 9-10 year old children from deprived neighbourhoods: a cross-sectional study.

BACKGROUND: Smoking often starts in early adolescence and addiction can occur rapidly. For effective smoking prevention there is a need to identify at risk groups of preadolescent children and whether gender-specific intervention components are necessary. This study aimed to examine associations between mother, father, sibling and friend smoking and cognitive vulnerability to smoking among preadolescent children living in deprived neighbourhoods. METHODS: Cross-sectional data was collected from 9-10 year old children (n =1143; 50.7% girls; 85.6% White British) from 43 primary schools in Merseyside, England. Children completed a questionnaire that assessed their smoking-related behaviour, intentions, attitudes, and refusal self-efficacy, as well as parent, sibling and friend smoking. Data for boys and girls were analysed separately using multilevel linear and logistic regression models, adjusting for individual cognitions and school and deprivation level. RESULTS: Compared to girls, boys had lower non-smoking intentions (P = 0.02), refusal self-efficacy (P = 0.04) and were less likely to agree that smoking is 'definitely' bad for health (P < 0.01). Friend smoking was negatively associated with non-smoking intentions in girls (P < 0.01) and boys (P < 0.01), and with refusal self-efficacy in girls (P < 0.01). Sibling smoking was negatively associated with non-smoking intentions in girls (P < 0.01) but a positive association was found in boys (P = 0.02). Boys who had a smoking friend were less likely to 'definitely' believe that the smoke from other people's cigarettes is harmful (OR 0.57, 95% CI: 0.35 to 0.91, P = 0.02). Further, boys with a smoking friend (OR 0.38, 95% CI: 0.21 to 0.69, P < 0.01) or a smoking sibling (OR 0.45, 95% CI: 0.21 to 0.98) were less likely to 'definitely' believe that smoking is bad for health. CONCLUSION: This study indicates that sibling and friend smoking may represent important influences on 9-10 year old children's cognitive vulnerability toward smoking. Whilst some differential findings by gender were observed, these may not be sufficient to warrant separate prevention interventions. However, further research is needed

SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19). Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis. Here, we comprehensively define the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. Finally, NSP8 and NSP9 bind to the 7SL RNA in the signal recognition particle and interfere with protein trafficking to the cell membrane upon infection. Disruption of each of these essential cellular functions acts to suppress the interferon response to viral infection. Our results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses

SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19). Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis. Here, we comprehensively define the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. Finally, NSP8 and NSP9 bind to the 7SL RNA in the signal recognition particle and interfere with protein trafficking to the cell membrane upon infection. Disruption of each of these essential cellular functions acts to suppress the interferon response to viral infection. Our results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.&lt;p&gt;&lt;/p&gt; Methods: Sixty-six non-HLA SNPs showing a P value &#60;10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.&lt;p&gt;&lt;/p&gt; Conclusion: Our results suggest a role of PPARG gene in the development of SSc