5 research outputs found
Association of RT-qPCR Ct Values and Disease Severity among COVID-19 Patients Visiting a Tertiary Care Hospital in Nepal
- Author
- Basu Dev Pandey
- Chet Raj Joshi
- Dhan Kumar Pant
- Guna Raj Awasthi
- Hem Raj Joshi
- Jagadish Joshi
- Kamal Singh Khadka
- Kishor Pandey
- Lok Raj Bhatt
- Om Prakash Joshi
- Pushpa Raj Padhaya
- Ram Prashad Ojha
- Ram Singh Dhami
- Ramesh Shahi
- Sandip Khadka
- Sher Bahadur Kamar
- Shyam Prakash Dumre
- Sita Ram Sapkota
- Sudip Regmi
- Sunil Bahadur Singh
- Yogendra Shah
- Publication venue
- Journal of Pure and Applied Microbiology
- Publication date
- 01/03/2024
- Field of study
COVID-19 pandemic due to SARS-CoV-2 has been one of the major global health issues of this aeon. The aim of this study was to evaluate the association of SARS-CoV-2 cycle threshold (Ct) values with multiple factors among COVID-19 patients visiting a tertiary care hospital in Sudurpashchim province of Nepal. A retrospective analysis was performed on the data of randomly selected COVID-19 cases among the total RT-qPCR tested patients from March 2020 to April 2022. The Ct values at the time of patient admission and their clinical outcomes (discharge or death) were compared. Among the COVID-19 patients, survivor group had significantly higher initial Ct value compared to non-survivors [median Ct values 23.21 and 24.39 (P < 0.0001)]. Selected haematological parameters; white blood cells (P<001), neutrophils (P<001), and monocytes (P<0.0001), and all the biochemical parameters were significantly different between these two groups (p < 0.005). Furthermore, significantly increased CRP (61.54±63.00, P<0.0017), D-dimer levels (0.8979± 1.480, P<0.0001), creatinine (0.7931±0.2551, P<0.0001), monocytes (0.6782±0.7981, P<0.0001), and random blood sugar (152.4±34.32, P<0.0001) were observed among non-survivors indicating as cause of disease severity in COVID-19. The findings of this study imply that the Ct value, CRP and D-dimer levels could be a crucial marker for the early detection of severe COVID-19 patients or those at higher risk of developing severe disease. This will eventually help to identify cases requiring immediate and critical medical care and reduce mortality
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Possible high risk of transmission of the Nipah virus in South and South East Asia: a review
- Author
- Publication venue
- BMC
- Publication date
- 01/08/2023
- Field of study
Abstract Nipah virus (NiV) is a zoonotic, single-stranded RNA virus from the family Paramyxoviridae, genus Henipavirus. NiV is a biosafety-level-4 pathogen that is mostly spread by Pteropus species, which serve as its natural reservoir host. NiV is one of the major public health challenges in South and South East Asia. However, few molecular studies have been conducted to characterise NiV in a specific region. The main objective of this review is to understand the epidemiology, pathogenesis, molecular surveillance, transmission dynamics, genetic diversity, reservoir host, clinical characteristics, and phylogenetics of NiV. South and South East Asian nations have experienced NiV outbreaks. Phylogenetic analysis confirmed that two primary clades of NiV are in circulation. In humans, NiV causes severe respiratory illness and/or deadly encephalitis. NiV is mainly diagnosed by ELISA along with PCR. Therefore, we recommend that the governments of the region support the One Health approach to reducing the risk of zoonotic disease transmission in their respective countries
Chitin butyrate coated electrospun nylon-6 fibers for biomedical applications
- Author
- Abdalla Abdal-hay
- Aguzzi
- Bhatt
- Bhattarai
- Bhattarai
- Chen
- Chen
- Cheng
- Cheol Sang Kim
- Chivrac
- Cui
- Elsabee
- Eun Kyo Kim
- Gray
- Han Joo Kim
- Hem Raj Pant
- Jayakumar
- Jayakumar
- Jeong In Kim
- K.S. Hui
- Khor
- Kim
- Koh
- Lee
- Lok Ranjan Bhatt
- Mahesh Kumar Joshi
- Ojha
- Pant
- Pant
- Pant
- Pant
- Pant
- Pant
- Pant
- Pant
- Park
- Pillai
- Ray
- Sanchez
- Sionkowska
- Springer
- Wang
- Wang
- Yang
- Yoo
- Zhang
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/11/2013
- Field of study
In this study, we describe the preparation and characterizations of chitin butyrate (CB) coated nylon-6 nanofibers using single-spinneret electrospinning of blends solution. The physicochemical properties of nylon-6 composite fibers with different proportions of CB to nylon-6 were determined using FE-SEM, TEM, FT-IR spectroscopy, and water contact angle measurement. FE-SEM and TEM images revealed that the nylon-6 and CB were immiscible in the as-spun nanofibers, and phase separated nanofiber morphology becomes more pronounced with increasing amounts of CB. The bone formation ability of composite fibers was evaluated by incubating in biomimetic simulated body fluid. In order to assay the cytocompatibility and cell behavior on the composite scaffolds, osteoblast cells were seeded on the matrix. Results suggest that the deposition of CB layer on the surface of nylon-6 could increase its cell compatibility and bone formation ability. Therefore, as-synthesized nanocomposite fibrous mat has great potentiality in hard tissue engineering
Antiviral drug discovery: broad-spectrum drugs from nature
- Author
- A. Meyerhans
- Abdel-Mageed
- Abdool Karim
- Ahlquist
- Ahmed
- Alexandre
- Allison
- Amet
- Arhel
- Baccala
- Baccam
- Back
- Bacon
- Bader
- Bahr
- Baize
- Barbier
- Barbier
- Barlow
- Barreiro
- Barrientos
- Barton
- Bauer
- BaumgÀrtel
- Beinhardt
- Belov
- Berenguer
- Bergmann
- Bergmann
- Bergmann
- Bhatt
- Bienkowska-Haba
- Bissig
- Blaising
- Blanc
- Blunt
- Bolmstedt
- Bose
- Boyd
- Breman
- Bridges
- Burger
- Butler
- Butler
- Buzzini
- Cahn
- Capon
- Carlton
- Carroll
- Chang
- Chang
- Chang
- Chapuis
- Chatterji
- Chauvin
- Chazal
- Cheung
- Chokshi
- Chu
- Chukkapalli
- Chung
- Clardy
- Cline
- Clouser
- Colonna
- Cureton
- Cutignano
- Damaso
- Damaso
- Darnall
- Davis
- de Chassey
- De Clercq
- De Clercq
- de Lemos
- de Wilde
- del Real
- Delang
- den Boon
- Diamond
- Diamond
- Diez
- Dixon
- Duggal
- Dunigan
- Duong
- Durantel
- Emau
- Endo
- F. Sasse
- Fedson
- Feld
- Feng
- Ferir
- Franklin
- Furuta
- FĂ©rir
- FĂ©rir
- Gallay
- GalĂĄn
- Ganz
- Garcia-Rivera
- Garcia-Sastre
- Gentzsch
- GiguĂšre
- Gong
- Gowen
- Gray
- Greber
- Gu
- Gubler
- GĂŒrel
- Hagiwara
- Haller
- Haller
- Hamzaoui
- Hancock
- Heaton
- Heaton
- Hedayat
- Helenius
- Helle
- Hemmi
- Henne
- Hennessy
- Henry
- Herfst
- Hinton
- Hoofnagle
- Hossain
- Hsu
- Hu
- Ichiba
- Ikeda
- Ikonen
- Imai
- Ishag
- J. Diez
- J. P. Martinez
- Jacob
- Jones
- Joshi
- Jung
- Kallifatidis
- Kamhi
- Keyes
- Kiser
- Konig
- Koplow
- Kourtis
- Krawczyk
- Kwak
- La Clair
- Lanke
- Larrubia
- Le Blanc
- Lin
- Lin
- Lin
- Liu
- Lok
- Luban
- M. Brönstrup
- Ma-Lauer
- Maasoumy
- Manns
- Margolis
- Martin
- Martinez
- Martinez
- MartĂnez-Gutierrez
- Matos
- Matsuda
- McDonald
- McLaren
- Meindl
- Melikian
- Membreno
- Merler
- Meuleman
- Montanuy
- Moore
- Mori
- Morrey
- Moulaei
- MĂŒller
- MĂŒller
- Nagy
- Nakashima
- Negredo
- Newman
- Newman
- Neyts
- Nieva
- Nigro
- Nishimura
- Nixon
- O'Hagan
- O'Keefe
- O'Keefe
- Operskalski
- Pan
- Pasqual
- Pazgier
- Peel
- Peng
- Perry
- Perry
- Pfefferle
- Qu
- Radtke
- Raj
- Rajendran
- Rathore
- Rehwinkel
- Reiss
- Rey
- Roja
- Rosen
- Sadanari
- Sagar
- Sahl
- Saito
- Salvador
- Sample
- Sarma
- Sasaki
- Scalbert
- Scheidel
- Scheller
- Schmitt
- Schoggins
- Schowalter
- SchÀberle
- Sessions
- Shaw
- Sheldon
- Silva-Ayala
- Silverman Kitchin
- Smee
- Smee
- Smee
- Sorbera
- Stadler
- Sun
- Sunkara
- Sunkara
- Tanaka
- Taylor
- Taylor
- Taylor
- Terlou
- Tsai
- Tsai
- Tseng
- Uyeki
- Vahlne
- van der Schaar
- van Heeswijk
- van Riel
- Verheije
- Viehrig
- Vieira
- Votteler
- Wang
- Wang
- Wardrop
- Warren
- Watanabe
- Watashi
- Watterson
- Weissman
- Whitby
- Whitby
- Willey
- Wilson
- Wu
- Wyles
- Xu
- Yan
- Yang
- Yap
- Yasuhara-Bell
- Ye
- Yeung
- Yousaf
- Yu
- Zasloff
- Zeisel
- Zhou
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2015
- Field of study