Processo de registo e depósito de dissertações no Politécnico de Leiria

A presente apresentação pretende descrever o processo de implementação do registo no Renates e depósito no Repositório IC-Online das dissertações de mestrado aprovadas no Instituto Politécnico de Leiria, na sequência da entrada em vigor do Decreto-Lei n.º 115/2013 de 7 de agosto. Após uma fase inicial de planeamento que envolveu vários serviços do Politécnico de Leiria, foi aprovado e implementado um processo de workflow que permitiu a agilização de todo o trabalho. Dois anos depois, o balanço deste processo é bastante positivo, uma vez que em três Escolas Superiores o trabalho retrospetivo se encontra totalmente concluído e, nas duas restantes, se prevê que fique concluído até final de 2018.info:eu-repo/semantics/publishedVersio

Bibliotecas do Instituto Politécnico de Leiria : espaços da comunicação

Uma Biblioteca que se encontra ao serviço de comunidades que lidam por natureza com a inovação e o empreendedorismo não pode alhear-se dessa realidade e tem que investir em novos procedimentos e novos serviços, adequados aos públicos-alvo que pretende atrair e envolver. A forma e os meios usados na comunicação com o público que se pretende atrair ditam o índice de capacidade de um serviço de envolver os seus públicos-alvo (...

SISTEMA DE REPRESENTAÇÕES SOCIAIS SOBRE O FUTURO DE JOVENS

From the future category, youth oriented the research. In order to analyze the social representations about the future and youth, we sought to identify the structure of the representations; central and peripheral elements related to social practices. Questionnaires were applied with 129 Senac-GO students, processed by SPSS and Iramuteq software and submitted to descriptive and similitude statistics analysis. It can be concluded that the system of social representations of young people about the future is constituted based on historical conditions that perpetuate an unequal reality.   Keywords: System of Social Representation, Future, Youth.A juventude, a partir da categoria futuro orientou a investigação. Com o objetivo de analisar as representações sociais sobre o futuro e juventude, buscou-se identificar a estrutura das representações; levantar elementos centrais e periféricos relacionados às práticas sociais. Foi realizada a aplicação de questionários com 129 estudantes do Senac-GO, processados pelos softwares SPSS e Iramuteq e submetidos à análise de estatística descritiva e de similitude. Conclui-se que o sistema de representações sociais dos jovens sobre o futuro é constituído a partir de condições históricas que perpetuam uma realidade desigual

CARACTERÍSTICAS Y PERCEPCIÓN DE LOS GRADUADOS DE LA CARRERA DE PSICOLOGÍA CLÍNICA

In order to know the characteristics and the perception that the graduates have during their professional training at the Technical University of Babahoyo, in relation to the skills acquired and the demands in the labor market, a follow-up process was carried out on the graduates. of the Clinical Psychology Career of the Faculty of Social Legal Sciences and Education of the academic period November 2020 - March 2021. For this purpose, non-experimental research was used, with a descriptive design, through the use of the diagnostic survey SAG00 that was applied to 58 graduates, through the Graduate Monitoring System. It was established that the highest percentage of graduates are female (70.69%) and 37.93% are from the Babahoyo Canton, where 70.69% belong to the urban area and 29.31% belong to the rural zone. 91.38% are satisfied with having developed several general skills, 98.27% feel satisfied with the teaching staff for the ability to articulate theory with professional practice. In relation to the employment situation, 98.28% of the graduates are unemployed. 81.03% feel emotionally identified with the institution. Regarding accessibility to academic and health spaces, 32.76% consider it to be unsatisfactory, 51.72% consider it to be satisfactory and 15.51% consider it to be very satisfactory. The results described in this study are a fundamental basis for the decision-making process.Con el objetivo de conocer las características y la percepción que tienen los graduados durante su formación profesional en la Universidad Técnica de Babahoyo, en relación a las competencias adquiridas y las demandas en el mercado laboral, se llevó a cabo un proceso de Seguimiento a los graduados de la Carrera de Psicología Clínica de la Facultad de Ciencias Jurídicas Sociales y de la Educación del periodo académico noviembre 2020 – marzo 2021. Para este efecto se empleó una investigación de tipo no experimental, con un diseño de carácter descriptivo, mediante el empleo de la encuesta de diagnóstico SAG00 que fue aplicada 58 graduados, a través del Sistema de Seguimiento a Graduados. Se estableció que el mayor porcentaje de graduados son del sexo femenino (70,69%) y el 37,93%, son del Cantón Babahoyo, donde el 70,69% pertenecen a la zona urbana y el 29,31% pertenecen a la zona rural. El 91,38% esta satisfecho por haber desarrollado varias competencias generales, el  98,27% se siente satisfecho con el cuerpo docente por la capacidad para articular la teoría con la práctica profesional. En relacion a la situacion laboral, el 98,28% de los graduados se encuentran desempleados. El 81,03% se siente identificados afectivamente con la institución. Sobre la accesibilidad a los espacios académicos y sanitarios, el 32,76% considera que es poco satisfactorio, el 51,72% considera que es satisfactorio y el 15,51% considera que es muy satisfactorio. Los resultados descritos en este estudio, son base fundamental para el proceso de toma de decisiones

Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model

Stroke is the most common cause of motor disabilities and is a major cause of mortality worldwide. Adult stem cells have been shown to be effective against neuronal degeneration through mechanisms that include both the recovery of neurotransmitter activity and a decrease in apoptosis and oxidative stress. We chose the lineage stroke-prone spontaneously hypertensive rat (SHRSP) as a model for stem cell therapy. SHRSP rats can develop such severe hypertension that they generally suffer a stroke at approximately 1 year of age. the aim of this study was to evaluate whether mesenchymal stem cells (MSCs) decrease apoptotic death and oxidative stress in existing SHRSP brain tissue. the results of qRT-PCR assays showed higher levels of the antiapoptotic BcI-2 gene in the MSC-treated animals, compared with untreated. Our study also showed that superoxide, apoptotic cells, and by-products of lipid peroxidation decreased in MSC-treated SHRSP to levels similar those found in the animal controls, Wistar Kyoto rats. in addition, we saw a repair of morphological damage at the hippocampal region after MSC transplantation. These data suggest that MSCs have neuroprotective and antioxidant potential in stroke-prone spontaneously hypertensive rats. (c) 2014 the Authors. Published by Elsevier Inc.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Ctr Desenvolvimento Modelos Expt Med & Biol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Morfol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Fisiol, BR-04023062 São Paulo, BrazilUniv Santa Cecilia, Dept Odontol, Santos, SP, BrazilUniversidade Federal de São Paulo, Dept Nefrol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Ctr Desenvolvimento Modelos Expt Med & Biol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Morfol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Fisiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Nefrol, BR-04023062 São Paulo, BrazilFAPESP: 05/60630-1FAPESP: 10/00106-5Web of Scienc

Effects of different exercise intensities on serum interleukins levels

O presente estudo teve como objetivo analisar os efeitos agudos e de curta duração de duas intensidades de exercício aeróbio sobre a concentração circulante de IL-6 e IL-10. Quinze homens jovens fisicamente ativos (21,0 ± 1,9 anos) foram submetidos a duas sessões de exercício (“crossover”): alta intensidade de exercício (AIE)- (80% VO2pico), e baixa intensidade de exercício (BIE)- (40% VO2pico), com intervalo de sete dias (“Wash out”). Amostras de sangue foram coletadas em tubos com EDTA, antes do exercício (basal), imediatamente após o exercício (agudo) e após 2 h de recuperação passiva. As concentrações séricas de IL-6 e IL-10 foram determinadas com a utilização de kits comerciais de ELISA. Os resultados demonstraram elevação aguda da IL- 6, em resposta ao AIE em relação ao BIE (p < 0,05), enquanto que a IL-10 apresentou maior redução sistêmica aguda para BIE em comparação a AIE (p < 0,05). Não houve diferença na variação das citocinas após 2 h do término do exercício. Conclui-se que ambas as sessões agudas de exercício são capazes de modular a concentração circulante destas citocinas, e que a magnitude das alterações são dependentes da intensidade do esforço.The aim of this study was to analyze the acute and short-term effects of high and low exercise intensities on IL-6 and IL-10. Fifteen young healthy physically active males (21.0 ± 1.9 yrs) were submitted to 2 experimental trials (cross-over) with a 7-dais wash-out: high exercise intensity (80% VO2peak) and low exercise intensity (40% VO2peak) session. Blood samples were collected before exercise (baseline), immediately after exercise (acute), and two hours after the end of the exercise session (2 h). IL-6 and IL-10 circulating levels were determinate by ELISA. The results demonstrated an acute increase in IL-6 levels after high intensity compared to low intensity exercise (p < 0.05), however, IL-10 presented an acute decrease in response to low intensity exercise (p < 0.05). No effects were observed after 2 h of recovery from the session. Thus we conclude that acute exercise sessions are able to modulate the circulating levels of the studies cytokines, and the magnitudes of these changes are dependent of the exercise intensity

The role of HLA-G in human pregnancy

Pregnancy in mammals featuring hemochorial placentation introduces a major conflict with the mother's immune system, which is dedicated to repelling invaders bearing foreign DNA and RNA. Numerous and highly sophisticated strategies for preventing mothers from rejecting their genetically different fetus(es) have now been identified. These involve production of novel soluble and membrane-bound molecules by uterine and placental cells. In humans, the placenta-derived molecules include glycoproteins derived from the HLA class Ib gene, HLA-G. Isoforms of HLA-G saturate the maternal-fetal interface and circulate in mothers throughout pregnancy. Uteroplacental immune privilege for the fetus and its associated tissues is believed to result when immune cells encounter HLA-G. Unequivocally demonstration of this concept requires experiments in animal models. Both the monkey and the baboon express molecules that are similar but not identical to HLA-G, and may comprise suitable animal models for establishing a central role for these proteins in pregnancy

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

CK2 represents an oncology target scientifically validated. However, clinical research with inhibitors of the CK2-mediated phosphorylation event is still insufficient to recognize it as a clinically validated target. CIGB-300, an investigational peptide-based drug that targets the phosphoaceptor site, binds to a CK2 substrate array in vitro but mainly to B23/nucleophosmin in vivo. The CIGB-300 proapoptotic effect is preceded by its nucleolar localization, inhibition of the CK2-mediated phosphorylation on B23/nucleophosmin and nucleolar disassembly. Importantly, CIGB-300 shifted a protein array linked to apoptosis, ribosome biogenesis, cell proliferation, glycolisis, and cell motility in proteomic studies which helped to understand its mechanism of action. In the clinical ground, CIGB-300 has proved to be safe and well tolerated in a First-in-Human trial in women with cervical malignancies who also experienced signs of clinical benefit. In a second Phase 1 clinical trial in women with cervical cancer stage IB2/II, the MTD and DLT have been also identified in the clinical setting. Interestingly, in cervical tumors the B23/nucleophosmin protein levels were significantly reduced after CIGB-300 treatment at the nucleus compartment. In addition, expanded use of CIGB-300 in case studies has evidenced antitumor activity when administered as compassional option. Collectively, our data outline important clues on translational and clinical research from this novel peptide-based drug reinforcing its perspectives to treat cancer and paving the way to validate CK2 as a promising target in oncology.Fil: Perea, Silvio E.. Center for Genetic Engineering and Biotechnology; CubaFil: Baladron, Idania. Center for Genetic Engineering and Biotechnology; CubaFil: Garcia, Yanelda. Center for Genetic Engineering and Biotechnology; CubaFil: Perera, Yasser. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Adlin. Center for Genetic Engineering and Biotechnology; CubaFil: Soriano, Jorge L.. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Batista, Noyde. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Palau, Aley. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Hernández, Ignacio. Center for Genetic Engineering and Biotechnology; CubaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Idrian. Center for Genetic Engineering and Biotechnology; CubaFil: Gonzalez, Lidia. Center for Genetic Engineering and Biotechnology; CubaFil: Gil, Jeovanis. Center for Genetic Engineering and Biotechnology; CubaFil: Rodriguez, Arielis. Center for Genetic Engineering and Biotechnology; CubaFil: Solares, Margarita. Center for Genetic Engineering and Biotechnology; CubaFil: Santana, Agueda. Center for Genetic Engineering and Biotechnology; CubaFil: Cruz, Marisol. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Matilde. Center for Genetic Engineering and Biotechnology; CubaFil: Valenzuela, Carmen. Center for Genetic Engineering and Biotechnology; CubaFil: Reyes, Osvaldo. Center for Genetic Engineering and Biotechnology; CubaFil: López Saura, Pedro A.. Center for Genetic Engineering and Biotechnology; CubaFil: González, Carlos A.. Center for Genetic Engineering and Biotechnology; CubaFil: Diaz, Alina. Center for Genetic Engineering and Biotechnology; CubaFil: Castellanos, Lila. Center for Genetic Engineering and Biotechnology; CubaFil: Sanchez, Aniel. Center for Genetic Engineering and Biotechnology; CubaFil: Betancourt, Lazaro. Center for Genetic Engineering and Biotechnology; CubaFil: Besada, Vladimir. Center for Genetic Engineering and Biotechnology; CubaFil: González, Luis J.. Center for Genetic Engineering and Biotechnology; CubaFil: Garay, Hilda. Center for Genetic Engineering and Biotechnology; CubaFil: Gómez, Roberto. Center for Genetic Engineering and Biotechnology; CubaFil: Gomez, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perrin, Phillipe. No especifíca;Fil: Renualt, Jean Yves. No especifíca;Fil: Sigman, Hugo. No especifíca;Fil: Herrera, Luis. Center for Genetic Engineering and Biotechnology; CubaFil: Acevedo, Boris. Center for Genetic Engineering and Biotechnology; Cub

Uma análise crítica das vacinas disponíveis para Sars-cov-2 / A critical analysis of the vaccines available for Sars-cov-2

INTRODUÇÃO: O desenvolvimento e a utilização de vacinas configuram-se de extrema importância para o enfrentamento e para a gestão da crise de saúde mundial devido à causa causada pelo novo Coronavírus. A pandemia impõe aos números desafios de ordem econômica, epidemiológica e, sobretudo, biomédica pela alta transmissibilidade do SARS-CoV-2 e pela gravidade da evolução clínica da doença para sua forma severa. A crise pandêmica tem levado os profissionais à exaustão e os sistemas de saúde em estados quase colapsados em todo o mundo.Além disso, no contexto brasileiro, os impactos da pandemia são ainda mais perceptíveis, pois existe, entre outros fatores, uma dificuldade de disponibilidade de testes diagnóstico para toda a população, o que impede a detecção de casos suspeitos, e o posterior emprego de medidas de propagação da doença. Nesse sentido, uma vacinação - modo de proporcionar uma memória imunológica de longa duração - demonstração-se uma saída eficiente de controle e contenção da disseminação do SARS-CoV-2. Assim, neste artigo buscou-se analisar como vacinas Sinovac, Astrazeneca, Janssen, Pfizer, importantes pelo seu uso ou potencial uso no Brasil, com um formulário de comparador de suas plataformas tecnológicas, segurança, efetivos, entre outros parâmetros.METODOLOGIA: Utilizando-se a base Pubmed e o site clinictrials.gov, foram selecionados 22 artigos a respeito de 13 vacinas desenvolvidas contra Sars-Cov-2. RESULTADOS / DISCUSSÃO: Os estudos têm como objetivo avaliar a produção de resposta imune e a ocorrência de efeitos adversos de componentes vacinais dos tipos: vírus inativado, RNA mensageiro, vetor recombinante e partícula recombinante. Tratam-se de ensaios clínicos randomizados, controlados de fase III, com cegamento, número e idade de participantes variados, que ainda conhecido-se em andamento. CONCLUSÃO: Os estudos sobre vacinas contra coronavírus que verdadeiro sendo realizados alcançados resultados promissores quanto à eficácia e segurança dos agentes imunológicos. No entanto, pesquisas que demandam mais tempo de seguimento e maiores populacionais são exigidos para melhores arquivos.

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe