Fluid phonons and inflaton quanta at the protoinflationary transition

Quantum and thermal fluctuations of an irrotational fluid are studied across the transition regime connecting a protoinflationary phase of decelerated expansion to an accelerated epoch driven by a single inflaton field. The protoinflationary inhomogeneities are suppressed when the transition to the slow roll phase occurs sharply over space-like hypersurfaces of constant energy density. If the transition is delayed, the interaction of the quasi-normal modes related, asymptotically, to fluid phonons and inflaton quanta leads to an enhancement of curvature perturbations. It is shown that the dynamics of the fluctuations across the protoinflationary boundaries is determined by the monotonicity properties of the pump fields controlling the energy transfer between the background geometry and the quasi-normal modes of the fluctuations. After corroborating the analytical arguments with explicit numerical examples, general lessons are drawn on the classification of the protoinflationary transition.Comment: 30 pages, 3 figure

Crossover from Isotropic to Directed Percolation

Percolation clusters are probably the simplest example for scale--invariant structures which either are governed by isotropic scaling--laws (``self--similarity'') or --- as in the case of directed percolation --- may display anisotropic scaling behavior (``self--affinity''). Taking advantage of the fact that both isotropic and directed bond percolation (with one preferred direction) may be mapped onto corresponding variants of (Reggeon) field theory, we discuss the crossover between self--similar and self--affine scaling. This has been a long--standing and yet unsolved problem because it is accompanied by different upper critical dimensions: $d_c^{\rm I} = 6$ for isotropic, and $d_c^{\rm D} = 5$ for directed percolation, respectively. Using a generalized subtraction scheme we show that this crossover may nevertheless be treated consistently within the framework of renormalization group theory. We identify the corresponding crossover exponent, and calculate effective exponents for different length scales and the pair correlation function to one--loop order. Thus we are able to predict at which characteristic anisotropy scale the crossover should occur. The results are subject to direct tests by both computer simulations and experiment. We emphasize the broad range of applicability of the proposed method.Comment: 19 pages, written in RevTeX, 12 figures available upon request (from [email protected] or [email protected]), EF/UCT--94/2, to be published in Phys. Rev. E (May 1994

Transcriptome-Guided Functional Analyses Reveal Novel Biological Properties and Regulatory Hierarchy of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes Crucial for Maturation

Human (h) embryonic stem cells (ESC) represent an unlimited source of cardiomyocytes (CMs); however, these differentiated cells are immature. Thus far, gene profiling studies have been performed with non-purified or non-chamber specific CMs. Here we took a combinatorial approach of using systems biology to guide functional discoveries of novel biological properties of purified hESC-derived ventricular (V) CMs. We profiled the transcriptomes of hESCs, hESC-, fetal (hF) and adult (hA) VCMs, and showed that hESC-VCMs displayed a unique transcriptomic signature. Not only did a detailed comparison between hESC-VCMs and hF-VCMs confirm known expression changes in metabolic and contractile genes, it further revealed novel differences in genes associated with reactive oxygen species (ROS) metabolism, migration and cell cycle, as well as potassium and calcium ion transport. Following these guides, we functionally confirmed that hESC-VCMs expressed IKATP with immature properties, and were accordingly vulnerable to hypoxia/reoxygenation-induced apoptosis. For mechanistic insights, our coexpression and promoter analyses uncovered a novel transcriptional hierarchy involving select transcription factors (GATA4, HAND1, NKX2.5, PPARGC1A and TCF8), and genes involved in contraction, calcium homeostasis and metabolism. These data highlight novel expression and functional differences between hESC-VCMs and their fetal counterparts, and offer insights into the underlying cell developmental state. These findings may lead to mechanism-based methods for in vitro driven maturation. © 2013 Poon et al.published_or_final_versio

Some doubts on the validity of the foreground Galactic contribution subtraction from microwave anisotropies

The Galactic foreground contamination in CMBR anisotropies, especially from the dust component, is not easily separable from the cosmological or extragalactic component. In this paper, some doubts will be raised concerning the validity of the methods used to date to remove Galactic dust emission in order to show that none of them achieves its goal. First, I review the recent bibliography on the topic and discuss critically the methods of foreground subtraction: the cross-correlation with templates, analysis assuming the spectral shape of the Galactic components, the "maximum entropy method", "internal linear combination", and "wavelet-based high resolution fitting of internal templates". Second, I analyse the galactic latitude dependence from WMAP data. The frequency dependence is discussed with the data in the available literature. The result is that all methods of subtracting the Galactic contamination are inaccurate. The galactic latitude dependence analysis or the frequency dependence of the anisotropies in the range 50-250 GHz put a constraint on the maximum Galactic contribution in the power spectrum to be less than a ~10% (68% C. L.) for a ~1 degree scale, and possibly higher for larger scales. The origin of most of the signal in the CMBR anisotropies is not Galactic. In any case, the subtraction of the Galaxy is not accurate enough to allow a "precision Cosmology"; other sources of contamination (extragalactic, solar system) are also present.Comment: 24 pages, 1 figure, accepted to be published in J. Astrophys. Ast

A Massive, Cooling-Flow-Induced Starburst in the Core of a Highly Luminous Galaxy Cluster

In the cores of some galaxy clusters the hot intracluster plasma is dense enough that it should cool radiatively in the cluster's lifetime, leading to continuous "cooling flows" of gas sinking towards the cluster center, yet no such cooling flow has been observed. The low observed star formation rates and cool gas masses for these "cool core" clusters suggest that much of the cooling must be offset by astrophysical feedback to prevent the formation of a runaway cooling flow. Here we report X-ray, optical, and infrared observations of the galaxy cluster SPT-CLJ2344-4243 at z = 0.596. These observations reveal an exceptionally luminous (L_2-10 keV = 8.2 x 10^45 erg/s) galaxy cluster which hosts an extremely strong cooling flow (dM/dt = 3820 +/- 530 Msun/yr). Further, the central galaxy in this cluster appears to be experiencing a massive starburst (740 +/- 160 Msun/yr), which suggests that the feedback source responsible for preventing runaway cooling in nearby cool core clusters may not yet be fully established in SPT-CLJ2344-4243. This large star formation rate implies that a significant fraction of the stars in the central galaxy of this cluster may form via accretion of the intracluster medium, rather than the current picture of central galaxies assembling entirely via mergers.Comment: 11 pages, 3 figures, 1 table. Supplemental material contains 15 additional pages. Published in Natur

Dissidents and God-Talk in the Johannine Epistles

Peer reviewe

The WIRCAM Deep Infrared Cluster Survey I: Groups and Clusters at z > 1.1

We use CFHTLS deep optical data, WIRCam Deep Survey (WIRDS) NIR data and XMM data to identify z>1.1 clusters in the CFHTLS D1 and D4 fields. Counterparts to such clusters can not be identified without deep NIR data and as such the total of =1deg2 of J , H & Ks band imaging provided by WIRDS is an indispensable tool in such work. Using public XMM X-ray data, we identify extended X-ray sources in the two fields. The resulting catalogue of extended X-ray sources was analyzed for optical/NIR counterparts, using a red-sequence algorithm. Redshifts of candidate groups and clusters were estimated using the median photometric redshifts of detected counterparts and where available spectroscopic data. Additionally, we surveyed X-ray point sources for potential group systems at the limit of our detection range in the X-ray data. A catalogue of z > 1.1 cluster candidates in the two fields has been compiled and cluster masses, radii and temperatures have been estimated using the scaling relations. The catalogue consists of 15 z > 1.1 candidates. Three of the detections are previously published extended X-ray sources. Of note is JKSC 041 for which we identify possible structures at z = 0.8, z = 0.96, z = 1.13 and z = 1.49. We also make an independent detection of the massive cluster, XMMXCS J2215.9-1738. We use the z > 1.1 catalogue to compare the cluster number counts in these fields with models based on WMAP 7-year cosmology and find that the models slightly over-predict the observations, whilst at z>1.5 we do not detect any clusters. We note that cluster number counts at z > 1.1 are highly sensitive to the cosmological model, however a significant reduction in present statistical (due to available survey area) and systematic (due to cluster scaling relations) uncertainties is required in order to confidently constrain cosmological parameters using cluster number counts at high redshift.Comment: 22 pages, 22 figures, Accepted 4 August 201

Magnetic fields and Sunyaev-Zel'dovich effect in galaxy clusters

In this work we study the contribution of magnetic fields to the Sunyaev Zeldovich (SZ) effect in the intracluster medium. In particular we calculate the SZ angular power spectrum and the central temperature decrement. The effect of magnetic fields is included in the hydrostatic equilibrium equation by splitting the Lorentz force into two terms one being the force due to magnetic pressure which acts outwards and the other being magnetic tension which acts inwards. A perturbative approach is adopted to solve for the gas density profile for weak magnetic fields (< 4 micro G}). This leads to an enhancement of the gas density in the central regions for nearly radial magnetic field configurations. Previous works had considered the force due to magnetic pressure alone which is the case only for a special set of field configurations. However, we see that there exists possible sets of configurations of ICM magnetic fields where the force due to magnetic tension will dominate. Subsequently, this effect is extrapolated for typical field strengths (~ 10 micro G) and scaling arguments are used to estimate the angular power due to secondary anisotropies at cluster scales. In particular we find that it is possible to explain the excess power reported by CMB experiments like CBI, BIMA, ACBAR at l > 2000 with sigma_8 ~ 0.8 (WMAP 5 year data) for typical cluster magnetic fields. In addition we also see that the magnetic field effect on the SZ temperature decrement is more pronounced for low mass clusters ( ~ 2 keV). Future SZ detections of low mass clusters at few arc second resolution will be able to probe this effect more precisely. Thus, it will be instructive to explore the implications of this model in greater detail in future works.Comment: 20 pages, 8 figure

Children with non-central nervous system tumors treated with platinum-based chemotherapy are at risk for hearing loss and cognitive impairments

BackgroundChildhood cancer survivors (CCS) with chemotherapy induced sensorineural hearing loss (SNHL) are at risk for neurocognitive impairments. The purpose of this study was to determine the relationship between SNHL and cognitive function among CCS.ProcedureInclusion: non-CNS solid tumor diagnosis; history of platinum chemotherapy (cisplatin and/or carboplatin); 8–17 years of age; off anti-cancer treatment for ≥6 months; and English speaking. Exclusion: history of intrathecal chemotherapy, cranial radiation, or baseline neurocognitive disorder. Participants completed the NIH Toolbox Cognition Battery at enrollment. T-tests were used to compare participants with normal hearing to those with hearing loss and the total sample with established Toolbox normative data (mean: 50; SD: 10).ResultsFifty-seven individuals enrolled; 52 completed full cognitive testing. Participants were on average 12.2 years of age and 7.0 years since treatment completion. Twenty-one participants (40%) received cisplatin, 27 (52%) carboplatin, and 4 (8%) received both. Fifteen participants (29%) demonstrated SNHL based on the better ear. CCS, regardless of the presence or absence of SNHL, demonstrated significantly lower mean cognitive skills compared to the normative sample in attention, executive function, language- vocabulary and oral reading, processing speed, and fluid, crystallized and total composite scores (all p &lt; 0.01). Participants with SNHL had significantly lower crystallized composite (vocabulary, oral reading) than those with normal hearing (41.9 vs. 47.2, p &lt; 0.05, Cohen's d = 0.62).ConclusionsCCS at risk for platinum induced hearing loss but without cranial radiation or intrathecal chemotherapy exposure demonstrate impaired cognitive skills and those with SNHL demonstrate lower crystallized composite scores